What is it about?

Blepharospasm is the involuntary and unpredictable spasm of the upper facial muscles, especially around the eyes. It usually involves both eyes and can lead to temporary blindness. Some patients lose confidence in performing activities or working outside because of accidents. These affected patients experience a decreased quality of life and loss of opportunities. We have shown the effect of botulinum toxin treatment in decreasing spasm and improving the quality of life in Thai patients.

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Why is it important?

Botulinum toxin is an effective treatment that improves quality of life and helps patients return to their normal daily activities. We also used the quality-of-life data from this study to conduct an economic analysis, a cost-utility analysis, for national reimbursement for our patients.


Doing this study and writing this article was a great opportunity to co-ordinate nationwide multi-center sites. We try to get the data from multiple part of Thailand, for represent the daily-life-affected blepharospasm patients. Our team's commitment, professionalism, and expertise have been exceptional throughout the entire process, from recruitment to data collection and analysis. I truly appreciate our co-authors efforts and dedication to our shared goal of advancing knowledge and the patient's benefit from national reimbursement.

Parima Hirunwiwatkul
Chulalongkorn University

Read the Original

This page is a summary of: Health-related quality of life of daily-life-affected benign essential blepharospasm: Multi-center observational study, PLoS ONE, March 2023, PLOS,
DOI: 10.1371/journal.pone.0283111.
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