All Stories

  1. A patent update on PDK1 inhibitors (2015-present)

    Article • Expert Opinion on Therapeutic Patents, March 2019, Taylor & Francis

    prof Simona Rapposelli

  2. New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective

    Article • Frontiers in Pharmacology, August 2018, Frontiers

    prof Simona Rapposelli

  3. A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer’s disease

    Article • Bioorganic & Medicinal Chemistry, February 2018, Elsevier

    prof Simona Rapposelli

  4. New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

    Article • Frontiers in Pharmacology, December 2017, Frontiers

    prof Simona Rapposelli

  5. Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease

    Article • Current Topics in Medicinal Chemistry, November 2017, Bentham Science Publishers

    Simona Rapposelli, prof Simona Rapposelli, Giulia Nesi

  6. Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, November 2017, Elsevier

    prof Simona Rapposelli

  7. Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease

    Article • European Journal of Medicinal Chemistry, October 2017, Elsevier

    Simona Rapposelli, prof Simona Rapposelli

  8. Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs

    Article • Frontiers in Chemistry, September 2017, Frontiers

    Simona Rapposelli, prof Simona Rapposelli

  9. Synthesis and Biological Evaluation of Cyclopropylamine Vitamin D-Like CYP24A1 Inhibitors

    Article • ChemistrySelect, September 2017, Wiley

    prof Simona Rapposelli

  10. A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions

    Article • Scientific Reports, September 2017, Nature

    Simona Rapposelli, prof Simona Rapposelli

  11. Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects

    Article • Journal of Medicinal Chemistry, August 2017, American Chemical Society (ACS)

    Simona Rapposelli, prof Simona Rapposelli

  12. Endogenous TH metabolite 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogues SG-1 and SG-2 induce autophagy in human glioblastoma cells (U-87MG)

    Article • Endocrine Abstracts, May 2017, Bioscientifica

    prof Simona Rapposelli

  13. Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold

    Article • The Open Medicinal Chemistry Journal, January 2017, Bentham Science Publishers

    Simona Rapposelli, prof Simona Rapposelli

  14. Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells

    Article • ACS Chemical Neuroscience, January 2017, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  15. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

    Article • European Journal of Medicinal Chemistry, January 2017, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  16. Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study

    Article • Journal of Medicinal Chemistry, November 2016, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  17. Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma

    Article • European Journal of Medicinal Chemistry, August 2016, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  18. Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels

    Article • Archives of Pharmacal Research, June 2016, Springer Science + Business Media

    prof Simona Rapposelli, Simona Rapposelli

  19. Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein

    Article • Molecular Imaging and Biology, May 2016, Springer Science + Business Media

    prof Simona Rapposelli, Simona Rapposelli

  20. Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

    Article • European Journal of Medicinal Chemistry, November 2015, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  21. Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists

    Article • Journal of Medicinal Chemistry, June 2015, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  22. Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

    Article • Scientific Reports, April 2015, Nature

    prof Simona Rapposelli, Simona Rapposelli

  23. Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications

    Article • Bioorganic & Medicinal Chemistry, February 2015, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  24. Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD

    Article • Bioorganic & Medicinal Chemistry Letters, February 2015, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  25. Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs

    Article • Medicinal Research Reviews, October 2014, Wiley

    prof Simona Rapposelli, Simona Rapposelli, Vincenzo Calderone

  26. SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity

    Article • European Journal of Medicinal Chemistry, April 2014, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  27. Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer

    Article • ACS Medicinal Chemistry Letters, December 2013, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  28. Arylthioamides as H2S Donors:l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

    Article • ACS Medicinal Chemistry Letters, October 2013, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  29. Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity

    Article • European Journal of Medicinal Chemistry, October 2013, Elsevier

    prof Simona Rapposelli

  30. Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells

    Article • CNS Neuroscience & Therapeutics, October 2012, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  31. Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease

    Article • Bioorganic & Medicinal Chemistry Letters, October 2012, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  32. Development of Classification Models for Identifying “True” P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays

    Article • International Journal of Molecular Sciences, June 2012, MDPI AG

    prof Simona Rapposelli, Simona Rapposelli

  33. NO-Releasing Hybrids of Cardiovascular Drugs

    Article • March 2012, Bentham Science Publishers

    prof Simona Rapposelli, Simona Rapposelli

  34. Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase

    Article • Steroids, February 2012, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  35. ChemInform Abstract: Synthesis and Biological Evaluation of [2′-Oxo-2,3-dihydro-3′H-spiro[chromene-4,5′- [1,3]oxazolidin]-3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors.

    Article • ChemInform, September 2011, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  36. ChemInform Abstract: Synthesis and Biological Evaluation of 5-Membered Spiro Heterocycle-Benzopyran Derivatives Against Myocardial Ischemia.

    Article • ChemInform, June 2011, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  37. Editorial [Hot topic: Effect of Stereochemistry in Medicinal Chemistry and Drug Discovery (Guest Editor: Simona Rapposelli)]

    Article • Current Topics in Medicinal Chemistry, April 2011, Bentham Science Publishers

    prof Simona Rapposelli, Simona Rapposelli

  38. Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia

    Article • European Journal of Medicinal Chemistry, March 2011, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  39. Synthesis and Biological Evaluation of 2′-Oxo-2,3-dihydro-3′H- spiro[chromene-4,5′-[1,3]oxazolidin]-3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors

    Article • Archiv der Pharmazie, February 2011, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  40. Novel adenosine 5′-triphosphate-sensitive potassium channel ligands: a patent overview (2005 – 2010)

    Article • Expert Opinion on Therapeutic Patents, January 2011, Informa Healthcare

    prof Simona Rapposelli, Simona Rapposelli

  41. SodiumN-(Methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use

    Article • Molecular Pharmaceutics, October 2010, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  42. ChemInform Abstract: Synthesis and Inhibitory Activity Towards Human Leukocyte Elastase of New 7α-Methoxy and 7α-Chloro (2-Acyloxymethyl) Cephem Derivatives.

    Article • ChemInform, May 2010, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  43. ChemInform Abstract: Enantiopure 3-(Arylmethylidene)aminoxy-2-methylpropionic Acids: Synthesis and Antiinflammatory Properties.

    Article • ChemInform, May 2010, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  44. Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel

    Article • Biochemical Pharmacology, January 2010, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  45. NO-glibenclamide derivatives: Prototypes of a new class of nitric oxide-releasing anti-diabetic drugs

    Article • Bioorganic & Medicinal Chemistry, August 2009, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  46. Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers

    Article • Bioorganic & Medicinal Chemistry, August 2009, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  47. Enantioselectivity in Cardioprotection induced by (S)- (−)-2,2-Dimethyl-N-(4′-acetamido-benzyl)-4-spiromorpholone-chromane

    Article • Journal of Medicinal Chemistry, March 2009, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  48. Structural Evolutions of Salicylaldoximes as Selective Agonists for Estrogen Receptor β

    Article • Journal of Medicinal Chemistry, February 2009, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  49. P-gp Transporter and its Role in Neurodegenerative Diseases

    Article • Current Topics in Medicinal Chemistry, February 2009, Bentham Science Publishers

    prof Simona Rapposelli, Simona Rapposelli

  50. 2-[(3-Methoxyphenylethyl)phenoxy]-Based ABCB1 Inhibitors: Effect of Different Basic Side-Chains on Their Biological Properties

    Article • Journal of Medicinal Chemistry, December 2008, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  51. Spirocyclic Benzopyran-Based Derivatives as New Anti-ischemic Activators of Mitochondrial ATP-Sensitive Potassium Channel

    Article • Journal of Medicinal Chemistry, November 2008, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  52. α-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors

    Article • ChemMedChem, October 2008, Wiley

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  53. Monoaryl-Substituted Salicylaldoximes as Ligands for Estrogen Receptor β

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  54. Synthesis and Biological Evaluation of (Hetero)Arylmethyloxy- and Arylmethylamine-phenyl Derivatives as Potent P-glycoprotein Modulating Agents

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  55. Evaluation of the NO-releasing properties of NO-donor linkers

    Article • Journal of Pharmacy and Pharmacology, February 2008, Wiley

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  56. New Emerging Prospects in the Pharmacotherapy of Hypertension

    Article • Cardiovascular & Hematological Agents in Medicinal Chemistry, January 2008, Bentham Science Publishers

    prof Simona Rapposelli, Simona Rapposelli

  57. Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans

    Article • Heterocycles, January 2008, Japan Institute of Heterocyclic Chemistry

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  58. Synthesis and 5-HT2A, 5-HT1Aand α1-Binding Affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes

    Article • Archiv der Pharmazie, March 2007, Wiley

    Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  59. Cardiac ATP-Sensitive Potassium Channels: A Potential Target for an Anti-Ischaemic Pharmacological Strategy

    Article • Cardiovascular & Hematological Agents in Medicinal Chemistry, January 2007, Bentham Science Publishers

    Simona Rapposelli, prof Simona Rapposelli

  60. New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

    Article • Journal of Medicinal Chemistry, December 2006, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  61. Arylmethyloxyphenyl Derivatives:  Small Molecules Displaying P-Glycoprotein Inhibition

    Article • Journal of Medicinal Chemistry, November 2006, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  62. Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes

    Article • Journal of Medicinal Chemistry, August 2006, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  63. Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists:  Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

    Article • Journal of Medicinal Chemistry, July 2006, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  64. New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite:  Design, Synthesis, and Biopharmacological Properties

    Article • Journal of Medicinal Chemistry, April 2006, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  65. NO-Releasing Hybrids of Cardiovascular Drugs

    Article • Current Medicinal Chemistry, March 2006, Bentham Science Publishers

    prof Simona Rapposelli, Simona Rapposelli

  66. Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

    Article • ChemMedChem, February 2006, Wiley

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  67. Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells

    Article • Journal of Medicinal Chemistry, November 2005, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  68. Variously Substituted (Phosphonoacetamido)Oxy Analogues of Geranylgeranyl Diphosphate (GGdP) as GGdP-transferase (GGTase) Inhibitors and Antiproliferative Agents

    Article • Medicinal Chemistry, May 2005, Bentham Science Publishers

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli

  69. A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs

    Article • Bioorganic & Medicinal Chemistry Letters, May 2005, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  70. Synthesis and Antimicrobial Activity of New 7?-(Benzo[a]dihydrocarbazolyloxyacetyl)-Substituted Cephalosporins.

    Article • ChemInform, January 2005, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  71. Diaryl-Substituted Salicyl- and Anthranyl-ketoximes as Potential Estrogen Receptor Ligands.

    Article • ChemInform, November 2004, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  72. Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

    Article • Il Farmaco, November 2004, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  73. Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

    Article • Il Farmaco, November 2004, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  74. NO-Sartans:  A New Class of Pharmacodynamic Hybrids as Cardiovascular Drugs

    Article • Journal of Medicinal Chemistry, November 2004, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  75. Synthesis and antimicrobial activity of new 7β-(benzo[a]dihydrocarbazolyloxyacetyl)-substituted cephalosporins

    Article • Il Farmaco, September 2004, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  76. Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

    Article • Il Farmaco, August 2004, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  77. Synthesis and COX-2 Inhibitory Properties of N-Phenyl- and N-Benzyl-Substituted Amides of 2-(4-Methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic Acid and of Their Pyrazole, Thiophene and Isoxazole Analogues.

    Article • ChemInform, June 2004, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  78. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)

    Article • Bioorganic & Medicinal Chemistry, May 2004, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  79. Synthesis and Prostaglandin Synthase Inhibitory Activity of New Aromatic O-Alkyloxime Ethers Substituted with Methylsulfonamido or Methylsulfonyl Groups on Their Aliphatic Portion.

    Article • ChemInform, January 2004, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  80. Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs

    Article • Il Farmaco, January 2004, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  81. Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity

    Article • Il Farmaco, December 2003, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  82. Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity

    Article • Bioorganic & Medicinal Chemistry Letters, December 2003, Elsevier

    Dr Filippo Minutolo, Dr Laura Betti, Dr Laura Betti, prof Simona Rapposelli, Simona Rapposelli

  83. Novel Estrogen Receptor Ligands Based on an Anthranylaldoxime Structure:  Role of the Phenol-Type Pseudocycle in the Binding Process

    Article • Journal of Medicinal Chemistry, September 2003, American Chemical Society (ACS)

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  84. Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion

    Article • Il Farmaco, September 2003, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  85. Ceramide Analogues in Apoptosis: A New Strategy for Anticancer Drug Development

    Article • ChemInform, July 2003, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  86. Conformationally Restrained Ceramide Analogues: Effects of Lipophilic Modifications on the Antiproliferative Activity.

    Article • ChemInform, June 2003, Wiley

    prof Simona Rapposelli, Simona Rapposelli

  87. Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-Substituted 3,4-Diarylsalicylaldoximes on estrogen receptors α and β

    Article • Bioorganic & Medicinal Chemistry, April 2003, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  88. Ceramide analogues in apoptosis: a new strategy for anticancer drug development

    Article • Il Farmaco, March 2003, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  89. Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring

    Article • European Journal of Medicinal Chemistry, February 2003, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  90. Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity

    Article • Il Farmaco, January 2003, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  91. Synthesis, Antifungal Activity, and Molecular Modeling Studies of New Inverted Oxime Ethers of Oxiconazole

    Article • Journal of Medicinal Chemistry, October 2002, American Chemical Society (ACS)

    prof Simona Rapposelli, Simona Rapposelli

  92. Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties

    Article • European Journal of Medicinal Chemistry, July 2002, Elsevier

    Dr Filippo Minutolo, prof Simona Rapposelli, Simona Rapposelli

  93. (E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties

    Article • European Journal of Medicinal Chemistry, May 2002, Elsevier

    prof Simona Rapposelli, Simona Rapposelli

  94. Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties

    Article • European Journal of Medicinal Chemistry, October 2001, Elsevier

    prof Simona Rapposelli

  95. Synthesis and inhibitory activity towards human leukocyte elastase of new 7α-methoxy and 7α-chloro (2-acyloxymethyl) cephem derivatives

    Article • European Journal of Medicinal Chemistry, February 2001, Elsevier

    prof Simona Rapposelli, Simona Rapposelli