All Stories

  1. A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region
  2. Age Effect Explorer: A Shiny application to browse and visualize tissue-specific age-related gene expression changes
  3. Predicting Phenoconversion to Clinically Manifest ALS: Results of a Large-Scale Proteomic Study
  4. DEDUCE: statistical inference on disease-associated genes uncovers tissue–disease associations
  5. Early-life nutrition supplementation and epigenetic age in middle-adulthood among Guatemalan adults
  6. A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region
  7. MammOnc-DB, an integrative breast cancer data analysis platform for target discovery
  8. Phenotypic Characterization of Subtype A and Recombinant AC Transmitted/Founder Viruses from a Rwandan HIV-1 Heterosexual Transmission Cohort
  9. A novel classification framework for genome-wide association study of whole brain MRI images using deep learning
  10. MammOnc-DB, an integrative breast cancer data analysis platform for target discovery
  11. This is a comprehensive survey paper regarding controllable data generation by deep learning.
  12. Unsupervised Hierarchical Clustering of Head and Neck Cancer Patients by Pre-Treatment Plasma Metabolomics Creates Prognostic Metabolic Subtypes
  13. Comprehensive 100-bp resolution genome-wide epigenomic profiling data for the hg38 human reference genome
  14. UALCAN: An update to the integrated cancer data analysis platform
  15. ATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development
  16. Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults
  17. Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma
  18. Approaches to Marker Gene Identification from Single-Cell RNA-Sequencing Data
  19. A wonderful time – exciting progress made in the past 20 years in genetics powered by the Human Genome Project
  20. Systematic Exploration in Tissue-Pathway Associations of Complex Traits Using Comprehensive eQTLs Catalog
  21. Disease category-specific annotation of variants using an ensemble learning framework
  22. 20th International Workshop on Data Mining in Bioinformatics (BIOKDD 2021)
  23. Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival
  24. LRcell: detecting the source of differential expression at the sub-cell type level from bulk RNA-seq data
  25. EWASplus: a computational tool to expand EWAS coverage from the array to the whole epigenome.
  26. Pan-cancer analysis of pathway-based gene expression pattern at the individual level reveals biomarkers of clinical prognosis
  27. Glucocorticoid receptor wields chromatin interactions to tune transcription for cytoskeleton stabilization in podocytes
  28. Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes
  29. Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants
  30. Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes
  31. Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
  32. Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC)
  33. An empirical bayesian approach for testing gene expression fold change and its application in detecting global dosage effects
  34. Proceedings of the 2019 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference
  35. DeconPeaker, a Deconvolution Model to Identify Cell Types Based on Chromatin Accessibility in ATAC-Seq Data of Mixture Samples
  36. Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
  37. Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice
  38. Application of topic models to a compendium of ChIP-Seq datasets uncovers recurrent transcriptional regulatory modules
  39. An Integrated System Biology Approach Yields Drug Repositioning Candidates for the Treatment of Heart Failure
  40. Regulatory annotation of genomic intervals based on tissue-specific expression QTLs
  41. Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment
  42. Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure
  43. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
  44. Chronic adolescent stress sex-specifically alters the hippocampal transcriptome in adulthood
  45. Inferring Spatial Organization of Individual Topologically Associated Domains via Piecewise Helical Model
  46. RT States: systematic annotation of the human genome using cell type-specific replication timing programs
  47. A comprehensive review of computational prediction of genome-wide features
  48. Use replication timing data from multiple cell types to annotate human genome
  49. EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins
  50. Use cloud-based distributed systems to speed up merging of large collection of VCF files.
  51. Probabilistic and machine learning-based retrieval approaches for biomedical dataset retrieval
  52. Special collection of bioinformatics in the era of precision medicine
  53. Using DIVAN to assess disease/trait-associated single nucleotide variants in genome-wide scale
  54. Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
  55. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease
  56. Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome
  57. Omicseq: searching omics data without using metadata
  58. 10.1038/srep46398
  59. An approach of identifying differential nucleosome regions in multiple samples
  60. Computationally Tractable Multivariate HMM in Genome-Wide Mapping Studies
  61. Disease-specific non-coding variant annotation
  62. Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells
  63. The single-species metagenome: subtyping Staphylococcus aureus core genome sequences from shotgun metagenomic data
  64. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
  65. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors
  66. Use historical data to improve detection of differential expressed genes.
  67. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
  68. Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease
  69. Statistical Challenges in Analyzing Methylation and Long-Range Chromosomal Interaction Data
  70. Gene integrated set profile analysis: a context-based approach for inferring biological endpoints
  71. R package to test GWAS SNP enrichment in any genomic interval(s)
  72. A hidden Markov random field-based Bayesian method for the detection of long-range chromosomal interactions in Hi-C data
  73. Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
  74. Bayesian inference with historical data-based informative priors improves detection of differentially expressed genes
  75. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency
  76. One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies
  77. Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates
  78. Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing
  79. Base-resolution methylation patterns accurately predict transcription factor bindings in vivo
  80. A novel statistical method for quantitative comparison of multiple ChIP-seq datasets
  81. Systems biology and metagenomics: a showcase of Chinese bioinformatics researchers and their work
  82. Integrated Analysis of Whole-Genome Paired-End and Mate-Pair Sequencing Data for Identifying Genomic Structural Variations in Multiple Myeloma
  83. Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3
  84. Direct Amplification, Sequencing and Profiling of Chlamydia trachomatis Strains in Single and Mixed Infection Clinical Samples
  85. H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb
  86. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
  87. The central role of EED in the orchestration of polycomb group complexes
  88. Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
  89. EgoNet: identification of human disease ego-network modules
  90. Insulator function and topological domain border strength scale with architectural protein occupancy
  91. Allogeneic T cell responses are regulated by a specific miRNA-mRNA network
  92. Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation
  93. Understanding spatial organizations of chromosomes via statistical analysis of Hi-C data
  94. Bayesian Inference of Spatial Organizations of Chromosomes
  95. Sparsely correlated hidden Markov models with application to genome-wide location studies
  96. A genome-wide MeSH-based literature mining system predicts implicit gene-to-gene relationships and networks
  97. Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer
  98. Exploring the Cooccurrence Patterns of Multiple Sets of Genomic Intervals
  99. MotifOrganizer a scalable model-based motif clustering tool for mammalian genomes
  100. Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains
  101. Read-mapping using personalized diploid reference genome for RNA sequencing data reduced bias for detecting allele-specific expression
  102. HiCNorm: removing biases in Hi-C data via Poisson regression
  103. The Histone Acetyltransferase MOF Is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network
  104. PM-Seq: Using Finite Poisson Mixture Models for RNA-Seq Data Analysis and Transcript Expression Level Quantification
  105. GPUmotif: An Ultra-Fast and Energy-Efficient Motif Analysis Program Using Graphics Processing Units
  106. Cooperation between Polycomb and androgen receptor during oncogenic transformation
  107. FOXP3 Orchestrates H4K16 Acetylation and H3K4 Trimethylation for Activation of Multiple Genes by Recruiting MOF and Causing Displacement of PLU-1
  108. Using Poisson mixed-effects model to quantify transcript-level gene expression in RNA-Seq
  109. Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer
  110. Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer
  111. C/EBPβ Mediates Growth Hormone-Regulated Expression of Multiple Target Genes
  112. SAINT: probabilistic scoring of affinity purification–mass spectrometry data
  113. Statistical Issues in the Analysis of ChIP-Seq and RNA-Seq Data
  114. A Global Protein Kinase and Phosphatase Interaction Network in Yeast
  115. An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
  116. A Double-Layered Mixture Model for the Joint Analysis of DNA Copy Number and Gene Expression Data
  117. On the detection and refinement of transcription factor binding sites using ChIP-Seq data
  118. HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data
  119. Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin
  120. Computational and Functional Analysis of Growth Hormone (GH)-Regulated Genes Identifies the Transcriptional Repressor B-Cell Lymphoma 6 (Bc16) as a Participant in GH-Regulated Transcription
  121. Drug–Drug Interaction Prediction Assessment
  122. Hierarchical hidden Markov model with application to joint analysis of ChIP-chip and ChIP-seq data
  123. Progress toward personalized medicine for glaucoma
  124. Query Large Scale Microarray Compendium Datasets Using a Model-Based Bayesian Approach with Variable Selection
  125. A new probabilistic rule for drug–dug interaction prediction
  126. Advances in Statistical Bioinformatics
  127. Comparison of laboratory-based and phylogenetic methods to distinguish between Haemophilus influenzae and H. haemolyticus
  128. Family‐based SNP association study on 8q24 in bipolar disorder
  129. Genome-wide detection and characterization of positive selection in human populations
  130. A second generation human haplotype map of over 3.1 million SNPs
  131. p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
  132. CRCView: a web server for analyzing and visualizing microarray gene expression data using model-based clustering
  133. Different normalization strategies for microarray gene expression traits affect the heritability estimation
  134. Operon Prediction for Sequenced Bacterial Genomes without Experimental Information
  135. Clustering microarray gene expression data using weighted Chinese restaurant process
  136. A Comparison of Phasing Algorithms for Trios and Unrelated Individuals
  137. Energy, quiescence and the cellular basis of animal life spans
  138. TAGSNP SELECTION BASED ON PAIRWISE LD CRITERIA AND POWER ANALYSIS IN ASSOCIATION STUDIES
  139. An efficient comprehensive search algorithm for tagSNP selection using linkage disequilibrium criteria
  140. Improved Classification of Mass Spectrometry Database Search Results Using Newer Machine Learning Approaches
  141. A haplotype map of the human genome
  142. High Throughput Screening of Co-Expressed Gene Pairs with Controlled False Discovery Rate (FDR) and Minimum Acceptable Strength (MAS)
  143. Protein Tyrosine Phosphatase Gene PTPN22 Polymorphism in Psoriasis: Lack of Evidence for Association
  144. Fine Mapping of the Psoriasis Susceptibility Gene PSORS1: A Reassessment of Risk Associated with a Putative Risk Haplotype Lacking HLA-Cw6
  145. HapBlock: haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms
  146. Haplotype Block Partitioning and Tag SNP Selection Using Genotype Data and Their Applications to Association Studies
  147. Incorporating Genotyping Uncertainty in Haplotype Inference for Single-Nucleotide Polymorphisms
  148. Statistical resynchronization and Bayesian detection of periodically expressed genes
  149. Dynamic Programming Algorithms for Haplotype Block Partitioning and Tag SNP Selection Using Haplotype Data or Genotype Data
  150. Haplotype Inference and Its Application in Linkage Disequilibrium Mapping
  151. Identification of co-regulated genes through Bayesian clustering of predicted regulatory binding sites
  152. Scale Mixture Models with Applications to Bayesian Inference
  153. Partition-Ligation–Expectation-Maximization Algorithm for Haplotype Inference with Single-Nucleotide Polymorphisms
  154. Bayesian Haplotype Inference for Multiple Linked Single-Nucleotide Polymorphisms
  155. Multipoint Metropolis Method with Application to Hybrid Monte Carlo
  156. Model-Based Methods for Transcript Expression-Level Quantification in RNA-Seq
  157. Plate section
  158. Preface
  159. Statistical resynchronization and detection of periodic transcripts