All Stories

  1. Structural basis of allosteric activation of Mycobacterium tuberculosis isocitrate lyase 2

    Article • Communications Biology, March 2026, Springer Science + Business Media

    Dr Ghader Bashiri

  2. Harnessing the Power of Bioinformatics Pipelines to Develop an Anti-SARS-CoV-2 Pan-Species Vaccine: A Post-Pandemic Description

    Article • Avicenna Journal of Clinical Microbiology and Infection, September 2025, MaadRayan Publishing Company

    Dr Ghader Bashiri

  3. Dynamic allostery drives acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Dr Ghader Bashiri

  4. Feedback regulation of iron-sulfur cluster biogenesis

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Dr Ghader Bashiri, Dr Stephanie S Dawes

  5. Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2–dependent statine pathway

    Article • Nature Communications, May 2025, Springer Science + Business Media

    Dr Ghader Bashiri

  6. Mycofactocin and the mycobacterial electron transport chain

    Article • eLife, March 2025, eLife

    Dr Ghader Bashiri

  7. Evidence of a Catalytic Dyad in F420-Dependent Glucose-6-phosphate Dehydrogenase from Mycobacterium tuberculosis

    Article • Biochemistry, December 2024, American Chemical Society (ACS)

    Dr Ghader Bashiri

  8. A Stable Dehydratase Complex Catalyzes the Formation of Dehydrated Amino Acids in a Class V Lanthipeptide

    Article • ACS Chemical Biology, November 2024, American Chemical Society (ACS)

    Dr Ghader Bashiri

  9. Illuminating Substrate Preferences of Promiscuous F420H2-Dependent Dehydroamino Acid Reductases with 4-Track mRNA Display

    Article • Journal of the American Chemical Society, October 2024, American Chemical Society (ACS)

    Dr Ghader Bashiri

  10. F420-dependent transformations in biosynthesis of secondary metabolites

    Article • Current Opinion in Chemical Biology, June 2024, Elsevier

    Dr Ghader Bashiri

  11. Poly-γ-glutamylation of biomolecules

    Article • Nature Communications, February 2024, Springer Science + Business Media

    Dr Ghader Bashiri

  12. DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid

    Article • Nature Communications, June 2023, Springer Science + Business Media

    Dr Ghader Bashiri

  13. Mycobacterium tuberculosis Rv1916 is an Acetyl‐CoA‐Binding Protein

    Article • ChemBioChem, June 2023, Wiley

    Dr Ghader Bashiri

  14. Iran: a biochemist on torment and hope

    Article • Nature, November 2022, Springer Science + Business Media

    Dr Ghader Bashiri

  15. AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis

    Article • Nature Communications, August 2022, Springer Science + Business Media

    Dr Ghader Bashiri

  16. Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Dr Stephanie S Dawes, Dr Ghader Bashiri

  17. Cofactor F420, an emerging redox power in biosynthesis of secondary metabolites

    Article • Biochemical Society Transactions, February 2022, Portland Press Ltd.

    Dr Ghader Bashiri

  18. Clusterin is involved in mediating the metabolic function of adipose SIRT1

    Article • iScience, January 2022, Elsevier

    Dr Ghader Bashiri

  19. β-NAD as a building block in natural product biosynthesis

    Article • Nature, December 2021, Springer Science + Business Media

    Dr Ghader Bashiri

  20. Lipid transport across the mycobacterial cell envelope

    Article • IUCrJ, September 2021, International Union of Crystallography

    Dr Ghader Bashiri

  21. Redox Modifications in the Biosynthesis of Alchivemycin A Enable the Formation of Its Key Pharmacophore

    Article • Journal of the American Chemical Society, March 2021, American Chemical Society (ACS)

    Dr Ghader Bashiri

  22. Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase

    Article • RSC Medicinal Chemistry, January 2021, Royal Society of Chemistry

    Dr Ghader Bashiri

  23. Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis

    Article • Journal of Biological Chemistry, March 2020, Elsevier

    Dr Ghader Bashiri

  24. Different Reaction Specificities of F420H2-Dependent Reductases Facilitate Pyrrolobenzodiazepines and Lincomycin To Fit Their Biological Targets

    Article • Journal of the American Chemical Society, January 2020, American Chemical Society (ACS)

    Dr Ghader Bashiri

  25. Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

    Article • Nature Communications, October 2019, Springer Science + Business Media

    Dr Ghader Bashiri

  26. The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe–2S cluster

    Article • Journal of Biological Chemistry, July 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Ghader Bashiri

  27. A revised biosynthetic pathway for the cofactor F420 in prokaryotes

    Article • Nature Communications, April 2019, Springer Science + Business Media

    Dr Colin Scott, Dr Ghader Bashiri

  28. A revised biosynthetic pathway for the cofactor F420 in bacteria

    Article • November 2018, Cold Spring Harbor Laboratory Press

    Dr Ghader Bashiri, Dr Colin Scott

  29. Biosynthesis of the Thiopeptins and Identification of an F420H2-Dependent Dehydropiperidine Reductase

    Article • Journal of the American Chemical Society, August 2018, American Chemical Society (ACS)

    Dr Ghader Bashiri

  30. Development of NMR and thermal shift assays for the evaluation ofMycobacterium tuberculosisisocitrate lyase inhibitors

    Article • MedChemComm, January 2017, Royal Society of Chemistry

    Dr Ghader Bashiri

  31. Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis

    Article • FEBS Open Bio, October 2016, Wiley

    Dr Ghader Bashiri

  32. A NADH-accepting imine reductase variant: Immobilization and cofactor regeneration by oxidative deamination

    Article • Journal of Biotechnology, July 2016, Elsevier

    Dr Ghader Bashiri

  33. Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms

    Article • Structure, July 2016, Elsevier

    Dr Ghader Bashiri

  34. Elongation of the Poly-γ-glutamate Tail of F420Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) ofMycobacterium tuberculosis

    Article • Journal of Biological Chemistry, February 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Ghader Bashiri

  35. PdxH proteins of mycobacteria are typical members of the classical pyridoxine/pyridoxamine 5′-phosphate oxidase family

    Article • FEBS Letters, February 2016, Wiley

    Dr Ghader Bashiri

  36. Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

    Article • Acta Crystallographica Section D Biological Crystallography, October 2015, International Union of Crystallography

    Dr Ghader Bashiri, Shaun Lott

  37. Regulation and Quality Control of Adiponectin Assembly by Endoplasmic Reticulum Chaperone ERp44

    Article • Journal of Biological Chemistry, June 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Ghader Bashiri

  38. A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

    Article • Proceedings of the National Academy of Sciences, March 2015, Proceedings of the National Academy of Sciences

    Dr Ghader Bashiri, Shaun Lott

  39. Use of a “silver bullet” to resolve crystal lattice dislocation disorder: A cobalamin complex of Δ1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis

    Article • Journal of Structural Biology, February 2015, Elsevier

    Dr Ghader Bashiri

  40. Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein

    Article • Journal of Structural Biology, December 2014, Elsevier

    Dr Ghader Bashiri

  41. Production of recombinant proteins inMycobacterium smegmatisfor structural and functional studies

    Article • Protein Science, November 2014, Wiley

    Dr Ghader Bashiri

  42. Characterization of the proline-utilization pathway inMycobacterium tuberculosisthrough structural and functional studies

    Article • Acta Crystallographica Section D Biological Crystallography, March 2014, International Union of Crystallography

    Dr Ghader Bashiri, Edward Baker

  43. Uncovering the Enzymes that Catalyze the Final Steps in Oxytetracycline Biosynthesis

    Article • Journal of the American Chemical Society, May 2013, American Chemical Society (ACS)

    Dr Ghader Bashiri

  44. Tat–Dependent Translocation of an F420–Binding Protein of Mycobacterium tuberculosis

    Article • PLOS One, October 2012, PLOS

    Dr Ghader Bashiri

  45. Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) fromMycobacterium tuberculosis

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, September 2011, International Union of Crystallography

    Dr Ghader Bashiri

  46. Metabolic Engineering of Cofactor F420 Production in Mycobacterium smegmatis

    Article • PLOS One, December 2010, PLOS

    Dr Ghader Bashiri

  47. Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver

    Article • Bone Marrow Transplantation, December 2010, Wiley

    Dr Ghader Bashiri

  48. Crystal Structures of F420-dependent Glucose-6-phosphate Dehydrogenase FGD1 Involved in the Activation of the Anti-tuberculosis Drug Candidate PA-824 Reveal the Basis of Coenzyme and Substrate Binding

    Article • Journal of Biological Chemistry, April 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Ghader Bashiri

  49. A new Gateway® vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis

    Article • Protein Expression and Purification, January 2008, Elsevier

    Dr Ghader Bashiri, Shaun Lott

  50. Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system

    Article • Protein Expression and Purification, July 2007, Elsevier

    Dr Ghader Bashiri