What is it about?

G proteins are critical for cell shape, movement and attachment. Various family members have not been systematically studied in the ocular surface. This is a study which shows the presence of subtypes of G proteins, including less commonly understood members on the surface of the eye.

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Why is it important?

Since many diseases of the ocular surface involve wound healing, which includes the component of epithelial and fibroblast migration, we think that these proteins may be therapeutic targets.

Perspectives

Rho GTPases have untapped potential in the treatment of ocular surface disease which involves aberrant wound healing.

Prof Louis Tong
National University of Singapore

Read the Original

This page is a summary of: Rho GTPases and Regulation of Cell Migration and Polarization in Human Corneal Epithelial Cells, PLoS ONE, October 2013, PLOS, DOI: 10.1371/journal.pone.0077107.
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