What is it about?
The exposed N-terminal or C-terminal residues of proteins can act as degradation signals (degrons) that are targeted by specific E3 ubiquitin ligases for proteasome-dependent degradation. We discovered a distinct C-degron pathway, termed the Gln/C-degron pathway, in which the B30.2 domain of E3 ubiquitin ligase TRIM7 mediates the recognition of proteins bearing a C-terminal glutamine.
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Why is it important?
We present crystal structures of TRIM7 B30.2 domain bound to various peptides ending with C-terminal glutamine. This advances our understanding of TRIM7 and will facilitate, in particular, studies of its functions, including its role in mammalian responses to viral infections.
Perspectives
I hope this research not only expands our understanding of C-degron pathways, but also sheds light on the future structure-based drug design for targeting proteolysis.
Cheng Dong
Tianjin Medical University
Read the Original
This page is a summary of: C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7, Proceedings of the National Academy of Sciences, July 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2203218119.
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