What is it about?
Cytochrome P450s (P450) comprise a superfamily of proteins that convert drugs and other foreign compounds into metabolites that are more rapidly excreted from the body. These proteins generally reside in membranes, and must form complexes with other proteins in order to function. The membrane provides a scaffold for the P450 system proteins to reside, and facilitates their interactions with their redox partners as well as other P450s. Biological membranes are heterogeneous in nature, with some phospholipids, cholesterol and sphingolipids forming ordered membrane regions with other membrane regions being more disordered. Interestingly, some of the P450 system proteins specifically reside in these ordered regions, whereas others localize in more disordered domains. .
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Why is it important?
This paper focuses on how specific phospholipids influence P450-dependent activities, how membrane characteristics can affect where proteins reside in the membrane, and how this can affect drug and foreign compound metabolism
Perspectives
There are a number of factors that affect how P450 is able to detoxify chemicals. These include control over the levels of different P450s, and their ability to form complexes that allow metabolism to occur. However, less is known about how the membrane, which is the platform where these protein reside. These interactions can affect how effectively foreign compounds are eliminated, and potentially how toxic metabolites are produced.
Wayne Louis Backes
Louisiana State University Health Sciences Center
Read the Original
This page is a summary of: Cytochrome P450 Organization and Function Are Modulated by Endoplasmic Reticulum Phospholipid Heterogeneity, Drug Metabolism and Disposition, May 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/dmd.115.068981.
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