All Stories

  1. Parkinson’s Disease and Alpha-Synucleinopathies: from Arising Pathways to Therapeutic Challenge

    Article • Central Nervous System Agents in Medicinal Chemistry, May 2015, Bentham Science Publishers

    Dr Laura Betti, Dr Laura Betti

  2. Meet Our Editorial Board Member:

    Article • Central Nervous System Agents in Medicinal Chemistry, May 2015, Bentham Science Publishers

    Dr Laura Betti, Dr Laura Betti

  3. Sulfur Metabolism and Sulfur-Containing Amino Acids: I- Molecular Effectors

    Article • Biochemistry & Pharmacology Open Access, January 2015, OMICS Publishing Group

    Dr Laura Betti, Dr Laura Betti

  4. Sulfur Metabolism and Sulfur-Containing Amino Acids Derivatives – II: Autism Spectrum Disorders, Schizophrenia and Fibromyalgia

    Article • Biochemistry & Pharmacology Open Access, January 2015, OMICS Publishing Group

    Dr Laura Betti, Dr Laura Betti

  5. The expression of platelet serotonin transporter (SERT) in human obesity

    Article • BMC Neuroscience, January 2013, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  6. Serotonin receptor of type 6 (5-HT6) in human prefrontal cortex and hippocampus post-mortem: An immunohistochemical and immunofluorescence study

    Article • Neurochemistry International, January 2013, Elsevier

    Dr Laura Betti, Dr Laura Betti

  7. A link between oxytocin and serotonin in humans: Supporting evidence from peripheral markers

    Article • European Neuropsychopharmacology, August 2012, Elsevier

    Dr Laura Betti, Dr Laura Betti

  8. The trace element content of top-soil and wild edible mushroom samples collected in Tuscany, Italy

    Article • Environmental Monitoring and Assessment, February 2012, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  9. Distribution of Serotonin Receptor of Type 6 (5-HT6) in Human Brain Post-mortem. A Pharmacology, Autoradiography and Immunohistochemistry Study

    Article • Neurochemical Research, January 2012, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  10. Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

    Article • Bioorganic & Medicinal Chemistry Letters, December 2011, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti

  11. N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

    Article • European Journal of Medicinal Chemistry, November 2011, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti

  12. New Insight into the Central Benzodiazepine Receptor–Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4 H -imidazo[1,5- a ][1,4]benzodiazepines and Related Compounds

    Article • Journal of Medicinal Chemistry, August 2011, American Chemical Society (ACS)

    Dr Laura Betti, Dr Laura Betti

  13. Discovery of N -Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

    Article • Journal of Medicinal Chemistry, March 2011, American Chemical Society (ACS)

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti

  14. Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti

  15. Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouse

    Article • BMC Neuroscience, January 2011, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  16. Rosiglitazone reverses salbutamol-induced β2-adrenoceptor tolerance in airway smooth muscle

    Article • British Journal of Pharmacology, December 2010, Wiley

    Dr Laura Betti, Dr Laura Betti, Prof Silvia Pellegrini

  17. ChemInform Abstract: New Amino Derivatives of 1,2,3-Triazolo[4,5-d]pyrimidines and Their Affinity Toward A1 and A2A Adenosine Receptors.

    Article • ChemInform, June 2010, Wiley

    Dr Laura Betti

  18. ChemInform Abstract: 1,2,3-Triazolo[4,5-d]pyridazines. Part 6. New 1-Substituted-4-amino Derivatives and Their Affinity Towards A1 and A2A Adenosine Receptors.

    Article • ChemInform, June 2010, Wiley

    Dr Laura Betti

  19. Male axillary extracts modify the affinity of the platelet serotonin transporter and impulsiveness in women

    Article • Physiology & Behavior, June 2010, Elsevier

    Dr Laura Betti, Dr Laura Betti

  20. ChemInform Abstract: Synthesis, Biological Evaluation, and Pharmacophore Generation of New Pyridazinone Derivatives with Affinity Toward α1- and α2-Adrenoceptors.

    Article • ChemInform, May 2010, Wiley

    Dr Laura Betti

  21. ChemInform Abstract: Synthesis and Biological Activity of New 1,4-Benzodioxanarylpiperazine Derivatives. Further Validation of a Pharmacophore Model for α1-Adrenoceptor Antagonists.

    Article • ChemInform, May 2010, Wiley

    Dr Laura Betti

  22. ChemInform Abstract: α1-Adrenoceptor Antagonists. Rational Design, Synthesis and Biological Evaluation of New Trazodone-Like Compounds.

    Article • ChemInform, May 2010, Wiley

    Dr Laura Betti

  23. ChemInform Abstract: New 1,2,3-Triazolo[1,5]quinoxalines: Synthesis and Binding to Benzodiazepine and Adenosine Receptors. Part 2.

    Article • ChemInform, May 2010, Wiley

    Dr Laura Betti

  24. Modified RP-LC of Phenylthiocarbamyl Amino Acid Adducts in Plasma Acetonitrile Extracts Using Multiple Internal Standards and Photo-Diode UV Detection

    Article • Chromatographia, January 2010, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  25. Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders

    Article • Psychiatry Research, January 2010, Elsevier

    Dr Laura Betti, Dr Laura Betti

  26. Human Serotonin Transporter Expression During Megakaryocytic Differentiation of MEG-01 Cells

    Article • Neurochemical Research, December 2009, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  27. [3H]-YM-09151-2 binding sites in human brain postmortem

    Article • December 2009, Elsevier

    Dr Laura Betti, Dr Laura Betti

  28. Altered amino acid homeostasis in subjects affected by fibromyalgia

    Article • Clinical Biochemistry, July 2009, Elsevier

    Dr Laura Betti, Dr Laura Betti

  29. ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

    Article • Clinical Biochemistry, September 2008, Elsevier

    Dr Laura Betti, Dr Laura Betti

  30. Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives: Further validation of a pharmacophore model for α1-adrenoceptor antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, September 2008, Elsevier

    Dr Laura Betti, Dr Laura Betti

  31. Ethyl 8-Fluoro-6-(3-nitrophenyl)-4 H -imidazo[1,5- a ][1,4]benzodiazepine-3-carboxylate as Novel, Highly Potent, and Safe Antianxiety Agent

    Article • Journal of Medicinal Chemistry, August 2008, American Chemical Society (ACS)

    Dr Laura Betti, Dr Laura Betti

  32. Short-term effects of 3,4-methylen-dioxy-metamphetamine (MDMA) on 5-HT1A receptors in the rat hippocampus

    Article • Neurochemistry International, December 2007, Elsevier

    Dr Laura Betti, Dr Laura Betti

  33. 1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems

    Article • Bioorganic & Medicinal Chemistry, December 2007, Elsevier

    Dr Laura Betti, Dr Laura Betti

  34. Presence and Characterization of the Dopamine Transporter in Human Resting Lymphocytes

    Article • Neurochemical Research, November 2007, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  35. Species Comparison of Adenosine Receptor Subtypes in Brain and Testis

    Article • Neurochemical Research, November 2007, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  36. [3H] muscimol receptors sites in the carp (Cyprinus carpio L.) brain: Binding assay and autoradiographic distribution

    Article • Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, October 2007, Elsevier

    Dr Laura Betti, Dr Laura Betti

  37. 3-[(aryl)(4-fluorobenzyloxy)methyl]piperidine derivatives: high-affinity ligands for the serotonin transporter

    Article • Journal of Pharmacy and Pharmacology, October 2007, Wiley

    Dr Laura Betti, Dr Laura Betti

  38. Tubby protein in human lymphocytes from normal weight and obese subjects

    Article • Clinical Biochemistry, July 2007, Elsevier

    Dr Laura Betti, Dr Laura Betti

  39. Presence of D4 dopamine receptors in human prefrontal cortex: a postmortem study

    Article • Brazilian Journal of Psychiatry, June 2007, FapUNIFESP (SciELO)

    Dr Laura Betti

  40. Synthesis and 5-HT2A, 5-HT1Aand α1-Binding Affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes

    Article • Archiv der Pharmazie, March 2007, Wiley

    Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  41. New 4-(4-methyl-phenyl)phthalazin-1(2H)-one derivatives and their effects on α1-receptors

    Article • Bioorganic & Medicinal Chemistry Letters, May 2006, Elsevier

    Dr Laura Betti, Dr Laura Betti

  42. Synthesis of new piperazine–pyridazinone derivatives and their binding affinity toward α1-, α2-adrenergic and 5-HT1A serotoninergic receptors

    Article • Bioorganic & Medicinal Chemistry, April 2006, Elsevier

    Dr Laura Betti, Dr Laura Betti

  43. Binding of 3H-WIN-35,428 and 125I-RTI-121 to Human Platelet Membranes

    Article • Neurochemical Research, March 2006, Springer Science + Business Media

    Dr Laura Betti, Dr Laura Betti

  44. Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

    Article • ChemMedChem, February 2006, Wiley

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  45. Autoradiographic localization and binding study of benzodiazepines receptor sites in carp brain (Cyprinus carpio L.)

    Article • Journal of Chemical Neuroanatomy, February 2006, Elsevier

    Dr Laura Betti, Dr Laura Betti

  46. 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors

    Article • Bioorganic & Medicinal Chemistry Letters, October 2005, Elsevier

    Dr Laura Betti, Dr Laura Betti

  47. Variously Substituted (Phosphonoacetamido)Oxy Analogues of Geranylgeranyl Diphosphate (GGdP) as GGdP-transferase (GGTase) Inhibitors and Antiproliferative Agents

    Article • Medicinal Chemistry, May 2005, Bentham Science Publishers

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli

  48. Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

    Article • Il Farmaco, November 2004, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  49. Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

    Article • Il Farmaco, November 2004, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  50. Immunohistochemical distribution of neuropeptide Y in the mesencephalon and rhombencephalon of carp, Cyprinus carpio L. (Cyprinidae: Teleostei)

    Article • Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, June 2004, Elsevier

    Dr Laura Betti, Dr Laura Betti

  51. Study on Affinity Profile toward Native Human and Bovine Adenosine Receptors of a Series of 1,8-Naphthyridine Derivatives

    Article • Journal of Medicinal Chemistry, June 2004, American Chemical Society (ACS)

    Dr Laura Betti, Dr Laura Betti

  52. Design, synthesis, and α1-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion

    Article • Bioorganic & Medicinal Chemistry, March 2004, Elsevier

    Dr Laura Betti, Dr Laura Betti

  53. [3H]PK11195 binding sites in human neutrophils: effect of fMLP stimulation and modulation in rheumatic diseases

    Article • Clinical Biochemistry, January 2004, Elsevier

    Dr Laura Betti, Dr Laura Betti

  54. Absence of NK1 Receptors in Human Blood Lymphocytes and Granulocytes

    Article • Neuropsychobiology, January 2004, Karger Publishers

    Dr Laura Betti, Dr Laura Betti

  55. Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity

    Article • Il Farmaco, December 2003, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  56. Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity

    Article • Bioorganic & Medicinal Chemistry Letters, December 2003, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  57. Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron

    Article • The American Journal of Gastroenterology, December 2003, Nature

    Dr Laura Betti, Dr Laura Betti

  58. α 1 -Adrenoceptor Antagonists. 6. 1 Structural Optimization of Pyridazinone−Arylpiperazines. Study of the Influence on Affinity and Selectivity of Cyclic Substituents at the Pyridazinone Ring and Alkoxy Groups at the Arylpiperazine Moiety

    Article • Journal of Medicinal Chemistry, July 2003, American Chemical Society (ACS)

    Dr Laura Betti, Dr Laura Betti

  59. [3H]-ketanserin binding sites in different psychiatric disorders

    Article • Neurochemistry International, May 2003, Elsevier

    Dr Laura Betti, Dr Laura Betti

  60. α1-Adrenoceptor Antagonists. Part 5. Pyridazinone-arylpiperazines. Probing the Influence on Affinity and Selectivity of Both ortho-Alkoxy Groups at the Arylpiperazine Moiety and Cyclic Substituents at the Pyridazinone Nucleus.

    Article • ChemInform, April 2003, Wiley

    Dr Laura Betti

  61. Autoradiographic distribution of neuropeptide Y binding sites in the brain of the carp Cyprinus carpio L. (Cyprinidae, Teleostei)

    Article • Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, April 2003, Elsevier

    Dr Laura Betti, Dr Laura Betti

  62. Peripheral-type benzodiazepine receptors in human mononuclear cells of patients affected by osteoarthritis, rheumatoid arthritis or psoriasic arthritis

    Article • Clinical Biochemistry, January 2003, Elsevier

    Dr Laura Betti, Dr Laura Betti

  63. α1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-Alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus

    Article • Bioorganic & Medicinal Chemistry Letters, January 2003, Elsevier

    Dr Laura Betti, Dr Laura Betti

  64. Studies of peripheral benzodiazepine receptors in mussels: comparison between a polluted and a nonpolluted site

    Article • Ecotoxicology and Environmental Safety, January 2003, Elsevier

    Dr Laura Betti, Dr Laura Betti

  65. α 1 -Adrenoceptor Antagonists. 4. 1 Pharmacophore-Based Design, Synthesis, and Biological Evaluation of New Imidazo-, Benzimidazo-, and Indoloarylpiperazine Derivatives

    Article • Journal of Medicinal Chemistry, August 2002, American Chemical Society (ACS)

    Dr Laura Betti, Dr Laura Betti

  66. New 1,2,3-triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors. II

    Article • European Journal of Medicinal Chemistry, July 2002, Elsevier

    Dr Laura Betti, Dr Laura Betti

  67. Synthesis and biological activity of new 1,4-benzodioxan-arylpiperazine derivatives. Further validation of a pharmacophore model for α1-adrenoceptor antagonists

    Article • Bioorganic & Medicinal Chemistry, February 2002, Elsevier

    Dr Laura Betti, Dr Laura Betti

  68. α1-Adrenoceptor antagonists. rational design, synthesis and biological evaluation of new trazodone-like compounds

    Article • Bioorganic & Medicinal Chemistry Letters, February 2002, Elsevier

    Dr Laura Betti, Dr Laura Betti

  69. Synthesis, Biological Evaluation, and Pharmacophore Generation of New Pyridazinone Derivatives with Affinity toward α 1 - and α 2 -Adrenoceptors 1

    Article • Journal of Medicinal Chemistry, June 2001, American Chemical Society (ACS)

    Dr Laura Betti, Dr Laura Betti

  70. Structure–activity relationships in a series of 8-substituted xanthines as A1-adenosine receptor antagonists

    Article • Bioorganic & Medicinal Chemistry, March 2001, Elsevier

    Dr Laura Betti, Dr Laura Betti

  71. Correlation between Platelet α2-Adrenoreceptors and Symptom Severity in Major Depression

    Article • Neuropsychobiology, January 2001, Karger Publishers

    Dr Laura Betti, Dr Laura Betti

  72. Peripheral-type benzodiazepine receptors in human blood cells of patients affected by migraine without aura

    Article • Neurochemistry International, October 2000, Elsevier

    Dr Laura Betti, Dr Laura Betti

  73. A Novel Class of Highly Potent and Selective A 1 Adenosine Antagonists:  Structure−Affinity Profile of a Series of 1,8-Naphthyridine Derivatives

    Article • Journal of Medicinal Chemistry, July 2000, American Chemical Society (ACS)

    Dr Laura Betti, Dr Laura Betti

  74. Autoradiographic distribution of peripheral benzodiazepine receptors in the retina of the albino rabbit, Lepus cunicula

    Article • Neuroscience Letters, February 2000, Elsevier

    Dr Laura Betti, Dr Laura Betti

  75. 1,2,3-Triazolo[4,5-d]pyridazines

    Article • Il Farmaco, September 1999, Elsevier

    Dr Laura Betti, Dr Laura Betti

  76. Synthesis of new pyridazinone derivatives and their affinity towards α1–α2-adrenoceptors

    Article • Bioorganic & Medicinal Chemistry, May 1999, Elsevier

    Dr Laura Betti, Dr Laura Betti

  77. Characterization of sulfonylurea receptors in isolated human pancreatic islets

    Article • Journal of Cellular Biochemistry, November 1998, Wiley

    Dr Laura Betti, Dr Laura Betti

  78. Adenosine receptors: synthesis, structure-activity relationships and biological activity of new 6-amino purine derivatives

    Article • European Journal of Medicinal Chemistry, June 1998, Elsevier

    Dr Laura Betti, Dr Laura Betti

  79. 1,2,3-Triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors

    Article • European Journal of Medicinal Chemistry, February 1998, Elsevier

    Dr Laura Betti, Dr Laura Betti

  80. Novel 3-Aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5- d ]pyrimidines with High Affinity toward A 1 Adenosine Receptors

    Article • Journal of Medicinal Chemistry, February 1998, American Chemical Society (ACS)

    Dr Laura Betti, Dr Laura Betti