All Stories

  1. 3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling

    Article • ACS Chemical Biology, March 2020, American Chemical Society (ACS)

    Dr Jose A Brito

  2. Structural biology techniques: X-ray crystallography, cryo-electron microscopy, and small-angle X-ray scattering

    Article • January 2020, Elsevier

    Dr Jose A Brito

  3. Hydrogen Sulfide Signaling and Enzymology

    Article • January 2020, Elsevier

    Dr Jose A Brito

  4. X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action

    Article • Scientific Reports, September 2018, Springer Science + Business Media

    Dr Jose A Brito

  5. Structural insights into the regulation and inhibition of human cystathionine β-synthase

    Article • Free Radical Biology and Medicine, May 2018, Elsevier

    Dr Jose A Brito

  6. Crosstalk between gasotransmitters at the H 2 S-synthesizing human cystathionine β-synthase: heme-based regulation by CO and NO

    Article • Free Radical Biology and Medicine, May 2018, Elsevier

    Dr Jose A Brito

  7. The key role of glutamate 172 in the mechanism of type II NADH:quinone oxidoreductase of Staphylococcus aureus

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, October 2017, Elsevier

    Dr Jose A Brito

  8. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionineβ-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    Dr Jose A Brito

  9. Electron Accepting Units of the Diheme CytochromecTsdA, a Bifunctional Thiosulfate Dehydrogenase/Tetrathionate Reductase

    Article • Journal of Biological Chemistry, September 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Inês A. C. Pereira, Dr Christiane Dahl, Dr Jose A Brito

  10. Investigating structural/function relationship in type II NADH:quinone oxidoreductases

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, August 2016, Elsevier

    Dr Jose A Brito

  11. Quinone interaction on Type II NADH:quinone oxidoreductase from Staphylococcus aureus

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, August 2016, Elsevier

    Dr Jose A Brito

  12. Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes

    Article • ChemMedChem, July 2016, Wiley

    Rui Moreira, Dr Jose A Brito

  13. Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking

    Article • Acta Crystallographica Section F Structural Biology Communications, September 2015, International Union of Crystallography

    Rui Moreira, Dr Jose A Brito

  14. Structural and Functional Characterization of an Ancient Bacterial Transglutaminase Sheds Light on the Minimal Requirements for Protein Cross-Linking

    Article • Biochemistry, September 2015, American Chemical Society (ACS)

    Dr Jose A Brito

  15. Type-II NADH:quinone oxidoreductase from Staphylococcus aureushas two distinct binding sites and is rate limited by quinone reduction

    Article • Molecular Microbiology, July 2015, Wiley

    Dr Jose A Brito

  16. Expression, purification, crystallization and preliminary X-ray diffraction analysis of a type II NADH:quinone oxidoreductase from the human pathogenStaphylococcus aureus

    Article • Acta Crystallographica Section F Structural Biology Communications, March 2015, International Union of Crystallography

    Dr Jose A Brito

  17. Thiosulfate Dehydrogenase (TsdA) from Allochromatium vinosum

    Article • Journal of Biological Chemistry, February 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Inês A. C. Pereira, Dr Christiane Dahl, Dr Jose A Brito

  18. Production, crystallization and preliminary crystallographic analysis ofAllochromatium vinosumthiosulfate dehydrogenase TsdA, an unusual acidophilicc-type cytochrome

    Article • Acta Crystallographica Section F Structural Biology Communications, September 2014, International Union of Crystallography

    Dr Jose A Brito, Dr Christiane Dahl

  19. Correction: An Efficient Strategy for Small-Scale Screening and Production of Archaeal Membrane Transport Proteins in Escherichia coli

    Article • PLoS ONE, November 2013, PLOS

    Dr Jose A Brito

  20. An Efficient Strategy for Small-Scale Screening and Production of Archaeal Membrane Transport Proteins in Escherichia coli

    Article • PLoS ONE, October 2013, PLOS

    Dr Jose A Brito

  21. X-ray Crystallography

    Article • January 2013, Elsevier

    Dr Jose A Brito

  22. Crystal Structure of Archaeoglobus fulgidus CTP:Inositol-1-Phosphate Cytidylyltransferase, a Key Enzyme for Di-myo-Inositol-Phosphate Synthesis in (Hyper)Thermophiles

    Article • Journal of Bacteriology, March 2011, ASM Journals

    Dr Jose A Brito

  23. Production, crystallization and preliminary X-ray analysis of CTP:inositol-1-phosphate cytidylyltransferase fromArchaeoglobus fulgidus

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, October 2010, International Union of Crystallography

    Dr Jose A Brito

  24. Structural and Functional Insights into Sulfide:Quinone Oxidoreductase,

    Article • Biochemistry, May 2009, American Chemical Society (ACS)

    Dr Jose A Brito

  25. Crystallisation and preliminary structure determination of a NADH: quinone oxidoreductase from the extremophile Acidianus ambivalens

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, April 2006, Elsevier

    Dr Jose A Brito

  26. Structure of NADH: quinone oxidoreductase fromAcidianus ambivalens: electron entry point of aerobic respiratory chain

    Article • Acta Crystallographica Section A Foundations of Crystallography, August 2005, International Union of Crystallography

    Dr Jose A Brito