What is it about?

Thrombus formation on a PFO closure device can lead to recurrent thromboembolic events but most frequently takes places within the first year after device implantation. In this case, we report on a patient with a delayed mobile thrombus-like mass formation 17 years after device implantation, leading to recurrent transient ischemic attacks.

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Why is it important?

Our case illustrates that device-associated adverse events can occur up to decades after implantation. In contrast to previous cases, histopathologic examination of the excised mass in our case suggested an inflammatory rather than purely thrombotic origin.


Our case illustrates that PFO closure device associated masses seen on TEE are not necessarily thrombotic in nature, as well as demonstrates the need further pathophysiologic and clinical research on the long-term sequelae of intracardiac device implantation.

Arne Ballet
Universiteit Antwerpen

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This page is a summary of: Inflammatory mass formation on a patent foramen ovale closure device seventeen years after implantation, Acta Cardiologica, June 2019, Taylor & Francis, DOI: 10.1080/00015385.2019.1630587.
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