All Stories

  1. Age Effect Explorer: A Shiny application to browse and visualize tissue-specific age-related gene expression changes
  2. Predicting Phenoconversion to Clinically Manifest ALS: Results of a Large-Scale Proteomic Study
  3. DEDUCE: statistical inference on disease-associated genes uncovers tissue–disease associations
  4. Early-life nutrition supplementation and epigenetic age in middle-adulthood among Guatemalan adults
  5. A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region
  6. MammOnc-DB, an integrative breast cancer data analysis platform for target discovery
  7. Phenotypic Characterization of Subtype A and Recombinant AC Transmitted/Founder Viruses from a Rwandan HIV-1 Heterosexual Transmission Cohort
  8. A novel classification framework for genome-wide association study of whole brain MRI images using deep learning
  9. MammOnc-DB, an integrative breast cancer data analysis platform for target discovery
  10. This is a comprehensive survey paper regarding controllable data generation by deep learning.
  11. Unsupervised Hierarchical Clustering of Head and Neck Cancer Patients by Pre-Treatment Plasma Metabolomics Creates Prognostic Metabolic Subtypes
  12. Comprehensive 100-bp resolution genome-wide epigenomic profiling data for the hg38 human reference genome
  13. UALCAN: An update to the integrated cancer data analysis platform
  14. ATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development
  15. Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults
  16. Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma
  17. Approaches to Marker Gene Identification from Single-Cell RNA-Sequencing Data
  18. A wonderful time – exciting progress made in the past 20 years in genetics powered by the Human Genome Project
  19. Systematic Exploration in Tissue-Pathway Associations of Complex Traits Using Comprehensive eQTLs Catalog
  20. Disease category-specific annotation of variants using an ensemble learning framework
  21. 20th International Workshop on Data Mining in Bioinformatics (BIOKDD 2021)
  22. Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival
  23. LRcell: detecting the source of differential expression at the sub-cell type level from bulk RNA-seq data
  24. EWASplus: a computational tool to expand EWAS coverage from the array to the whole epigenome.
  25. Pan-cancer analysis of pathway-based gene expression pattern at the individual level reveals biomarkers of clinical prognosis
  26. Glucocorticoid receptor wields chromatin interactions to tune transcription for cytoskeleton stabilization in podocytes
  27. Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes
  28. Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants
  29. Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes
  30. Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
  31. Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC)
  32. An empirical bayesian approach for testing gene expression fold change and its application in detecting global dosage effects
  33. Proceedings of the 2019 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference
  34. DeconPeaker, a Deconvolution Model to Identify Cell Types Based on Chromatin Accessibility in ATAC-Seq Data of Mixture Samples
  35. Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
  36. Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice
  37. Application of topic models to a compendium of ChIP-Seq datasets uncovers recurrent transcriptional regulatory modules
  38. An Integrated System Biology Approach Yields Drug Repositioning Candidates for the Treatment of Heart Failure
  39. Regulatory annotation of genomic intervals based on tissue-specific expression QTLs
  40. Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment
  41. Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure
  42. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
  43. Chronic adolescent stress sex-specifically alters the hippocampal transcriptome in adulthood
  44. Inferring Spatial Organization of Individual Topologically Associated Domains via Piecewise Helical Model
  45. RT States: systematic annotation of the human genome using cell type-specific replication timing programs
  46. A comprehensive review of computational prediction of genome-wide features
  47. Use replication timing data from multiple cell types to annotate human genome
  48. EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins
  49. Use cloud-based distributed systems to speed up merging of large collection of VCF files.
  50. Probabilistic and machine learning-based retrieval approaches for biomedical dataset retrieval
  51. Special collection of bioinformatics in the era of precision medicine
  52. Using DIVAN to assess disease/trait-associated single nucleotide variants in genome-wide scale
  53. Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
  54. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease
  55. Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome
  56. Omicseq: searching omics data without using metadata
  57. 10.1038/srep46398
  58. An approach of identifying differential nucleosome regions in multiple samples
  59. Computationally Tractable Multivariate HMM in Genome-Wide Mapping Studies
  60. Disease-specific non-coding variant annotation
  61. Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells
  62. The single-species metagenome: subtyping Staphylococcus aureus core genome sequences from shotgun metagenomic data
  63. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
  64. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors
  65. Use historical data to improve detection of differential expressed genes.
  66. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
  67. Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease
  68. Statistical Challenges in Analyzing Methylation and Long-Range Chromosomal Interaction Data
  69. Gene integrated set profile analysis: a context-based approach for inferring biological endpoints
  70. R package to test GWAS SNP enrichment in any genomic interval(s)
  71. A hidden Markov random field-based Bayesian method for the detection of long-range chromosomal interactions in Hi-C data
  72. Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
  73. Bayesian inference with historical data-based informative priors improves detection of differentially expressed genes
  74. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency
  75. One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies
  76. Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates
  77. Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing
  78. Base-resolution methylation patterns accurately predict transcription factor bindings in vivo
  79. A novel statistical method for quantitative comparison of multiple ChIP-seq datasets
  80. Systems biology and metagenomics: a showcase of Chinese bioinformatics researchers and their work
  81. Integrated Analysis of Whole-Genome Paired-End and Mate-Pair Sequencing Data for Identifying Genomic Structural Variations in Multiple Myeloma
  82. Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3
  83. Direct Amplification, Sequencing and Profiling of Chlamydia trachomatis Strains in Single and Mixed Infection Clinical Samples
  84. H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb
  85. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
  86. The central role of EED in the orchestration of polycomb group complexes
  87. Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
  88. EgoNet: identification of human disease ego-network modules
  89. Insulator function and topological domain border strength scale with architectural protein occupancy
  90. Allogeneic T cell responses are regulated by a specific miRNA-mRNA network
  91. Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation
  92. Understanding spatial organizations of chromosomes via statistical analysis of Hi-C data
  93. Bayesian Inference of Spatial Organizations of Chromosomes
  94. Sparsely correlated hidden Markov models with application to genome-wide location studies
  95. A genome-wide MeSH-based literature mining system predicts implicit gene-to-gene relationships and networks
  96. Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer
  97. Exploring the Cooccurrence Patterns of Multiple Sets of Genomic Intervals
  98. MotifOrganizer a scalable model-based motif clustering tool for mammalian genomes
  99. Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains
  100. Read-mapping using personalized diploid reference genome for RNA sequencing data reduced bias for detecting allele-specific expression
  101. HiCNorm: removing biases in Hi-C data via Poisson regression
  102. The Histone Acetyltransferase MOF Is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network
  103. PM-Seq: Using Finite Poisson Mixture Models for RNA-Seq Data Analysis and Transcript Expression Level Quantification
  104. GPUmotif: An Ultra-Fast and Energy-Efficient Motif Analysis Program Using Graphics Processing Units
  105. Cooperation between Polycomb and androgen receptor during oncogenic transformation
  106. FOXP3 Orchestrates H4K16 Acetylation and H3K4 Trimethylation for Activation of Multiple Genes by Recruiting MOF and Causing Displacement of PLU-1
  107. Using Poisson mixed-effects model to quantify transcript-level gene expression in RNA-Seq
  108. Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer
  109. Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer
  110. C/EBPβ Mediates Growth Hormone-Regulated Expression of Multiple Target Genes
  111. SAINT: probabilistic scoring of affinity purification–mass spectrometry data
  112. Statistical Issues in the Analysis of ChIP-Seq and RNA-Seq Data
  113. A Global Protein Kinase and Phosphatase Interaction Network in Yeast
  114. An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
  115. A Double-Layered Mixture Model for the Joint Analysis of DNA Copy Number and Gene Expression Data
  116. On the detection and refinement of transcription factor binding sites using ChIP-Seq data
  117. HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data
  118. Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin
  119. Computational and Functional Analysis of Growth Hormone (GH)-Regulated Genes Identifies the Transcriptional Repressor B-Cell Lymphoma 6 (Bc16) as a Participant in GH-Regulated Transcription
  120. Drug–Drug Interaction Prediction Assessment
  121. Hierarchical hidden Markov model with application to joint analysis of ChIP-chip and ChIP-seq data
  122. Progress toward personalized medicine for glaucoma
  123. Query Large Scale Microarray Compendium Datasets Using a Model-Based Bayesian Approach with Variable Selection
  124. A new probabilistic rule for drug–dug interaction prediction
  125. Advances in Statistical Bioinformatics
  126. Comparison of laboratory-based and phylogenetic methods to distinguish between Haemophilus influenzae and H. haemolyticus
  127. Family‐based SNP association study on 8q24 in bipolar disorder
  128. Genome-wide detection and characterization of positive selection in human populations
  129. A second generation human haplotype map of over 3.1 million SNPs
  130. p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
  131. CRCView: a web server for analyzing and visualizing microarray gene expression data using model-based clustering
  132. Different normalization strategies for microarray gene expression traits affect the heritability estimation
  133. Operon Prediction for Sequenced Bacterial Genomes without Experimental Information
  134. Clustering microarray gene expression data using weighted Chinese restaurant process
  135. A Comparison of Phasing Algorithms for Trios and Unrelated Individuals
  136. Energy, quiescence and the cellular basis of animal life spans
  137. TAGSNP SELECTION BASED ON PAIRWISE LD CRITERIA AND POWER ANALYSIS IN ASSOCIATION STUDIES
  138. An efficient comprehensive search algorithm for tagSNP selection using linkage disequilibrium criteria
  139. Improved Classification of Mass Spectrometry Database Search Results Using Newer Machine Learning Approaches
  140. A haplotype map of the human genome
  141. High Throughput Screening of Co-Expressed Gene Pairs with Controlled False Discovery Rate (FDR) and Minimum Acceptable Strength (MAS)
  142. Protein Tyrosine Phosphatase Gene PTPN22 Polymorphism in Psoriasis: Lack of Evidence for Association
  143. Fine Mapping of the Psoriasis Susceptibility Gene PSORS1: A Reassessment of Risk Associated with a Putative Risk Haplotype Lacking HLA-Cw6
  144. HapBlock: haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms
  145. Haplotype Block Partitioning and Tag SNP Selection Using Genotype Data and Their Applications to Association Studies
  146. Incorporating Genotyping Uncertainty in Haplotype Inference for Single-Nucleotide Polymorphisms
  147. Statistical resynchronization and Bayesian detection of periodically expressed genes
  148. Dynamic Programming Algorithms for Haplotype Block Partitioning and Tag SNP Selection Using Haplotype Data or Genotype Data
  149. Haplotype Inference and Its Application in Linkage Disequilibrium Mapping
  150. Identification of co-regulated genes through Bayesian clustering of predicted regulatory binding sites
  151. Scale Mixture Models with Applications to Bayesian Inference
  152. Partition-Ligation–Expectation-Maximization Algorithm for Haplotype Inference with Single-Nucleotide Polymorphisms
  153. Bayesian Haplotype Inference for Multiple Linked Single-Nucleotide Polymorphisms
  154. Multipoint Metropolis Method with Application to Hybrid Monte Carlo
  155. Model-Based Methods for Transcript Expression-Level Quantification in RNA-Seq
  156. Plate section
  157. Preface
  158. Statistical resynchronization and detection of periodic transcripts