What is it about?
Vitamin C is an essential nutrient and lack of Vitamin C causes scurvy, a health problem with a range of issues including problems with bone homeostasis, loss of bone in the jaw and loose teeth. Vitamin C is also the active ingredient of biological mixtures that mediate differentiation of mesenchymal stem cells into bone forming cells (osteoblasts). This study shows that Vitamin C works in bone forming cells by modifying DNA and proteins that control expression of genes that encode bone specific proteins.
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Why is it important?
Vitamin C deficiency and scurvy symptoms still occur in groups of people that differ in demographics, behaviors and/or environmental conditions. The role of Vitamin C in skeletal health has been linked to a requirement for the assembly of collagen fibers that form the molecular scaffolds for mineralization of bones. The study shows that another very important function of Vitamin C is to support biosynthesis of non-collagenous proteins that mediate biomineralization of collagen. This new mechanistic insight provides a new concept for understanding bone formation and bone healing after injury.
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This page is a summary of: Vitamin C epigenetically controls osteogenesis and bone mineralization, Nature Communications, October 2022, Springer Science + Business Media, DOI: 10.1038/s41467-022-32915-8.
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