What is it about?
Cheng-Hsiang Kuo et al. investigated the mechanoregulation of renal tubulogenesis. The authors established an innovative co-axial system comprising atomic force microscopy and confocal microscopy to directly measure biomechanical signals during tube formation. They delineated a previously unexplored mechanism regulating asymmetry cell contractility via the CD29-CXCL1 axis elicited by matrix stiffness.
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Why is it important?
Complex and dynamic interstitial matrix expression has been recently associated with kidney development, suggesting a mechanical cue guiding tubulogenesis from the microenvironment. Various biochemical pathways regulating ureteric bud outgrowth, branching morphogenesis, and nephron generation have been demonstrated. However, how the mechanical cues regulate renal tubulogenesis remains elusive. In this report, we study mechanoregulation on renal tubulogenesis by using a simple cell culture system and an innovative co-axial system to directly depict biomechanics during tubulogenesis. Therefore, we depict a previously unexplored regulation network on renal tubulogenesis.
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This page is a summary of: Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization, Proceedings of the National Academy of Sciences, February 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2315894121.
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