What is it about?
Cytochrome P450s are responsible for the conversion of drugs and environmental pollutants into chemicals that can be more rapidly removed from the body. Our studies on two the these P450s (CYP1A2 and CYP2B4) show that they form complexes in the membrane, and that these complexes change their function, making CYP1A2 more effective and CYP2B4 less effective.
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Why is it important?
The levels of different CYPs are affected by exposure to components of cigarette smoke (CYP1A), and drugs (CYP2B). Consequently, individuals who have CYP1A and are also exposed to drugs that generate CYP2B, will breakdown drugs differently due to their ability to form these CYP1A-CYP2B complexes. Such mechanisms are an additional important reason that there is so much individual variation in drug and foreign compound metabolism.
Perspectives
These studies show that the complexes among the P450 system proteins are complex, and that the proteins exist in the membranes as larger complexes that are specific for the ensemble of P450s that are present in an individual.
Wayne Louis Backes
Louisiana State University Health Sciences Center
Read the Original
This page is a summary of: Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes, Drug Metabolism and Disposition, December 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET),
DOI: 10.1124/dmd.117.078642.
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