All Stories

  1. Regulation of Transgenic Insects

    Article • November 2022, CABI Publishing

    Dr Nathan R Rose

  2. New self-sexing Aedes aegypti strain eliminates barriers to scalable and sustainable vector control for governments and communities in dengue-prone environments

    Article • Frontiers in Bioengineering and Biotechnology, October 2022, Frontiers

    Dr Nathan R Rose

  3. Self-limiting fall armyworm: a new approach in development for sustainable crop protection and resistance management

    Article • BMC Biotechnology, January 2022, Springer Science + Business Media

    Dr Nathan R Rose

  4. Biochemical Identification of Nonmethylated DNA by BioCAP-Seq

    Article • January 2018, Springer Science + Business Media

    Dr Nathan R Rose

  5. RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

    Article • eLife, October 2016, eLife

    Dr Nathan R Rose

  6. Targeting Polycomb systems to regulate gene expression: modifications to a complex story

    Article • Nature Reviews Molecular Cell Biology, September 2015, Springer Science + Business Media

    Dr Nathan R Rose

  7. Understanding the relationship between DNA methylation and histone lysine methylation

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, December 2014, Elsevier

    Dr Nathan R Rose

  8. Evaluation of Baylis–Hillman Routes to 3-(Aminomethyl)coumarin Derivatives

    Article • Synthetic Communications, October 2013, Taylor & Francis

    Oluwole Familoni, Dr Nathan R Rose

  9. Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases

    Article • ACS Chemical Biology, July 2013, American Chemical Society (ACS)

    Dr Nathan R Rose

  10. Is JmjC Oxygenase Catalysis Limited to Demethylation?

    Article • Angewandte Chemie, June 2013, Wiley

    Dr Nathan R Rose

  11. 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

    Article • Chemical Science, January 2013, Royal Society of Chemistry

    Dr Nathan R Rose

  12. KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Article • eLife, December 2012, eLife

    Dr David Sims, Dr Nathan R Rose

  13. Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

    Article • Journal of Medicinal Chemistry, July 2012, American Chemical Society (ACS)

    Dr Nathan R Rose

  14. Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post‐Translational Modifications

    Article • Angewandte Chemie, January 2012, Wiley

    Justin Chalker, Dr Nathan R Rose

  15. Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

    Article • Angewandte Chemie, January 2012, Wiley

    Dr Nathan R Rose

  16. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

    Article • EMBO Reports, April 2011, EMBO

    Dr Nathan R Rose

  17. Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

    Article • ChemMedChem, March 2011, Wiley

    Dr Nathan R Rose

  18. Inhibition of 2-oxoglutarate dependent oxygenases

    Article • Chemical Society Reviews, January 2011, Royal Society of Chemistry

    Dr Nathan R Rose

  19. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Prof. Dr. Jasmin Mecinovic, Dr Nathan R Rose

  20. Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

    Article • PLOS One, November 2010, PLOS

    Dr Nathan R Rose

  21. Development of homogeneous luminescence assays for histone demethylase catalysis and binding

    Article • Analytical Biochemistry, September 2010, Elsevier

    Dr Nathan R Rose

  22. Monitoring the Activity of 2-Oxoglutarate Dependent Histone Demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde

    Article • ChemBioChem, March 2010, Wiley

    Dr Refaat B Hamed, Dr Nathan R Rose

  23. Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

    Article • Journal of Medicinal Chemistry, February 2010, American Chemical Society (ACS)

    Dr Nathan R Rose, Prof. Dr. Jasmin Mecinovic

  24. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals

    Article • Metallomics, January 2010, Oxford University Press (OUP)

    Prof. Dr. Jasmin Mecinovic, Dr Nathan R Rose

  25. A miniaturized screen for inhibitors of Jumonji histone demethylases

    Article • Molecular BioSystems, January 2010, Royal Society of Chemistry

    Dr Nathan R Rose

  26. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N -dimethyl lysine demethylase

    Article • Human Molecular Genetics, October 2009, Oxford University Press (OUP)

    Dr Nathan R Rose

  27. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)

    Article • Chemical Communications, January 2009, Royal Society of Chemistry

    Prof. Dr. Jasmin Mecinovic, Dr Nathan R Rose

  28. Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases ⊥

    Article • Journal of Medicinal Chemistry, November 2008, American Chemical Society (ACS)

    Dr Nathan R Rose, Prof. Dr. Jasmin Mecinovic

  29. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

    Article • Nature, June 2007, Springer Science + Business Media

    Dr Nathan R Rose, Dr john offer