All Stories

  1. Proton co-transport and voltage dependence enforce unidirectional metal transport in an Nramp transporter
  2. Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter
  3. D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain
  4. A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases
  5. A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15
  6. Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters
  7. Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4
  8. Antiparallel protocadherin homodimers use distinct affinity- and specificity mediating regions in cadherin repeats 1-4
  9. Data publication with the structural biology data grid supports live analysis
  10. Functional Modification of Bacterial Voltage-Gated Sodium Channels by Batrachotoxin
  11. Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity
  12. Novel mutations highlight the key role of the ankyrin repeat domain inTRPV4-mediated neuropathy
  13. How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy
  14. The Touching Tail of a Mechanotransduction Channel
  15. Structural characterization of the late competence protein ComFB from Bacillus subtilis
  16. Insights into the molecular foundations of electrical excitation
  17. Structural Determinants of TRPV Channel Activation and Modulation
  18. Structural Study of a Novel Partial Calcium-Free Linker and a Positively Selected Variation in Protocadherin-15: Implications for Hearing and Cell Adhesion
  19. Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter
  20. Sorting out a promiscuous superfamily: towards cadherin connectomics
  21. Structural Biology of TRP Channels
  22. Molecular Mechanisms of Deafness Mutations Disrupting Tip-Link Function in Hair-Cell Mechanotransduction
  23. High-Resolution Views of TRPV1 and Their Implications for the TRP Channel Superfamily
  24. What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?
  25. Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli
  26. Noddy, a Mouse Harboring a Missense Mutation in Protocadherin-15, Reveals the Impact of Disrupting a Critical Interaction Site between Tip-Link Cadherins in Inner Ear Hair Cells
  27. Structures and Simulated Dynamics of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
  28. Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction
  29. Distinct properties of Ca 2+ –calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel
  30. Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel
  31. Exome sequencing identifies a novel TRPV4 mutation in a CMT2C family
  32. Chicken TAP genes are polymorphic and co-evolve with the dominantly-expressed class I gene
  33. Biophysical Characterization of TRPV2 Ion Channel
  34. Structural Comparison of Ankyrin Repeat Domain of TRPV Channels
  35. Molecular Mechanics of Tip-Link Cadherins
  36. Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies
  37. Structural Determinants of Cadherin-23 Function in Hearing and Deafness
  38. Heat and Spice: Setting the Sensitivity of TRPV Channels
  39. Structural Determinants of Cadherin-23 Function in Hearing and Deafness
  40. Characterization and Structural Studies of the Plasmodium falciparum Ubiquitin and Nedd8 Hydrolase UCHL3
  41. Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C
  42. Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain
  43. Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments
  44. Antigen processing and presentation: TAPping into ABC transporters
  45. The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter
  46. The ABCs of trans(porter) inhibition
  47. TRP channels entering the structural era
  48. Functionally Important Interactions between the Nucleotide-Binding Domains of an Antigenic Peptide Transporter †
  49. Structural Analyses of the Ankyrin Repeat Domain of TRPV6 and Related TRPV Ion Channels † , ‡
  50. A primer on ankyrin repeat function in TRP channels and beyond
  51. Genome-wide detection and characterization of positive selection in human populations
  52. The Role of the N Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization
  53. The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity
  54. Insights into the Roles of Conserved and Divergent Residues in the Ankyrin Repeats of TRPV Ion Channels
  55. Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
  56. Distinct Structural and Functional Properties of the ATPase Sites in an Asymmetric ABC Transporter
  57. Structural Insights into the Function of TRP Channels
  58. Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 Ion Channel
  59. Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I
  60. Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate
  61. Structural and Functional Analysis of Human Cytomegalovirus US3 Protein
  62. Ubiquitylation of the Transducin beta gamma Subunit Complex. REGULATION BY PHOSDUCIN
  63. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing
  64. Virus subversion of immunity: a structural perspective
  65. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2
  66. Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1
  67. A Molecular Mechanism for the Phosphorylation-Dependent Regulation of Heterotrimeric G Proteins by Phosducin
  68. Structural aspects of heterotrimeric G-protein signaling
  70. Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin