All Stories

  1. Shaping Future Medicinal Chemists: Perspectives from European Schools of Pharmacy within the GP2A Network

    Article • Journal of Medicinal Chemistry, January 2025, American Chemical Society (ACS)

    Dr Shailesh Natvarbhai Mistry, DR Jean-Jacques HELESBEUX

  2. 32nd Annual GP2A Medicinal Chemistry Conference

    Article • Drugs and Drug Candidates, January 2025, MDPI AG

    DR Jean-Jacques HELESBEUX

  3. Boronate Ester Hydrogels for Biomedical Applications: Challenges and Opportunities

    Article • Chemistry of Materials, July 2024, American Chemical Society (ACS)

    DR Jean-Jacques HELESBEUX

  4. Natural Products Targeting the Fungal Unfolded Protein Response as an Alternative Crop Protection Strategy

    Article • Journal of Agricultural and Food Chemistry, September 2023, American Chemical Society (ACS)

    DR Jean-Jacques HELESBEUX

  5. 30th Annual GP2A Medicinal Chemistry Conference

    Article • Pharmaceuticals, March 2023, MDPI AG

    DR Jean-Jacques HELESBEUX

  6. A new boronate ester-based crosslinking strategy allows the design of nonswelling and long-term stable dynamic covalent hydrogels

    Article • Biomaterials Science, January 2023, Royal Society of Chemistry

    DR Jean-Jacques HELESBEUX

  7. Role of Phenylpropanoids and Flavonoids in Plant Resistance to Pests and Diseases

    Article • Molecules, November 2022, MDPI AG

    DR Jean-Jacques HELESBEUX

  8. Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3

    Article • Metabolites, January 2022, MDPI AG

    DR Jean-Jacques HELESBEUX

  9. 29th Annual GP2A Medicinal Chemistry Conference

    Article • Pharmaceuticals, December 2021, MDPI AG

    DR Jean-Jacques HELESBEUX

  10. Novel Insights into the Mode of Action of Vasorelaxant Synthetic Polyoxygenated Chalcones

    Article • International Journal of Molecular Sciences, February 2020, MDPI AG

    DR Jean-Jacques HELESBEUX

  11. Design, Synthesis, Pharmacological Evaluation and Vascular Effects of Delphinidin Analogues

    Article • Current Pharmaceutical Design, April 2019, Bentham Science Publishers

    DR Jean-Jacques HELESBEUX

  12. Efficient Semi-Synthesis of Natural δ-(R)-Tocotrienols from a Renewable Vegetal Source

    Article • Journal of Natural Products, January 2019, American Chemical Society (ACS)

    DR Jean-Jacques HELESBEUX

  13. Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

    Article • Nature Communications, September 2018, Springer Science + Business Media

    Professor Stefan Lorkowski, DR Jean-Jacques HELESBEUX

  14. Concise semisynthesis of novel phenazine-vitamin E hybrids via regioselective tocopheryl ortho -quinone formation

    Article • Tetrahedron Letters, July 2018, Elsevier

    DR Jean-Jacques HELESBEUX

  15. Aldaulactone – An Original Phytotoxic Secondary Metabolite Involved in the Aggressiveness of Alternaria dauci on Carrot

    Article • Frontiers in Plant Science, May 2018, Frontiers

    DR Jean-Jacques HELESBEUX

  16. Efficient ortho-formylation in vitamin E series, application to the semi-synthesis of natural 5- and 7-formyl-δ-tocotrienols revealing an unprecedented 5-bromo-7-formyl exchange

    Article • Tetrahedron, December 2017, Elsevier

    DR Jean-Jacques HELESBEUX

  17. Pro-Angiogenic Effects of Low Dose Ethoxidine in a Murine Model of Ischemic Hindlimb: Correlation between Ethoxidine Levels and Increased Activation of the Nitric Oxide Pathway

    Article • Molecules, April 2017, MDPI AG

    DR Jean-Jacques HELESBEUX

  18. Influence of fungal exudates of Alternaria dauci on carrot partial resistance

    Article • Acta Horticulturae, March 2017, International Society for Horticultural Science (ISHS)

    DR Jean-Jacques HELESBEUX

  19. “The 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A)

    Article • Pharmaceuticals, January 2017, MDPI AG

    DR Jean-Jacques HELESBEUX

  20. Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors

    Article • Planta Medica, June 2016, Thieme Publishing Group

    Professor Stefan Lorkowski, DR Jean-Jacques HELESBEUX

  21. Ethoxyfagaronine, a synthetic analogue of fagaronine that inhibits vascular endothelial growth factor-1, as a new anti-angiogeneic agent

    Article • Investigational New Drugs, November 2014, Springer Science + Business Media

    DR Jean-Jacques HELESBEUX

  22. Partial Resistance of Carrot to Alternaria dauci Correlates with In Vitro Cultured Carrot Cell Resistance to Fungal Exudates

    Article • PLOS One, July 2014, PLOS

    DR Jean-Jacques HELESBEUX

  23. Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea

    Article • Phytochemistry Letters, August 2013, Elsevier

    DR Jean-Jacques HELESBEUX

  24. Hydroxamate, a Key Pharmacophore Exhibiting a Wide Range of Biological Activities

    Article • Mini-Reviews in Medicinal Chemistry, June 2013, Bentham Science Publishers

    DR Jean-Jacques HELESBEUX

  25. Synthesis, crystal structure, and characterization of thiophene-3-carboxaldoxime complexes with cobalt(II), nickel(II) and copper(II) halides

    Article • Journal of Molecular Structure, July 2012, Elsevier

    DR Jean-Jacques HELESBEUX

  26. ortho-Lithium/Magnesium Carboxylate-Driven Aromatic Nucleophilic Substitution Reactions on Unprotected Naphthoic Acids

    Article • The Journal of Organic Chemistry, December 2011, American Chemical Society (ACS)

    DR Jean-Jacques HELESBEUX

  27. Triazolobithiophene Light Absorbing Self-Assembled Monolayers: Synthesis and Mass Spectrometry Applications

    Article • Molecules, October 2011, MDPI AG

    DR Jean-Jacques HELESBEUX

  28. Free and immobilized matrix molecules: impairing ionization by quenching secondary ion formation in laser desorption MS

    Article • Journal of Mass Spectrometry, September 2011, Wiley

    DR Jean-Jacques HELESBEUX

  29. Synthesis of New Benzylic Di-, Tri-, and Tetraphosphonic Acids as Potential Chelating Agents

    Article • Phosphorus Sulfur and Silicon and the Related Elements, February 2011, Taylor & Francis

    DR Jean-Jacques HELESBEUX

  30. Crystal Structure of Ethoxidine, A Synthetic Quaternary Benzo[c]phenanthridine

    Article • Journal of Chemical Crystallography, January 2011, Springer Science + Business Media

    DR Jean-Jacques HELESBEUX

  31. Paradoxical effects of ethoxidine, a topoisomerase I inhibitor, in the cellular processes leading to angiogenesis on endothelial cells

    Article • Carcinogenesis, December 2010, Oxford University Press (OUP)

    DR Jean-Jacques HELESBEUX

  32. Synthesis of the trans-fusarinine scaffold

    Article • Tetrahedron Letters, April 2010, Elsevier

    DR Jean-Jacques HELESBEUX

  33. The anti-invasive activity of synthetic alkaloid ethoxyfagaronine on L1210 leukemia cells is mediated by down-regulation of plasminogen activators and MT1-MMP expression and activity

    Article • Investigational New Drugs, March 2010, Springer Science + Business Media

    DR Jean-Jacques HELESBEUX

  34. Novel polydentate phosphonic acids: Protonation and stability constants of complexes with Fe(III) and Cu(II) in aqueous medium

    Article • Heteroatom Chemistry, January 2010, Wiley

    DR Jean-Jacques HELESBEUX

  35. 2H‐Pyran‐2‐one‐3‐carbothioamide derivatives: Synthesis and reaction with hydrazine hydrate

    Article • Journal of Heterocyclic Chemistry, January 2009, Wiley

    DR Jean-Jacques HELESBEUX

  36. Antimicrobial Lexitropsins Containing Amide, Amidine, and Alkene Linking Groups

    Article • Journal of Medicinal Chemistry, October 2007, American Chemical Society (ACS)

    DR Jean-Jacques HELESBEUX

  37. Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2007, Taylor & Francis

    DR Jean-Jacques HELESBEUX

  38. Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii

    Article • Life Sciences, November 2004, Elsevier

    DR Jean-Jacques HELESBEUX

  39. Synthesis of 2-hydroxy-3-methylbut-3-enyl substituted coumarins and xanthones as natural products. Application of the Schenck ene reaction of singlet oxygen with ortho-prenylphenol precursors

    Article • Tetrahedron, March 2004, Elsevier

    DR Jean-Jacques HELESBEUX

  40. Regioselectivity in the ene reaction of singlet oxygen with ortho-prenylphenol derivatives

    Article • Tetrahedron, June 2003, Elsevier

    DR Jean-Jacques HELESBEUX

  41. Synthesis and Cytotoxic Activity Against a Non-small-cell Bronchopulmonary Carcinoma Line (NSCLC-N6) of Benzofuran Enantiomeric Derivatives

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, April 2003, Taylor & Francis

    DR Jean-Jacques HELESBEUX

  42. First 2-Hydroxy-3-Methylbut-3-Enyl Substituted Xanthones Isolated From Plants: Structure Elucidation, Synthesis and Antifungal Activity

    Article • Natural Product Research, January 2003, Taylor & Francis

    DR Jean-Jacques HELESBEUX

  43. Synthesis and Antimalarial Activity of Some New 1,2-Dioxolane Derivatives

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2002, Taylor & Francis

    DR Jean-Jacques HELESBEUX

  44. Studies on the reactivity of a tertiary allylic alcohol in an acetophenonic series, a model for natural products synthesis

    Article • Journal of Pharmacy and Pharmacology, July 2001, Oxford University Press (OUP)

    DR Jean-Jacques HELESBEUX

  45. Novel Cytotoxic 4-Phenylfuranocoumarins from Calophyllum dispar

    Article • Journal of Natural Products, April 2001, American Chemical Society (ACS)

    DR Jean-Jacques HELESBEUX

  46. ortho-Prenylphenol photooxygenation as a straightforward access to ortho-(2-hydroxy-3-methylbut-3-enyl)phenols

    Article • Tetrahedron Letters, June 2000, Elsevier

    DR Jean-Jacques HELESBEUX