What is it about?

We present a technology to render cellulose-based dressings antimicrobial. The core component is a fusion of a protein that binds very well to cellulose with a peptide that can kill bacteria or amper their proliferation. We focused on the modification of hydrogels, paper, and microfibrillated cellulose (MFC) with fusions of the CBM3 from Clostridium thermocellum with derivatives of the antimicrobial hexapeptide MP196. The CBM3-MP196-modified materials displayed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus that was significantly higher when compared with the activity of materials prepared by physical adsorption of MP196.

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Why is it important?

The emergence of antibiotic-resistant bacteria is a critical worldwide healthcare problem. In the specific case of wound care, new and effective alternatives to currently available solutions are urgently needed. Cellulose-based dressings, for example, could be made more attractive if rendered antimicrobial.

Read the Original

This page is a summary of: Fusions of a carbohydrate binding module with the small cationic hexapeptide RWRWRW confer antimicrobial properties to cellulose-based materials, Acta Biomaterialia, March 2022, Elsevier, DOI: 10.1016/j.actbio.2022.02.042.
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