All Stories

  1. Ligating NEMO with a single ubiquitin chain.

    Article • Communications Chemistry, September 2019, Springer Science + Business Media

    Dr john offer

  2. Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation

    Article • Chemical Communications, January 2019, Royal Society of Chemistry

    Dr john offer

  3. A method for the unbiased and efficient segmental labelling of RNA-binding proteins for structure and biophysics

    Article • Scientific Reports, October 2017, Nature

    Dr john offer

  4. HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

    Article • Angewandte Chemie, October 2016, Wiley

    Dr john offer

  5. HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

    Article • Angewandte Chemie International Edition, October 2016, Wiley

    Dr john offer

  6. a general amide bond substitution improves peptide synthesis

    Article • Journal of Peptide Science, April 2016, Wiley

    Dr john offer

  7. review of current Fmoc solid phase

    Article • Journal of Peptide Science, January 2016, Wiley

    Dr john offer

  8. Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation

    Article • Molecular Cell, March 2015, Elsevier

    Dr john offer

  9. using an amide bond as an activated ester for peptide coupling reactions

    Article • Chemical Science, January 2014, Royal Society of Chemistry

    Dr john offer

  10. An easy to use method for solubilising peptides

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Dr john offer

  11. Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism

    Article • PLoS Biology, September 2013, PLOS

    Dr. Petra Kienesberger, Dr john offer

  12. Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein

    Article • Protein Engineering Design and Selection, January 2013, Oxford University Press (OUP)

    Dr john offer

  13. Chemical labelling of active serum thioester proteins for quantification

    Article • Immunobiology, February 2012, Elsevier

    Dr john offer

  14. Simplifying native chemical ligation with an N-acylsulfonamide linker

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Dr john offer

  15. The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein

    Article • Molecular Membrane Biology, May 2011, Taylor & Francis

    Dr john offer

  16. Native chemical ligation with Nα acyl transfer auxiliaries

    Article • Biopolymers, June 2010, Wiley

    Dr john offer

  17. Cholesterol Secosterol Adduction Inhibits the Misfolding of a Mutant Prion Protein Fragment that Induces Neurodegeneration

    Article • Angewandte Chemie International Edition, November 2009, Wiley

    Dr john offer

  18. A Chemical Approach to Immunoprotein Engineering: Chemoselective Functionalization of Thioester Proteins in Their Native State

    Article • ChemBioChem, May 2009, Wiley

    Dr john offer

  19. Cholesterolseco-Sterol-Induced Aggregation of Methylated Amyloid-β Peptides—Insights into Aldehyde-Initiated Fibrillization of Amyloid-β

    Article • Angewandte Chemie International Edition, May 2008, Wiley

    Dr john offer

  20. Orthogonal ligation: a three piece assembly of a PNA–peptide–PNA conjugate

    Article • Chemical Communications, January 2008, Royal Society of Chemistry

    Professor Robert Doyle, Dr john offer

  21. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

    Article • Nature, June 2007, Springer Science + Business Media

    Dr Nathan R Rose, Dr john offer

  22. Exploiting the defensive sugars of HIV-1 for drug and vaccine design

    Article • Nature, April 2007, Nature

    Dr john offer

  23. An o-nitrobenzyl scaffold for peptide ligation: synthesis and applications

    Article • Bioorganic & Medicinal Chemistry, May 2004, Elsevier

    Dr john offer

  24. Tandem IMAC–HPLC purification of a cocaine-binding scFv antibody

    Article • Journal of Immunological Methods, October 2003, Elsevier

    Dr john offer

  25. Extending Synthetic Access to Proteins with a Removable Acyl Transfer Auxiliary

    Article • Journal of the American Chemical Society, May 2002, American Chemical Society (ACS)

    Dr john offer

  26. A new scaffold for amide ligation

    Article • Bioorganic & Medicinal Chemistry, September 2001, Elsevier

    Dr john offer

  27. N α -2-Mercaptobenzylamine-Assisted Chemical Ligation

    Article • Organic Letters, January 2000, American Chemical Society (ACS)

    Dr john offer

  28. Application of reversible amide-bond protection to suppress peptide segment epimerisation

    Article • Tetrahedron Letters, December 1997, Elsevier

    Dr john offer

  29. On-resin solid-phase synthesis of asparagine N-linked glycopeptides: use of N-(2-acetoxy-4-methoxybenzyl)(AcHmb) aspartyl amide-bond protection to prevent unwanted aspartimide formation

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1996, Royal Society of Chemistry

    Dr john offer

  30. The proximal pathway of metabolism of the chlorinated signal molecule differentiation-inducing factor-1 (DIF-1) in the cellular slime mouldDictyostelium

    Article • Biochemical Journal, March 1995, Portland Press Ltd.

    Dr john offer

  31. Effects of fluorinated inositols on the proliferation of Swiss 3T3 fibroblasts

    Article • Biochemical Journal, June 1993, Portland Press Ltd.

    Dr john offer

  32. The uptake of3H-labelled monodeoxyfluoro-myo-inositols into thymocytes and their incorporation into phospholipid in permeabilized cells

    Article • Biochemical Journal, April 1993, Portland Press Ltd.

    Dr john offer

  33. Synthesis and tritium radiolabelling of fluorinated analogues of myo-inositol

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1992, Royal Society of Chemistry

    Dr john offer

  34. Synthesis of fluorodeoxy analogues ofmyo-inositol

    Article • Biochemical Society Transactions, August 1990, Portland Press Ltd.

    Dr john offer

  35. Synthesis of some deoxy-fluoro analogues of myo-inositol

    Article • Journal of the Chemical Society Chemical Communications, January 1990, Royal Society of Chemistry

    Dr john offer