All Stories

  1. Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin
  2. Structure and dynamics of the active Gs-coupled human secretin receptor
  3. Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins
  4. Activation of the GLP-1 receptor by a non-peptidic agonist
  5. The nature of efficacy at G protein-coupled receptors
  6. TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum
  7. Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors
  8. Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor
  9. Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas
  10. The Molecular Control of Calcitonin Receptor Signaling
  11. Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1
  12. Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination
  13. Faculty of 1000 evaluation for Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.
  14. Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
  15. Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy
  16. Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
  17. Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms
  18. Coding GPCR-G protein specificity
  19. Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma
  20. Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
  21. Faculty of 1000 evaluation for Universal allosteric mechanism for Gα activation by GPCRs.
  22. Editorial on efficacy at G protein coupled receptors
  23. Calcitonin ☆
  24. Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor
  25. Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy
  26. The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism
  27. A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures
  28. Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
  29. Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias
  30. Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP‐1R activation
  31. A simple method to generate stable cell lines for the analysis of transient protein-protein interactions
  32. Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function
  33. Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
  34. Xenobiotics and Loss of Cell Adhesion Drive Distinct Transcriptional Outcomes by Aryl Hydrocarbon Receptor Signaling
  35. Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin
  36. Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse  3-Adrenoceptor
  37. Consequences of splice variation on Secretin family G protein‐coupled receptor function
  38. The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172
  39. Amino Acid Substitutions in the Aryl Hydrocarbon Receptor Ligand Binding Domain Reveal YH439 As an Atypical AhR Activator
  40. The pleiotropy of dioxin toxicity — Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles
  41. Understanding Amylin Receptors
  42. Sulfonation and Phosphorylation of Regions of the Dioxin Receptor Susceptible to Methionine Modifications
  43. Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors
  44. Identification of N,Nɛ-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS
  45. The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors
  46. Na+/H+ Exchanger Regulatory Factor-1 Is a Hematopoietic Ligand for a Subset of the CD34 Family of Stem Cell Surface Proteins
  47. Beyond Mere Markers: Functions for CD34 Family of Sialomucins in Hematopoiesis
  48. Faculty of 1000 evaluation for Molecular control of δ-opioid receptor signalling.
  49. Faculty of 1000 evaluation for Structure of the chemokine receptor CXCR1 in phospholipid bilayers.
  50. Faculty of 1000 evaluation for Academia's obsession with quantity.
  51. Faculty of 1000 evaluation for Molecular basis for negative regulation of the glucagon receptor.
  52. Faculty of 1000 evaluation for Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release.
  53. Faculty of 1000 evaluation for The dynamic process of β(2)-adrenergic receptor activation.
  54. Faculty of 1000 evaluation for Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet.
  55. Faculty of 1000 evaluation for Direct Molecular Evolution of Detergent-Stable G-Protein-Coupled Receptors Using Polymer Encapsulated Cells.
  56. Faculty of 1000 evaluation for Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor.
  57. Faculty of 1000 evaluation for SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.
  58. Faculty of 1000 evaluation for A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.