All Stories

  1. An analysis of Relative Telomere Length (RTL) during chemotherapy in patients with advanced gastro-oesophageal adenocarcinoma v1

    Article • June 2022, ZappyLab, Inc.

    Professor Nicol Keith

  2. An analysis of Relative Telomere Length (RTL) during peri-operative chemotherapy in patients with operable gastric or gastro-oesophageal junction adenocarcinoma v1

    Article • June 2022, ZappyLab, Inc.

    Professor Nicol Keith

  3. A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation

    Article • Neoplasia, September 2019, Elsevier

    Professor Nicol Keith

  4. A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds

    Article • PLoS Genetics, August 2017, PLOS

    Professor Nicol Keith

  5. Extensive telomere erosion is consistent with localised clonal expansions in Barrett’s metaplasia

    Article • PLoS ONE, March 2017, PLOS

    Professor Nicol Keith

  6. A multi-targeted approach to suppress tumor-promoting inflammation

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha, Dr. H.P. Vasantha Rupasinghe

  7. Broad targeting of angiogenesis for cancer prevention and therapy

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha

  8. Broad targeting of resistance to apoptosis in cancer

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha

  9. Cancer prevention and therapy through the modulation of the tumor microenvironment

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha, Dr. H.P. Vasantha Rupasinghe

  10. Designing a broad-spectrum integrative approach for cancer prevention and treatment

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr. H.P. Vasantha Rupasinghe, Colleen Curran

  11. Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Gloria Huang

  12. Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha

  13. Immune evasion in cancer: Mechanistic basis and therapeutic strategies

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha

  14. Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha

  15. Therapeutic targeting of replicative immortality

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha

  16. Tissue invasion and metastasis: Molecular, biological and clinical perspectives

    Article • Seminars in Cancer Biology, December 2015, Elsevier

    Professor Nicol Keith, Dr Gunjan Guha

  17. Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks

    Article • Neoplasia, September 2015, Elsevier

    Professor Nicol Keith

  18. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

    Article • Molecular Biology of the Cell, July 2015, American Society for Cell Biology (ASCB)

    Professor Nicol Keith

  19. Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome

    Article • Future Oncology, January 2015, Future Medicine

    Professor Nicol Keith

  20. Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias

    Article • Neoplasia, July 2014, Elsevier

    Professor Nicol Keith

  21. Isolation, Culture, and Transfection of Melanocytes

    Article • Current Protocols in Cell Biology, June 2014, Wiley

    Professor Nicol Keith

  22. Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms

    Article • PLoS Computational Biology, February 2014, PLOS

    Professor Nicol Keith

  23. A Small Molecule Modulator of Prion Protein Increases Human Mesenchymal Stem Cell Lifespan, Ex Vivo Expansion, and Engraftment to Bone Marrow in NOD/SCID Mice

    Article • Stem Cells, May 2012, Oxford University Press (OUP)

    Professor Nicol Keith

  24. Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

    Article • Neuro-Oncology, April 2012, Oxford University Press (OUP)

    Professor Nicol Keith

  25. Cancer cell senescence: a new frontier in drug development

    Article • Drug Discovery Today, March 2012, Elsevier

    Professor Nicol Keith

  26. Mesenchymal Stem Cells as Therapeutic Delivery Vehicles Targeting Tumor Stroma

    Article • Cancer Biotherapy & Radiopharmaceuticals, December 2011, Mary Ann Liebert Inc

    Professor Nicol Keith

  27. Response to ‘Validating a gene expression signature proposed to differentiate liposarcomas that use different telomere maintenance mechanisms’

    Article • Oncogene, August 2011, Nature

    Professor Nicol Keith

  28. Progeroid syndromes: models for stem cell aging?

    Article • Biogerontology, July 2011, Springer Science + Business Media

    Professor Nicol Keith

  29. Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

    Article • Pigment Cell & Melanoma Research, April 2011, Wiley

    Professor Nicol Keith

  30. Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives

    Article • Journal of Cellular and Molecular Medicine, February 2011, Wiley

    Professor Nicol Keith

  31. TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression

    Article • Neoplasia, May 2010, Elsevier

    Professor Nicol Keith

  32. Telomerase upregulation is a postcrisis event during senescence bypass and immortalization of two Nijmegen breakage syndrome T cell cultures

    Article • Aging Cell, April 2010, Wiley

    Professor Nicol Keith

  33. Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in pe...

    Article • BMC Genomics, January 2010, Springer Science + Business Media

    Mr Nigel B Jamieson, Professor Nicol Keith

  34. Modulation of Gene Expression Using Zinc Finger-Based Artificial Transcription Factors

    Article • January 2010, Springer Science + Business Media

    Professor Nicol Keith

  35. Mining Cellular Senescence for Drug Targets

    Article • October 2009, Springer Science + Business Media

    Professor Nicol Keith

  36. A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

    Article • Oncogene, August 2009, Nature

    Professor Nicol Keith

  37. The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma

    Article • International Journal of Cancer, August 2009, Wiley

    Professor Nicol Keith

  38. Dynamic Telomerase Gene Suppression via Network Effects of GSK3 Inhibition

    Article • PLoS ONE, July 2009, PLOS

    Professor Nicol Keith

  39. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, April 2009, Elsevier

    Mr Nigel B Jamieson, Professor Nicol Keith

  40. A systems biology approach to Down syndrome: Identification of Notch/Wnt dysregulation in a model of stem cells aging

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, April 2009, Elsevier

    Professor Nicol Keith

  41. A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

    Article • The Journal of Cell Biology, January 2009, Rockefeller University Press

    Professor Nicol Keith

  42. Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells

    Article • Regenerative Medicine, July 2008, Future Medicine

    Professor Nicol Keith

  43. High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma

    Article • British Journal of Cancer, April 2008, Nature

    Professor Nicol Keith

  44. Downregulation of Multiple Stress Defense Mechanisms During Differentiation of Human Embryonic Stem Cells

    Article • Stem Cells, February 2008, Wiley

    Professor Nicol Keith

  45. Targeting telomerase for cancer therapeutics

    Article • British Journal of Cancer, January 2008, Nature

    Professor Nicol Keith

  46. Targeting Telomerase: Therapeutic Options for Cancer Treatment

    Article • January 2008, Springer Science + Business Media

    Professor Nicol Keith

  47. Telomerase redefined: Integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity

    Article • Biochimie, January 2008, Elsevier

    Professor Nicol Keith

  48. Stem cell ageing: does it happen and can we intervene?

    Article • Expert Reviews in Molecular Medicine, November 2007, Cambridge University Press

    Professor Nicol Keith

  49. Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells

    Article • Drug Discovery Today, August 2007, Elsevier

    Professor Nicol Keith

  50. Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart

    Article • Experimental Cell Research, March 2007, Elsevier

    Professor Nicol Keith

  51. Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention

    Article • Expert Reviews in Molecular Medicine, March 2007, Cambridge University Press

    Professor Nicol Keith

  52. Modulation of Telomerase Promoter Tumor Selectivity in the Context of Oncolytic Adenoviruses

    Article • Cancer Research, February 2007, American Association for Cancer Research (AACR)

    Professor Nicol Keith

  53. Cancer stem cells: Opportunities for novel diagnostics and drug discovery

    Article • European Journal of Cancer, June 2006, Elsevier

    Professor Nicol Keith

  54. Therapeutic potential of adult stem cells

    Article • European Journal of Cancer, June 2006, Elsevier

    Professor Nicol Keith

  55. Transcriptional Repression of Telomerase RNA Gene Expression by c-Jun-NH2-Kinase and Sp1/Sp3

    Article • Cancer Research, February 2006, American Association for Cancer Research (AACR)

    Professor Nicol Keith

  56. Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell

    Article • Regenerative Medicine, January 2006, Future Medicine

    Professor Nicol Keith

  57. Properties of a Telomerase-Specific Cre/Lox Switch for Transcriptionally Targeted Cancer Gene Therapy

    Article • Neoplasia, November 2005, Elsevier

    Professor Nicol Keith

  58. Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

    Article • Oncogene, September 2005, Nature

    Professor Nicol Keith

  59. Synthetic Anticancer Gene Medicine Exploits Intrinsic Antitumor Activity of Cationic Vector to Cure Established Tumors

    Article • Cancer Research, September 2005, American Association for Cancer Research (AACR)

    Professor Nicol Keith

  60. Lack of Telomerase Gene Expression in Alternative Lengthening of Telomere Cells Is Associated with Chromatin Remodeling of thehTRandhTERTGene Promoters

    Article • Cancer Research, September 2005, American Association for Cancer Research (AACR)

    Professor Nicol Keith

  61. Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients

    Article • Annals of Oncology, June 2005, Oxford University Press (OUP)

    Professor Nicol Keith

  62. The hTERT and hTERC Telomerase Gene Promoters Are Activated by the Second Exon of the Adenoviral Protein, E1 A, Identifying the Transcriptional Corepressor CtBP as a Potential Rearessor of Both Genes

    Article • Neoplasia, June 2005, Elsevier

    Professor Nicol Keith

  63. Markers of Adenocarcinoma Characteristic of the Site of Origin: Development of a Diagnostic Algorithm

    Article • Clinical Cancer Research, May 2005, American Association for Cancer Research (AACR)

    Professor Nicol Keith

  64. Application of Targeted Radiotherapy/Gene Therapy to Bladder Cancer Cell Lines

    Article • European Urology, February 2005, Elsevier

    Professor Nicol Keith

  65. Dysregulated expression of the major telomerase components in leukaemic stem cells

    Article • Leukemia, January 2005, Nature

    Professor Nicol Keith

  66. MDM2 negatively regulates the human telomerase RNA gene promoter

    Article • BMC Cancer, January 2005, Springer Science + Business Media

    Professor Nicol Keith

  67. Drug Insight: cancer cell immortality—telomerase as a target for novel cancer gene therapies

    Article • Nature Clinical Practice Oncology, December 2004, Nature

    Professor Nicol Keith

  68. Combining a targeted radiotherapy and gene therapy approach for adenocarcinoma of prostate

    Article • Prostate Cancer and Prostatic Diseases, October 2004, Nature

    Professor Nicol Keith

  69. An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects

    Article • The Journal of Gene Medicine, July 2004, Wiley

    Professor Nicol Keith

  70. A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria

    Article • BMC Hematology, June 2004, Springer Science + Business Media

    Professor Nicol Keith

  71. Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation

    Article • The Journal of Pathology, June 2004, Wiley

    Professor Nicol Keith

  72. From stem cells to cancer: balancing immortality and neoplasia

    Article • Oncogene, April 2004, Nature

    Professor Nicol Keith

  73. Profiling, comparison and validation of gene expression in gastric carcinoma and normal stomach

    Article • Oncogene, July 2003, Nature

    Professor Nicol Keith

  74. Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

    Article • Oncogene, January 2003, Nature

    Professor Nicol Keith

  75. Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene

    Article • FEBS Letters, January 2003, Wiley

    Professor Nicol Keith

  76. Why a Special Issue on Gene Therapy?

    Article • Journal of Biomedicine and Biotechnology, January 2003, Hindawi Publishing Corporation

    Professor Nicol Keith

  77. Telomerase-directed molecular therapeutics

    Article • Expert Reviews in Molecular Medicine, April 2002, Cambridge University Press

    Professor Nicol Keith

  78. ?Senescence-associated? ?-galactosidase activity in the upper gastrointestinal tract

    Article • The Journal of Pathology, January 2002, Wiley

    Professor Nicol Keith

  79. Somatic cell hybrids

    Article • Trends in Biochemical Sciences, August 1995, Elsevier

    Professor Nicol Keith

  80. Genetic Analysis of Drug Resistance by Fluorescence In Situ Hybridization

    Article • Springer Science + Business Media

    Professor Nicol Keith

  81. Genetic Analysis of Drug Resistance by Reverse In Situ Hybridization

    Article • Springer Science + Business Media

    Professor Nicol Keith

  82. Detection of Telomerase Enzyme Activity by TRAP Assay

    Article • Springer Science + Business Media

    Professor Nicol Keith

  83. Detection of Telomerase hTERT Gene Expression and Its Splice Variants by RT-PCR

    Article • Springer Science + Business Media

    Professor Nicol Keith