All Stories

  1. Diazaborines as New Inhibitors of Human Neutrophil Elastase

    Article • ACS Omega, July 2018, American Chemical Society (ACS)

    Rui Moreira

  2. Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2018, Elsevier

    Rui Moreira, Dr Luis F Gouveia

  3. Design of Modular G-quadruplex Ligands

    Article • ChemMedChem, April 2018, Wiley

    Rui Moreira

  4. Drug discovery in tuberculosis. New drug targets and antimycobacterial agents

    Article • European Journal of Medicinal Chemistry, April 2018, Elsevier

    Rui Moreira

  5. Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

    Article • European Journal of Medicinal Chemistry, April 2018, Elsevier

    Rui Moreira

  6. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties

    Article • European Journal of Medicinal Chemistry, November 2017, Elsevier

    Rui Moreira

  7. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation

    Article • ACS Chemical Neuroscience, January 2017, American Chemical Society (ACS)

    Rui Moreira

  8. Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?

    Article • ACS Chemical Neuroscience, October 2016, American Chemical Society (ACS)

    Rui Moreira

  9. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

    Article • ChemMedChem, August 2016, Wiley

    Rui Moreira

  10. Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes

    Article • ChemMedChem, July 2016, Wiley

    Rui Moreira, Dr Jose A Brito

  11. Chemical Variations on the p53 Reactivation Theme

    Article • Pharmaceuticals, May 2016, MDPI AG

    Rui Moreira

  12. Novel squaramides with in vitro liver stage antiplasmodial activity

    Article • Bioorganic & Medicinal Chemistry, April 2016, Elsevier

    Rui Moreira

  13. 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry

    Article • Pharmaceuticals, March 2016, MDPI AG

    Rui Moreira, Teresa Pinho e Melo

  14. Spirooxadiazoline oxindoles with promising in vitro antitumor activities

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Rui Moreira, Maria Santos

  15. Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

    Article • ChemMedChem, November 2015, Wiley

    Rui Moreira

  16. Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking

    Article • Acta Crystallographica Section F Structural Biology Communications, September 2015, International Union of Crystallography

    Rui Moreira, Dr Jose A Brito

  17. Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties

    Article • Journal of Lipid Research, September 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Susana Dias Lucas, Rui Moreira

  18. Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

    Article • European Journal of Medicinal Chemistry, September 2015, Elsevier

    Rui Moreira

  19. From hybrid compounds to targeted drug delivery in antimalarial therapy

    Article • Bioorganic & Medicinal Chemistry, August 2015, Elsevier

    Rui Moreira

  20. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

    Article • PLoS ONE, May 2015, PLOS

    Rui Moreira, Ana Francisco

  21. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

    Article • Scientific Reports, April 2015, Nature

    Rui Moreira

  22. N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity

    Article • Bioorganic & Medicinal Chemistry, April 2015, Elsevier

    Rui Moreira

  23. Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex

    Article • ChemMedChem, March 2015, Wiley

    Rui Moreira

  24. Targeting the Erythrocytic and Liver Stages of Malaria Parasites withs-Triazine-Based Hybrids

    Article • ChemMedChem, March 2015, Wiley

    Rui Moreira

  25. 1.2 Designing Covalent Inhibitors: A Medicinal Chemistry Challenge

    Article • January 2015, De Gruyter

    Rui Moreira

  26. Activity-based probes as molecular tools for biomarker discovery

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Dr Susana Dias Lucas, Rui Moreira

  27. A unified approach toward the rational design of selective low nanomolar human neutrophil elastase inhibitors

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Dr Susana Dias Lucas, Rui Moreira

  28. Discovery of C-shaped aurone human neutrophil elastase inhibitors

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Dr Susana Dias Lucas, Rui Moreira

  29. The Cytotoxic Bile Acid DCA Modulates Apoptotic Signalling through Alteration of Mitochondrial Membrane Properties

    Article • Biophysical Journal, January 2015, Elsevier

    Rui Moreira

  30. Analytical profiles of “legal highs” containing cathinones available in the area of Lisbon, Portugal

    Article • Forensic Science International, November 2014, Elsevier

    Rui Moreira

  31. Antiplasmodial Drugs in the Gas Phase: A CID and DFT Study of Quinolon-4(1H)-Imine Derivatives

    Article • Journal of the American Society for Mass Spectrometry, July 2014, Springer Science + Business Media

    Rui Moreira

  32. Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

    Article • Journal of Medicinal Chemistry, June 2014, American Chemical Society (ACS)

    Rui Moreira

  33. Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

    Article • European Journal of Medicinal Chemistry, June 2014, Elsevier

    Rui Moreira

  34. Bis-alkylamine Indolo[3,2- b ]quinolines as Hemozoin Ligands: Implications for Antimalarial Cytostatic and Cytocidal Activities

    Article • Journal of Medicinal Chemistry, April 2014, American Chemical Society (ACS)

    Rui Moreira

  35. Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

    Article • ACS Medicinal Chemistry Letters, February 2014, American Chemical Society (ACS)

    Rui Moreira

  36. Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents

    Article • Bioorganic & Medicinal Chemistry, January 2014, Elsevier

    Rui Moreira

  37. Optimization of O 3 -Acyl Kojic Acid Derivatives as Potent and Selective Human Neutrophil Elastase Inhibitors

    Article • Journal of Medicinal Chemistry, December 2013, American Chemical Society (ACS)

    Dr Susana Dias Lucas, Rui Moreira

  38. Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

    Article • European Journal of Medicinal Chemistry, November 2013, Elsevier

    Rui Moreira

  39. Squaric acid/4-aminoquinoline conjugates: Novel potent antiplasmodial agents

    Article • European Journal of Medicinal Chemistry, November 2013, Elsevier

    Rui Moreira

  40. Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

    Article • Journal of Medicinal Chemistry, October 2013, American Chemical Society (ACS)

    Rui Moreira

  41. Novel anti-Plasmodial hits identified by virtual screening of the ZINC database

    Article • Journal of Computer-Aided Molecular Design, October 2013, Springer Science + Business Media

    Rui Moreira

  42. Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, September 2013, Elsevier

    Dr Susana Dias Lucas, Rui Moreira

  43. Synthesis, G-Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains

    Article • ChemMedChem, August 2013, Wiley

    Rui Moreira

  44. An Endoperoxide‐Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites

    Article • ChemMedChem, July 2013, Wiley

    Rui Moreira

  45. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

    Article • Proceedings of the National Academy of Sciences, July 2013, Proceedings of the National Academy of Sciences

    Rui Moreira

  46. Exploring the Molecular Basis of Qo bc 1 Complex Inhibitors Activity to Find Novel Antimalarials Hits

    Article • Molecular Informatics, June 2013, Wiley

    Rui Moreira

  47. Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

    Article • Journal of Medicinal Chemistry, June 2013, American Chemical Society (ACS)

    Rui Moreira

  48. Contribution of Mass Spectrometry to the Study of Antimalarial Agents

    Article • May 2013, IntechOpen

    Rui Moreira

  49. Five-membered iminocyclitol α-glucosidase inhibitors: Synthetic, biological screening and in silico studies

    Article • Bioorganic & Medicinal Chemistry, April 2013, Elsevier

    Anthony Burke, Rui Moreira

  50. Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Susana Dias Lucas, Rui Moreira

  51. Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog

    Article • Phytomedicine, December 2012, Elsevier

    Rui Moreira

  52. Synthetic Condensed 1,4-naphthoquinone Derivative Shifts Neural Stem Cell Differentiation by Regulating Redox State

    Article • Molecular Neurobiology, October 2012, Springer Science + Business Media

    Rui Moreira

  53. Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, October 2012, Elsevier

    Rui Moreira

  54. Peptidomimetic and Organometallic Derivatives of Primaquine Active against Leishmania infantum

    Article • Antimicrobial Agents and Chemotherapy, August 2012, ASM Journals

    Rui Moreira

  55. ChemInform Abstract: Microwave-Assisted Wittig Reaction of Semistabilized Nitro-Substituted Benzyltriphenyl-Phosphorous Ylides with Aldehydes in Phase-Transfer Conditions.

    Article • ChemInform, July 2012, Wiley

    Rui Moreira

  56. N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases

    Article • Bioorganic & Medicinal Chemistry Letters, June 2012, Elsevier

    Dr Susana Dias Lucas, Rui Moreira

  57. Comparative Analysis of In Vitro Rat Liver Metabolism of the Antimalarial Primaquine and a Derived Imidazoquine

    Article • Drug Metabolism Letters, May 2012, Bentham Science Publishers

    Rui Moreira

  58. ChemInform Abstract: Efficient Synthesis of Spiroisoxazoline Oxindoles.

    Article • ChemInform, April 2012, Wiley

    Rui Moreira

  59. Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

    Article • The Journal of Infectious Diseases, March 2012, Oxford University Press (OUP)

    Rui Moreira

  60. 1 H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities

    Article • Magnetic Resonance in Chemistry, February 2012, Wiley

    Rui Moreira

  61. Four-Component Assembly of Chiral N–B Heterocycles with a Natural Product-Like Framework

    Article • Organic Letters, February 2012, American Chemical Society (ACS)

    Rui Moreira

  62. Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal

    Article • Journal of Medicinal Chemistry, February 2012, American Chemical Society (ACS)

    Rui Moreira

  63. Squaric acid: a valuable scaffold for developing antimalarials?

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Rui Moreira

  64. Structure based virtual screening for discovery of novel human neutrophil elastase inhibitors

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Dr Susana Dias Lucas, Rui Moreira

  65. A carbamate-based approach to primaquine prodrugs: Antimalarial activity, chemical stability and enzymatic activation

    Article • Bioorganic & Medicinal Chemistry, January 2012, Elsevier

    Rui Moreira

  66. Efficient synthesis of spiroisoxazoline oxindoles

    Article • Tetrahedron Letters, January 2012, Elsevier

    Rui Moreira

  67. Novel Potent Metallocenes against Liver Stage Malaria

    Article • Antimicrobial Agents and Chemotherapy, December 2011, ASM Journals

    Rui Moreira

  68. Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents

    Article • Bioorganic & Medicinal Chemistry, December 2011, Elsevier

    Rui Moreira

  69. Identification of new antimalarial leads by use of virtual screening against cytochrome bc1

    Article • Bioorganic & Medicinal Chemistry, November 2011, Elsevier

    Rui Moreira

  70. Microwave-Assisted Wittig Reaction of Semistabilized Nitro-Substituted Benzyltriphenyl-Phosphorous Ylides with Aldehydes in Phase-Transfer Conditions

    Article • Synthetic Communications, August 2011, Taylor & Francis

    Rui Moreira

  71. Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Antimalarial Strategy

    Article • Antimicrobial Agents and Chemotherapy, August 2011, ASM Journals

    Rui Moreira

  72. Characterizing the Dynamics and Ligand-Specific Interactions in the Human Leukocyte Elastase through Molecular Dynamics Simulations

    Article • Journal of Chemical Information and Computer Sciences, July 2011, American Chemical Society (ACS)

    Rui Moreira

  73. Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase

    Article • Medicinal Research Reviews, June 2011, Wiley

    Dr Susana Dias Lucas, Rui Moreira

  74. Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway

    Article • European Journal of Medicinal Chemistry, June 2011, Elsevier

    Rui Moreira

  75. Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

    Article • European Journal of Medicinal Chemistry, March 2011, Elsevier

    Rui Moreira

  76. Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure−Antimalarial Activity Relationships and Mechanistic Studies

    Article • Journal of Medicinal Chemistry, February 2011, American Chemical Society (ACS)

    Rui Moreira

  77. New hope in the fight against malaria?

    Article • Future Medicinal Chemistry, January 2011, Future Science

    Rui Moreira

  78. C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: Anticancer profile and G-quadruplex stabilization

    Article • Bioorganic & Medicinal Chemistry Letters, December 2010, Elsevier

    Rui Moreira

  79. Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity

    Article • Journal of Medicinal Chemistry, November 2010, American Chemical Society (ACS)

    Rui Moreira

  80. Bis-alkylamine quindolone derivatives as new antimalarial leads

    Article • Bioorganic & Medicinal Chemistry Letters, October 2010, Elsevier

    Rui Moreira

  81. Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure–activity study

    Article • European Journal of Medicinal Chemistry, September 2010, Elsevier

    Rui Moreira

  82. A quantum mechanical study of novel potential inhibitors of cytochrome bc1 as antimalarial compounds

    Article • International Journal of Quantum Chemistry, August 2010, Wiley

    Rui Moreira

  83. Indoloquinolines as Scaffolds for Drug Discovery

    Article • Current Medicinal Chemistry, August 2010, Bentham Science Publishers

    Rui Moreira

  84. Cell Death Targets and Potential Modulators in Alzheimers Disease

    Article • Current Pharmaceutical Design, August 2010, Bentham Science Publishers

    Rui Moreira

  85. Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, June 2010, Taylor & Francis

    Rui Moreira

  86. Inhibitors of the Mitochondrial Electron Transport Chain and de novo Pyrimidine Biosynthesis as Antimalarials: The Present Status

    Article • Current Medicinal Chemistry, April 2010, Bentham Science Publishers

    Rui Moreira

  87. Effect of Synthesized Inhibitors on Babesipain-1, a New Cysteine Protease from the Bovine Piroplasm Babesia Bigemina

    Article • Transboundary and Emerging Diseases, April 2010, Wiley

    Rui Moreira

  88. 4-Oxo-β-lactams (Azetidine-2,4-diones) Are Potent and Selective Inhibitors of Human Leukocyte Elastase

    Article • Journal of Medicinal Chemistry, January 2010, American Chemical Society (ACS)

    Rui Moreira, Dr Luis F Gouveia

  89. PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity

    Article • MedChemComm, January 2010, Royal Society of Chemistry

    Rui Moreira

  90. Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones

    Article • Bioorganic & Medicinal Chemistry Letters, January 2010, Elsevier

    Dr Simon J Coles, Rui Moreira

  91. Imidazoquines as Antimalarial and Antipneumocystis Agents †

    Article • Journal of Medicinal Chemistry, December 2009, American Chemical Society (ACS)

    Rui Moreira

  92. Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine

    Article • Bioorganic & Medicinal Chemistry Letters, December 2009, Elsevier

    Rui Moreira

  93. Dopamine- and tyramine-based derivatives of triazenes: Activation by tyrosinase and implications for prodrug design

    Article • European Journal of Medicinal Chemistry, August 2009, Elsevier

    Rui Moreira, Ana Francisco

  94. Design, synthesis and structure–activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials

    Article • Bioorganic & Medicinal Chemistry Letters, July 2009, Elsevier

    Rui Moreira

  95. Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: Potent, non-cytotoxic, antiapoptotic agents

    Article • Chemico-Biological Interactions, July 2009, Elsevier

    Rui Moreira

  96. Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition

    Article • Bioorganic & Medicinal Chemistry Letters, June 2009, Elsevier

    Rui Moreira

  97. Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs

    Article • European Journal of Medicinal Chemistry, June 2009, Elsevier

    Rui Moreira

  98. Structure–activity relationships for dipeptide prodrugs of acyclovir: Implications for prodrug design

    Article • European Journal of Medicinal Chemistry, June 2009, Elsevier

    Rui Moreira, Dr Luis F Gouveia

  99. Primaquine revisited six decades after its discovery

    Article • European Journal of Medicinal Chemistry, March 2009, Elsevier

    Rui Moreira

  100. Bis{(E)-3-[(diethylmethylammonio)methyl]-N-[3-(N,N-dimethylsulfamoyl)-1-methylpyridin-4-ylidene]-4-methoxyanilinium} tetraiodide pentahydrate

    Article • Acta Crystallographica Section E Structure Reports Online, January 2009, International Union of Crystallography

    Rui Moreira

  101. Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives

    Article • European Journal of Mass Spectrometry, January 2009, IM Publications

    Rui Moreira

  102. Amino acids as selective acylating agents: regioselective N1-acylation of imidazolidin-4-one derivatives of the antimalarial drug primaquine

    Article • Tetrahedron, December 2008, Elsevier

    Rui Moreira

  103. Electrospray Ionization-Ion Trap Mass Spectrometry Study of PQAAPro and PQProAA Mimetic Derivatives of the Antimalarial Primaquine

    Article • Journal of the American Society for Mass Spectrometry, October 2008, Springer Science + Business Media

    Rui Moreira

  104. Imidazolidin-4-one peptidomimetic derivatives of primaquine: Synthesis and antimalarial activity

    Article • Bioorganic & Medicinal Chemistry Letters, July 2008, Elsevier

    Rui Moreira

  105. Dipeptide Derivatives of AZT: Synthesis, Chemical Stability, Activation in Human Plasma, hPEPT1 Affinity, and Antiviral Activity

    Article • ChemMedChem, June 2008, Wiley

    Rui Moreira, Dr Luis F Gouveia

  106. Unanticipated Acyloxymethylation of Sumatriptan Indole Nitrogen Atom and its Implications in Prodrug Design

    Article • Archiv der Pharmazie, June 2008, Wiley

    Rui Moreira

  107. Malaria Combination Therapies: Advantages and Shortcomings

    Article • Mini-Reviews in Medicinal Chemistry, March 2008, Bentham Science Publishers

    Rui Moreira

  108. Azetidine-2,4-diones (4-Oxo-β-lactams) as Scaffolds for Designing Elastase Inhibitors

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    Rui Moreira

  109. Characterization of primaquine imidazolidin-4-ones with antimalarial activity by electrospray ionization-ion trap mass spectrometry

    Article • International Journal of Mass Spectrometry, February 2008, Elsevier

    Rui Moreira

  110. Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity

    Article • Bioorganic & Medicinal Chemistry Letters, February 2008, Elsevier

    Rui Moreira

  111. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones

    Article • Bioorganic & Medicinal Chemistry Letters, January 2008, Elsevier

    Ricardo Ferraz, Rui Moreira

  112. Cyclization-activated Prodrugs

    Article • Molecules, November 2007, MDPI AG

    Rui Moreira

  113. Michael Acceptors as Cysteine Protease Inhibitors

    Article • Mini-Reviews in Medicinal Chemistry, October 2007, Bentham Science Publishers

    Rui Moreira

  114. The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors

    Article • Bioorganic & Medicinal Chemistry, August 2007, Elsevier

    Rui Moreira

  115. Unanticipated Stereoselectivity in the Reaction of Primaquine α-Aminoamides with Substituted Benzaldehydes:  A Computational and Experimental Study †

    Article • The Journal of Organic Chemistry, May 2007, American Chemical Society (ACS)

    Rui Moreira, José Gomes

  116. The efficiency of C-4 substituents in activating the β-lactam scaffold towards serine proteases and hydroxide ion

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Rui Moreira

  117. Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

    Article • Protein and Peptide Letters, January 2007, Bentham Science Publishers

    Rui Moreira

  118. Aminocarbonyloxymethyl Ester Prodrugs of Flufenamic Acid and Diclofenac: Suppressing the Rearrangement Pathway in Aqueous Media

    Article • Archiv der Pharmazie, January 2007, Wiley

    Rui Moreira

  119. Reactivity of imidazolidin-4-one derivatives of primaquine: implications for prodrug design

    Article • Tetrahedron, October 2006, Elsevier

    Rui Moreira, Dr Luis F Gouveia, José Gomes

  120. The Bsmoc Group as a Novel Scaffold for the Design of Irreversible Inhibitors of Cysteine Proteases.

    Article • ChemInform, August 2006, Wiley

    Rui Moreira

  121. Dipeptide vinyl sultams: Synthesis via the Wittig–Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

    Article • Bioorganic & Medicinal Chemistry Letters, August 2006, Elsevier

    Rui Moreira

  122. The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases

    Article • Bioorganic & Medicinal Chemistry Letters, May 2006, Elsevier

    Rui Moreira

  123. Design, Synthesis, and Enzymatic Evaluation of N 1 -Acyloxyalkyl- and N 1 -Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase

    Article • Journal of Medicinal Chemistry, July 2005, American Chemical Society (ACS)

    Rui Moreira

  124. Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol

    Article • Bioorganic & Medicinal Chemistry Letters, March 2005, Elsevier

    Rui Moreira

  125. Imidazolidin-4-one Derivatives of Primaquine as Novel Transmission-Blocking Antimalarials

    Article • Journal of Medicinal Chemistry, February 2005, American Chemical Society (ACS)

    Rui Moreira

  126. Amidomethylation of Amodiaquine: Antimalarial N-Mannich Base Derivatives.

    Article • ChemInform, January 2005, Wiley

    Rui Moreira

  127. Amidomethylation of amodiaquine: antimalarial N-Mannich base derivatives

    Article • Tetrahedron Letters, October 2004, Elsevier

    Rui Moreira

  128. Synthesis of imidazolidin-4-one and 1H-imidazo[2,1-a]isoindole-2,5(3H,9bH)-dione derivatives of primaquine: scope and limitations

    Article • Tetrahedron, June 2004, Elsevier

    Rui Moreira

  129. Kinetics and Mechanism of Hydrolysis of N -Acyloxymethyl Derivatives of Azetidin-2-one

    Article • The Journal of Organic Chemistry, May 2004, American Chemical Society (ACS)

    Rui Moreira, José Gomes

  130. Novel 3+1 mixed-ligand Technetium-99m complexes carrying dipeptides as monodentate ligands

    Article • Nuclear Medicine and Biology, January 2004, Elsevier

    Rui Moreira

  131. Improved Synthesis of Amino Acid and Dipeptide Chloromethyl Esters Using Bromochloromethane.

    Article • ChemInform, September 2003, Wiley

    Rui Moreira

  132. Amino acids as selective sulfonamide acylating agents

    Article • Tetrahedron, September 2003, Elsevier

    Rui Moreira, José Gomes

  133. Improved Synthesis of Amino Acid and Dipeptide Chloromethyl Esters Using Bromochloromethane

    Article • Synthetic Communications, January 2003, Taylor & Francis

    Rui Moreira

  134. Synthesis, Stability and In Vitro Dermal Evaluation of Aminocarbonyloxymethyl Esters as Prodrugs of Carboxylic Acid Agents

    Article • Bioorganic & Medicinal Chemistry, March 2002, Elsevier

    Rui Moreira

  135. Design, Synthesis and Stability of N-Acyloxymethyl- and N-Aminocarbonyloxymethyl-2-azetidinones as Human Leukocyte Elastase Inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2001, Elsevier

    Rui Moreira

  136. Kinetics and mechanism of hydrolysis of N-amidomethylsulfonamides

    Article • Journal of the Chemical Society Perkin Transactions 2, January 2001, Royal Society of Chemistry

    Rui Moreira

  137. Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: chemical hydrolysis and anti-bacterial activity

    Article • Bioorganic & Medicinal Chemistry, July 2000, Elsevier

    Rui Moreira

  138. Acyloxymethyl as a drug protecting group. Part 6

    Article • Bioorganic & Medicinal Chemistry, April 2000, Elsevier

    Rui Moreira

  139. Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates

    Article • European Journal of Pharmaceutical Sciences, December 1999, Elsevier

    Rui Moreira

  140. Metabolism of primaquine by liver homogenate fractions

    Article • Experimental and Toxicologic Pathology, July 1999, Elsevier

    Rui Moreira

  141. Article • Pharmaceutical Research, January 1999, Springer Science + Business Media

    Rui Moreira

  142. Phthalimidomethyl as a drug Pro-moiety. Probing its reactivity

    Article • Bioorganic & Medicinal Chemistry Letters, April 1998, Elsevier

    Rui Moreira

  143. Article • Pharmaceutical Research, January 1997, Springer Science + Business Media

    Rui Moreira

  144. Article • Pharmaceutical Research, January 1996, Springer Science + Business Media

    Rui Moreira

  145. Acyloxymethyl as a drug protecting group. Synthesis and reactivity of N-acyloxymethylsulfonamide prodrugs

    Article • Bioorganic & Medicinal Chemistry Letters, May 1995, Elsevier

    Rui Moreira

  146. A new direct synthesis of tertiary N-acyloxymethylamide prodrugs of carboxylic acid drugs

    Article • Tetrahedron Letters, September 1994, Elsevier

    Rui Moreira

  147. Acyloxymethyl as a drug protecting group. Kinetics and mechanism of the hydrolysis of N-acyloxymethylbenzamides

    Article • Journal of the Chemical Society Perkin Transactions 2, January 1991, Royal Society of Chemistry

    Rui Moreira

  148. Triazene drug metabolites. Part 11. Synthesis of S-cysteinyl and related derivatives of N-hydroxymethyltriazenes

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1991, Royal Society of Chemistry

    Rui Moreira

  149. Triazene drug metabolites. Part 10. Metal-ion catalysed decomposition of monoalkyltriazenes in ethanol solutions

    Article • Journal of the Chemical Society Perkin Transactions 2, January 1991, Royal Society of Chemistry

    Rui Moreira

  150. Synthesis of S-cysteinyl, S(N-acetylcysteinyl) and S-glutathionyl conjugates op N-hydroxymethyltriazenes

    Article • Tetrahedron Letters, January 1988, Elsevier

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  151. Alkylating Agents

    Article • Wiley

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