All Stories

  1. The combination of tetracyclines effectively ameliorates liver fibrosis via inhibition of EphB1/2

    Article • International Immunopharmacology, January 2024, Elsevier

    Prof. Yijun Chen

  2. Selective biosynthesis of a rhamnosyl nosiheptide by a novel bacterial rhamnosyltransferase

    Article • Microbial Biotechnology, January 2024, Wiley

    Prof. Yijun Chen

  3. Constructing Escherichia coli co-display systems for biodegradation of polyethylene terephthalate

    Article • Bioresources and Bioprocessing, December 2023, Springer Science + Business Media

    Prof. Yijun Chen

  4. Design of a chimeric glycosyltransferase OleD for the site‐specific O‐monoglycosylation of 3‐hydroxypyridine in nosiheptide

    Article • Microbial Biotechnology, August 2023, Wiley

    Prof. Yijun Chen

  5. The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma

    Article • Cell Death and Disease, June 2023, Springer Science + Business Media

    Prof. Yijun Chen

  6. A Type I/Type III PKS Hybrid Generates Cinnamomycin A–D

    Article • Organic Letters, April 2023, American Chemical Society (ACS)

    Prof. Yijun Chen

  7. Efficient snailase-based production of mogrol from Luo Han Guo extract in an aqueous-organic system

    Article • Enzyme and Microbial Technology, April 2023, Elsevier

    Prof. Yijun Chen

  8. Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Prof. Yijun Chen

  9. Enzymatic hydrolyzation of mogrosides in Luo Han Guo extract by NKA-adsorbed snailase improves its sensory profile

    Article • Food Chemistry, October 2022, Elsevier

    Prof. Yijun Chen

  10. MD2 Is a Potential Biomarker Associated with Immune Cell Infiltration in Gliomas

    Article • Frontiers in Oncology, March 2022, Frontiers

    Prof. Yijun Chen

  11. Correction to “Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue”

    Article • ACS Synthetic Biology, March 2022, American Chemical Society (ACS)

    Prof. Yijun Chen

  12. Engineering of a UDP-Glycosyltransferase for the Efficient Whole-Cell Biosynthesis of Siamenoside I in Escherichia coli

    Article • Journal of Agricultural and Food Chemistry, January 2022, American Chemical Society (ACS)

    Prof. Yijun Chen

  13. Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue

    Article • ACS Synthetic Biology, January 2022, American Chemical Society (ACS)

    Prof. Yijun Chen

  14. Selective enzymatic α-1,6- monoglucosylation of mogroside IIIE for the bio-creation of α-siamenoside I, a potential high-intensity sweetener

    Article • Food Chemistry, October 2021, Elsevier

    Prof. Yijun Chen

  15. Efficient whole-cell biosynthesis of l-gulose by coupling mannitol-1-dehydrogenase with NADH oxidase

    Article • Enzyme and Microbial Technology, August 2021, Elsevier

    Prof. Yijun Chen

  16. The interaction of SET and protein phosphatase 2A as target for cancer therapy

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, August 2021, Elsevier

    Prof. Yijun Chen

  17. Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats

    Article • Drug Design Development and Therapy, August 2021, Taylor & Francis

    Prof. Yijun Chen

  18. Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers

    Article • Scientific Reports, April 2021, Springer Science + Business Media

    Prof. Yijun Chen

  19. Enzymatic Monoglucosylation of Rubusoside and the Structure–Sweetness/Taste Relationship of Monoglucosyl Derivatives

    Article • Journal of Agricultural and Food Chemistry, July 2020, American Chemical Society (ACS)

    Prof. Yijun Chen

  20. Riboflavin Is Directly Involved in N‐Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases

    Article • ChemBioChem, April 2020, Wiley

    Prof. Yijun Chen

  21. Efficient Biocatalytic Preparation of Rebaudioside KA: Highly Selective Glycosylation Coupled with UDPG Regeneration

    Article • Scientific Reports, April 2020, Springer Science + Business Media

    Prof. Yijun Chen

  22. Identification of a heparosan heptasaccharide as an effective anti-inflammatory agent by partial desulfation of low molecular weight heparin

    Article • Carbohydrate Polymers, January 2020, Elsevier

    Prof. Yijun Chen

  23. Correction to “Bifunctional Fusion Proteins Derived from Tumstatin and 4–1BBL for Targeted Cancer Therapy”

    Article • Molecular Pharmaceutics, November 2019, American Chemical Society (ACS)

    Prof. Yijun Chen

  24. Riboflavin Directly Mediates the Dealkylation by Microbial Cytochrome P450 Monooxygeneses

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Prof. Yijun Chen

  25. Bifunctional Fusion Proteins Derived from Tumstatin and 4-1BBL for Targeted Cancer Therapy

    Article • Molecular Pharmaceutics, December 2018, American Chemical Society (ACS)

    Prof. Yijun Chen

  26. Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells

    Article • Redox Biology, October 2018, Elsevier

    Prof. Yijun Chen

  27. Quantitative Assessment of the Absolute Purity of Thiopeptcin Reference Standard by 1H-NMR

    Article • Analytical Sciences, September 2018, Japan Society for Analytical Chemistry

    Prof. Yijun Chen

  28. Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT

    Article • European Journal of Pharmacology, August 2018, Elsevier

    Prof. Yijun Chen

  29. A novel compound for the treatment of HCC

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Prof. Yijun Chen

  30. On/off photo-switch of heparinase III to prepare LMWH

    Article • Organic Letters, December 2017, American Chemical Society (ACS)

    Prof. Yijun Chen

  31. Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo

    Article • Small, December 2017, Wiley

    Prof. Yijun Chen

  32. The involvement of nosP in the biosynthesis of nosiheptide---a typical thiopeptide

    Article • The FASEB Journal, September 2017, Federation of American Societies For Experimental Biology (FASEB)

    Prof. Yijun Chen

  33. Optimization of critical medium components for enhancing antibacterial thiopeptide nocathiacin I production with significantly improved quality

    Article • Chinese Journal of Natural Medicines, April 2017, Elsevier

    Prof. Yijun Chen

  34. Cooperative down-regulation of ribosomal protein L10 and NF-κB signaling pathway is responsible for the anti-proliferative effects by DMAPT in pancreatic cancer cells

    Article • Oncotarget, March 2017, Impact Journals, LLC

    Prof. Yijun Chen

  35. Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking

    Article • Journal of Medicinal Chemistry, February 2017, American Chemical Society (ACS)

    Prof. Yijun Chen

  36. Expanding the Catalytic Promiscuity of Heparinase III from Pedobacter heparinus

    Article • Chemistry - A European Journal, January 2017, Wiley

    Prof. Yijun Chen

  37. Rearranged limonoids with unique 6/5/6/5 tetracarbocyclic skeletons from Toona ciliata and biomimetic structure divergence

    Article • Organic Chemistry Frontiers, January 2017, Royal Society of Chemistry

    Prof. Yijun Chen

  38. Mutagenesis of NosM Leader Peptide Reveals Important Elements in Nosiheptide Biosynthesis

    Article • Applied and Environmental Microbiology, December 2016, ASM Journals

    Prof. Yijun Chen

  39. Highly specific quantification of microRNA by coupling probe–rolling circle amplification and Förster resonance energy transfer

    Article • Analytical Biochemistry, June 2016, Elsevier

    Prof. Yijun Chen

  40. Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids fromTrichilia connaroides

    Article • Organic Letters, April 2016, American Chemical Society (ACS)

    Prof. Yijun Chen

  41. Selection of Reference Genes for Gene Expression Normalization in Peucedanum praeruptorum Dunn under Abiotic Stresses, Hormone Treatments and Different Tissues

    Article • PLoS ONE, March 2016, PLOS

    Prof. Yijun Chen

  42. The catalytic characteristics of NocB in nocathiacin biosynthesis from Nocardia sp. ATCC 202099

    Article • RSC Advances, January 2016, Royal Society of Chemistry

    Prof. Yijun Chen

  43. Mutagenesis of precursor peptide for the generation of nosiheptide analogues

    Article • RSC Advances, January 2016, Royal Society of Chemistry

    Prof. Yijun Chen

  44. ChemInform Abstract: Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons from Stahlianthus involucratus.

    Article • ChemInform, January 2016, Wiley

    Prof. Yijun Chen

  45. Integration of a Decrescent Transcriptome and Metabolomics Dataset of Peucedanum praeruptorum to Investigate the CYP450 and MDR Genes Involved in Coumarins Biosynthesis and Transport

    Article • Frontiers in Plant Science, December 2015, Frontiers

    Prof. Yijun Chen

  46. The importance of start codon of nosM in nosiheptide production

    Article • Chinese Journal of Natural Medicines, November 2015, Elsevier

    Prof. Yijun Chen

  47. Involudispirones A and B: Sesterterpenes Containing a Dispiro Ring fromStahlianthus involucratus

    Article • Asian Journal of Organic Chemistry, October 2015, Wiley

    Prof. Yijun Chen

  48. Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons fromStahlianthus involucratus

    Article • Chemistry - A European Journal, July 2015, Wiley

    Prof. Yijun Chen

  49. Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia

    Article • Oncotarget, May 2015, Impact Journals, LLC

    Prof. Yijun Chen

  50. Genetic incorporation of d-amino acids into green fluorescent protein based on polysubstrate specificity

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Prof. Yijun Chen

  51. Isolation and biomimetic synthesis of (±)-calliviminones A and B, two novel Diels–Alder adducts, from Callistemon viminalis

    Article • Tetrahedron Letters, January 2015, Elsevier

    Prof. Yijun Chen

  52. Enzymatic preparation of t-butyl-6-cyano-(3R, 5R)-dihydroxyhexanoate by a whole-cell biocatalyst co-expressing carbonyl reductase and glucose dehydrogenase

    Article • Process Biochemistry, January 2015, Elsevier

    Prof. Yijun Chen

  53. The “Gate Keeper” Role of Trp222 Determines the Enantiopreference of Diketoreductase toward 2-Chloro-1-Phenylethanone

    Article • PLoS ONE, July 2014, PLOS

    Prof. Yijun Chen

  54. Enzymatic synthesis of l-norephedrine by coupling recombinant pyruvate decarboxylase and ω-transaminase

    Article • Applied Microbiology and Biotechnology, May 2014, Springer Science + Business Media

    Prof. Yijun Chen

  55. Microparticle-Based Strategy for Controlled Release of Substrate for the Biocatalytic Preparation ofl-Homophenylalanine

    Article • ACS Catalysis, May 2014, American Chemical Society (ACS)

    Prof. Yijun Chen

  56. Oral Delivery of Exenatide via Microspheres Prepared by Cross-Linking of Alginate and Hyaluronate

    Article • PLoS ONE, January 2014, PLOS

    Prof. Yijun Chen

  57. Efficient access to the non-reducing end of low molecular weight heparin for fluorescent labeling

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Prof. Yijun Chen

  58. Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Prof. Yijun Chen

  59. Multiple Oxidative Routes towards the Maturation of Nosiheptide

    Article • ChemBioChem, August 2013, Wiley

    Prof. Yijun Chen

  60. Enhancement of biocatalytic efficiency by increasing substrate loading: enzymatic preparation of l-homophenylalanine

    Article • Applied Microbiology and Biotechnology, July 2013, Springer Science + Business Media

    Prof. Yijun Chen

  61. Inside Cover: The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation (ChemBioChem 5/2013)

    Article • ChemBioChem, March 2013, Wiley

    Prof. Yijun Chen

  62. The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation

    Article • ChemBioChem, February 2013, Wiley

    Prof. Yijun Chen

  63. Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells

    Article • Toxicology in Vitro, February 2013, Elsevier

    Prof. Yijun Chen

  64. The Apoptotic Effects of Toosendanin Are Partially Mediated by Activation of Deoxycytidine Kinase in HL-60 Cells

    Article • PLoS ONE, December 2012, PLOS

    Prof. Yijun Chen

  65. Functional roles of Tryptophan residues in diketoreductase from Acinetobacter baylyi

    Article • BMB Reports, August 2012, Korean Society for Biochemistry and Molecular Biology - BMB Reports

    Prof. Yijun Chen

  66. Chirality plays critical roles in enhancing the aqueous solubility of nocathiacin I by block copolymer micelles

    Article • Journal of Pharmacy and Pharmacology, July 2012, Wiley

    Prof. Yijun Chen

  67. ChemInform Abstract: Dicarbonyl Reduction by Single Enzyme for the Preparation of Chiral Diols

    Article • ChemInform, May 2012, Wiley

    Prof. Yijun Chen

  68. Genetic incorporation of d-lysine into diketoreductase in Escherichia coli cells

    Article • Amino Acids, May 2012, Springer Science + Business Media

    Prof. Yijun Chen

  69. Identification of important residues in diketoreductase from Acinetobacter baylyi by molecular modeling and site-directed mutagenesis

    Article • Biochimie, February 2012, Elsevier

    Prof. Yijun Chen

  70. One ketoreductase works in two-steps by two active sites

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Prof. Yijun Chen

  71. Dicarbonyl reduction by single enzyme for the preparation of chiral diols

    Article • Chemical Society Reviews, January 2012, Royal Society of Chemistry

    Prof. Yijun Chen

  72. Correlation between Intracellular Cofactor Concentrations and Biocatalytic Efficiency: Coexpression of Diketoreductase and Glucose Dehydrogenase for the Preparation of Chiral Diol for Statin Drugs

    Article • ACS Catalysis, December 2011, American Chemical Society (ACS)

    Prof. Yijun Chen

  73. Soluble expression of recombinant human CD137 ligand in Escherichia coli by co-expression of chaperones

    Article • Journal of Industrial Microbiology & Biotechnology, October 2011, Springer Science + Business Media

    Prof. Yijun Chen

  74. Recombinant human CD137L for cancer immunotherapy: effects of different fusions and linkers on its activity

    Article • Cancer Immunology Immunotherapy, October 2011, Springer Science + Business Media

    Prof. Yijun Chen

  75. Preparation of ethyl 3R,5S-6-(benzyloxy)-3,5-dihydroxy-hexanoate by recombinant diketoreductase in a biphasic system

    Article • Bioresource Technology, February 2011, Elsevier

    Prof. Yijun Chen

  76. Enzymatic Preparation of an (S)-Amino Acid from a Racemic Amino Acid

    Article • Organic Process Research & Development, January 2011, American Chemical Society (ACS)

    Prof. Yijun Chen

  77. Catalytic Effects of Different Heparin Analogs on the Hydrolysis of Auramine O

    Article • Journal of Biomaterials Science Polymer Edition, January 2011, Taylor & Francis

    Prof. Yijun Chen

  78. A simple reverse genetics approach to elucidating the biosynthetic pathway of nocathiacin

    Article • Biotechnology Letters, November 2010, Springer Science + Business Media

    Prof. Yijun Chen

  79. Editorial [Hot topic: Biotransformation in Drug Discovery and Development (Guest Editor: Yijun Chen)]

    Article • Current Organic Chemistry, August 2010, Bentham Science Publishers

    Prof. Yijun Chen

  80. Dehydrogenases/Reductases for the Synthesis of Chiral Pharmaceutical Intermediates

    Article • Current Organic Chemistry, August 2010, Bentham Science Publishers

    Prof. Yijun Chen

  81. Universal Method Facilitating the Amplification of Extremely GC-Rich DNA Fragments from Genomic DNA

    Article • Analytical Chemistry, July 2010, American Chemical Society (ACS)

    Prof. Yijun Chen

  82. Microbial generation of nocathiacin acid from nocathiacin I

    Article • Bioresource Technology, May 2010, Elsevier

    Prof. Yijun Chen

  83. Efficient amplification of genes involved in microbial secondary metabolism by an improved genome walking method

    Article • Applied Microbiology and Biotechnology, April 2010, Springer Science + Business Media

    Prof. Yijun Chen

  84. PhD: routine technical work of sequencing is no substitute

    Article • Nature, April 2010, Springer Science + Business Media

    Prof. Yijun Chen

  85. Separation of structurally similar nocathiacin analogues by reversed phase chromatography

    Article • Journal of Chromatography A, April 2010, Elsevier

    Prof. Yijun Chen

  86. A Bacterial Enzyme Catalyzing Double Reduction of a β,δ-Diketo Ester with Unprecedented Stereoselectivity

    Article • Nature Reports Climate Change, February 2010, Springer Science + Business Media

    Prof. Yijun Chen

  87. A Bacterial Enzyme Catalyzing Double Reduction of a β,δ-Diketo Ester with Unprecedented Stereoselectivity

    Article • Nature Reports Climate Change, February 2010, Springer Science + Business Media

    Prof. Yijun Chen

  88. A diketoreductase exhibits unique renaturation profile from thermal-induced protein unfolding

    Article • Amino Acids, February 2010, Springer Science + Business Media

    Prof. Yijun Chen

  89. Stereoselective introduction of two chiral centers by a single diketoreductase: an efficient biocatalytic route for the synthesis of statin side chains

    Article • Amino Acids, November 2009, Springer Science + Business Media

    Prof. Yijun Chen

  90. Enantioselective synthesis of ethyl (S)-2-hydroxy-4-phenylbutyrate by recombinant diketoreductase

    Article • Tetrahedron Asymmetry, November 2009, Elsevier

    Prof. Yijun Chen

  91. Cloning, expression, and characterization of a novel diketoreductase from Acinetobacter baylyi

    Article • Acta Biochimica et Biophysica Sinica, February 2009, Oxford University Press (OUP)

    Prof. Yijun Chen

  92. Olympics may have a negative impact on China's research

    Article • Nature, August 2008, Springer Science + Business Media

    Prof. Yijun Chen

  93. Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase fromBacillus megaterium

    Article • Advanced Synthesis & Catalysis, June 2008, Wiley

    Prof. Yijun Chen

  94. Determination of enantiomeric excess of ethyl 3,5-dihydroxy-6-benzyloxy hexanoate by chiral reverse phase high performance liquid chromatography

    Article • Chirality, January 2007, Wiley

    Prof. Yijun Chen

  95. A Novel Ketone Derivative of Artemisinin Biotransformed by Streptomyces griseus ATCC 13273.

    Article • ChemInform, July 2006, Wiley

    Prof. Yijun Chen

  96. Synthesis of ethyl and t-butyl (3R,5S)-dihydroxy-6-benzyloxy hexanoates via diastereo- and enantioselective microbial reduction

    Article • Tetrahedron Asymmetry, June 2006, Elsevier

    Prof. Yijun Chen

  97. A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273

    Article • Bioorganic & Medicinal Chemistry Letters, April 2006, Elsevier

    Prof. Yijun Chen

  98. Purification, cloning, and functional expression of phenylalanine aminomutase: The first committed step in Taxol side-chain biosynthesis

    Article • Archives of Biochemistry and Biophysics, June 2005, Elsevier

    Prof. Yijun Chen

  99. Core-modified sordaricin derivatives: Synthesis and antifungal activity

    Article • Bioorganic & Medicinal Chemistry Letters, December 2002, Elsevier

    Prof. Yijun Chen

  100. Sordarin Oxazepine Derivatives as Potent Antifungal Agents

    Article • Bioorganic & Medicinal Chemistry Letters, October 2002, Elsevier

    Prof. Yijun Chen

  101. Chemical Protein Synthesis by Solid Phase Ligation of Unprotected Peptide Segments

    Article • Journal of the American Chemical Society, September 1999, American Chemical Society (ACS)

    Prof. Yijun Chen

  102. Group-Specific Assays That Distinguish between the Four Major Types of Mammalian Phospholipase A2

    Article • Analytical Biochemistry, May 1999, Elsevier

    Prof. Yijun Chen

  103. Expression and characterization of human group V phospholipase A2

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, October 1998, Elsevier

    Prof. Yijun Chen

  104. Microbial models of soil metabolism: biotransformations of danofloxacin

    Article • Journal of Industrial Microbiology & Biotechnology, November 1997, Springer Science + Business Media

    Prof. Yijun Chen

  105. Oligopeptides as Substrates and Inhibitors for a New Constitutive Nitric Oxide Synthase from Rat Cerebellum

    Article • Biochemical and Biophysical Research Communications, July 1996, Elsevier

    Prof. Yijun Chen

  106. Purification and characterization of nitric oxide synthase (NOSNoc) from a Nocardia species.

    Article • Journal of Bacteriology, January 1995, ASM Journals

    Prof. Yijun Chen

  107. A Bacterial, Nitric Oxide Synthase from a Nocardia Species

    Article • Biochemical and Biophysical Research Communications, September 1994, Elsevier

    Prof. Yijun Chen

  108. Effects of Antiglaucoma Drugs on Ocular Blood Flow in Ocular Hypertensive Rabbits

    Article • Journal of Ocular Pharmacology and Therapeutics, January 1993, Mary Ann Liebert Inc

    Prof. Yijun Chen

  109. Effects of Dopamine Agonist, Bromocriptine, and Some Dopamine Antagonists on Ocular Blood Flow

    Article • Journal of Ocular Pharmacology and Therapeutics, January 1992, Mary Ann Liebert Inc

    Prof. Yijun Chen

  110. Enhancement of systemic delivery of peptide drugs via ocular route with surfactants

    Article • Drug Development Research, January 1992, Wiley

    Prof. Yijun Chen

  111. Effects of D- and L-Isomers of Timolol on Retinal and Choroidal Blood Flow in Ocular Hypertensive Rabbit Eyes

    Article • Journal of Ocular Pharmacology and Therapeutics, January 1992, Mary Ann Liebert Inc

    Prof. Yijun Chen