Determination of fluoxetine

What is it about?

In this study, a simple and sensitive spectrofluorimetric method is presented for the determination of fluoxetine based on the enhancing effect of silver nanoparticles (AgNPs) on the terbium–fluoxetine fluorescence emission. In this study, a simple and sensitive spectrofluorimetric method is presented for the determination of fluoxetine based on the enhancing effect of silver nanoparticles (AgNPs) on the terbium–fluoxetine fluorescence emission. The AgNPs were prepared by a simple reduction method and characterized by UV–Vis spectroscopy and transmission electron microscopy. It was indicated that these AgNPs have a remarkable amplifying effect on the terbium-sensitized fluorescence of fluoxetine. The effects of various parameters such as AgNP and Tb3+ concentration and the pH of the media were investigated. Under obtained optimal conditions, the fluorescence intensity of the terbium–fluoxetine–AgNP system was enhanced linearly by increasing the concen- tration of fluoxetine in the range of 0.008 to 19 mg/L.

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Photo by Christina Victoria Craft on Unsplash

Photo by Christina Victoria Craft on Unsplash

Why is it important?

A fast, economic, simple, sensitive and selective method was developed for the determination of FLX by exploiting of the increasing effect of AgNPs on the fluorescence intensities of its Tb–FLX complex. The reported method showed a wide linear range and better LOD than other recently reported techniques. Furthermore, this method was successfully employed for the quantitative determination of FLX concentrations in different media such as commercial tablet formulations, and human plasma and urine samples with an acceptable recovery and excellent reproducibility.

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