All Stories

  1. Family 1 P450s Form Complexes that Effect Enzyme Function

    Article • May 2023, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Wayne Louis Backes

  2. Identification of the contact region responsible for the formation of the homomeric CYP1A2•CYP1A2 complex

    Article • Biochemical Journal, June 2021, Portland Press Ltd.

    Wayne Louis Backes

  3. Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1

    Article • Biochemical Journal, January 2021, Portland Press Ltd.

    Wayne Louis Backes

  4. Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1

    Article • Journal of Biological Chemistry, January 2021, Elsevier

    Wayne Louis Backes

  5. Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Wayne Louis Backes

  6. The Search Continues: Determination of a Lipid Raft Targeting Motif in Cytochromes P450

    Article • The FASEB Journal, April 2020, Wiley

    Wayne Louis Backes

  7. The Effect of Cholesterol Depletion on the Localization of CYP2D6

    Article • The FASEB Journal, April 2019, Wiley

    Wayne Louis Backes

  8. Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition

    Article • January 2018, Frontiers

    Wayne Louis Backes

  9. Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

    Article • January 2018, Frontiers

    Wayne Louis Backes

  10. Drug metabolizing enzymes form specific complexes in membranes

    Article • Drug Metabolism and Disposition, December 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Wayne Louis Backes

  11. Membrane Heterogeneity affects where different cytochrome P450s reside and affects P450 function.

    Article • Drug Metabolism and Disposition, May 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Wayne Louis Backes

  12. Different Cytochrome P450s Reside in Unique Sections of the Endoplasmic Reticulum

    Article • Drug Metabolism and Disposition, February 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Wayne Louis Backes

  13. Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter

    Article • Biochemical Pharmacology, May 2015, Elsevier

    Wayne Louis Backes

  14. CYP1A2 and CYP2B4 Form Complexes Associated with Altered Catalytic Activity

    Article • The FASEB Journal, April 2015, Wiley

    Wayne Louis Backes

  15. Physical interaction between CYP1A2 and CYP2B4 causes a disruption of inhibitory CYP1A2 complexes (LB592)

    Article • The FASEB Journal, April 2014, Wiley

    Wayne Louis Backes

  16. Effect of homomeric P450–P450 complexes on P450 function

    Article • Biochemical Journal, August 2012, Portland Press Ltd.

    Wayne Louis Backes

  17. Formation of P450·P450 complexes and their effect on P450 function

    Article • Pharmacology & Therapeutics, March 2012, Elsevier

    Wayne Louis Backes

  18. Assay of Heme Oxygenase‐1 through the Direct Measurement of Biliverdin Formation or Iron Release

    Article • The FASEB Journal, April 2010, Wiley

    Wayne Louis Backes

  19. Quantitation of heme oxygenase 1: Heme titration increases yield of purified protein

    Article • Analytical Biochemistry, February 2008, Elsevier

    Wayne Louis Backes

  20. Pharmacodynamics

    Article • January 2007, Elsevier

    Wayne Louis Backes

  21. Pharmacokinetics

    Article • January 2007, Elsevier

    Wayne Louis Backes

  22. Phase I Biotransformation Reactions- Cytochrome P450s

    Article • January 2007, Elsevier

    Wayne Louis Backes

  23. Drug Transport Across Membranes

    Article • January 2007, Elsevier

    Wayne Louis Backes

  24. Passive Diffusion of Drugs Across Membranes

    Article • January 2007, Elsevier

    Wayne Louis Backes

  25. Filtration of Drugs Across Membranes

    Article • January 2007, Elsevier

    Wayne Louis Backes

  26. Phase I Biotransformation Reactions-NADPH-Cytochrome P450 Reductase

    Article • January 2007, Elsevier

    Wayne Louis Backes

  27. Heteromeric Complex Formation between CYP2E1 and CYP1A2:  Evidence for the Involvement of Electrostatic Interactions†

    Article • Biochemistry, December 2006, American Chemical Society (ACS)

    Wayne Louis Backes

  28. Effects of Ionic Strength on the Functional Interactions between CYP2B4 and CYP1A2

    Article • Biochemistry, January 2005, American Chemical Society (ACS)

    Wayne Louis Backes

  29. Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes

    Article • Pharmacology & Therapeutics, May 2003, Elsevier

    Wayne Louis Backes

  30. Altered Ethylbenzene-Mediated Hepatic CYP2E1 Expression in Growth Hormone-Deficient Dwarf Rats

    Article • Toxicology and Applied Pharmacology, March 2002, Elsevier

    Wayne Louis Backes

  31. Reply

    Article • Toxicology and Applied Pharmacology, June 2001, Elsevier

    Wayne Louis Backes

  32. Possible involvement of cytochrome P-450 in the epithelium-modulated response to methacholine in guinea pig trachea

    Article • Biochemical Pharmacology, February 1988, Elsevier

    Wayne Louis Backes

  33. Association of hydrophobic substances with hemin

    Article • Biochemical Pharmacology, December 1986, Elsevier

    Wayne Louis Backes

  34. Methods for the evaluation of hydrophobic substrate binding to cytochrome P-450

    Article • Pharmacology & Therapeutics, January 1981, Elsevier

    Wayne Louis Backes

  35. Cytochrome P-450 reduction exhibits burst kinetics

    Article • Biochemical and Biophysical Research Communications, December 1980, Elsevier

    Wayne Louis Backes