All Stories

  1. Phosphorylation of PACSIN2 at S313 Regulates Podocyte Architecture in Coordination with N-WASP

    Article • Cells, May 2023, MDPI AG

    Sanna Lehtonen

  2. Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Sanna Lehtonen

  3. Increased Heparanase Levels in Urine during Acute Puumala Orthohantavirus Infection Are Associated with Disease Severity

    Article • Viruses, February 2022, MDPI AG

    Sanna Lehtonen

  4. PACSIN proteins in vivo: Roles in development and physiology

    Article • Acta Physiologica, January 2022, Wiley

    Sanna Lehtonen

  5. Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice

    Article • International Journal of Biological Sciences, January 2022, Ivyspring International Publisher

    Sanna Lehtonen

  6. Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo

    Article • Diabetologia, May 2021, Springer Science + Business Media

    Sanna Lehtonen

  7. Urinary Excretion of Iohexol as a Permeability Marker in a Mouse Model of Intestinal Inflammation: Time Course, Performance and Welfare Considerations

    Article • Animals, January 2021, MDPI AG

    Sanna Lehtonen

  8. Cold Saline Perfusion before Ischemia-Reperfusion Is Harmful to the Kidney and Is Associated with the Loss of Ezrin, a Cytoskeletal Protein, in Rats

    Article • Biomedicines, January 2021, MDPI AG

    Sanna Lehtonen

  9. Metformin Protects against Podocyte Injury in Diabetic Kidney Disease

    Article • Pharmaceuticals, December 2020, MDPI AG

    Sanna Lehtonen

  10. Elevated TLR5 expression in vivo and loss of NF-κΒ activation via TLR5 in vitro detected in HPV-negative oropharyngeal squamous cell carcinoma

    Article • Experimental and Molecular Pathology, June 2020, Elsevier

    Sanna Lehtonen

  11. Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice

    Article • International Journal of Obesity, April 2020, Springer Science + Business Media

    Sanna Lehtonen

  12. In memoriam: Marilyn Gist Farquhar, 1928–2019

    Article • Kidney International, March 2020, Elsevier

    Sanna Lehtonen

  13. Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes

    Article • ACS Omega, January 2020, American Chemical Society (ACS)

    Sanna Lehtonen

  14. SHIPping out diabetes—Metformin, an old friend among new SHIP2 inhibitors

    Article • Acta Physiologica, August 2019, Wiley

    Sanna Lehtonen

  15. Editorial: Podocyte Pathology and Nephropathy—An Update

    Article • Frontiers in Endocrinology, July 2019, Frontiers

    Sanna Lehtonen

  16. Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

    Article • The FASEB Journal, February 2019, Federation of American Societies For Experimental Biology (FASEB)

    Sanna Lehtonen, Vincent Dumont, SURJYA DASH, Mervi Van

  17. Septins in kidney: A territory little explored

    Article • Cytoskeleton, August 2018, Wiley

    Sanna Lehtonen

  18. Glucose Transporters in Diabetic Kidney Disease—Friends or Foes?

    Article • Frontiers in Endocrinology, April 2018, Frontiers

    Sanna Lehtonen

  19. Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis

    Article • Scientific Reports, September 2017, Springer Science + Business Media

    Sanna Lehtonen

  20. PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease

    Article • The FASEB Journal, May 2017, Federation of American Societies For Experimental Biology (FASEB)

    Vincent Dumont, Sanna Lehtonen

  21. Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish

    Article • AJP Heart and Circulatory Physiology, May 2017, American Physiological Society

    Päivi Lakkisto, Sanna Lehtonen

  22. Kidney morphology and candidate gene expression shows plasticity in sticklebacks adapted to divergent osmotic environments

    Article • Journal of Experimental Biology, April 2017, The Company of Biologists

    Chair Professor Juha Merilä, Sanna Lehtonen

  23. Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion

    Article • Experimental Cell Research, January 2017, Elsevier

    Sanna Lehtonen

  24. Tankyrase inhibition aggravates kidney injury in the absence of CD2AP

    Article • Cell Death and Disease, July 2016, Springer Science + Business Media

    Sanna Lehtonen

  25. sept7b is required for the differentiation of pancreatic endocrine progenitors

    Article • Scientific Reports, April 2016, Springer Science + Business Media

    Sanna Lehtonen

  26. Data supporting the regulation of FOXC2 in podocyte dysfunction

    Article • Data in Brief, March 2016, Elsevier

    Sanna Lehtonen

  27. Cyclin-dependent kinase 2 protects podocytes from apoptosis

    Article • Scientific Reports, February 2016, Springer Science + Business Media

    Sanna Lehtonen

  28. Overexpression of transcription factor FOXC2 in cultured human podocytes upregulates injury markers and increases motility

    Article • Experimental Cell Research, January 2016, Elsevier

    Sanna Lehtonen

  29. Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents

    Article • RSC Advances, January 2016, Royal Society of Chemistry

    Sanna Lehtonen

  30. Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes

    Article • Journal of Cell Science, November 2015, The Company of Biologists

    Sanna Lehtonen

  31. Toll-like receptors 2, 4, and 9 in primary, metastasized, and recurrent oral tongue squamous cell carcinomas

    Article • Journal of Oral Pathology and Medicine, October 2015, Wiley

    Sanna Lehtonen

  32. Nephrin Trafficking beyond the Kidney--Role in Glucose-Stimulated Insulin Secretion in   Cells

    Article • Journal of the American Society of Nephrology, September 2015, American Society of Nephrology

    Sanna Lehtonen

  33. Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae

    Article • The FASEB Journal, July 2015, Federation of American Societies For Experimental Biology (FASEB)

    Sanna Lehtonen

  34. Expression of toll-like receptors in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma—an in vivo and in vitro study

    Article • Tumor Biology, May 2015, Springer Science + Business Media

    Sanna Lehtonen

  35. Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway

    Article • Cell Death and Disease, May 2015, Springer Science + Business Media

    Sanna Lehtonen

  36. Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Dr päivi miettinen, Sanna Lehtonen

  37. Predictive role of toll-like receptors 2, 4, and 9 in oral tongue squamous cell carcinoma

    Article • Oral Oncology, January 2015, Elsevier

    Sanna Lehtonen

  38. Ezrin Is Down-Regulated in Diabetic Kidney Glomeruli and Regulates Actin Reorganization and Glucose Uptake via GLUT1 in Cultured Podocytes

    Article • American Journal Of Pathology, June 2014, Elsevier

    Sanna Lehtonen

  39. Functions of the podocyte proteins nephrin and Neph3 and the transcriptional regulation of their genes

    Article • Clinical Science, March 2014, Portland Press Ltd.

    Sanna Lehtonen

  40. sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis

    Article • Journal of Cell Science, February 2014, The Company of Biologists

    Sanna Lehtonen

  41. CD2AP is associated with end-stage renal disease in patients with type 1 diabetes

    Article • Acta Diabetologica, May 2013, Springer Science + Business Media

    Sanna Lehtonen, Prof Alexander P Maxwell

  42. Report of the Second European Zebrafish Principal Investigator Meeting in Karlsruhe, Germany, March 21–24, 2012

    Article • Zebrafish, March 2013, Mary Ann Liebert Inc

    Sanna Lehtonen

  43. Regulation of nephrin gene by the Ets transcription factor, GA-binding protein

    Article • Nephrology Dialysis Transplantation, November 2012, Oxford University Press (OUP)

    Sanna Lehtonen

  44. INPPL1is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy

    Article • Diabetic Medicine, November 2012, Wiley

    Sanna Lehtonen

  45. Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking

    Article • Molecular Biology of the Cell, September 2012, American Society for Cell Biology (ASCB)

    Sanna Lehtonen

  46. Neph3 associates with regulation of glomerular and neural development in zebrafish

    Article • Differentiation, January 2012, Elsevier

    Sanna Lehtonen

  47. Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF- B and silenced by DNA methylation

    Article • Nephrology Dialysis Transplantation, October 2011, Oxford University Press (OUP)

    Sanna Lehtonen

  48. Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin

    Article • Biochemical Journal, May 2011, Portland Press Ltd.

    Sanna Lehtonen

  49. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

    Article • Journal of Cell Science, March 2011, The Company of Biologists

    Sanna Lehtonen

  50. Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes

    Article • Molecular and Cellular Endocrinology, October 2010, Elsevier

    Moin Saleem, Sanna Lehtonen

  51.  -Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys

    Article • Nephrology Dialysis Transplantation, March 2010, Oxford University Press (OUP)

    Sanna Lehtonen

  52. Regulation of Neph3 gene in podocytes – key roles of transcription factors NF-κB and Sp1

    Article • BMC Molecular Biology, August 2009, Springer Science + Business Media

    Moin Saleem, Sanna Lehtonen

  53. The Endocytic Adaptor Protein ARH Associates with Motor and Centrosomal Proteins and Is Involved in Centrosome Assembly and Cytokinesis

    Article • Molecular Biology of the Cell, July 2008, American Society for Cell Biology (ASCB)

    Sanna Lehtonen

  54. CD2-associated protein is widely expressed and differentially regulated during embryonic development

    Article • Differentiation, June 2008, Elsevier

    Sanna Lehtonen

  55. Connecting the interpodocyte slit diaphragm and actin dynamics: Emerging role for the nephrin signaling complex

    Article • Kidney International, April 2008, Elsevier

    Sanna Lehtonen

  56. The R-Ras interaction partner ORP3 regulates cell adhesion

    Article • Journal of Cell Science, February 2008, The Company of Biologists

    Sanna Lehtonen, Mikko I. Mäyränpää

  57. Densin and beta-catenin form a complex and co-localize in cultured podocyte cell junctions

    Article • Molecular and Cellular Biochemistry, June 2007, Springer Science + Business Media

    Sanna Lehtonen

  58. CD2AP contributes to cell migration and adhesion in cultured gastric epithelium

    Article • Biochemical and Biophysical Research Communications, July 2005, Elsevier

    Sanna Lehtonen

  59. Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and α-actinin are components of the nephrin multiprotein complex

    Article • Proceedings of the National Academy of Sciences, July 2005, Proceedings of the National Academy of Sciences

    Sanna Lehtonen

  60. CD2-associated protein in human urogenital system and in adult kidney tumours

    Article • Virchows Archiv, March 2005, Springer Science + Business Media

    Sanna Lehtonen

  61. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7

    Article • Cell and Tissue Research, January 2004, Springer Science + Business Media

    Sanna Lehtonen

  62. CD2-associated protein directly interacts with the actin cytoskeleton

    Article • AJP Renal Physiology, October 2002, American Physiological Society

    Sanna Lehtonen

  63. Interaction of Endogenous Nephrin and CD2-Associated Protein in Mouse Epithelial M-1 Cell Line

    Article • Journal of the American Society of Nephrology, July 2002, American Society of Nephrology

    Sanna Lehtonen

  64. Nephrin TRAP Mice Lack Slit Diaphragms and Show Fibrotic Glomeruli and Cystic Tubular Lesions

    Article • Journal of the American Society of Nephrology, June 2002, American Society of Nephrology

    Sanna Lehtonen