What is it about?
We present a technology to render cellulose-based dressings antimicrobial. The core component is a fusion of a protein that binds very well to cellulose with a peptide that can kill bacteria or amper their proliferation. We focused on the modification of hydrogels, paper, and microfibrillated cellulose (MFC) with fusions of the CBM3 from Clostridium thermocellum with derivatives of the antimicrobial hexapeptide MP196. The CBM3-MP196-modified materials displayed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus that was significantly higher when compared with the activity of materials prepared by physical adsorption of MP196.
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Why is it important?
The emergence of antibiotic-resistant bacteria is a critical worldwide healthcare problem. In the specific case of wound care, new and effective alternatives to currently available solutions are urgently needed. Cellulose-based dressings, for example, could be made more attractive if rendered antimicrobial.
Read the Original
This page is a summary of: Fusions of a carbohydrate binding module with the small cationic hexapeptide RWRWRW confer antimicrobial properties to cellulose-based materials, Acta Biomaterialia, March 2022, Elsevier, DOI: 10.1016/j.actbio.2022.02.042.
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News of the project CBM-X: Biorecognition as a Tool for the Functionalization of Cellulose-based Materials
Collection of short news related to the project "CBM-X: Biorecognition as a Tool for the Functionalization of Cellulose-based Materials with Biomolecules and Nanostructures", funded by FCT (2017 Call for SR&TD Project Grants). The goal of CBM-X is to develop biomolecular constructs for the precise modification of cellulose matrices with nanostructures and/or biomolecules, and for the anchoring of nanocellulose onto a range of materials.
Biorecognition as a tool for the functionalization of cellulose
A brief overview of my research on the use of carbohydrate binding modules as a tool for the functionalization of cellulose-based materials.
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