All Stories

  1. Fatty Acid–Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells

    Article • Journal of Pharmaceutical Sciences, April 2018, Elsevier

    Professor Martin J Scanlon, Christopher Porter

  2. Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

    Article • Antibiotics, February 2018, MDPI AG

    Professor Martin J Scanlon

  3. Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme inNeisseria meningitidis

    Article • Acta Crystallographica Section F Structural Biology Communications, January 2018, International Union of Crystallography

    Begoña Heras, Professor Martin J Scanlon

  4. Assembly of Fragment Screening Libraries

    Article • July 2017, Wiley

    Professor Martin J Scanlon

  5. HN, N, Cα and Cβ assignments of the two periplasmic domains of Neisseria meningitidis DsbD

    Article • Biomolecular NMR Assignments, June 2017, Springer Science + Business Media

    Professor Martin J Scanlon

  6. Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

    Article • Science Translational Medicine, May 2017, American Association for the Advancement of Science

    Christopher Porter, Professor Martin J Scanlon

  7. Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

    Article • PLoS ONE, March 2017, PLOS

    Professor Martin J Scanlon

  8. Molecular Insights into the Interaction Between the SPRY Domain-Containing SOCS Box Protein SPSB2 and Peptides Based on the Binding Motif from iNOS

    Article • Australian Journal of Chemistry, January 2017, CSIRO Publishing

    Professor Martin J Scanlon

  9. Applications of NMR Spectroscopy in FBDD

    Article • January 2017, Springer Science + Business Media

    Professor Martin J Scanlon

  10. Fatty Acid-Binding Protein 5 at the Blood–Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function

    Article • Journal of Neuroscience, November 2016, Society for Neuroscience

    Christopher Porter, Professor Martin J Scanlon, Dr Kwok Ho Christopher Choy

  11. The ways and means of fragment-based drug design

    Article • Pharmacology & Therapeutics, November 2016, Elsevier

    Professor Martin J Scanlon

  12. Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data

    Article • Journal of Biomolecular NMR, October 2016, Springer Science + Business Media

    Professor Martin J Scanlon

  13. Structure–Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1–RON2 Interaction

    Article • Journal of Molecular Biology, October 2016, Elsevier

    Professor Martin J Scanlon

  14. Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents

    Article • Molecules, July 2016, MDPI AG

    Professor Martin J Scanlon

  15. Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein–Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2...

    Article • Journal of Medicinal Chemistry, June 2016, American Chemical Society (ACS)

    Professor Martin J Scanlon

  16. Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 Is Mediated by the Minor Pilin CfaE

    Article • Infection and Immunity, March 2016, ASM Journals

    Professor Martin J Scanlon

  17. Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin

    Article • Biochimie, March 2016, Elsevier

    Professor Martin J Scanlon

  18. Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

    Article • FEBS Letters, March 2016, Wiley

    Professor Martin J Scanlon

  19. Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

    Article • Journal of Molecular Recognition, January 2016, Wiley

    Dr Shane M Devine, Professor Martin J Scanlon

  20. Fatty Acid-Binding Protein 5 Facilitates the Blood–Brain Barrier Transport of Docosahexaenoic Acid

    Article • Molecular Pharmaceutics, December 2015, American Chemical Society (ACS)

    Christopher Porter, Professor Martin J Scanlon

  21. Sent packing: protein engineering generates a new crystal form ofPseudomonas aeruginosaDsbA1 with increased catalytic surface accessibility

    Article • Acta Crystallographica Section D Biological Crystallography, November 2015, International Union of Crystallography

    Professor Martin J Scanlon

  22. Inhibitors of BCATm: A Tough Nut To Crack

    Article • Journal of Medicinal Chemistry, September 2015, American Chemical Society (ACS)

    Professor Martin J Scanlon

  23. Determinants of Proteolysis and Cell-Binding for the Shigella flexneri Cytotoxin, SigA

    Article • Current Microbiology, August 2015, Springer Science + Business Media

    Professor Martin J Scanlon

  24. Fatty Acid Binding Proteins Expressed at the Human Blood–Brain Barrier Bind Drugs in an Isoform-Specific Manner

    Article • Pharmaceutical Research, August 2015, Springer Science + Business Media

    Christopher Porter, Professor Martin J Scanlon

  25. Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module

    Article • Scientific Reports, August 2015, Nature

    Professor Trevor Lithgow, Professor Martin J Scanlon

  26. Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

    Article • Journal of Biological Chemistry, April 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Christopher Porter, Professor Martin J Scanlon

  27. Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX

    Article • Journal of Molecular Recognition, February 2015, Wiley

    Professor Martin J Scanlon

  28. Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold

    Article • Journal of Medicinal Chemistry, February 2015, American Chemical Society (ACS)

    Dr Shane M Devine, Professor Martin J Scanlon

  29. Small Molecule Inhibitors of Disulfide Bond Formation by the Bacterial DsbA–DsbB Dual Enzyme System

    Article • ACS Chemical Biology, January 2015, American Chemical Society (ACS)

    Professor Martin J Scanlon

  30. Targeting virulence not viability in the search for future antibacterials

    Article • British Journal of Clinical Pharmacology, January 2015, Wiley

    Professor Martin J Scanlon

  31. Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic Peptides

    Article • Australian Journal of Chemistry, January 2015, CSIRO Publishing

    Professor Martin J Scanlon

  32. Application of Fragment-Based Screening to the Design of Inhibitors ofEscherichia coliDsbA

    Article • Angewandte Chemie International Edition, December 2014, Wiley

    Professor Martin J Scanlon

  33. Structure and Dynamics of Apical Membrane Antigen 1 from Plasmodium falciparum FVO

    Article • Biochemistry, November 2014, American Chemical Society (ACS)

    Professor Martin J Scanlon

  34. Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide

    Article • PLoS ONE, October 2014, PLOS

    Professor Martin J Scanlon

  35. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

    Article • Proceedings of the National Academy of Sciences, October 2014, Proceedings of the National Academy of Sciences

    Professor Martin J Scanlon

  36. The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin

    Article • PLoS ONE, September 2014, PLOS

    Professor Martin J Scanlon

  37. Characterization of Two Distinct Modes of Drug Binding to Human Intestinal Fatty Acid Binding Protein

    Article • ACS Chemical Biology, September 2014, American Chemical Society (ACS)

    Christopher Porter, Professor Martin J Scanlon

  38. Ligand-Induced Conformational Change of Plasmodium falciparum AMA1 Detected Using 19F NMR

    Article • Journal of Medicinal Chemistry, August 2014, American Chemical Society (ACS)

    Dr Shane M Devine, Professor Martin J Scanlon

  39. 19F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2

    Article • Chemical Biology & Drug Design, June 2014, Wiley

    Professor Martin J Scanlon

  40. Structure of the Chicken CD3ϵδ/γ Heterodimer and Its Assembly with the αβT Cell Receptor

    Article • Journal of Biological Chemistry, January 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Martin J Scanlon

  41. A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Dr Shane M Devine, Professor Martin J Scanlon

  42. Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

    Article • PLoS ONE, November 2013, PLOS

    Professor Martin J Scanlon

  43. The Structure of Integrin α1I Domain in Complex with a Collagen-mimetic Peptide

    Article • Journal of Biological Chemistry, November 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Martin J Scanlon

  44. Distinct binding properties of TIAR RRMs and linker region

    Article • RNA Biology, April 2013, Taylor & Francis

    Professor Martin J Scanlon

  45. Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?

    Article • SLAS DISCOVERY, February 2013, Elsevier

    Dr Thomas S Peat, Professor Martin J Scanlon

  46. Assignments of human integrin α1I domain in the apo and Mg2+ bound states

    Article • Biomolecular NMR Assignments, January 2013, Springer Science + Business Media

    Professor Martin J Scanlon

  47. Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening

    Article • Australian Journal of Chemistry, January 2013, CSIRO Publishing

    Dr Shane M Devine, Professor Martin J Scanlon

  48. Blind Man’s Bluff – Elaboration of Fragment Hits in the Absence of Structure for the Development of Antitrypsin Deficiency Inhibitors

    Article • Australian Journal of Chemistry, January 2013, CSIRO Publishing

    Professor Martin J Scanlon

  49. Design and Evaluation of the Performance of an NMR Screening Fragment Library

    Article • Australian Journal of Chemistry, January 2013, CSIRO Publishing

    Professor Martin J Scanlon

  50. Detection and Prevention of Aggregation-based False Positives in STD-NMR-based Fragment Screening

    Article • Australian Journal of Chemistry, January 2013, CSIRO Publishing

    Professor Martin J Scanlon

  51. Interrogating Fragments Using a Protein Thermal Shift Assay

    Article • Australian Journal of Chemistry, January 2013, CSIRO Publishing

    Professor Martin J Scanlon

  52. The 1.2 Å resolution crystal structure of TcpG, theVibrio choleraeDsbA disulfide-forming protein required for pilus and cholera-toxin production

    Article • Acta Crystallographica Section D Biological Crystallography, September 2012, International Union of Crystallography

    Professor Martin J Scanlon

  53. Colloidal characteristics and formulation of pure protein particulate vaccines

    Article • Journal of Pharmacy and Pharmacology, May 2012, Wiley

    Professor Martin J Scanlon

  54. Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?

    Article • Pharmaceutical Research, April 2011, Springer Science + Business Media

    Christopher Porter, Professor Martin J Scanlon

  55. Characterization of the N-Methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase

    Article • Chemistry & Biology, April 2011, Elsevier

    Professor Martin J Scanlon

  56. Corrigendum: Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1

    Article • ChemMedChem, March 2011, Wiley

    Professor Martin J Scanlon

  57. Synthesis of Unsymmetrical 1,1′-Disubstituted Bis(1,2,3-triazole)s Using Monosilylbutadiynes

    Article • Organic Letters, February 2011, American Chemical Society (ACS)

    Professor Martin J Scanlon

  58. Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, January 2011, International Union of Crystallography

    Christopher Porter, Professor Martin J Scanlon

  59. Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1

    Article • ChemMedChem, December 2010, Wiley

    Professor Martin J Scanlon

  60. Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation

    Article • Proceedings of the National Academy of Sciences, May 2010, Proceedings of the National Academy of Sciences

    Professor Martin J Scanlon

  61. Characterization of the DsbA Oxidative Folding Catalyst fromPseudomonas aeruginosaReveals a Highly Oxidizing Protein that Binds Small Molecules

    Article • Antioxidants & Redox Signaling, April 2010, Mary Ann Liebert Inc

    Professor Martin J Scanlon

  62. Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site

    Article • FEBS Letters, March 2010, Wiley

    Professor Martin J Scanlon

  63. Structure and Function of the Oxidoreductase DsbA1 from Neisseria meningitidis

    Article • Journal of Molecular Biology, December 2009, Elsevier

    Dr Travis Beddoe, Professor Martin J Scanlon

  64. Backbone and side chain 1H, 15N and 13C assignments for the oxidised and reduced forms of the oxidoreductase protein DsbA from Staphylococcus aureus

    Article • Biomolecular NMR Assignments, November 2009, Springer Science + Business Media

    Professor Martin J Scanlon

  65. Probing the Fibrate Binding Specificity of Rat Liver Fatty Acid Binding Protein

    Article • Journal of Medicinal Chemistry, September 2009, American Chemical Society (ACS)

    Christopher Porter, Professor Martin J Scanlon

  66. The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes

    Article • Journal of Biological Chemistry, April 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Martin J Scanlon

  67. Molecular Dynamics of Poly(l-lysine) Dendrimers with Naphthalene Disulfonate Caps

    Article • Macromolecules, April 2009, American Chemical Society (ACS)

    Professor Martin J Scanlon

  68. Molecular Dynamics of Variegated Polyamide Dendrimers

    Article • Macromolecules, April 2009, American Chemical Society (ACS)

    Professor Martin J Scanlon

  69. Backbone and sidechain 1H, 13C and 15N resonance assignments of the human brain-type fatty acid binding protein (FABP7) in its apo form and the holo forms binding to DHA, oleic acid, linoleic acid and elaidic acid

    Article • Biomolecular NMR Assignments, March 2009, Springer Science + Business Media

    Professor Martin J Scanlon

  70. DSB proteins and bacterial pathogenicity

    Article • Nature Reviews Microbiology, February 2009, Springer Science + Business Media

    Professor Mark A Schembri, Professor Martin J Scanlon

  71. Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein

    Article • Molecular and Cellular Biochemistry, January 2009, Springer Science + Business Media

    Christopher Porter, Professor Martin J Scanlon

  72. The Structural Impact of a Polyglutamine Tract Is Location-Dependent

    Article • Biophysical Journal, December 2008, Elsevier

    Professor Martin J Scanlon

  73. Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 fromNeisseria meningitidis

    Article • Journal of Biological Chemistry, August 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Martin J Scanlon

  74. Characterization of the Drug Binding Specificity of Rat Liver Fatty Acid Binding Protein

    Article • Journal of Medicinal Chemistry, July 2008, American Chemical Society (ACS)

    Christopher Porter, Professor Martin J Scanlon

  75. Multidimensional Nuclear Magnetic Resonance of Biomolecules

    Article • June 2008, Wiley

    Professor Martin J Scanlon

  76. Backbone assignments of the 34 kDa ketopantoate reductase from E. coli

    Article • Biomolecular NMR Assignments, April 2008, Springer Science + Business Media

    Professor Martin J Scanlon

  77. The Dotted Cap Notation: A concise notation for describing variegated dendrimers

    Article • New Journal of Chemistry, January 2008, Royal Society of Chemistry

    Professor Martin J Scanlon

  78. Probing the Flexibility of the DsbA Oxidoreductase from Vibrio cholerae—a 15N - 1H Heteronuclear NMR Relaxation Analysis of Oxidized and Reduced Forms of DsbA

    Article • Journal of Molecular Biology, August 2007, Elsevier

    Associate Professor Paul R Gooley, Professor Martin J Scanlon

  79. Backbone and side chain 1H, 15N and 13C assignments for the reduced form of the oxidoreductase protein DsbA from Vibrio cholerae

    Article • Biomolecular NMR Assignments, June 2007, Springer Science + Business Media

    Professor Martin J Scanlon

  80. Examination of the Role of Intestinal Fatty Acid-Binding Protein in Drug Absorption Using a Parallel Artificial Membrane Permeability Assay

    Article • Chemistry & Biology, April 2007, Elsevier

    Christopher Porter, Professor Martin J Scanlon

  81. The Cysteine-rich Secretory Protein Domain of Tpx-1 Is Related to Ion Channel Toxins and Regulates Ryanodine Receptor Ca2+ Signaling

    Article • Journal of Biological Chemistry, January 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Martin J Scanlon

  82. The binding interaction of synthetic ozonide antimalarials with natural and modified β-cyclodextrins

    Article • Journal of Pharmaceutical Sciences, January 2006, Elsevier

    Professor Martin J Scanlon

  83. An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli

    Article • Protein Expression and Purification, November 2005, Elsevier

    Christopher Porter, Professor Martin J Scanlon

  84. A Three-dimensional Model of the Human Immunodeficiency Virus Type 1 Integration Complex

    Article • Journal of Computer-Aided Molecular Design, May 2005, Springer Science + Business Media

    Professor Martin J Scanlon

  85. The Interaction of Lipophilic Drugs with Intestinal Fatty Acid-binding Protein

    Article • Journal of Biological Chemistry, February 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Christopher Porter, Professor Martin J Scanlon

  86. Isolation, Solution Structure, and Insecticidal Activity of Kalata B2, a Circular Protein with a Twist:  Do Möbius Strips Exist in Nature?†,‡

    Article • Biochemistry, January 2005, American Chemical Society (ACS)

    Professor Martin J Scanlon

  87. Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

    Article • Biochemical and Biophysical Research Communications, September 2004, Elsevier

    Professor Martin J Scanlon

  88. Difficult Macrocyclizations:  New Strategies for Synthesizing Highly Strained Cyclic Tetrapeptides

    Article • Organic Letters, July 2003, American Chemical Society (ACS)

    Professor Martin J Scanlon

  89. The Three-dimensional Solution Structure of NaD1, a New Floral Defensin from Nicotiana alata and its Application to a Homology Model of the Crop Defense Protein alfAFP

    Article • Journal of Molecular Biology, January 2003, Elsevier

    Dr Fung T Lay, Professor Martin J Scanlon

  90. Article • Pharmaceutical Research, January 2003, Springer Science + Business Media

    Professor Martin J Scanlon

  91. Conformationally Constrained Macrocycles That Mimic Tripeptide β-Strands in Water and Aprotic Solvents

    Article • Journal of the American Chemical Society, May 2002, American Chemical Society (ACS)

    Professor Martin J Scanlon

  92. Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology

    Article • Immunology and Cell Biology, April 2002, Wiley

    Professor Martin J Scanlon

  93. Solution Structure of BSTI:  A New Trypsin Inhibitor from Skin Secretions ofBombina bombina†,‡

    Article • Biochemistry, April 2001, American Chemical Society (ACS)

    Professor Martin J Scanlon

  94. The solution structure of C1-T1, a two-domain proteinase inhibitor derived from a circular precursor protein from Nicotiana alata11Edited by P. E. Wright

    Article • Journal of Molecular Biology, February 2001, Elsevier

    Professor Martin J Scanlon

  95. Conformational Selection of Inhibitors and Substrates by Proteolytic Enzymes:  Implications for Drug Design and Polypeptide Processing

    Article • Journal of Medicinal Chemistry, April 2000, American Chemical Society (ACS)

    Professor Martin J Scanlon

  96. Pharmaceutical applications of NMR

    Article • January 2000, Elsevier

    Professor Martin J Scanlon

  97. A Marine Snail Neurotoxin Shares with Scorpion Toxins a Convergent Mechanism of Blockade on the Pore of Voltage-Gated K Channels

    Article • The Journal of General Physiology, July 1999, Rockefeller University Press

    Professor Martin J Scanlon

  98. Structure of a putative ancestral protein encoded by a single sequence repeat from a multidomain proteinase inhibitor gene fromNicotiana alata

    Article • Structure, July 1999, Elsevier

    Professor Martin J Scanlon

  99. Article • Nature Structural Biology, June 1999, Springer Science + Business Media

    Professor Martin J Scanlon

  100. A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization:  Synthesis of Stylostatin 1†,§

    Article • The Journal of Organic Chemistry, April 1999, American Chemical Society (ACS)

    Professor Martin J Scanlon

  101. Cyclooligomerization of Thiazole-Containing Tetrapeptides. Symmetrical Macrocycles with up to 76 Amino Acids

    Article • Journal of the American Chemical Society, March 1999, American Chemical Society (ACS)

    Professor Martin J Scanlon

  102. THREE-DIMENSIONAL STRUCTURE OF A CYSTEINE-RICH REPEAT FROM THE LOW-DENSITY LIPOPROTEIN RECEPTOR

    Article • March 1996, Protein Data Bank, Rutgers University

    Professor Martin J Scanlon

  103. Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A

    Article • Structure, August 1995, Elsevier

    Professor Martin J Scanlon

  104. A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 1995, Elsevier

    Professor Martin J Scanlon

  105. Primary sequence determination and molecular modelling of the variable region of an antiMUC1 mucin monoclonal antibody

    Article • European Journal of Cancer, January 1995, Elsevier

    Professor Martin J Scanlon

  106. Peptide epitope binding and fluorescence quenching with the anti-mucin antibody C595

    Article • Cancer Letters, April 1992, Elsevier

    Professor Martin J Scanlon