What is it about?

A gene drive system based on Cas9 endonuclease and guide RNA (gRNA) biology was developed for population modification of the African malaria vector mosquito, Anopheles gambiae. It serves as the basis for technologies to introduce rapidly and effectively parasite-resistance genes into this species to prevent parasite transmission.

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Why is it important?

This system is the most efficient one developed for mosquito population modification.

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This page is a summary of: Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae, Proceedings of the National Academy of Sciences, August 2020, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2010214117.
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