All Stories

  1. Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease
  2. Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease
  3. Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs
  4. A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions
  5. Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects
  6. Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold
  7. Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells
  8. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease
  9. Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study
  10. Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma
  11. Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels
  12. Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein
  13. Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme
  14. Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists
  15. Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells
  16. Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications
  17. Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD
  18. Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs
  19. SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity
  20. Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer
  21. Arylthioamides as H2S Donors:l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo
  22. Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells
  23. Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease
  24. Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays
  25. NO-Releasing Hybrids of Cardiovascular Drugs
  26. Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase
  27. ChemInform Abstract: Synthesis and Biological Evaluation of [2′-Oxo-2,3-dihydro-3′H-spiro[chromene-4,5′- [1,3]oxazolidin]-3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors.
  28. ChemInform Abstract: Synthesis and Biological Evaluation of 5-Membered Spiro Heterocycle-Benzopyran Derivatives Against Myocardial Ischemia.
  29. Editorial [Hot topic: Effect of Stereochemistry in Medicinal Chemistry and Drug Discovery (Guest Editor: Simona Rapposelli)]
  30. Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia
  31. Synthesis and Biological Evaluation of 2′-Oxo-2,3-dihydro-3′H- spiro[chromene-4,5′-[1,3]oxazolidin]-3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors
  32. Novel adenosine 5′-triphosphate-sensitive potassium channel ligands: a patent overview (2005 – 2010)
  33. SodiumN-(Methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use
  34. ChemInform Abstract: Synthesis and Inhibitory Activity Towards Human Leukocyte Elastase of New 7α-Methoxy and 7α-Chloro (2-Acyloxymethyl) Cephem Derivatives.
  35. ChemInform Abstract: Enantiopure 3-(Arylmethylidene)aminoxy-2-methylpropionic Acids: Synthesis and Antiinflammatory Properties.
  36. Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel
  37. NO-glibenclamide derivatives: Prototypes of a new class of nitric oxide-releasing anti-diabetic drugs
  38. Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers
  39. Enantioselectivity in Cardioprotection induced by (S)- (−)-2,2-Dimethyl-N-(4′-acetamido-benzyl)-4-spiromorpholone-chromane
  40. Structural Evolutions of Salicylaldoximes as Selective Agonists for Estrogen Receptor β
  41. P-gp Transporter and its Role in Neurodegenerative Diseases
  42. 2-[(3-Methoxyphenylethyl)phenoxy]-Based ABCB1 Inhibitors: Effect of Different Basic Side-Chains on Their Biological Properties
  43. Spirocyclic Benzopyran-Based Derivatives as New Anti-ischemic Activators of Mitochondrial ATP-Sensitive Potassium Channel
  44. α-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors
  45. Monoaryl-Substituted Salicylaldoximes as Ligands for Estrogen Receptor β
  46. Synthesis and Biological Evaluation of (Hetero)Arylmethyloxy- and Arylmethylamine-phenyl Derivatives as Potent P-glycoprotein Modulating Agents
  47. Evaluation of the NO-releasing properties of NO-donor linkers
  48. New Emerging Prospects in the Pharmacotherapy of Hypertension
  49. Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans
  50. Synthesis and 5-HT2A, 5-HT1Aand α1-Binding Affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes
  51. Cardiac ATP-Sensitive Potassium Channels: A Potential Target for an Anti-Ischaemic Pharmacological Strategy
  52. New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties
  53. Arylmethyloxyphenyl Derivatives:  Small Molecules Displaying P-Glycoprotein Inhibition
  54. Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes
  55. Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists:  Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis
  56. New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite:  Design, Synthesis, and Biopharmacological Properties
  57. NO-Releasing Hybrids of Cardiovascular Drugs
  58. Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition
  59. Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells
  60. A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs
  61. Synthesis and Antimicrobial Activity of New 7?-(Benzo[a]dihydrocarbazolyloxyacetyl)-Substituted Cephalosporins.
  62. Diaryl-Substituted Salicyl- and Anthranyl-ketoximes as Potential Estrogen Receptor Ligands.
  63. Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase
  64. Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors
  65. NO-Sartans:  A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs
  66. Synthesis and antimicrobial activity of new 7β-(benzo[a]dihydrocarbazolyloxyacetyl)-substituted cephalosporins
  67. Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands
  68. Synthesis and COX-2 Inhibitory Properties of N-Phenyl- and N-Benzyl-Substituted Amides of 2-(4-Methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic Acid and of Their Pyrazole, Thiophene and Isoxazole Analogues.
  69. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)
  70. Synthesis and Prostaglandin Synthase Inhibitory Activity of New Aromatic O-Alkyloxime Ethers Substituted with Methylsulfonamido or Methylsulfonyl Groups on Their Aliphatic Portion.
  71. Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs
  72. Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity
  73. Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity
  74. Novel Estrogen Receptor Ligands Based on an Anthranylaldoxime Structure:  Role of the Phenol-Type Pseudocycle in the Binding Process
  75. Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion
  76. Ceramide Analogues in Apoptosis: A New Strategy for Anticancer Drug Development
  77. Conformationally Restrained Ceramide Analogues: Effects of Lipophilic Modifications on the Antiproliferative Activity.
  78. Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-Substituted 3,4-Diarylsalicylaldoximes on estrogen receptors α and β
  79. Ceramide analogues in apoptosis: a new strategy for anticancer drug development
  80. Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring
  81. Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity
  82. Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole
  83. Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties
  84. (E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties
  85. Synthesis and inhibitory activity towards human leukocyte elastase of new 7α-methoxy and 7α-chloro (2-acyloxymethyl) cephem derivatives