What is it about?
The mechanism of a unique reduction catalyzed by a single ketoreductase, in which the proton transfer in the two-step process is catalyzed by two active sites, and the stereochemistry of respective reductions is amazingly orchestrated by the enzyme.
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Why is it important?
The stereoselective production of two chiral hydroxyl groups involves two active sites in a single enzyme.
Perspectives
Nature empowers such unprecedented and surprised reactions, which offers a new type of templates for enzyme engineering. I think we should fully take the advantages of nature's giving, while appreciate the great efforts from mankind. With the understanding of catalytic mechanism, construction of an active packet containing multiple active sites for efficient electron transfer will become possible and feasible for cascaded reactions to produce complex and valuable compounds. I hope you find this article informative and useful with regard to the discovery of new enzymes and new reactions.
Prof. Yijun Chen
China Pharmaceutical University
Read the Original
This page is a summary of: Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase, Chemical Communications, January 2012, Royal Society of Chemistry,
DOI: 10.1039/c2cc36334h.
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