All Stories

  1. Synthesis and Application of a Glucoconjugated Organometallic Rhenium Complex as an IR Imaging Probe for Glycolytic Cancer Cells

    Article • Molecules, December 2025, MDPI AG

    Dr Filippo Minutolo

  2. Identification of a Possible Endocannabinoid-Mediated Mechanism of Action of Cetylated Fatty Acids

    Article • Biomolecules, March 2025, MDPI AG

    Dr Filippo Minutolo

  3. A patent review of lactate dehydrogenase inhibitors (2014–present)

    Article • Expert Opinion on Therapeutic Patents, October 2024, Taylor & Francis

    Dr Filippo Minutolo

  4. Effects of lactate dehydrogenase A and GLUT1 inhibition on human endothelial cell migration in relation to their intracellular nucleotide pool

    Article • Nucleosides Nucleotides & Nucleic Acids, July 2024, Taylor & Francis

    Professor Godefridus J Peters, Dr Filippo Minutolo

  5. Evaluation of the combination of gemcitabine, carboplatin, and lactate dehydrogenase A inhibitor on malignant mesothelioma

    Article • Nucleosides Nucleotides & Nucleic Acids, June 2024, Taylor & Francis

    Professor Godefridus J Peters, Dr Filippo Minutolo

  6. The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry: A Comprehensive Review

    Article • Molecules, April 2024, MDPI AG

    Dr Filippo Minutolo

  7. Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying in vivo cardioprotective activities

    Article • RSC Medicinal Chemistry, January 2024, Royal Society of Chemistry

    Dr Filippo Minutolo

  8. Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing

    Article • Cancer Letters, November 2023, Elsevier

    Dr Filippo Minutolo, Professor Godefridus J Peters

  9. Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Professor Godefridus J Peters, Dr Filippo Minutolo

  10. Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives

    Article • Molecules, October 2022, MDPI AG

    Dr Filippo Minutolo

  11. MAGL inhibitor NanoMicellar formulation (MAGL-NanoMicellar) for the development of an antiglaucoma eye drop

    Article • International Journal of Pharmaceutics, September 2022, Elsevier

    Dr Filippo Minutolo

  12. New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds

    Article • Pharmaceuticals, March 2022, MDPI AG

    Dr Filippo Minutolo

  13. The effect of lactate dehydrogenase-A inhibition on intracellular nucleotides and mitochondrial respiration in pancreatic cancer cells

    Article • Nucleosides Nucleotides & Nucleic Acids, February 2022, Taylor & Francis

    Professor Godefridus J Peters, Dr Filippo Minutolo

  14. New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, December 2021, Taylor & Francis

    Dr Filippo Minutolo

  15. Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold

    Article • European Journal of Medicinal Chemistry, November 2021, Elsevier

    Dr Filippo Minutolo

  16. Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study

    Article • Molecules, December 2020, MDPI AG

    Dr Filippo Minutolo

  17. An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

    Article • Expert Opinion on Therapeutic Patents, November 2020, Taylor & Francis

    Dr Filippo Minutolo

  18. Glycoconjugated Metal Complexes as Cancer Diagnostic and Therapeutic Agents

    Article • ChemMedChem, September 2020, Wiley

    Dr Filippo Minutolo

  19. Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study

    Article • Journal of Biomolecular Structure and Dynamics, June 2020, Taylor & Francis

    Dr Filippo Minutolo

  20. Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents

    Article • Molecules, September 2019, MDPI AG

    Dr Filippo Minutolo

  21. First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent

    Article • ACS Medicinal Chemistry Letters, February 2019, American Chemical Society (ACS)

    Dr Filippo Minutolo

  22. First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

    Article • Bioconjugate Chemistry, January 2019, American Chemical Society (ACS)

    Dr Filippo Minutolo

  23. Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2019, Taylor & Francis

    Dr Filippo Minutolo

  24. Activators of Sirtuin-1 and their Involvement in Cardioprotection

    Article • Current Medicinal Chemistry, December 2018, Bentham Science Publishers

    Dr Filippo Minutolo

  25. An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade

    Article • ChemMedChem, October 2018, Wiley

    Dr Filippo Minutolo

  26. Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2018, Taylor & Francis

    Dr Filippo Minutolo

  27. A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017)

    Article • Expert Opinion on Therapeutic Patents, October 2017, Taylor & Francis

    Dr Filippo Minutolo

  28. Correction to Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase

    Article • Journal of Natural Products, September 2017, American Chemical Society (ACS)

    Dr Filippo Minutolo

  29. Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase

    Article • Journal of Natural Products, July 2017, American Chemical Society (ACS)

    Dr Filippo Minutolo

  30. Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer

    Article • Journal of Agricultural and Food Chemistry, June 2017, American Chemical Society (ACS)

    Dr Filippo Minutolo

  31. Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2017, Taylor & Francis

    Dr Filippo Minutolo

  32. Immune by Heart: Unexpected Observations Inspiring Perspective Therapeutic/Preventive Strategies against Cancer

    Article • ChemMedChem, November 2016, Wiley

    Dr Filippo Minutolo

  33. Risks and benefits related to alimentary exposure to xenoestrogens

    Article • Critical Reviews in Food Science and Nutrition, January 2016, Taylor & Francis

    Dr Filippo Minutolo

  34. Anticancer agents interacting with membrane glucose transporters

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Dr Filippo Minutolo

  35. Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase

    Article • Phytochemistry, August 2015, Elsevier

    Dr Filippo Minutolo

  36. Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model

    Article • Journal of Medicinal Chemistry, February 2015, American Chemical Society (ACS)

    Dr Filippo Minutolo

  37. Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Dr Filippo Minutolo

  38. CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1 H )-one-3-carboxamides

    Article • Journal of Medicinal Chemistry, November 2014, American Chemical Society (ACS)

    Dr Filippo Minutolo

  39. Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

    Article • Steroids, November 2014, Elsevier

    Dr Filippo Minutolo

  40. An update on therapeutic opportunities offered by cancer glycolytic metabolism

    Article • Bioorganic & Medicinal Chemistry Letters, November 2014, Elsevier

    Dr Filippo Minutolo

  41. Identification and characterization of a new reversible MAGL inhibitor

    Article • Bioorganic & Medicinal Chemistry, July 2014, Elsevier

    Dr Filippo Minutolo

  42. Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

    Article • Oncogenesis, May 2014, Nature

    Dr Filippo Minutolo

  43. Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells

    Article • Bioorganic & Medicinal Chemistry Letters, December 2013, Elsevier

    Dr Filippo Minutolo

  44. Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

    Article • British Journal of Cancer, October 2013, Nature

    Dr Filippo Minutolo, Professor Godefridus J Peters

  45. Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor

    Article • ChemBioChem, October 2013, Wiley

    Dr Filippo Minutolo

  46. Identification of New Fyn Kinase Inhibitors Using a FLAP-Based Approach

    Article • Journal of Chemical Information and Modeling, October 2013, American Chemical Society (ACS)

    Dr Filippo Minutolo

  47. Small-molecule inhibitors of human LDH5

    Article • Future Medicinal Chemistry, October 2013, Future Science

    Dr Filippo Minutolo

  48. Estrogen receptor ligands: a patent review update

    Article • Expert Opinion on Therapeutic Patents, May 2013, Informa Healthcare

    Dr Filippo Minutolo

  49. Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors

    Article • Bioorganic & Medicinal Chemistry, March 2013, Elsevier

    Dr Filippo Minutolo

  50. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Filippo Minutolo

  51. Anticancer Agents That Counteract Tumor Glycolysis

    Article • ChemMedChem, June 2012, Wiley

    Dr Filippo Minutolo

  52. Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

    Article • Bioorganic & Medicinal Chemistry Letters, December 2011, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti

  53. N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

    Article • European Journal of Medicinal Chemistry, November 2011, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, Professor Godefridus J Peters

  54. Carbazole-containing arylcarboxamides as BACE1 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, November 2011, Elsevier

    Dr Filippo Minutolo

  55. Curaxins: A New Family of Non-genotoxic Multitargeted Anticancer Agents

    Article • ChemMedChem, October 2011, Wiley

    Dr Filippo Minutolo

  56. Antiproliferative Activity and Cell Cycle Analysis of 2-(3,5-Dihydroxyphenyl)-6-Hydroxybenzothiazole on MCF-7 Breast and HCT-15 Colon Cancer Cell Lines

    Article • DNA and Cell Biology, August 2011, Mary Ann Liebert Inc

    Dr Filippo Minutolo

  57. Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes

    Article • European Journal of Medicinal Chemistry, June 2011, Elsevier

    Dr Filippo Minutolo

  58. Discovery of N -Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

    Article • Journal of Medicinal Chemistry, March 2011, American Chemical Society (ACS)

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, Professor Godefridus J Peters

  59. Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti

  60. BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides

    Article • Bioorganic & Medicinal Chemistry, November 2010, Elsevier

    Dr Filippo Minutolo

  61. Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties

    Article • Bioorganic & Medicinal Chemistry, September 2010, Elsevier

    Dr Filippo Minutolo

  62. Biphenyl-Derivatives Possessing Tertiary Amino Groups as β-Secretase (BACE1) Inhibitors

    Article • Letters in Drug Design & Discovery, August 2010, Bentham Science Publishers

    Dr Filippo Minutolo

  63. Study of Apoptosis Induction and Deoxycytidine Kinase/Cytidine Deaminase Modulation in the Synergistic Interaction of a Novel Ceramide Analog and Gemcitabine in Pancreatic Cancer Cells

    Article • Nucleosides Nucleotides & Nucleic Acids, June 2010, Taylor & Francis

    Dr Filippo Minutolo, Professor Godefridus J Peters

  64. Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials

    Article • Current Medicinal Chemistry, March 2010, Bentham Science Publishers

    Dr Filippo Minutolo

  65. Estrogen receptor β ligands: Recent advances and biomedical applications

    Article • Medicinal Research Reviews, December 2009, Wiley

    Dr Filippo Minutolo

  66. Bioreductively Activated Lysyl Oxidase Inhibitors against Hypoxic Tumours

    Article • ChemMedChem, October 2009, Wiley

    Dr Filippo Minutolo

  67. QSAR models for predicting enzymatic hydrolysis of new chemical entities in ‘soft-drug’ design

    Article • Bioorganic & Medicinal Chemistry, May 2009, Elsevier

    Dr Filippo Minutolo

  68. Structural Evolutions of Salicylaldoximes as Selective Agonists for Estrogen Receptor β

    Article • Journal of Medicinal Chemistry, February 2009, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  69. Spirocyclic Benzopyran-Based Derivatives as New Anti-ischemic Activators of Mitochondrial ATP-Sensitive Potassium Channel

    Article • Journal of Medicinal Chemistry, November 2008, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  70. α-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors

    Article • ChemMedChem, October 2008, Wiley

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  71. Monoaryl-Substituted Salicylaldoximes as Ligands for Estrogen Receptor β

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  72. Evaluation of the NO-releasing properties of NO-donor linkers

    Article • Journal of Pharmacy and Pharmacology, February 2008, Wiley

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  73. Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans

    Article • Heterocycles, January 2008, Japan Institute of Heterocyclic Chemistry

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  74. Metabolically labile cannabinoid esters: A ‘soft drug’ approach for the development of cannabinoid-based therapeutic drugs

    Article • Bioorganic & Medicinal Chemistry Letters, September 2007, Elsevier

    Dr Filippo Minutolo

  75. New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

    Article • Journal of Medicinal Chemistry, December 2006, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  76. Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes

    Article • Journal of Medicinal Chemistry, August 2006, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  77. New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite:  Design, Synthesis, and Biopharmacological Properties

    Article • Journal of Medicinal Chemistry, April 2006, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  78. N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation

    Article • The FASEB Journal, March 2006, Federation of American Societies For Experimental Biology (FASEB)

    Dr Filippo Minutolo

  79. Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

    Article • ChemMedChem, February 2006, Wiley

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  80. Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells

    Article • Journal of Medicinal Chemistry, November 2005, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  81. Variously Substituted (Phosphonoacetamido)Oxy Analogues of Geranylgeranyl Diphosphate (GGdP) as GGdP-transferase (GGTase) Inhibitors and Antiproliferative Agents

    Article • Medicinal Chemistry, May 2005, Bentham Science Publishers

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli

  82. Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

    Article • Il Farmaco, November 2004, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  83. Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

    Article • Il Farmaco, November 2004, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  84. NO-Sartans:  A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs

    Article • Journal of Medicinal Chemistry, November 2004, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  85. Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

    Article • Il Farmaco, August 2004, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  86. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)

    Article • Bioorganic & Medicinal Chemistry, May 2004, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  87. Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs

    Article • Il Farmaco, January 2004, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  88. Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity

    Article • Il Farmaco, December 2003, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  89. Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity

    Article • Bioorganic & Medicinal Chemistry Letters, December 2003, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  90. Novel Estrogen Receptor Ligands Based on an Anthranylaldoxime Structure:  Role of the Phenol-Type Pseudocycle in the Binding Process

    Article • Journal of Medicinal Chemistry, September 2003, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  91. Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-Substituted 3,4-Diarylsalicylaldoximes on estrogen receptors α and β

    Article • Bioorganic & Medicinal Chemistry, April 2003, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  92. Ceramide analogues in apoptosis: a new strategy for anticancer drug development

    Article • Il Farmaco, March 2003, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  93. Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring

    Article • European Journal of Medicinal Chemistry, February 2003, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  94. New N - n -Propyl-Substituted 3-Aryl- and 3-Cyclohexylpiperidines as Partial Agonists at the D 4 Dopamine Receptor

    Article • Journal of Medicinal Chemistry, January 2003, American Chemical Society (ACS)

    Dr Filippo Minutolo

  95. Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity

    Article • Il Farmaco, January 2003, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  96. 4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor

    Article • Il Farmaco, September 2002, Elsevier

    Dr Filippo Minutolo

  97. Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties

    Article • European Journal of Medicinal Chemistry, July 2002, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  98. 7-Nitrobenzofurazan (NBD) derivatives of 5′-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A3 adenosine receptors

    Article • Bioorganic & Medicinal Chemistry Letters, December 2001, Elsevier

    Dr Filippo Minutolo

  99. Design, Synthesis, and Characterization of the Antitumor Activity of Novel Ceramide Analogues †

    Article • Journal of Medicinal Chemistry, November 2001, American Chemical Society (ACS)

    Dr Filippo Minutolo

  100. Salicylaldoxime Moiety as a Phenolic “A-Ring” Substitute in Estrogen Receptor Ligands

    Article • Journal of Medicinal Chemistry, November 2001, American Chemical Society (ACS)

    Dr Filippo Minutolo

  101. Purification, Enzymatic Characterization, and Inhibition of the Z-Farnesyl Diphosphate Synthase from Mycobacterium tuberculosis

    Article • Journal of Biological Chemistry, January 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Filippo Minutolo

  102. Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand

    Article • Bioorganic & Medicinal Chemistry Letters, January 2001, Elsevier

    Dr Filippo Minutolo

  103. Synthesis and antiviral properties of novel analogues of monophosphate and diphosphate bioactive forms of acyclovir

    Article • Il Farmaco, April 2000, Elsevier

    Dr Filippo Minutolo

  104. Synthesis and antiviral properties of 9-[(2-methyleneaminoxyethoxy)methyl]guanine derivatives as novel Acyclovir analogues

    Article • Il Farmaco, February 2000, Elsevier

    Dr Filippo Minutolo

  105. Crystallographic evidence for the electronic distribution in (2,4-cyclopentadien-1-ylidenehydrazono)triphenylphosphorane

    Article • Acta Crystallographica Section C Crystal Structure Communications, June 1999, International Union of Crystallography

    Dr Filippo Minutolo

  106. Three-Component Synthesis of Substituted η 5 -Cyclopentadienyltricarbonylrhenium Complexes:  Scope, Limitations, and Mechanistic Interpretations

    Article • Organometallics, June 1999, American Chemical Society (ACS)

    Dr Filippo Minutolo

  107. A Polymer-Supported Phosphazine as a Stable and Practical Reagent in the Three-Component Synthesis of Substituted (Cyclopentadienyl)tricarbonylrhenium Complexes

    Article • Angewandte Chemie, June 1999, Wiley

    Dr Filippo Minutolo

  108. Boronic Acids in the Three-Component Synthesis of Carbon-Substituted Cyclopentadienyl Tricarbonyl Rhenium Complexes

    Article • Journal of the American Chemical Society, December 1998, American Chemical Society (ACS)

    Dr Filippo Minutolo

  109. A Convenient Three-Component Synthesis of Substituted Cyclopentadienyl Tricarbonyl Rhenium Complexes

    Article • Journal of the American Chemical Society, May 1998, American Chemical Society (ACS)

    Dr Filippo Minutolo

  110. Heterogeneous asymmetric epoxidation of unfunctionalized olefins catalyzed by polymer-bound (salen)manganese complexes

    Article • Tetrahedron Asymmetry, August 1996, Elsevier

    Dr Filippo Minutolo

  111. Polymer-bound chiral (salen)Mn(III) complex as heterogeneous catalyst in rapid and clean enantioselective epoxidation of unfunctionalised olefins

    Article • Tetrahedron Letters, May 1996, Elsevier

    Dr Filippo Minutolo

  112. Efficient application of lipase-catalyzed transesterification to the resolution of γ-hydroxy ketones

    Article • Tetrahedron Asymmetry, May 1996, Elsevier

    Dr Filippo Minutolo

  113. Asymmetric Synthesis of the Dihydroisocoumarin Moiety of AI-77-B via Copper-Mediated Cross-Coupling and Sharpless Asymmetric Dihydroxylation

    Article • The Journal of Organic Chemistry, January 1996, American Chemical Society (ACS)

    Dr Filippo Minutolo

  114. Anomalous Face-Selectivity in Sharpless Asymmetric Dihydroxylation of o -Allylbenzamides

    Article • The Journal of Organic Chemistry, January 1996, American Chemical Society (ACS)

    Dr Filippo Minutolo

  115. Aromatic substituent effect on the stereoselectivity of the gas-phase acid-induced ring opening in 9,10-oxides derived from trans-1,2,3,4,4a,10a-hexahydrophenanthrene

    Article • Tetrahedron, June 1993, Elsevier

    Dr Filippo Minutolo