All Stories

  1. Locus-specific stratification and prioritization unveil genetic risk mechanism underlying complex diseases
  2. Can a blood test tell us when ALS is approaching—before symptoms begin?
  3. A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region
  4. Age Effect Explorer: A Shiny application to browse and visualize tissue-specific age-related gene expression changes
  5. S-BEED: Sparse Bayesian Ensemble with Entropy-Calibrated Debate for Medical Multiple-Choice Question Answering
  6. Predicting Phenoconversion to Clinically Manifest ALS: Results of a Large-Scale Proteomic Study
  7. DEDUCE: statistical inference on disease-associated genes uncovers tissue–disease associations
  8. Early-life nutrition supplementation and epigenetic age in middle-adulthood among Guatemalan adults
  9. A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region
  10. MammOnc-DB, an integrative breast cancer data analysis platform for target discovery
  11. Phenotypic Characterization of Subtype A and Recombinant AC Transmitted/Founder Viruses from a Rwandan HIV-1 Heterosexual Transmission Cohort
  12. A novel classification framework for genome-wide association study of whole brain MRI images using deep learning
  13. MammOnc-DB, an integrative breast cancer data analysis platform for target discovery
  14. This is a comprehensive survey paper regarding controllable data generation by deep learning.
  15. Unsupervised Hierarchical Clustering of Head and Neck Cancer Patients by Pre-Treatment Plasma Metabolomics Creates Prognostic Metabolic Subtypes
  16. Comprehensive 100-bp resolution genome-wide epigenomic profiling data for the hg38 human reference genome
  17. UALCAN: An update to the integrated cancer data analysis platform
  18. ATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development
  19. Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults
  20. Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma
  21. Approaches to Marker Gene Identification from Single-Cell RNA-Sequencing Data
  22. A wonderful time – exciting progress made in the past 20 years in genetics powered by the Human Genome Project
  23. Systematic Exploration in Tissue-Pathway Associations of Complex Traits Using Comprehensive eQTLs Catalog
  24. Disease category-specific annotation of variants using an ensemble learning framework
  25. 20th International Workshop on Data Mining in Bioinformatics (BIOKDD 2021)
  26. Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival
  27. LRcell: detecting the source of differential expression at the sub-cell type level from bulk RNA-seq data
  28. EWASplus: a computational tool to expand EWAS coverage from the array to the whole epigenome.
  29. Pan-cancer analysis of pathway-based gene expression pattern at the individual level reveals biomarkers of clinical prognosis
  30. Glucocorticoid receptor wields chromatin interactions to tune transcription for cytoskeleton stabilization in podocytes
  31. Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes
  32. Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants
  33. Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes
  34. Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
  35. Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC)
  36. An empirical bayesian approach for testing gene expression fold change and its application in detecting global dosage effects
  37. Proceedings of the 2019 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference
  38. DeconPeaker, a Deconvolution Model to Identify Cell Types Based on Chromatin Accessibility in ATAC-Seq Data of Mixture Samples
  39. Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
  40. Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice
  41. Application of topic models to a compendium of ChIP-Seq datasets uncovers recurrent transcriptional regulatory modules
  42. An Integrated System Biology Approach Yields Drug Repositioning Candidates for the Treatment of Heart Failure
  43. Regulatory annotation of genomic intervals based on tissue-specific expression QTLs
  44. Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment
  45. Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure
  46. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
  47. Chronic adolescent stress sex-specifically alters the hippocampal transcriptome in adulthood
  48. Inferring Spatial Organization of Individual Topologically Associated Domains via Piecewise Helical Model
  49. RT States: systematic annotation of the human genome using cell type-specific replication timing programs
  50. A comprehensive review of computational prediction of genome-wide features
  51. Use replication timing data from multiple cell types to annotate human genome
  52. EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins
  53. Use cloud-based distributed systems to speed up merging of large collection of VCF files.
  54. Probabilistic and machine learning-based retrieval approaches for biomedical dataset retrieval
  55. Special collection of bioinformatics in the era of precision medicine
  56. Using DIVAN to assess disease/trait-associated single nucleotide variants in genome-wide scale
  57. Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
  58. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease
  59. Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome
  60. Omicseq: searching omics data without using metadata
  61. 10.1038/srep46398
  62. An approach of identifying differential nucleosome regions in multiple samples
  63. Computationally Tractable Multivariate HMM in Genome-Wide Mapping Studies
  64. Disease-specific non-coding variant annotation
  65. Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells
  66. The single-species metagenome: subtyping Staphylococcus aureus core genome sequences from shotgun metagenomic data
  67. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
  68. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors
  69. Use historical data to improve detection of differential expressed genes.
  70. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
  71. Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease
  72. Statistical Challenges in Analyzing Methylation and Long-Range Chromosomal Interaction Data
  73. Gene integrated set profile analysis: a context-based approach for inferring biological endpoints
  74. R package to test GWAS SNP enrichment in any genomic interval(s)
  75. A hidden Markov random field-based Bayesian method for the detection of long-range chromosomal interactions in Hi-C data
  76. Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
  77. Bayesian inference with historical data-based informative priors improves detection of differentially expressed genes
  78. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency
  79. One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies
  80. Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates
  81. Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing
  82. Base-resolution methylation patterns accurately predict transcription factor bindings in vivo
  83. A novel statistical method for quantitative comparison of multiple ChIP-seq datasets
  84. Systems biology and metagenomics: a showcase of Chinese bioinformatics researchers and their work
  85. Integrated Analysis of Whole-Genome Paired-End and Mate-Pair Sequencing Data for Identifying Genomic Structural Variations in Multiple Myeloma
  86. Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3
  87. Direct Amplification, Sequencing and Profiling of Chlamydia trachomatis Strains in Single and Mixed Infection Clinical Samples
  88. H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb
  89. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
  90. The central role of EED in the orchestration of polycomb group complexes
  91. Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
  92. EgoNet: identification of human disease ego-network modules
  93. Insulator function and topological domain border strength scale with architectural protein occupancy
  94. Allogeneic T cell responses are regulated by a specific miRNA-mRNA network
  95. Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation
  96. Understanding spatial organizations of chromosomes via statistical analysis of Hi-C data
  97. Bayesian Inference of Spatial Organizations of Chromosomes
  98. Sparsely correlated hidden Markov models with application to genome-wide location studies
  99. A genome-wide MeSH-based literature mining system predicts implicit gene-to-gene relationships and networks
  100. Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer
  101. Exploring the Cooccurrence Patterns of Multiple Sets of Genomic Intervals
  102. MotifOrganizer a scalable model-based motif clustering tool for mammalian genomes
  103. Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains
  104. Read-mapping using personalized diploid reference genome for RNA sequencing data reduced bias for detecting allele-specific expression
  105. HiCNorm: removing biases in Hi-C data via Poisson regression
  106. The Histone Acetyltransferase MOF Is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network
  107. PM-Seq: Using Finite Poisson Mixture Models for RNA-Seq Data Analysis and Transcript Expression Level Quantification
  108. GPUmotif: An Ultra-Fast and Energy-Efficient Motif Analysis Program Using Graphics Processing Units
  109. Cooperation between Polycomb and androgen receptor during oncogenic transformation
  110. FOXP3 Orchestrates H4K16 Acetylation and H3K4 Trimethylation for Activation of Multiple Genes by Recruiting MOF and Causing Displacement of PLU-1
  111. Using Poisson mixed-effects model to quantify transcript-level gene expression in RNA-Seq
  112. Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer
  113. Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer
  114. C/EBPβ Mediates Growth Hormone-Regulated Expression of Multiple Target Genes
  115. SAINT: probabilistic scoring of affinity purification–mass spectrometry data
  116. Statistical Issues in the Analysis of ChIP-Seq and RNA-Seq Data
  117. A Global Protein Kinase and Phosphatase Interaction Network in Yeast
  118. An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
  119. A Double-Layered Mixture Model for the Joint Analysis of DNA Copy Number and Gene Expression Data
  120. On the detection and refinement of transcription factor binding sites using ChIP-Seq data
  121. HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data
  122. Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin
  123. Computational and Functional Analysis of Growth Hormone (GH)-Regulated Genes Identifies the Transcriptional Repressor B-Cell Lymphoma 6 (Bc16) as a Participant in GH-Regulated Transcription
  124. Drug–Drug Interaction Prediction Assessment
  125. Hierarchical hidden Markov model with application to joint analysis of ChIP-chip and ChIP-seq data
  126. Progress toward personalized medicine for glaucoma
  127. Query Large Scale Microarray Compendium Datasets Using a Model-Based Bayesian Approach with Variable Selection
  128. A new probabilistic rule for drug–dug interaction prediction
  129. Advances in Statistical Bioinformatics
  130. Comparison of laboratory-based and phylogenetic methods to distinguish between Haemophilus influenzae and H. haemolyticus
  131. Family‐based SNP association study on 8q24 in bipolar disorder
  132. Genome-wide detection and characterization of positive selection in human populations
  133. A second generation human haplotype map of over 3.1 million SNPs
  134. p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
  135. CRCView: a web server for analyzing and visualizing microarray gene expression data using model-based clustering
  136. Different normalization strategies for microarray gene expression traits affect the heritability estimation
  137. Operon Prediction for Sequenced Bacterial Genomes without Experimental Information
  138. Clustering microarray gene expression data using weighted Chinese restaurant process
  139. A Comparison of Phasing Algorithms for Trios and Unrelated Individuals
  140. Energy, quiescence and the cellular basis of animal life spans
  141. TAGSNP SELECTION BASED ON PAIRWISE LD CRITERIA AND POWER ANALYSIS IN ASSOCIATION STUDIES
  142. An efficient comprehensive search algorithm for tagSNP selection using linkage disequilibrium criteria
  143. Improved Classification of Mass Spectrometry Database Search Results Using Newer Machine Learning Approaches
  144. A haplotype map of the human genome
  145. High Throughput Screening of Co-Expressed Gene Pairs with Controlled False Discovery Rate (FDR) and Minimum Acceptable Strength (MAS)
  146. Protein Tyrosine Phosphatase Gene PTPN22 Polymorphism in Psoriasis: Lack of Evidence for Association
  147. Fine Mapping of the Psoriasis Susceptibility Gene PSORS1: A Reassessment of Risk Associated with a Putative Risk Haplotype Lacking HLA-Cw6
  148. HapBlock: haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms
  149. Haplotype Block Partitioning and Tag SNP Selection Using Genotype Data and Their Applications to Association Studies
  150. Incorporating Genotyping Uncertainty in Haplotype Inference for Single-Nucleotide Polymorphisms
  151. Statistical resynchronization and Bayesian detection of periodically expressed genes
  152. Dynamic Programming Algorithms for Haplotype Block Partitioning and Tag SNP Selection Using Haplotype Data or Genotype Data
  153. Haplotype Inference and Its Application in Linkage Disequilibrium Mapping
  154. Identification of co-regulated genes through Bayesian clustering of predicted regulatory binding sites
  155. Scale Mixture Models with Applications to Bayesian Inference
  156. Partition-Ligation–Expectation-Maximization Algorithm for Haplotype Inference with Single-Nucleotide Polymorphisms
  157. Bayesian Haplotype Inference for Multiple Linked Single-Nucleotide Polymorphisms
  158. Multipoint Metropolis Method with Application to Hybrid Monte Carlo
  159. Model-Based Methods for Transcript Expression-Level Quantification in RNA-Seq
  160. Plate section
  161. Preface
  162. Statistical resynchronization and detection of periodic transcripts