Contact

All Stories

  1. Membrane Permeability Drives the Extreme Potency of Fentanyl

    Article • JACS Au, February 2026, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  2. Design, Synthesis, and Characterization of Novel, Subtype-Selective Fluorescent Antagonists Targeting the Nociceptin/Orphanin FQ Opioid Peptide Receptor

    Article • Journal of Medicinal Chemistry, December 2025, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  3. Shaping Future Medicinal Chemists: Perspectives from European Schools of Pharmacy within the GP2A Network

    Article • Journal of Medicinal Chemistry, January 2025, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry, DR Jean-Jacques HELESBEUX

  4. Assessment of the potential of novel and classical opioids to induce respiratory depression in mice

    Article • British Journal of Pharmacology, August 2023, Wiley

    Dr Shailesh Natvarbhai Mistry

  5. Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2

    Article • Journal of Medicinal Chemistry, July 2023, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  6. M 1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease

    Article • Science Signaling, November 2022, American Association for the Advancement of Science

    Dr Shailesh Natvarbhai Mistry

  7. Development of fluorescent peptide G protein‐coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators

    Article • The FASEB Journal, October 2022, Wiley

    Dr Shailesh Natvarbhai Mistry

  8. Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor

    Article • Journal of Medicinal Chemistry, June 2022, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  9. Development of fluorescent peptide G Protein Coupled Receptor activation biosensors for NanoBRET characterisation of intracellular allosteric modulators

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Dr Shailesh Natvarbhai Mistry

  10. 27th Annual GP2A Medicinal Chemistry Conference

    Article • Pharmaceuticals, December 2019, MDPI AG

    Dr Shailesh Natvarbhai Mistry

  11. Structure–Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

    Article • Journal of Medicinal Chemistry, October 2019, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  12. A Thieno[2,3-d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

    Article • Journal of Medicinal Chemistry, May 2018, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  13. Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

    Article • The FASEB Journal, July 2017, Federation of American Societies For Experimental Biology (FASEB)

    Jeanette Woolard, Dr Shailesh Natvarbhai Mistry, Gopal Jadhav

  14. New strategy to improve the current antipsychotics for treating symptoms of schizophrenia

    Article • Journal of Pharmacology and Experimental Therapeutics, September 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Shailesh Natvarbhai Mistry, Dr Kwok Ho Christopher Choy

  15. GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors

    Article • Journal of Biomolecular Structure and Dynamics, September 2016, Taylor & Francis

    Dr Shailesh Natvarbhai Mistry

  16. Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor

    Article • ACS Chemical Neuroscience, March 2016, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  17. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

    Article • European Journal of Medicinal Chemistry, March 2016, Elsevier

    Dr Shailesh Natvarbhai Mistry

  18. 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor

    Article • Journal of Medicinal Chemistry, December 2015, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  19. Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand

    Article • Journal of Medicinal Chemistry, August 2015, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  20. Structure–Activity Study of N-((trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a Bitopic Ligand That Acts as a Negative Allosteric Modulator of the Dopamine D2 Receptor

    Article • Journal of Medicinal Chemistry, June 2015, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  21. Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

    Article • PLOS One, February 2015, PLOS

    Dr Shailesh Natvarbhai Mistry

  22. Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

    Article • British Journal of Pharmacology, December 2014, Wiley

    Dr Sebastian George Barton Furness, Dr Shailesh Natvarbhai Mistry

  23. Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors

    Article • Journal of Medicinal Chemistry, October 2014, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  24. Mechanistic Insights into Allosteric Structure-Function Relationships at the M1Muscarinic Acetylcholine Receptor

    Article • Journal of Biological Chemistry, October 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Shailesh Natvarbhai Mistry

  25. Triphenylphosphonium Anhydride Trifluoromethanesulfonate

    Article • May 2014, Wiley

    Dr Shailesh Natvarbhai Mistry

  26. Molecular Determinants of Allosteric Modulation at the M1Muscarinic Acetylcholine Receptor

    Article • Journal of Biological Chemistry, January 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Shailesh Natvarbhai Mistry

  27. Synthesis and Pharmacological Profiling of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) as Allosteric Modulators of the M1 Muscarinic Receptor

    Article • Journal of Medicinal Chemistry, June 2013, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  28. Synthesis and in Vitro and in Vivo Characterization of Highly β1-Selective β-Adrenoceptor Partial Agonists

    Article • Journal of Medicinal Chemistry, May 2013, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  29. 4,5-Dihydro-1-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-3-(2,4,6-trimethylphenyl)-1H-imidazolium Hexafluorophosphate

    Article • September 2012, Wiley

    Dr Shailesh Natvarbhai Mistry

  30. Synthesis and Characterization of High-Affinity 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene-Labeled Fluorescent Ligands for Human β-Adrenoceptors

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry

  31. Triphenylphosphonium Anhydride Trifluoromethanesulfonate

    Article • September 2011, Wiley

    Dr Shailesh Natvarbhai Mistry