All Stories

  1. Predicting Phenoconversion to Clinically Manifest ALS: Results of a Large-Scale Proteomic Study
  2. DEDUCE: statistical inference on disease-associated genes uncovers tissue–disease associations
  3. Early-life nutrition supplementation and epigenetic age in middle-adulthood among Guatemalan adults
  4. A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region
  5. MammOnc-DB, an integrative breast cancer data analysis platform for target discovery
  6. Phenotypic Characterization of Subtype A and Recombinant AC Transmitted/Founder Viruses from a Rwandan HIV-1 Heterosexual Transmission Cohort
  7. A novel classification framework for genome-wide association study of whole brain MRI images using deep learning
  8. MammOnc-DB, an integrative breast cancer data analysis platform for target discovery
  9. This is a comprehensive survey paper regarding controllable data generation by deep learning.
  10. Unsupervised Hierarchical Clustering of Head and Neck Cancer Patients by Pre-Treatment Plasma Metabolomics Creates Prognostic Metabolic Subtypes
  11. Comprehensive 100-bp resolution genome-wide epigenomic profiling data for the hg38 human reference genome
  12. UALCAN: An update to the integrated cancer data analysis platform
  13. ATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development
  14. Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults
  15. Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma
  16. Approaches to Marker Gene Identification from Single-Cell RNA-Sequencing Data
  17. A wonderful time – exciting progress made in the past 20 years in genetics powered by the Human Genome Project
  18. Systematic Exploration in Tissue-Pathway Associations of Complex Traits Using Comprehensive eQTLs Catalog
  19. Disease category-specific annotation of variants using an ensemble learning framework
  20. 20th International Workshop on Data Mining in Bioinformatics (BIOKDD 2021)
  21. Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival
  22. LRcell: detecting the source of differential expression at the sub-cell type level from bulk RNA-seq data
  23. EWASplus: a computational tool to expand EWAS coverage from the array to the whole epigenome.
  24. Pan-cancer analysis of pathway-based gene expression pattern at the individual level reveals biomarkers of clinical prognosis
  25. Glucocorticoid receptor wields chromatin interactions to tune transcription for cytoskeleton stabilization in podocytes
  26. Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes
  27. Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants
  28. Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes
  29. Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
  30. Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC)
  31. An empirical bayesian approach for testing gene expression fold change and its application in detecting global dosage effects
  32. Proceedings of the 2019 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference
  33. DeconPeaker, a Deconvolution Model to Identify Cell Types Based on Chromatin Accessibility in ATAC-Seq Data of Mixture Samples
  34. Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
  35. Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice
  36. Application of topic models to a compendium of ChIP-Seq datasets uncovers recurrent transcriptional regulatory modules
  37. An Integrated System Biology Approach Yields Drug Repositioning Candidates for the Treatment of Heart Failure
  38. Regulatory annotation of genomic intervals based on tissue-specific expression QTLs
  39. Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment
  40. Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure
  41. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
  42. Chronic adolescent stress sex-specifically alters the hippocampal transcriptome in adulthood
  43. Inferring Spatial Organization of Individual Topologically Associated Domains via Piecewise Helical Model
  44. RT States: systematic annotation of the human genome using cell type-specific replication timing programs
  45. A comprehensive review of computational prediction of genome-wide features
  46. Use replication timing data from multiple cell types to annotate human genome
  47. EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins
  48. Use cloud-based distributed systems to speed up merging of large collection of VCF files.
  49. Probabilistic and machine learning-based retrieval approaches for biomedical dataset retrieval
  50. Special collection of bioinformatics in the era of precision medicine
  51. Using DIVAN to assess disease/trait-associated single nucleotide variants in genome-wide scale
  52. Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
  53. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease
  54. Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome
  55. Omicseq: searching omics data without using metadata
  56. 10.1038/srep46398
  57. An approach of identifying differential nucleosome regions in multiple samples
  58. Computationally Tractable Multivariate HMM in Genome-Wide Mapping Studies
  59. Disease-specific non-coding variant annotation
  60. Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells
  61. The single-species metagenome: subtyping Staphylococcus aureus core genome sequences from shotgun metagenomic data
  62. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
  63. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors
  64. Use historical data to improve detection of differential expressed genes.
  65. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
  66. Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease
  67. Statistical Challenges in Analyzing Methylation and Long-Range Chromosomal Interaction Data
  68. Gene integrated set profile analysis: a context-based approach for inferring biological endpoints
  69. R package to test GWAS SNP enrichment in any genomic interval(s)
  70. A hidden Markov random field-based Bayesian method for the detection of long-range chromosomal interactions in Hi-C data
  71. Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
  72. Bayesian inference with historical data-based informative priors improves detection of differentially expressed genes
  73. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency
  74. One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies
  75. Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates
  76. Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing
  77. Base-resolution methylation patterns accurately predict transcription factor bindings in vivo
  78. A novel statistical method for quantitative comparison of multiple ChIP-seq datasets
  79. Systems biology and metagenomics: a showcase of Chinese bioinformatics researchers and their work
  80. Integrated Analysis of Whole-Genome Paired-End and Mate-Pair Sequencing Data for Identifying Genomic Structural Variations in Multiple Myeloma
  81. Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3
  82. Direct Amplification, Sequencing and Profiling of Chlamydia trachomatis Strains in Single and Mixed Infection Clinical Samples
  83. H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb
  84. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
  85. The central role of EED in the orchestration of polycomb group complexes
  86. Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
  87. EgoNet: identification of human disease ego-network modules
  88. Insulator function and topological domain border strength scale with architectural protein occupancy
  89. Allogeneic T cell responses are regulated by a specific miRNA-mRNA network
  90. Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation
  91. Understanding spatial organizations of chromosomes via statistical analysis of Hi-C data
  92. Bayesian Inference of Spatial Organizations of Chromosomes
  93. Sparsely correlated hidden Markov models with application to genome-wide location studies
  94. A genome-wide MeSH-based literature mining system predicts implicit gene-to-gene relationships and networks
  95. Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer
  96. Exploring the Cooccurrence Patterns of Multiple Sets of Genomic Intervals
  97. MotifOrganizer a scalable model-based motif clustering tool for mammalian genomes
  98. Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains
  99. Read-mapping using personalized diploid reference genome for RNA sequencing data reduced bias for detecting allele-specific expression
  100. HiCNorm: removing biases in Hi-C data via Poisson regression
  101. The Histone Acetyltransferase MOF Is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network
  102. PM-Seq: Using Finite Poisson Mixture Models for RNA-Seq Data Analysis and Transcript Expression Level Quantification
  103. GPUmotif: An Ultra-Fast and Energy-Efficient Motif Analysis Program Using Graphics Processing Units
  104. Cooperation between Polycomb and androgen receptor during oncogenic transformation
  105. FOXP3 Orchestrates H4K16 Acetylation and H3K4 Trimethylation for Activation of Multiple Genes by Recruiting MOF and Causing Displacement of PLU-1
  106. Using Poisson mixed-effects model to quantify transcript-level gene expression in RNA-Seq
  107. Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer
  108. Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer
  109. C/EBPβ Mediates Growth Hormone-Regulated Expression of Multiple Target Genes
  110. SAINT: probabilistic scoring of affinity purification–mass spectrometry data
  111. Statistical Issues in the Analysis of ChIP-Seq and RNA-Seq Data
  112. A Global Protein Kinase and Phosphatase Interaction Network in Yeast
  113. An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
  114. A Double-Layered Mixture Model for the Joint Analysis of DNA Copy Number and Gene Expression Data
  115. On the detection and refinement of transcription factor binding sites using ChIP-Seq data
  116. HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data
  117. Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin
  118. Computational and Functional Analysis of Growth Hormone (GH)-Regulated Genes Identifies the Transcriptional Repressor B-Cell Lymphoma 6 (Bc16) as a Participant in GH-Regulated Transcription
  119. Drug–Drug Interaction Prediction Assessment
  120. Hierarchical hidden Markov model with application to joint analysis of ChIP-chip and ChIP-seq data
  121. Progress toward personalized medicine for glaucoma
  122. Query Large Scale Microarray Compendium Datasets Using a Model-Based Bayesian Approach with Variable Selection
  123. A new probabilistic rule for drug–dug interaction prediction
  124. Advances in Statistical Bioinformatics
  125. Comparison of laboratory-based and phylogenetic methods to distinguish between Haemophilus influenzae and H. haemolyticus
  126. Family‐based SNP association study on 8q24 in bipolar disorder
  127. Genome-wide detection and characterization of positive selection in human populations
  128. A second generation human haplotype map of over 3.1 million SNPs
  129. p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
  130. CRCView: a web server for analyzing and visualizing microarray gene expression data using model-based clustering
  131. Different normalization strategies for microarray gene expression traits affect the heritability estimation
  132. Operon Prediction for Sequenced Bacterial Genomes without Experimental Information
  133. Clustering microarray gene expression data using weighted Chinese restaurant process
  134. A Comparison of Phasing Algorithms for Trios and Unrelated Individuals
  135. Energy, quiescence and the cellular basis of animal life spans
  136. TAGSNP SELECTION BASED ON PAIRWISE LD CRITERIA AND POWER ANALYSIS IN ASSOCIATION STUDIES
  137. An efficient comprehensive search algorithm for tagSNP selection using linkage disequilibrium criteria
  138. Improved Classification of Mass Spectrometry Database Search Results Using Newer Machine Learning Approaches
  139. A haplotype map of the human genome
  140. High Throughput Screening of Co-Expressed Gene Pairs with Controlled False Discovery Rate (FDR) and Minimum Acceptable Strength (MAS)
  141. Protein Tyrosine Phosphatase Gene PTPN22 Polymorphism in Psoriasis: Lack of Evidence for Association
  142. Fine Mapping of the Psoriasis Susceptibility Gene PSORS1: A Reassessment of Risk Associated with a Putative Risk Haplotype Lacking HLA-Cw6
  143. HapBlock: haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms
  144. Haplotype Block Partitioning and Tag SNP Selection Using Genotype Data and Their Applications to Association Studies
  145. Incorporating Genotyping Uncertainty in Haplotype Inference for Single-Nucleotide Polymorphisms
  146. Statistical resynchronization and Bayesian detection of periodically expressed genes
  147. Dynamic Programming Algorithms for Haplotype Block Partitioning and Tag SNP Selection Using Haplotype Data or Genotype Data
  148. Haplotype Inference and Its Application in Linkage Disequilibrium Mapping
  149. Identification of co-regulated genes through Bayesian clustering of predicted regulatory binding sites
  150. Scale Mixture Models with Applications to Bayesian Inference
  151. Partition-Ligation–Expectation-Maximization Algorithm for Haplotype Inference with Single-Nucleotide Polymorphisms
  152. Bayesian Haplotype Inference for Multiple Linked Single-Nucleotide Polymorphisms
  153. Multipoint Metropolis Method with Application to Hybrid Monte Carlo
  154. Model-Based Methods for Transcript Expression-Level Quantification in RNA-Seq
  155. Plate section
  156. Preface
  157. Statistical resynchronization and detection of periodic transcripts