All Stories

  1. Gut-brain communication: nerve circuits and chemical messengers of colorectal motility and defection control

    Article • AJP Regulatory Integrative and Comparative Physiology, December 2025, American Physiological Society

    Dr Sebastian George Barton Furness

  2. Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling

    Article • Molecular Cell, June 2025, Elsevier

    Dr Sebastian George Barton Furness

  3. A novel pH-sensitive probe to quantify autophagy on high throughput/content imaging platforms

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Dr Sebastian George Barton Furness

  4. Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

    Article • PLoS Biology, July 2024, PLOS

    Dr Sebastian George Barton Furness

  5. Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake

    Article • Pharmacology Research & Perspectives, February 2024, Wiley

    Dr Sebastian George Barton Furness

  6. Cardiac human bitter taste receptors contain naturally occurring variants that alter function

    Article • Biochemical Pharmacology, January 2024, Elsevier

    Dr Sebastian George Barton Furness

  7. Re-coding of G protein-coupled receptor signaling enables emergent cellular behavior

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Dr Sebastian George Barton Furness

  8. Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre

    Article • The Journal of Physiology, September 2023, Wiley

    Dr Sebastian George Barton Furness

  9. Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors

    Article • Biochemical Pharmacology, August 2022, Elsevier

    Dr Sebastian George Barton Furness

  10. G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a

    Article • Journal of Neuroendocrinology, December 2021, Wiley

    Dr Sebastian George Barton Furness

  11. Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

    Article • Frontiers in Endocrinology, December 2021, Frontiers

    Dr Sebastian George Barton Furness

  12. Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

    Article • PLoS Biology, June 2021, PLOS

    Dr Sebastian George Barton Furness

  13. AM833 Is a Novel Agonist of Calcitonin Family G Protein–Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2021, Elsevier

    Dr Sebastian George Barton Furness

  14. Dopamine and ghrelin receptor co‐expression and interaction in the spinal defecation centers

    Article • Neurogastroenterology & Motility, December 2020, Wiley

    Dr Sebastian George Barton Furness

  15. Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

    Article • Molecular Cell, November 2020, Elsevier

    Dr Sebastian George Barton Furness

  16. Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

    Article • Biochemical and Biophysical Research Communications, September 2020, Elsevier

    Dr Sebastian George Barton Furness

  17. Structure and dynamics of the active Gs-coupled human secretin receptor

    Article • Nature Communications, August 2020, Springer Science + Business Media

    Dr Sebastian George Barton Furness

  18. Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

    Article • ACS Pharmacology & Translational Science, March 2020, American Chemical Society (ACS)

    Dr Sebastian George Barton Furness

  19. Activation of the GLP-1 receptor by a non-peptidic agonist

    Article • Nature, January 2020, Springer Science + Business Media

    Dr Sebastian George Barton Furness

  20. Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

    Article • Therapeutic Advances in Medical Oncology, January 2020, SAGE Publications

    Dr Sebastian George Barton Furness

  21. The nature of efficacy at G protein-coupled receptors

    Article • Biochemical Pharmacology, October 2019, Elsevier

    Dr Sebastian George Barton Furness

  22. TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

    Article • Frontiers in Molecular Neuroscience, August 2019, Frontiers

    Dr Sebastian George Barton Furness

  23. Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors

    Article • ACS Pharmacology & Translational Science, July 2019, American Chemical Society (ACS)

    Dr Sebastian George Barton Furness

  24. Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

    Article • ACS Pharmacology & Translational Science, March 2019, American Chemical Society (ACS)

    Dr Sebastian George Barton Furness

  25. Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

    Article • BMC Cancer, February 2019, Springer Science + Business Media

    Dr Sebastian George Barton Furness

  26. The Molecular Control of Calcitonin Receptor Signaling

    Article • ACS Pharmacology & Translational Science, January 2019, American Chemical Society (ACS)

    Dr Sebastian George Barton Furness

  27. Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

    Article • Biochemical Pharmacology, October 2018, Elsevier

    Dr Sebastian George Barton Furness

  28. Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination

    Article • ACS Pharmacology & Translational Science, July 2018, American Chemical Society (ACS)

    Dr Sebastian George Barton Furness

  29. Faculty of 1000 evaluation for Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.

    Article • June 2018, Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  30. Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

    Article • Nature, June 2018, Springer Science + Business Media

    Dr Sebastian George Barton Furness

  31. Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

    Article • Biochemical Pharmacology, April 2018, Elsevier

    Dr Sebastian George Barton Furness

  32. Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

    Article • Nature, February 2018, Springer Science + Business Media

    Dr Sebastian George Barton Furness

  33. Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

    Article • Biochemical Pharmacology, February 2018, Elsevier

    Dr Sebastian George Barton Furness

  34. Coding GPCR-G protein specificity

    Article • BDJ, July 2017, Nature

    Dr Sebastian George Barton Furness

  35. Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

    Article • Medical Oncology, May 2017, Springer Science + Business Media

    Dr Sebastian George Barton Furness

  36. Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

    Article • Nature, April 2017, Nature

    Dr Sebastian George Barton Furness

  37. Faculty of 1000 evaluation for Universal allosteric mechanism for Gα activation by GPCRs.

    Article • April 2017, Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  38. Editorial on efficacy at G protein coupled receptors

    Article • Cell Cycle, January 2017, Taylor & Francis

    Dr Sebastian George Barton Furness

  39. Calcitonin ☆

    Article • January 2017, Elsevier

    Dr Sebastian George Barton Furness

  40. Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

    Article • Biochemical Pharmacology, October 2016, Elsevier

    Dr Sebastian George Barton Furness

  41. Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

    Article • Cell, October 2016, Elsevier

    Dr Sebastian George Barton Furness

  42. The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

    Article • Cell, June 2016, Elsevier

    Dr Sebastian George Barton Furness

  43. A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

    Article • Molecular Pharmacology, December 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Sebastian George Barton Furness

  44. Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

    Article • British Journal of Pharmacology, December 2014, Wiley

    Dr Sebastian George Barton Furness, Dr Shailesh Natvarbhai Mistry

  45. Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

    Article • PLOS One, March 2014, PLOS

    Dr Sebastian George Barton Furness

  46. Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP‐1R activation

    Article • British Journal of Pharmacology, February 2014, Wiley

    Dr Sebastian George Barton Furness

  47. A simple method to generate stable cell lines for the analysis of transient protein-protein interactions

    Article • BioTechniques, April 2013, Informa UK (Informa Life Sciences)

    Dr Sebastian George Barton Furness

  48. Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

    Article • Biochemical Society Transactions, February 2013, Portland Press Ltd.

    Dr Sebastian George Barton Furness

  49. Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

    Article • Proceedings of the National Academy of Sciences, October 2012, Proceedings of the National Academy of Sciences

    Dr Sebastian George Barton Furness

  50. Xenobiotics and Loss of Cell Adhesion Drive Distinct Transcriptional Outcomes by Aryl Hydrocarbon Receptor Signaling

    Article • Molecular Pharmacology, August 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Sebastian George Barton Furness

  51. Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin

    Article • Molecular Pharmacology, August 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Sebastian George Barton Furness

  52. Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse  3-Adrenoceptor

    Article • Journal of Biological Chemistry, April 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Sebastian George Barton Furness

  53. Consequences of splice variation on Secretin family G protein‐coupled receptor function

    Article • British Journal of Pharmacology, April 2012, Wiley

    Dr Sebastian George Barton Furness

  54. The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172

    Article • Histopathology, February 2012, Wiley

    Dr Sebastian George Barton Furness

  55. Amino Acid Substitutions in the Aryl Hydrocarbon Receptor Ligand Binding Domain Reveal YH439 As an Atypical AhR Activator

    Article • Molecular Pharmacology, March 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Sebastian George Barton Furness

  56. The pleiotropy of dioxin toxicity — Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

    Article • Pharmacology & Therapeutics, December 2009, Elsevier

    Dr Sebastian George Barton Furness, Dr Fiona Whelan

  57. Understanding Amylin Receptors

    Article • September 2009, Springer Science + Business Media

    Dr Sebastian George Barton Furness

  58. Sulfonation and Phosphorylation of Regions of the Dioxin Receptor Susceptible to Methionine Modifications

    Article • Molecular & Cellular Proteomics, December 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Sebastian George Barton Furness

  59. Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors

    Article • Endocrinology, November 2008, Endocrine Society

    Dr Sebastian George Barton Furness

  60. Identification of N,Nɛ-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS

    Article • International Journal of Mass Spectrometry, December 2007, Elsevier

    Dr Sebastian George Barton Furness

  61. The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors

    Article • FEBS Letters, April 2007, Wiley

    Dr Sebastian George Barton Furness

  62. Na+/H+ Exchanger Regulatory Factor-1 Is a Hematopoietic Ligand for a Subset of the CD34 Family of Stem Cell Surface Proteins

    Article • Stem Cells, January 2006, Oxford University Press (OUP)

    Dr Sebastian George Barton Furness

  63. Beyond Mere Markers: Functions for CD34 Family of Sialomucins in Hematopoiesis

    Article • Immunologic Research, January 2006, Springer Science + Business Media

    Dr Sebastian George Barton Furness

  64. Faculty of 1000 evaluation for Molecular control of δ-opioid receptor signalling.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  65. Faculty of 1000 evaluation for Structure of the chemokine receptor CXCR1 in phospholipid bilayers.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  66. Faculty of 1000 evaluation for Academia's obsession with quantity.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  67. Faculty of 1000 evaluation for Molecular basis for negative regulation of the glucagon receptor.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  68. Faculty of 1000 evaluation for Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  69. Faculty of 1000 evaluation for The dynamic process of β(2)-adrenergic receptor activation.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  70. Faculty of 1000 evaluation for Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  71. Faculty of 1000 evaluation for Direct Molecular Evolution of Detergent-Stable G-Protein-Coupled Receptors Using Polymer Encapsulated Cells.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  72. Faculty of 1000 evaluation for Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  73. Faculty of 1000 evaluation for SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness

  74. Faculty of 1000 evaluation for A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.

    Article • Faculty of 1000, Ltd.

    Dr Sebastian George Barton Furness