All Stories

  1. Engineering a cytochrome P450 enzyme as a peroxygenase for selective hydroxylation of steroids
  2. Protein dynamics-assisted engineering of a selective debenzylase for replacing Pd/C-catalyzed debenzylation in statin precursor synthesis
  3. Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression
  4. Pharmacokinetic and pharmacodynamic studies of injectable nocathiacin as a novel antibacterial agent
  5. Gene conversion-associated successive engineering of modular polyketide synthases
  6. A broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance
  7. Engineering Bacillus Spores to Display Nicotine Oxidase: In Situ Specific and Sensitive Nicotine Detection
  8. A novel broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance
  9. Gene Conversion Directed Successive Engineering of Modular Polyketide Synthases
  10. Antiviral signaling of a type III CRISPR-associated deaminase
  11. Investigation of AMA Synthase from Pyrenophora teres f. teres 0–1 for the Synthesis of Aspergillomarasmine A Analogues and Non‐Canonical Amino Acids
  12. Improving regioselectivity of phenylalanine aminomutase from Taxus chinensis by semi-rational mutagenesis for the biocatalytic amination of cinnamates
  13. RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia
  14. Comparative Analysis of the Techniques for the Determination of Binding Affinity between a Small Molecule Inhibitor and a Protein Target
  15. Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN
  16. RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia
  17. The combination of tetracyclines effectively ameliorates liver fibrosis via inhibition of EphB1/2
  18. Selective biosynthesis of a rhamnosyl nosiheptide by a novel bacterial rhamnosyltransferase
  19. Constructing Escherichia coli co-display systems for biodegradation of polyethylene terephthalate
  20. Design of a chimeric glycosyltransferase OleD for the site‐specific O‐monoglycosylation of 3‐hydroxypyridine in nosiheptide
  21. The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma
  22. A Type I/Type III PKS Hybrid Generates Cinnamomycin A–D
  23. Efficient snailase-based production of mogrol from Luo Han Guo extract in an aqueous-organic system
  24. Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis
  25. Enzymatic hydrolyzation of mogrosides in Luo Han Guo extract by NKA-adsorbed snailase improves its sensory profile
  26. MD2 Is a Potential Biomarker Associated with Immune Cell Infiltration in Gliomas
  27. Correction to “Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue”
  28. Engineering of a UDP-Glycosyltransferase for the Efficient Whole-Cell Biosynthesis of Siamenoside I in Escherichia coli
  29. Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue
  30. Selective enzymatic α-1,6- monoglucosylation of mogroside IIIE for the bio-creation of α-siamenoside I, a potential high-intensity sweetener
  31. Efficient whole-cell biosynthesis of l-gulose by coupling mannitol-1-dehydrogenase with NADH oxidase
  32. The interaction of SET and protein phosphatase 2A as target for cancer therapy
  33. Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats
  34. Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers
  35. Enzymatic Monoglucosylation of Rubusoside and the Structure–Sweetness/Taste Relationship of Monoglucosyl Derivatives
  36. Riboflavin Is Directly Involved in N‐Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases
  37. Efficient Biocatalytic Preparation of Rebaudioside KA: Highly Selective Glycosylation Coupled with UDPG Regeneration
  38. Identification of a heparosan heptasaccharide as an effective anti-inflammatory agent by partial desulfation of low molecular weight heparin
  39. Correction to “Bifunctional Fusion Proteins Derived from Tumstatin and 4–1BBL for Targeted Cancer Therapy”
  40. Riboflavin Directly Mediates the Dealkylation by Microbial Cytochrome P450 Monooxygeneses
  41. Bifunctional Fusion Proteins Derived from Tumstatin and 4-1BBL for Targeted Cancer Therapy
  42. Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells
  43. Quantitative Assessment of the Absolute Purity of Thiopeptcin Reference Standard by 1H-NMR
  44. Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT
  45. A novel compound for the treatment of HCC
  46. On/off photo-switch of heparinase III to prepare LMWH
  47. Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo
  48. The involvement of nosP in the biosynthesis of nosiheptide---a typical thiopeptide
  49. Optimization of critical medium components for enhancing antibacterial thiopeptide nocathiacin I production with significantly improved quality
  50. Cooperative down-regulation of ribosomal protein L10 and NF-κB signaling pathway is responsible for the anti-proliferative effects by DMAPT in pancreatic cancer cells
  51. Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking
  52. Expanding the Catalytic Promiscuity of Heparinase III from Pedobacter heparinus
  53. Rearranged limonoids with unique 6/5/6/5 tetracarbocyclic skeletons from Toona ciliata and biomimetic structure divergence
  54. Mutagenesis of NosM Leader Peptide Reveals Important Elements in Nosiheptide Biosynthesis
  55. Highly specific quantification of microRNA by coupling probe–rolling circle amplification and Förster resonance energy transfer
  56. Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids fromTrichilia connaroides
  57. Selection of Reference Genes for Gene Expression Normalization in Peucedanum praeruptorum Dunn under Abiotic Stresses, Hormone Treatments and Different Tissues
  58. The catalytic characteristics of NocB in nocathiacin biosynthesis from Nocardia sp. ATCC 202099
  59. Mutagenesis of precursor peptide for the generation of nosiheptide analogues
  60. ChemInform Abstract: Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons from Stahlianthus involucratus.
  61. Integration of a Decrescent Transcriptome and Metabolomics Dataset of Peucedanum praeruptorum to Investigate the CYP450 and MDR Genes Involved in Coumarins Biosynthesis and Transport
  62. The importance of start codon of nosM in nosiheptide production
  63. Involudispirones A and B: Sesterterpenes Containing a Dispiro Ring fromStahlianthus involucratus
  64. Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons fromStahlianthus involucratus
  65. Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia
  66. Genetic incorporation of d-amino acids into green fluorescent protein based on polysubstrate specificity
  67. Isolation and biomimetic synthesis of (±)-calliviminones A and B, two novel Diels–Alder adducts, from Callistemon viminalis
  68. Enzymatic preparation of t-butyl-6-cyano-(3R, 5R)-dihydroxyhexanoate by a whole-cell biocatalyst co-expressing carbonyl reductase and glucose dehydrogenase
  69. The “Gate Keeper” Role of Trp222 Determines the Enantiopreference of Diketoreductase toward 2-Chloro-1-Phenylethanone
  70. Enzymatic synthesis of l-norephedrine by coupling recombinant pyruvate decarboxylase and ω-transaminase
  71. Microparticle-Based Strategy for Controlled Release of Substrate for the Biocatalytic Preparation ofl-Homophenylalanine
  72. Oral Delivery of Exenatide via Microspheres Prepared by Cross-Linking of Alginate and Hyaluronate
  73. Efficient access to the non-reducing end of low molecular weight heparin for fluorescent labeling
  74. Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide
  75. Multiple Oxidative Routes towards the Maturation of Nosiheptide
  76. Enhancement of biocatalytic efficiency by increasing substrate loading: enzymatic preparation of l-homophenylalanine
  77. Inside Cover: The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation (ChemBioChem 5/2013)
  78. The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation
  79. Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells
  80. The Apoptotic Effects of Toosendanin Are Partially Mediated by Activation of Deoxycytidine Kinase in HL-60 Cells
  81. Functional roles of Tryptophan residues in diketoreductase from Acinetobacter baylyi
  82. Chirality plays critical roles in enhancing the aqueous solubility of nocathiacin I by block copolymer micelles
  83. ChemInform Abstract: Dicarbonyl Reduction by Single Enzyme for the Preparation of Chiral Diols
  84. Genetic incorporation of d-lysine into diketoreductase in Escherichia coli cells
  85. Identification of important residues in diketoreductase from Acinetobacter baylyi by molecular modeling and site-directed mutagenesis
  86. One ketoreductase works in two-steps by two active sites
  87. Dicarbonyl reduction by single enzyme for the preparation of chiral diols
  88. Correlation between Intracellular Cofactor Concentrations and Biocatalytic Efficiency: Coexpression of Diketoreductase and Glucose Dehydrogenase for the Preparation of Chiral Diol for Statin Drugs
  89. Soluble expression of recombinant human CD137 ligand in Escherichia coli by co-expression of chaperones
  90. Recombinant human CD137L for cancer immunotherapy: effects of different fusions and linkers on its activity
  91. Preparation of ethyl 3R,5S-6-(benzyloxy)-3,5-dihydroxy-hexanoate by recombinant diketoreductase in a biphasic system
  92. Enzymatic Preparation of an (S)-Amino Acid from a Racemic Amino Acid
  93. Catalytic Effects of Different Heparin Analogs on the Hydrolysis of Auramine O
  94. A simple reverse genetics approach to elucidating the biosynthetic pathway of nocathiacin
  95. Editorial [Hot topic: Biotransformation in Drug Discovery and Development (Guest Editor: Yijun Chen)]
  96. Dehydrogenases/Reductases for the Synthesis of Chiral Pharmaceutical Intermediates
  97. Universal Method Facilitating the Amplification of Extremely GC-Rich DNA Fragments from Genomic DNA
  98. Microbial generation of nocathiacin acid from nocathiacin I
  99. Efficient amplification of genes involved in microbial secondary metabolism by an improved genome walking method
  100. PhD: routine technical work of sequencing is no substitute
  101. Separation of structurally similar nocathiacin analogues by reversed phase chromatography
  102. A Bacterial Enzyme Catalyzing Double Reduction of a β,δ-Diketo Ester with Unprecedented Stereoselectivity
  103. A Bacterial Enzyme Catalyzing Double Reduction of a β,δ-Diketo Ester with Unprecedented Stereoselectivity
  104. A diketoreductase exhibits unique renaturation profile from thermal-induced protein unfolding
  105. Stereoselective introduction of two chiral centers by a single diketoreductase: an efficient biocatalytic route for the synthesis of statin side chains
  106. Enantioselective synthesis of ethyl (S)-2-hydroxy-4-phenylbutyrate by recombinant diketoreductase
  107. Cloning, expression, and characterization of a novel diketoreductase from Acinetobacter baylyi
  108. Olympics may have a negative impact on China's research
  109. Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase fromBacillus megaterium
  110. Determination of enantiomeric excess of ethyl 3,5-dihydroxy-6-benzyloxy hexanoate by chiral reverse phase high performance liquid chromatography
  111. A Novel Ketone Derivative of Artemisinin Biotransformed by Streptomyces griseus ATCC 13273.
  112. Synthesis of ethyl and t-butyl (3R,5S)-dihydroxy-6-benzyloxy hexanoates via diastereo- and enantioselective microbial reduction
  113. A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273
  114. Purification, cloning, and functional expression of phenylalanine aminomutase: The first committed step in Taxol side-chain biosynthesis
  115. Core-modified sordaricin derivatives: Synthesis and antifungal activity
  116. Sordarin Oxazepine Derivatives as Potent Antifungal Agents
  117. Chemical Protein Synthesis by Solid Phase Ligation of Unprotected Peptide Segments
  118. Group-Specific Assays That Distinguish between the Four Major Types of Mammalian Phospholipase A2
  119. Expression and characterization of human group V phospholipase A2
  120. Microbial models of soil metabolism: biotransformations of danofloxacin
  121. Oligopeptides as Substrates and Inhibitors for a New Constitutive Nitric Oxide Synthase from Rat Cerebellum
  122. Purification and characterization of nitric oxide synthase (NOSNoc) from a Nocardia species.
  123. A Bacterial, Nitric Oxide Synthase from a Nocardia Species
  124. Microbial Transformation of Ibuprofen by a Nocardia Species
  125. Effects of Antiglaucoma Drugs on Ocular Blood Flow in Ocular Hypertensive Rabbits
  126. Effects of Dopamine Agonist, Bromocriptine, and Some Dopamine Antagonists on Ocular Blood Flow
  127. Enhancement of systemic delivery of peptide drugs via ocular route with surfactants
  128. Effects of D- and L-Isomers of Timolol on Retinal and Choroidal Blood Flow in Ocular Hypertensive Rabbit Eyes