What is it about?

Magnetic nanoparticles (MNPs) generate heat when exposed to an alternating magnetic field. Consequently, MNPs are used for magnetic fluid hyperthermia (MFH) for cancer treatment, and have been also shown to increase the efficacy of chemotherapy and/or radiation treatment in clinical trials. A downfall of current MFH treatment is the inability to deliver sufficient heat to the tumor due to: insufficient amounts of MNPs, unequal distribution of MNPs throughout the tumor, or heat loss to the surrounding environment. To further the magnetic fluid hyperthermia, we evaluated the ability of 31 commercially available magnetic nanoparticles to heat up in alternating magnetic field and discussed physicochemical properties of nanoparticles which correlate with their high heating efficacies and can be used for targeted synthesis of next-generation MNPs for MFH.

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Why is it important?

Heating efficiencies of magnetic nanoparticles in alternating magnetic field can be quantified by their specific absorption rate (SAR). To facilitate the magnetic fluid hyperthermia research, the SAR calculation methods must be standardized. Our work provides an in-depth analysis of common calculation methods and suggestions on standardization of SAR calculation methods and data presentation.

Perspectives

Science is generalized knowledge and I truly hope that our suggestions on standardization of SAR calculation methods and data presentation will help to combine the collective effort and knowledge of scientists working to advance fluid magnetic hyperthermia for cancer treatment.

Dr. Olena Korotych
University of Tennessee

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This page is a summary of: Evaluation of magnetic nanoparticles for magnetic fluid hyperthermia, International Journal of Hyperthermia, January 2019, Taylor & Francis, DOI: 10.1080/02656736.2019.1628313.
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