All Stories

  1. Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma
  2. Enhancing Mass spectrometry-based tumor immunopeptide identification: machine learning filter leveraging HLA binding affinity, aliphatic index and retention time deviation
  3. Characterization of pre- and on-treatment soluble immune mediators and the tumor microenvironment in NSCLC patients receiving PD-1/L1 inhibitor monotherapy
  4. Prognostic Significance of Plasma Neutrophil Extracellular Trap Levels in Patients with Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors
  5. Recent Trends and Potential of Radiotherapy in the Treatment of Anaplastic Thyroid Cancer
  6. MMP1, IL-1β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors
  7. Characterization of Pre- and Post-treatment Soluble Immune Mediators and the Tumor Microenvironment in NSCLC Patients Receiving PD-1/L1 Inhibitor Monotherapy
  8. Circulating IL-6 and not its circulating signaling components sIL-6R and sgp130 demonstrate clinical significance in NSCLC patients treated with immune checkpoint inhibitors
  9. Novel chimeric antigen receptor‐expressing T cells targeting the malignant mesothelioma‐specific antigen sialylated HEG1
  10. Circulating cytokine signatures as a soluble biomarker of immune checkpoint inhibitor therapy in non-small-cell lung cancer
  11. Immune mediators as predictive biomarkers for anti-PD-1 antibody therapy in urothelial carcinoma
  12. Survival and soluble immune mediators of immune checkpoint inhibitor-induced interstitial lung disease in patients with non-small cell lung cancer
  13. Survival and biomarkers for cachexia in non‐small cell lung cancer receiving immune checkpoint inhibitors
  14. Machine learning for prediction of immunotherapeutic outcome in non-small-cell lung cancer based on circulating cytokine signatures
  15. Clinical roles of soluble PD-1 and PD-L1 in plasma of NSCLC patients treated with immune checkpoint inhibitors
  16. PD-L1 expression in anaplastic thyroid carcinoma treated with lenvatinib
  17. A phase 1 trial of NY‐ESO‐1‐specific TCR‐engineered T‐cell therapy combined with a lymph node‐targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma
  18. Clinical roles of soluble PD-1 and PD-L1 in plasma of NSCLC patients treated with immune checkpoint inhibitors
  19. Evaluation of X-ray and carbon-ion beam irradiation with chemotherapy for the treatment of cervical adenocarcinoma cells in 2D and 3D cultures
  20. Evaluation of X-ray and carbon-ion beam irradiation with chemotherapy for the treatment of cervical adenocarcinoma cells on 2D and 3D cultures
  21. NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome
  22. Exhaustion of CAR T cells: potential causes and solutions
  23. Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model
  24. Personalized peptide vaccines
  25. Personalized Cancer Vaccines Targeting Neoantigens
  26. Possible Role of Cytochrome P450 1B1 in the Mechanism of Gemcitabine Resistance in Pancreatic Cancer
  27. Clinical significance of peripheral TCR and BCR repertoire diversity in EGFR/ALK wild-type NSCLC treated with anti-PD-1 antibody
  28. Investigation of factors associated with reduced clinical benefits of personalized peptide vaccination for pancreatic cancer
  29. Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy
  30. High levels of human epididymis protein 4 mRNA and protein expression are associated with chemoresistance and a poor prognosis in pancreatic cancer
  31. C-reactive protein at 1 month after treatment of nivolumab as a predictive marker of efficacy in advanced renal cell carcinoma
  32. Galectin-9 expression as a poor prognostic factor in patients with renal cell carcinoma
  33. High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer
  34. Identification of biomarkers for personalized peptide vaccination in 2,588 cancer patients
  35. Mixed 20-peptide cancer vaccine in combination with docetaxel and dexamethasone for castration-resistant prostate cancer: a randomized phase II trial
  36. High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer
  37. Distribution of Regulatory T-Cells and Other Phenotypes of T-Cells in Tumors and Regional Lymph Nodes of Colorectal Cancer Patients
  38. Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial
  39. Prospects for a personalized peptide vaccine against lung cancer
  40. Assessment of soluble immune mediators as potential biomarkers during immune checkpoint inhibitor therapy
  41. Identification of Novel HLA Class II-Restricted Neoantigens Derived from Driver Mutations
  42. A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma
  43. Association between soluble immune mediators and tumor responses in patients with nonsmall cell lung cancer treated with anti‐PD‐1 inhibitor
  44. Enhanced expression of PD-L1 in non-muscle-invasive bladder cancer after treatment with Bacillus Calmette-Guerin
  45. Identification of a novel HLA-A24-restricted cytotoxic T lymphocyte epitope peptide derived from mesothelin in pancreatic cancer
  46. Prognostic stratification of patients with nasopharyngeal carcinoma based on tumor immune microenvironment
  47. Use of patient-derived xenograft mouse models in cancer research and treatment
  48. Personalized peptide vaccines for cancer therapy: current progress and state of the art
  49. Feasibility Study of Personalized Peptide Vaccination for Advanced Small Cell Lung Cancer
  50. Personalized peptide vaccination as second-line treatment for metastatic upper tract urothelial carcinoma
  51. Association between PD-L1 expression combined with tumor-infiltrating lymphocytes and the prognosis of patients with advanced hypopharyngeal squamous cell carcinoma
  52. Are peptide vaccines viable in combination with other cancer immunotherapies?
  53. Feasibility study of personalized peptide vaccination for hepatocellular carcinoma patients refractory to locoregional therapies
  54. Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical Trial
  55. Programmed cell death-ligand 1 expression and immunoscore in stage II and III non-small cell lung cancer patients receiving adjuvant chemotherapy
  56. A randomized phase II trial of personalized peptide vaccine with low dose cyclophosphamide in biliary tract cancer
  57. Immunological evaluation of peptide vaccination for cancer patients with the HLA ‐A11+ or ‐A33+ allele
  58. Enhancement of humoral and cell mediated immune response to HPV16 L1-derived peptides subsequent to vaccination with prophylactic bivalent HPV L1 virus-like particle vaccine in healthy females
  59. Current Status and Future Prospects of Peptide-Based Cancer vaccines
  60. Immune Responses to Epidermal Growth Factor Receptor (EGFR) and Their Application for Cancer Treatment
  61. Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma
  62. Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients
  63. Personalized immunotherapy in colorectal cancer
  64. Prospect and progress of personalized peptide vaccinations for advanced cancers
  65. A randomized phase II clinical trial of personalized peptide vaccination with metronomic low-dose cyclophosphamide in patients with metastatic castration-resistant prostate cancer
  66. An Open-Label, Randomized Phase II Trial of Personalized Peptide Vaccination in Patients with Bladder Cancer that Progressed after Platinum-Based Chemotherapy
  67. Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Cell Lung Cancer
  68. Designing a broad-spectrum integrative approach for cancer prevention and treatment
  69. Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients
  70. Immunological evaluation of peptide vaccination for cancer patients with the HLA ‐A26 allele
  71. Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination
  72. Phase I trial of a cancer vaccine consisting of 20 mixed peptides in patients with castration-resistant prostate cancer: dose-related immune boosting and suppression
  73. Personalized peptide vaccination for advanced colorectal cancer
  74. Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advanced Hepatocellular Carcinoma Patients
  75. Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer
  76. Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens
  77. Human dermal fibroblast migration induced by fibronectin in autocrine and paracrine manners
  78. Artificial antigen-presenting cells expressing CD80, CD70, and 4-1BB ligand efficiently expand functional T cells specific to tumor-associated antigens
  79. Feasibility study of personalized peptide vaccination for metastatic recurrent triple-negative breast cancer patients
  80. Bevacizumab plus Ipilimumab in Patients with Metastatic Melanoma
  81. Genetic factors associated with serum haptoglobin level in a Japanese population
  82. Personalized Peptide Vaccine for Treatment of Advanced Cancer
  83. Feasibility study of personalized peptide vaccination for recurrent ovarian cancer patients
  84. Combinational Delivery of Lipid-Enveloped Polymeric Nanoparticles Carrying Different Peptides for Anti-Tumor Immunotherapy
  85. Humoral Immune Responses to EGFR-Derived Peptides Predict Progression-Free and Overall Survival of Non-Small Cell Lung Cancer Patients Receiving Gefitinib
  86. A phase II trial of personalized peptide vaccination in castration-resistant prostate cancer patients: prolongation of prostate-specific antigen doubling time
  87. EGFR T790M Mutation as a Possible Target for Immunotherapy; Identification of HLA-A*0201-Restricted T Cell Epitopes Derived from the EGFR T790M Mutation
  88. Humoral immune responses to CTL epitope peptides from tumor-associated antigens are widely detectable in humans: A new biomarker for overall survival of patients with malignant diseases
  89. Identification of human leucocyte antigen (HLA)‐A*0201‐restricted cytotoxic T lymphocyte epitopes derived from HLA‐DOβ as a novel target for multiple myeloma
  90. Phase II study of personalized peptide vaccination for refractory bone and soft tissue sarcoma patients
  91. Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells
  92. A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients
  93. Current status of immunotherapy for the treatment of biliary tract cancer
  94. Haptoglobin Proved a Prognostic Biomarker in Peripheral Blood of Patients with Personalized Peptide Vaccinations for Advanced Castration-Resistant Prostate Cancer
  95. Juzentaihoto Failed to Augment Antigen-Specific Immunity but Prevented Deterioration of Patients’ Conditions in Advanced Pancreatic Cancer under Personalized Peptide Vaccine
  96. Next-generation peptide vaccines for advanced cancer
  97. Prognostic significance of total lesion glycolysis in patients with advanced non-small cell lung cancer receiving chemotherapy
  98. Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine
  99. Detecting T-cell reactivity to whole cell vaccines
  100. Personalized peptide vaccination: A novel immunotherapeutic approach for advanced cancer
  101. Identification of B cell epitopes reactive to human papillomavirus type-16L1- derived peptides
  102. Chemotherapy for non-small cell lung cancer complicated by idiopathic interstitial pneumonia
  103. Immunological evaluation of personalized peptide vaccination in refractory small cell lung cancer
  104. Personalized peptide vaccination in patients with refractory non-small cell lung cancer
  105. Controversies in Clinical Trials of Cancer Vaccines for Glioblastoma
  106. Personalized peptide vaccination for advanced biliary tract cancer: IL-6, nutritional status and pre-existing antigen-specific immunity as possible biomarkers for patient prognosis
  107. Gene expression profiles in peripheral blood as a biomarker in cancer patients receiving peptide vaccination
  108. Variation of Tumor-Infiltrating Lymphocytes in Human Cancers: Controversy on Clinical Significance
  109. Phase II study of personalized peptide vaccination for castration‐resistant prostate cancer patients who failed in docetaxel‐based chemotherapy
  110. Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery
  111. Impaired tumor antigen processing by immunoproteasome-expressing CD40-activated B cells and dendritic cells
  112. Diffusion‐weighted Magnetic Resonance Imaging for Detecting Lymph Node Metastasis of Rectal Cancer
  113. Prognostic value of SUVmax measurements obtained by FDG-PET in patients with non-small cell lung cancer receiving chemotherapy
  114. Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination
  115. Overcoming the hurdles of randomised clinical trials of therapeutic cancer vaccines
  116. Graft-versus-Leukemia Antigen CML66 Elicits Coordinated B-Cell and T-Cell Immunity after Donor Lymphocyte Infusion
  117. Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation
  118. Expression of ERCC1 and class III β-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel
  119. Expression of ERCC1 and class III β-tubulin in non-small cell lung cancer patients treated with a combination of cisplatin/docetaxel and concurrent thoracic irradiation
  120. Preventive effect of a traditional herbal medicine, Hochu-ekki-to, on immunosuppression induced by surgical stress
  121. Intra-arterial Infusion Chemotherapy With 5-Fluorouracil and Cisplatin in Advanced Pancreatic Cancer
  122. Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer
  123. Excision repair cross-complementation group 1 predicts progression-free and overall survival in non-small cell lung cancer patients treated with platinum-based chemotherapy
  124. Uneventful splenectomy and cholecystectomy in a patient treated with anti-interleukin-6 receptor antibody therapy
  125. Increased levels of IgG antibodies against peptides of the prostate stem cell antigen in the plasma of pancreatic cancer patients
  126. New Peptide Vaccine Candidates for Epithelial Cancer Patients With HLA-A3 Supertype Alleles
  127. The TCR Cβ FG Loop Regulates αβ T Cell Development
  128. Re: “The immunophenotype and activation status of the lymphocytic infiltrate in human breast cancers, the role of the major histocompatibility complex in cell-mediated immune mechanisms, and their association with prognostic indicators”
  129. Ran, a Small GTPase Gene, Encodes Cytotoxic T Lymphocyte (CTL) Epitopes Capable of Inducing HLA-A33–restricted and Tumor-Reactive CTLs in Cancer Patients
  130. Usefulness of 99mTc-Sestamibi Scintigraphy in Suggesting the Therapeutic Effect of Chemotherapy against Gastric Cancer
  131. Immediate Early Response Gene X-1, a Stress-Inducible Antiapoptotic Gene, Encodes Cytotoxic T-Lymphocyte (CTL) Epitopes Capable of Inducing Human Leukocyte Antigen-A33-Restricted and Tumor-Reactive CTLs in Gastric Cancer Patients
  132. CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies
  133. Change in Mitochondrial Membrane Potential in Peripheral Blood Lymphocytes, Especially in Natural Killer Cells, Is a Possible Marker for Surgical Stress on the Immune System
  134. Disparate peptide‐dependent thymic selection outcomes in β2M‐deficient mice versus TAP‐1‐deficient mice: implications for repertoire formation
  135. Involvement of the TCR Cβ FG Loop in Thymic Selection and T Cell Function
  136. Peptide-Induced Negative Selection of Thymocytes Activates Transcription of an NF-ΚB Inhibitor
  137. Baicalin induces apoptosis via mitochondrial pathway as prooxidant
  138. CD2 Facilitates Differentiation of CD4 Th Cells Without Affecting Th1/Th2 Polarization
  139. Thioredoxin-mediated redox control of human T cell lymphotropic virus type I (HTLV-I) gene expression
  140. Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis -diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
  141. A Naturally Processed Mitochondrial Self-Peptide in Complex with Thymic Mhc Molecules Functions as a Selecting Ligand for a Viral-Specific T Cell Receptor
  142. Expression of thioredoxin in bleomycin-injured airway epithelium
  143. A Critical Role for CD2 in Both Thymic Selection Events and Mature T Cell Function
  144. Secretion of Thioredoxin Enhances Cellular Resistance tocis-Diamminedichloroplatinum (II)
  145. Thymic selection is influenced by subtle structural variation involving the p4 residue of an MHC class I-bound peptide
  146. Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II)
  147. Redox Control of Epstein-Barr Virus Replication by Human Thioredoxin/ATL-Derived Factor: Differential Regulation of Lytic and Latent Infection
  148. Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax
  149. Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.
  150. Thioredoxin/Adult T-Cell Leukemia-Derived Factor(ADF) and Redox Regulation.
  151. Recurrent splenic artery aneurysms developing after aneurysmectomy without splenectomy: Report of a case
  152. A Case of Focal Fatty Replacement of the Pancreas.