What is it about?

Recent advances in the field of next generation sequencing and functional genomics have brought us closer towards unravelling the complexities of tumor microenvironment (tumor heterogeneity) and deregulated signaling cascades responsible for proliferation and survival of tumor cells.

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Why is it important?

Phytochemicals have begun to emerge as potent beneficial substances aimed to target deregulated signaling pathways. Isoflavonoid genistein is an essential phytochemical involved in regulation of key biological processes including those in different types of cancer.

Perspectives

Understanding the pleiotropic potential of genistein to regulate key cellular pathways and development of efficient drug delivery system will bring us a step towards designing better chemotherapeutics.

habilitated doctor, chemist Monica BUTNARIU
Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara

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This page is a summary of: Genistein as a regulator of signaling pathways and microRNAs in different types of cancers, Cancer Cell International, July 2021, Springer Science + Business Media, DOI: 10.1186/s12935-021-02091-8.
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