What is it about?

The Fontan operation (FO) is a palliative surgical procedure performed in patients with single ventricle physiology. A progressive deterioration in functional status of patients is observed after FO. Patients suffer from both systolic and diastolic ventricular dysfunction. The aim of the study was to quantify non-invasively the systolic and diastolic function in adult Fontan patients and to assess its effect on exercise tolerance.

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Why is it important?

Our study has demonstrated severe diastolic single ventricle dysfunction by the tissue dopper imaging technique. The ratio of early mitral inflow velocity to early diastolic lateral mitral annulus velocity (E/E') assessed by echocardiography is a powerfull predictor of oxygen uptake and ventilator response in adult patients after Fontan operation.

Perspectives

The results may have implications for the tretment of patients after FO. The detection of single vetricle diastolic dysfunction should stimulate efforts to limit fibrosis progression.

Leszek Drabik
Uniwersytet Jagiellonski w Krakowie

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This page is a summary of: Single ventricle function and exercise tolerance in adult patients after Fontan operation, Acta Cardiologica, April 2014, Taylor & Francis, DOI: 10.1080/ac.69.2.3017296.
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