What is it about?
Catechyl lignin (C-lignin) is a unique naturally occurring linear homogeneous biopolymer, only exited in several plant seed coats. We used castor seed coats, a solid waste that is rich in unique Catechyl lignin, as starting materials to prepare a series of bioactive molecules.
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Why is it important?
Starting from castor seed coats, annuloline (natural product) and CC-5079 (antitumor) were synthesized using facile and inexpensive reagents in only four- and five-sequence reactions, respectively, thereby demonstrating a superior step-efficiency to that of reported synthetic routes. Almost all atoms in the C-lignin biopolymer were incorporated into the final products owing to the intrinsic structures of naturally occurring C-lignin.
Perspectives
Bioactive molecules produced from C-lignin integrate a low-carbon footprint with high-quality and economical manufacture of pharmaceuticals.
Guoyong Song
Beijing Forestry University
Read the Original
This page is a summary of: Sustainable Production of Bioactive Molecules from C‐Lignin‐Derived Propenylcatechol, ChemSusChem, June 2022, Wiley,
DOI: 10.1002/cssc.202200646.
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