What is it about?
Almost all sequenced eukaryotes have LisH-containing proteins, which range in function from transcriptional regulators to cytoskeletal remodelers. Although this had not been previously characterized as a repression domain, we found repressive function to be conserved across LisH-Helix1 sequences representing over one thousand different eukaryotic proteins.
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Why is it important?
This work suggests the existence of a novel conserved mechanism for transcriptional repression. Many LisH-containing proteins previously unrecognized as having roles in transcriptional regulation might be repressors in their native contexts. From a synthetic biology perspective, this is the smallest autonomous repression motif described, and can be used as a repressive tag in eukaryotes.
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This page is a summary of: A single helix repression domain is functional across diverse eukaryotes, Proceedings of the National Academy of Sciences, October 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2206986119.
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