What is it about?
Caspase-3 is an enzyme in cells that help regulate cell health. When activated, it triggers events that end up eradicating the cell. As a result, many cancer drugs are designed to activate caspase-3 in tumor cells to selectively kill these cells and preserve normal cells. Here, we developed an ultrasensitive method to detect caspase-3 induced cell death Our method can be used to visualize the functional status of other diagnostic enzymes. To prevent interference from other cellular events, we used a type of light called near-infrared fluorescence, which is produced by our sensor but not by cells.
Photo by Dušan veverkolog on Unsplash
Why is it important?
We hope to use our approach to monitor the response of patients to cancer drugs.
Read the Original
This page is a summary of: Multifunctional Thio-Stabilized Gold Nanoparticles for Near-Infrared Fluorescence Detection and Imaging of Activated Caspase-3, Current Analytical Chemistry, January 2021, Bentham Science Publishers, DOI: 10.2174/1573411017999210112175743.
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