What is it about?

Caspase-3 is an enzyme in cells that help regulate cell health. When activated, it triggers events that end up eradicating the cell. As a result, many cancer drugs are designed to activate caspase-3 in tumor cells to selectively kill these cells and preserve normal cells. Here, we developed an ultrasensitive method to detect caspase-3 induced cell death Our method can be used to visualize the functional status of other diagnostic enzymes. To prevent interference from other cellular events, we used a type of light called near-infrared fluorescence, which is produced by our sensor but not by cells.

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Why is it important?

We hope to use our approach to monitor the response of patients to cancer drugs.

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This page is a summary of: Multifunctional Thio-Stabilized Gold Nanoparticles for Near-Infrared Fluorescence Detection and Imaging of Activated Caspase-3, Current Analytical Chemistry, January 2021, Bentham Science Publishers, DOI: 10.2174/1573411017999210112175743.
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