All Stories

  1. Hepatic demethylation of methoxy-bromodiphenyl ethers and conjugation of the resulting hydroxy-bromodiphenyl ethers in a marine fish, the red snapper, Lutjanus campechanus, and a freshwater fish, the channel catfish, Ictalurus punctatus

    Article • Chemosphere, January 2022, Elsevier

    Professor Margaret Olive James

  2. Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses

    Article • Drug Metabolism and Disposition, June 2021, Elsevier

    Professor Margaret Olive James

  3. Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats

    Article • Drug Metabolism and Disposition, November 2020, Elsevier

    Professor Margaret Olive James

  4. Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1

    Article • Drug Metabolism and Disposition, November 2020, Elsevier

    Professor Margaret Olive James

  5. Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes

    Article • Drug Metabolism and Disposition, May 2020, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  6. Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver

    Article • Chemical Research in Toxicology, September 2019, American Chemical Society (ACS)

    Professor Margaret Olive James

  7. Sulfonation and glucuronidation of hydroxylated bromodiphenyl ethers in human liver

    Article • Chemosphere, July 2019, Elsevier

    Professor Margaret Olive James

  8. Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1

    Article • Drug Metabolism and Disposition, May 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  9. Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children

    Article • The Journal of Clinical Pharmacology, September 2017, Wiley

    Professor Margaret Olive James

  10. A multi-year study of hepatic biomarkers in coastal fishes from the Gulf of Mexico after the Deepwater Horizon Oil Spill

    Article • Marine Environmental Research, August 2017, Elsevier

    Professor Margaret Olive James

  11. GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, June 2016, Elsevier

    Professor Margaret Olive James

  12. Celecoxib influences steroid sulfonation catalyzed by human recombinant sulfotransferase 2A1

    Article • The Journal of Steroid Biochemistry and Molecular Biology, August 2015, Elsevier

    Professor Margaret Olive James

  13. The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression

    Article • Pharmacogenetics and Genomics, May 2015, Wolters Kluwer Health

    Professor Margaret Olive James

  14. Chloride concentrations in human hepatic cytosol and mitochondria are a function of age

    Article • Biochemical and Biophysical Research Communications, April 2015, Elsevier

    Professor Margaret Olive James

  15. Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner

    Article • Chemico-Biological Interactions, May 2014, Elsevier

    Professor Margaret Olive James

  16. Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a)

    Article • Acta Crystallographica Section F Structural Biology Communications, January 2014, International Union of Crystallography

    Professor Margaret Olive James

  17. Interactions of cytosolic sulfotransferases with xenobiotics

    Article • Drug Metabolism Reviews, November 2013, Taylor & Francis

    Professor Margaret Olive James

  18. Pharmacokinetics of Oral Dichloroacetate in Dogs

    Article • Journal of Biochemical and Molecular Toxicology, September 2013, Wiley

    Professor Margaret Olive James

  19. Seasonal influences on PCB retention and biotransformation in fish

    Article • Environmental Science and Pollution Research, March 2013, Springer Science + Business Media

    Professor Margaret Olive James

  20. Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine

    Article • Aquatic Toxicology, November 2012, Elsevier

    Professor Margaret Olive James

  21. Correction to "Glucuronidation of Polychlorinated Biphenylols and UDP-Glucuronic Acid Concentrations in Channel Catfish Liver and Intestine"

    Article • Drug Metabolism and Disposition, June 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  22. Steroid catabolism in marine and freshwater fish

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 2011, Elsevier

    Professor Margaret Olive James

  23. Prenatal and Postnatal Expression of Glutathione Transferase ζ 1 in Human Liver and the Roles of Haplotype and Subject Age in Determining Activity with Dichloroacetate

    Article • Drug Metabolism and Disposition, October 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ronald N. Hines, Professor Margaret Olive James

  24. Biological effects ofByrsocarpus coccineus in vitro

    Article • Pharmaceutical Biology, November 2010, Taylor & Francis

    Professor Margaret Olive James

  25. Triclosan is a potent inhibitor of estradiol and estrone sulfonation in sheep placenta

    Article • Environment International, November 2010, Elsevier

    Professor Margaret Olive James

  26. Mitochondrion as a Novel Site of Dichloroacetate Biotransformation by Glutathione Transferase ζ1

    Article • Journal of Pharmacology and Experimental Therapeutics, September 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  27. Influence of Dietary Coexposure to Benzo(a)pyrene on the Biotransformation and Distribution of 14C-Methoxychlor in the Channel Catfish (Ictalurus punctatus)

    Article • Toxicological Sciences, January 2009, Oxford University Press (OUP)

    Professor Margaret Olive James

  28. The state of in vitro science for use in bioaccumulation assessments for fish

    Article • Environmental Toxicology and Chemistry, January 2009, Oxford University Press (OUP)

    Professor Margaret Olive James

  29. Effects of the pesticide methoxychlor on gene expression in the liver and testes of the male largemouth bass (Micropterus salmoides)

    Article • Aquatic Toxicology, March 2008, Elsevier

    Professor Margaret Olive James

  30. Effects of food natural products on the biotransformation of PCBs

    Article • Environmental Toxicology and Pharmacology, March 2008, Elsevier

    Professor Margaret Olive James

  31. Glucuronidation of Polychlorinated Biphenylols and UDP-Glucuronic Acid Concentrations in Channel Catfish Liver and Intestine

    Article • Drug Metabolism and Disposition, January 2008, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  32. Glucuronidation and sulfonation, in vitro, of the major endocrine-active metabolites of methoxychlor in the channel catfish, Ictalurus punctatus, and induction following treatment with 3-methylcholanthrene

    Article • Aquatic Toxicology, January 2008, Elsevier

    Professor Margaret Olive James

  33. Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells

    Article • The Journal of Steroid Biochemistry and Molecular Biology, January 2008, Elsevier

    Professor Margaret Olive James

  34. Age-Dependent Kinetics and Metabolism of Dichloroacetate: Possible Relevance to Toxicity

    Article • Journal of Pharmacology and Experimental Therapeutics, December 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  35. Use ofIn VitroAbsorption, Distribution, Metabolism, and Excretion (ADME) Data in Bioaccumulation Assessments for Fish

    Article • Human and Ecological Risk Assessment An International Journal, November 2007, Taylor & Francis

    Professor Margaret Olive James

  36. Sulfonation of 17β-estradiol and inhibition of sulfotransferase activity by polychlorobiphenylols and celecoxib in channel catfish, Ictalurus punctatus

    Article • Aquatic Toxicology, March 2007, Elsevier

    Professor Margaret Olive James

  37. Intestinal bioavailability and biotransformation of 3,3′,4,4′-tetrachlorobiphenyl (CB 77) in in situ preparations of channel catfish following dietary induction of CYP1A

    Article • Aquatic Toxicology, April 2006, Elsevier

    Professor Margaret Olive James

  38. DEMETHYLATION OF THE PESTICIDE METHOXYCHLOR IN LIVER AND INTESTINE FROM UNTREATED, METHOXYCHLOR-TREATED, AND 3-METHYLCHOLANTHRENE-TREATED CHANNEL CATFISH (ICTALURUS PUNCTATUS): EVIDENCE FOR ROLES OF CYP1 AND CYP3A FAMILY ISOZYMES

    Article • Drug Metabolism and Disposition, March 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  39. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate

    Article • Chemico-Biological Interactions, February 2006, Elsevier

    Professor Margaret Olive James

  40. Inhibition of Sulfotransferases by Xenobiotics

    Article • Current Drug Metabolism, January 2006, Bentham Science Publishers

    Professor Margaret Olive James

  41. Abstracts from Thirteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO 13) - Organic xenobiotics: mechanisms of detoxification and mechanisms of toxicity

    Article • Marine Environmental Research, January 2006, Elsevier

    Professor Margaret Olive James

  42. INHIBITION AND RECOVERY OF RAT HEPATIC GLUTATHIONE S-TRANSFERASE ZETA AND ALTERATION OF TYROSINE METABOLISM FOLLOWING DICHLOROACETATE EXPOSURE AND WITHDRAWAL

    Article • Drug Metabolism and Disposition, September 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  43. Sulfotransferase 2A1 forms estradiol-17-sulfate and celecoxib switches the dominant product from estradiol-3-sulfate to estradiol-17-sulfate

    Article • The Journal of Steroid Biochemistry and Molecular Biology, September 2005, Elsevier

    Professor Margaret Olive James

  44. Research needs identified at the second PCB workshop in Brno, Czech Republic, May 7–11, 2002

    Article • Toxicological and Environmental Chemistry, July 2005, Taylor & Francis

    Professor Margaret Olive James

  45. SULFONATION OF ENVIRONMENTAL CHEMICALS AND THEIR METABOLITES IN THE POLAR BEAR (Ursus maritimus)

    Article • Drug Metabolism and Disposition, June 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  46. In Vitro Inhibition of Human Hepatic and cDNA-Expressed Sulfotransferase Activity with 3-Hydroxybenzo[ a ]pyrene by Polychlorobiphenylols

    Article • Environmental Health Perspectives, June 2005, Environmental Health Perspectives

    Professor Margaret Olive James

  47. Properties and regional expression of a CYP3A-like protein in channel catfish intestine

    Article • Aquatic Toxicology, May 2005, Elsevier

    Professor Margaret Olive James

  48. Liquid chromatography–tandem mass spectrometry method for the simultaneous determination of δ-ALA, tyrosine and creatinine in biological fluids

    Article • Clinica Chimica Acta, December 2004, Elsevier

    Professor Margaret Olive James

  49. Unified gas chromatographic?mass spectrometric method for quantitating tyrosine metabolites in urine and plasma

    Article • Journal of Chromatography B, September 2004, Elsevier

    Professor Margaret Olive James

  50. Glucuronidation in the polar bear (Ursus maritimus)

    Article • Marine Environmental Research, August 2004, Elsevier

    Professor Margaret Olive James

  51. Increased toxicity of benzo(a)pyrene-7,8-dihydrodiol in the presence of polychlorobiphenylols

    Article • Marine Environmental Research, August 2004, Elsevier

    Professor Margaret Olive James

  52. PRIMO 12

    Article • Marine Environmental Research, August 2004, Elsevier

    Professor Margaret Olive James

  53. TRICLOSAN AS A SUBSTRATE AND INHIBITOR OF 3′-PHOSPHOADENOSINE 5′-PHOSPHOSULFATE-SULFOTRANSFERASE AND UDP-GLUCURONOSYL TRANSFERASE IN HUMAN LIVER FRACTIONS

    Article • Drug Metabolism and Disposition, July 2004, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Margaret Olive James

  54. Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents

    Article • Biochemical Pharmacology, November 2003, Elsevier

    Professor Margaret Olive James

  55. Binding of 3‐hydroxybenzo[a]pyrene to bovine hemoglobin and albumin

    Article • Journal of Biochemical and Molecular Toxicology, July 2003, Wiley

    Professor Margaret Olive James

  56. Intestinal and hepatic microsomal metabolism of testosterone and progesterone by a 3α-hydroxysteroid dehydrogenase to the 3α-hydroxy derivatives in the channel catfish, Ictalurus punctatus

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 2002, Elsevier

    Professor Margaret Olive James

  57. Bioavailability and biotransformation of 3,4,3′,4′-tetrachlorobiphenyl (TCB) in in situ intestinal preparations of uninduced and TCB induced channel catfish

    Article • Marine Environmental Research, July 2000, Elsevier

    Professor Margaret Olive James

  58. Differential expression of α-like glutathione S-transferase (GST) isoforms in catfish intestine

    Article • Marine Environmental Research, July 2000, Elsevier

    Professor Margaret Olive James

  59. Sulfation and glucuronidation of benzo[a]pyrene-7,8-dihydrodiol in intestinal mucosa of channel catfish (Ictalurus punctatus)

    Article • Marine Environmental Research, July 2000, Elsevier

    Professor Margaret Olive James

  60. Activities of affinity-isolated glutathione S-transferase (GST) from channel catfish whole intestine

    Article • Aquatic Toxicology, May 2000, Elsevier

    Professor Margaret Olive James

  61. Purification and Characterization of Hepatic and Intestinal Phenol Sulfotransferase with High Affinity for Benzo[a]pyrene Phenols from Channel Catfish, Ictalurus punctatus

    Article • Archives of Biochemistry and Biophysics, April 2000, Elsevier

    Professor Margaret Olive James

  62. Inhibition of Glutathione S-Transferase ζ and Tyrosine Metabolism by Dichloroacetate: A Potential Unifying Mechanism for Its Altered Biotransformation and Toxicity

    Article • Biochemical and Biophysical Research Communications, September 1999, Elsevier

    Professor Margaret Olive James

  63. Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 1999, Elsevier

    Professor Margaret Olive James

  64. Cytochromes P450 in crustacea

    Article • Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology, November 1998, Elsevier

    Professor Margaret Olive James

  65. Expression of CYP2L1 in the yeast Pichia pastoris, and determination of catalytic activity with progesterone and testosterone

    Article • Marine Environmental Research, July 1998, Elsevier

    Professor Margaret Olive James

  66. Isolation of CYP2L2 and two other cytochrome P450 sequences from a spiny lobster, Panulirus argus, hepatopancreas cDNA library

    Article • Marine Environmental Research, July 1998, Elsevier

    Professor Margaret Olive James

  67. Isolation of a Pi class glutathione S-transferase (GST) from catfish intestinal mucosa

    Article • Marine Environmental Research, July 1998, Elsevier

    Professor Margaret Olive James

  68. The oral bioavailability, pharmacokinetics and biotransformation of 9-hydroxybenzo[a]pyrene in the American lobster, Homarus americanus

    Article • Marine Environmental Research, July 1998, Elsevier

    Professor Margaret Olive James

  69. Carcinogenic effects of 1,2-dibromoethane (ethylene dibromide; EDB) in Japanese medaka (Oryzias latipes)

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, March 1998, Elsevier

    Professor Margaret Olive James

  70. Determination of dichloroacetate and its metabolites in human plasma by gas chromatography–mass spectrometry

    Article • Journal of Chromatography B Biomedical Sciences and Applications, December 1997, Elsevier

    Professor Margaret Olive James

  71. Kinetics and Metabolism of Chloral Hydrate in Children: Identification of Dichloroacetate as a Metabolite

    Article • Biochemical and Biophysical Research Communications, June 1997, Elsevier

    Professor Margaret Olive James

  72. Pharmacokinetics of 2-naphthol following intrapericardial administration, and formation of 2-naphthyl- beta --glucoside and 2-naphthyl sulphate D in the American lobster, Homarus americanus

    Article • Xenobiotica, January 1997, Taylor & Francis

    Professor Margaret Olive James

  73. Bioavailability and biotransformation of 3H-benzo[a]pyrene metabolites in in Situ intestinal preparations of uninduced and BNF-induced channel catfish

    Article • Marine Environmental Research, June 1996, Elsevier

    Professor Margaret Olive James

  74. Cross-reactivity of an antibody to spiny lobster P450 2l with microsomes from other species

    Article • Marine Environmental Research, June 1996, Elsevier

    Professor Margaret Olive James

  75. cDNA and Protein Sequence of a Major Form of P450, CYP2L, in the Hepatopancreas of the Spiny Lobster,Panulirus argus

    Article • Archives of Biochemistry and Biophysics, May 1996, Elsevier

    Professor Margaret Olive James

  76. The effect of ecdysis on DNA of the hepatopancreas and green gland of the Florida spiny lobster (Panulirus argus)

    Article • Comparative Biochemistry and Physiology Part B Comparative Biochemistry, March 1994, Elsevier

    Professor Margaret Olive James

  77. Dose- and time-dependent formation of benzo[a]pyrene metabolite DNA adducts in the spiny lobster, Panulirus argus

    Article • Marine Environmental Research, January 1992, Elsevier

    Professor Margaret Olive James

  78. Southern flounder hepatic and intestinal metabolism and DNA binding of benzo[a]pyrene (BaP) metabolites following dietary administration of low doses of BaP, BaP-7,8-dihydrodiol or a BaP metabolite mixture

    Article • Chemico-Biological Interactions, January 1991, Elsevier

    Professor Margaret Olive James

  79. Effect of 3-methylcholanthrene on monooxygenase, epoxide hydrolase, and glutathione S-transferase activities in small estuarine and freshwater fish

    Article • Aquatic Toxicology, January 1988, Elsevier

    Professor Margaret Olive James

  80. Polyhalogenated biphenyls and phenobarbital: Evaluation as inducers of drug metabolizing enzymes in the sheepshead, Archosargus probatocephalus

    Article • Chemico-Biological Interactions, August 1981, Elsevier

    Professor Margaret Olive James

  81. Characteristics and development of drug metabolism by pulmonary microsomes

    Article • Agents and Actions, July 1976, Springer Science + Business Media

    Professor Margaret Olive James

  82. The conjugation of phenylacetic acid in phenylketonurics

    Article • European Journal of Clinical Pharmacology, April 1973, Springer Science + Business Media

    Professor Margaret Olive James