All Stories

  1. Protein dynamics-assisted engineering of a selective debenzylase for replacing Pd/C-catalyzed debenzylation in statin precursor synthesis
  2. Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression
  3. Pharmacokinetic and pharmacodynamic studies of injectable nocathiacin as a novel antibacterial agent
  4. Gene conversion-associated successive engineering of modular polyketide synthases
  5. A broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance
  6. Engineering Bacillus Spores to Display Nicotine Oxidase: In Situ Specific and Sensitive Nicotine Detection
  7. A novel broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance
  8. Gene Conversion Directed Successive Engineering of Modular Polyketide Synthases
  9. Antiviral signaling of a type III CRISPR-associated deaminase
  10. Investigation of AMA Synthase from Pyrenophora teres f. teres 0–1 for the Synthesis of Aspergillomarasmine A Analogues and Non‐Canonical Amino Acids
  11. Improving regioselectivity of phenylalanine aminomutase from Taxus chinensis by semi-rational mutagenesis for the biocatalytic amination of cinnamates
  12. RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia
  13. Comparative Analysis of the Techniques for the Determination of Binding Affinity between a Small Molecule Inhibitor and a Protein Target
  14. Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN
  15. RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia
  16. The combination of tetracyclines effectively ameliorates liver fibrosis via inhibition of EphB1/2
  17. Selective biosynthesis of a rhamnosyl nosiheptide by a novel bacterial rhamnosyltransferase
  18. Constructing Escherichia coli co-display systems for biodegradation of polyethylene terephthalate
  19. Design of a chimeric glycosyltransferase OleD for the site‐specific O‐monoglycosylation of 3‐hydroxypyridine in nosiheptide
  20. The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma
  21. A Type I/Type III PKS Hybrid Generates Cinnamomycin A–D
  22. Efficient snailase-based production of mogrol from Luo Han Guo extract in an aqueous-organic system
  23. Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis
  24. Enzymatic hydrolyzation of mogrosides in Luo Han Guo extract by NKA-adsorbed snailase improves its sensory profile
  25. MD2 Is a Potential Biomarker Associated with Immune Cell Infiltration in Gliomas
  26. Correction to “Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue”
  27. Engineering of a UDP-Glycosyltransferase for the Efficient Whole-Cell Biosynthesis of Siamenoside I in Escherichia coli
  28. Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue
  29. Selective enzymatic α-1,6- monoglucosylation of mogroside IIIE for the bio-creation of α-siamenoside I, a potential high-intensity sweetener
  30. Efficient whole-cell biosynthesis of l-gulose by coupling mannitol-1-dehydrogenase with NADH oxidase
  31. The interaction of SET and protein phosphatase 2A as target for cancer therapy
  32. Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats
  33. Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers
  34. Enzymatic Monoglucosylation of Rubusoside and the Structure–Sweetness/Taste Relationship of Monoglucosyl Derivatives
  35. Riboflavin Is Directly Involved in N‐Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases
  36. Efficient Biocatalytic Preparation of Rebaudioside KA: Highly Selective Glycosylation Coupled with UDPG Regeneration
  37. Identification of a heparosan heptasaccharide as an effective anti-inflammatory agent by partial desulfation of low molecular weight heparin
  38. Correction to “Bifunctional Fusion Proteins Derived from Tumstatin and 4–1BBL for Targeted Cancer Therapy”
  39. Riboflavin Directly Mediates the Dealkylation by Microbial Cytochrome P450 Monooxygeneses
  40. Bifunctional Fusion Proteins Derived from Tumstatin and 4-1BBL for Targeted Cancer Therapy
  41. Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells
  42. Quantitative Assessment of the Absolute Purity of Thiopeptcin Reference Standard by 1H-NMR
  43. Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT
  44. A novel compound for the treatment of HCC
  45. On/off photo-switch of heparinase III to prepare LMWH
  46. Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo
  47. The involvement of nosP in the biosynthesis of nosiheptide---a typical thiopeptide
  48. Optimization of critical medium components for enhancing antibacterial thiopeptide nocathiacin I production with significantly improved quality
  49. Cooperative down-regulation of ribosomal protein L10 and NF-κB signaling pathway is responsible for the anti-proliferative effects by DMAPT in pancreatic cancer cells
  50. Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking
  51. Expanding the Catalytic Promiscuity of Heparinase III from Pedobacter heparinus
  52. Rearranged limonoids with unique 6/5/6/5 tetracarbocyclic skeletons from Toona ciliata and biomimetic structure divergence
  53. Mutagenesis of NosM Leader Peptide Reveals Important Elements in Nosiheptide Biosynthesis
  54. Highly specific quantification of microRNA by coupling probe–rolling circle amplification and Förster resonance energy transfer
  55. Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids fromTrichilia connaroides
  56. Selection of Reference Genes for Gene Expression Normalization in Peucedanum praeruptorum Dunn under Abiotic Stresses, Hormone Treatments and Different Tissues
  57. The catalytic characteristics of NocB in nocathiacin biosynthesis from Nocardia sp. ATCC 202099
  58. Mutagenesis of precursor peptide for the generation of nosiheptide analogues
  59. ChemInform Abstract: Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons from Stahlianthus involucratus.
  60. Integration of a Decrescent Transcriptome and Metabolomics Dataset of Peucedanum praeruptorum to Investigate the CYP450 and MDR Genes Involved in Coumarins Biosynthesis and Transport
  61. The importance of start codon of nosM in nosiheptide production
  62. Involudispirones A and B: Sesterterpenes Containing a Dispiro Ring fromStahlianthus involucratus
  63. Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons fromStahlianthus involucratus
  64. Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia
  65. Genetic incorporation of d-amino acids into green fluorescent protein based on polysubstrate specificity
  66. Isolation and biomimetic synthesis of (±)-calliviminones A and B, two novel Diels–Alder adducts, from Callistemon viminalis
  67. Enzymatic preparation of t-butyl-6-cyano-(3R, 5R)-dihydroxyhexanoate by a whole-cell biocatalyst co-expressing carbonyl reductase and glucose dehydrogenase
  68. The “Gate Keeper” Role of Trp222 Determines the Enantiopreference of Diketoreductase toward 2-Chloro-1-Phenylethanone
  69. Enzymatic synthesis of l-norephedrine by coupling recombinant pyruvate decarboxylase and ω-transaminase
  70. Microparticle-Based Strategy for Controlled Release of Substrate for the Biocatalytic Preparation ofl-Homophenylalanine
  71. Oral Delivery of Exenatide via Microspheres Prepared by Cross-Linking of Alginate and Hyaluronate
  72. Efficient access to the non-reducing end of low molecular weight heparin for fluorescent labeling
  73. Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide
  74. Multiple Oxidative Routes towards the Maturation of Nosiheptide
  75. Enhancement of biocatalytic efficiency by increasing substrate loading: enzymatic preparation of l-homophenylalanine
  76. Inside Cover: The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation (ChemBioChem 5/2013)
  77. The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation
  78. Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells
  79. The Apoptotic Effects of Toosendanin Are Partially Mediated by Activation of Deoxycytidine Kinase in HL-60 Cells
  80. Functional roles of Tryptophan residues in diketoreductase from Acinetobacter baylyi
  81. Chirality plays critical roles in enhancing the aqueous solubility of nocathiacin I by block copolymer micelles
  82. ChemInform Abstract: Dicarbonyl Reduction by Single Enzyme for the Preparation of Chiral Diols
  83. Genetic incorporation of d-lysine into diketoreductase in Escherichia coli cells
  84. Identification of important residues in diketoreductase from Acinetobacter baylyi by molecular modeling and site-directed mutagenesis
  85. One ketoreductase works in two-steps by two active sites
  86. Dicarbonyl reduction by single enzyme for the preparation of chiral diols
  87. Correlation between Intracellular Cofactor Concentrations and Biocatalytic Efficiency: Coexpression of Diketoreductase and Glucose Dehydrogenase for the Preparation of Chiral Diol for Statin Drugs
  88. Soluble expression of recombinant human CD137 ligand in Escherichia coli by co-expression of chaperones
  89. Recombinant human CD137L for cancer immunotherapy: effects of different fusions and linkers on its activity
  90. Preparation of ethyl 3R,5S-6-(benzyloxy)-3,5-dihydroxy-hexanoate by recombinant diketoreductase in a biphasic system
  91. Enzymatic Preparation of an (S)-Amino Acid from a Racemic Amino Acid
  92. Catalytic Effects of Different Heparin Analogs on the Hydrolysis of Auramine O
  93. A simple reverse genetics approach to elucidating the biosynthetic pathway of nocathiacin
  94. Editorial [Hot topic: Biotransformation in Drug Discovery and Development (Guest Editor: Yijun Chen)]
  95. Dehydrogenases/Reductases for the Synthesis of Chiral Pharmaceutical Intermediates
  96. Universal Method Facilitating the Amplification of Extremely GC-Rich DNA Fragments from Genomic DNA
  97. Microbial generation of nocathiacin acid from nocathiacin I
  98. Efficient amplification of genes involved in microbial secondary metabolism by an improved genome walking method
  99. PhD: routine technical work of sequencing is no substitute
  100. Separation of structurally similar nocathiacin analogues by reversed phase chromatography
  101. A Bacterial Enzyme Catalyzing Double Reduction of a β,δ-Diketo Ester with Unprecedented Stereoselectivity
  102. A Bacterial Enzyme Catalyzing Double Reduction of a β,δ-Diketo Ester with Unprecedented Stereoselectivity
  103. A diketoreductase exhibits unique renaturation profile from thermal-induced protein unfolding
  104. Stereoselective introduction of two chiral centers by a single diketoreductase: an efficient biocatalytic route for the synthesis of statin side chains
  105. Enantioselective synthesis of ethyl (S)-2-hydroxy-4-phenylbutyrate by recombinant diketoreductase
  106. Cloning, expression, and characterization of a novel diketoreductase from Acinetobacter baylyi
  107. Olympics may have a negative impact on China's research
  108. Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase fromBacillus megaterium
  109. Determination of enantiomeric excess of ethyl 3,5-dihydroxy-6-benzyloxy hexanoate by chiral reverse phase high performance liquid chromatography
  110. A Novel Ketone Derivative of Artemisinin Biotransformed by Streptomyces griseus ATCC 13273.
  111. Synthesis of ethyl and t-butyl (3R,5S)-dihydroxy-6-benzyloxy hexanoates via diastereo- and enantioselective microbial reduction
  112. A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273
  113. Purification, cloning, and functional expression of phenylalanine aminomutase: The first committed step in Taxol side-chain biosynthesis
  114. Core-modified sordaricin derivatives: Synthesis and antifungal activity
  115. Sordarin Oxazepine Derivatives as Potent Antifungal Agents
  116. Chemical Protein Synthesis by Solid Phase Ligation of Unprotected Peptide Segments
  117. Group-Specific Assays That Distinguish between the Four Major Types of Mammalian Phospholipase A2
  118. Expression and characterization of human group V phospholipase A2
  119. Microbial models of soil metabolism: biotransformations of danofloxacin
  120. Oligopeptides as Substrates and Inhibitors for a New Constitutive Nitric Oxide Synthase from Rat Cerebellum
  121. Purification and characterization of nitric oxide synthase (NOSNoc) from a Nocardia species.
  122. A Bacterial, Nitric Oxide Synthase from a Nocardia Species
  123. Microbial Transformation of Ibuprofen by a Nocardia Species
  124. Effects of Antiglaucoma Drugs on Ocular Blood Flow in Ocular Hypertensive Rabbits
  125. Effects of Dopamine Agonist, Bromocriptine, and Some Dopamine Antagonists on Ocular Blood Flow
  126. Enhancement of systemic delivery of peptide drugs via ocular route with surfactants
  127. Effects of D- and L-Isomers of Timolol on Retinal and Choroidal Blood Flow in Ocular Hypertensive Rabbit Eyes