All Stories

  1. Fatty Acid–Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells
  2. Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction
  3. Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme inNeisseria meningitidis
  4. Assembly of Fragment Screening Libraries
  5. HN, N, Cα and Cβ assignments of the two periplasmic domains of Neisseria meningitidis DsbD
  6. Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
  7. Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1
  8. Molecular Insights into the Interaction Between the SPRY Domain-Containing SOCS Box Protein SPSB2 and Peptides Based on the Binding Motif from iNOS
  9. Applications of NMR Spectroscopy in FBDD
  10. Fatty Acid-Binding Protein 5 at the Blood–Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function
  11. The ways and means of fragment-based drug design
  12. Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data
  13. Structure–Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1–RON2 Interaction
  14. Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents
  15. Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein–Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2...
  16. Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 Is Mediated by the Minor Pilin CfaE
  17. Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin
  18. Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction
  19. Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials
  20. Fatty Acid-Binding Protein 5 Facilitates the Blood–Brain Barrier Transport of Docosahexaenoic Acid
  21. Sent packing: protein engineering generates a new crystal form ofPseudomonas aeruginosaDsbA1 with increased catalytic surface accessibility
  22. Inhibitors of BCATm: A Tough Nut To Crack
  23. Determinants of Proteolysis and Cell-Binding for the Shigella flexneri Cytotoxin, SigA
  24. Fatty Acid Binding Proteins Expressed at the Human Blood–Brain Barrier Bind Drugs in an Isoform-Specific Manner
  25. Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module
  26. Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner
  27. Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX
  28. Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold
  29. Small Molecule Inhibitors of Disulfide Bond Formation by the Bacterial DsbA–DsbB Dual Enzyme System
  30. Targeting virulence not viability in the search for future antibacterials
  31. Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic Peptides
  32. Application of Fragment-Based Screening to the Design of Inhibitors ofEscherichia coliDsbA
  33. Structure and Dynamics of Apical Membrane Antigen 1 from Plasmodium falciparum FVO
  34. Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide
  35. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
  36. The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin
  37. Characterization of Two Distinct Modes of Drug Binding to Human Intestinal Fatty Acid Binding Protein
  38. Ligand-Induced Conformational Change of Plasmodium falciparum AMA1 Detected Using 19F NMR
  39. 19F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2
  40. Structure of the Chicken CD3ϵδ/γ Heterodimer and Its Assembly with the αβT Cell Receptor
  41. A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors
  42. Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes
  43. The Structure of Integrin α1I Domain in Complex with a Collagen-mimetic Peptide
  44. Distinct binding properties of TIAR RRMs and linker region
  45. Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
  46. Assignments of human integrin α1I domain in the apo and Mg2+ bound states
  47. Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening
  48. Blind Man’s Bluff – Elaboration of Fragment Hits in the Absence of Structure for the Development of Antitrypsin Deficiency Inhibitors
  49. Design and Evaluation of the Performance of an NMR Screening Fragment Library
  50. Detection and Prevention of Aggregation-based False Positives in STD-NMR-based Fragment Screening
  51. Interrogating Fragments Using a Protein Thermal Shift Assay
  52. The 1.2 Å resolution crystal structure of TcpG, theVibrio choleraeDsbA disulfide-forming protein required for pilus and cholera-toxin production
  53. Colloidal characteristics and formulation of pure protein particulate vaccines
  54. Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?
  55. Characterization of the N-Methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase
  56. Corrigendum: Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1
  57. Synthesis of Unsymmetrical 1,1′-Disubstituted Bis(1,2,3-triazole)s Using Monosilylbutadiynes
  58. Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid
  59. Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1
  60. Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation
  61. Characterization of the DsbA Oxidative Folding Catalyst fromPseudomonas aeruginosaReveals a Highly Oxidizing Protein that Binds Small Molecules
  62. Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site
  63. Structure and Function of the Oxidoreductase DsbA1 from Neisseria meningitidis
  64. Backbone and side chain 1H, 15N and 13C assignments for the oxidised and reduced forms of the oxidoreductase protein DsbA from Staphylococcus aureus
  65. Probing the Fibrate Binding Specificity of Rat Liver Fatty Acid Binding Protein
  66. The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes
  67. Molecular Dynamics of Poly(l-lysine) Dendrimers with Naphthalene Disulfonate Caps
  68. Molecular Dynamics of Variegated Polyamide Dendrimers
  69. Backbone and sidechain 1H, 13C and 15N resonance assignments of the human brain-type fatty acid binding protein (FABP7) in its apo form and the holo forms binding to DHA, oleic acid, linoleic acid and elaidic acid
  70. DSB proteins and bacterial pathogenicity
  71. Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein
  72. The Structural Impact of a Polyglutamine Tract Is Location-Dependent
  73. Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 fromNeisseria meningitidis
  74. Characterization of the Drug Binding Specificity of Rat Liver Fatty Acid Binding Protein
  75. Multidimensional Nuclear Magnetic Resonance of Biomolecules
  76. Backbone assignments of the 34 kDa ketopantoate reductase from E. coli
  77. The Dotted Cap Notation: A concise notation for describing variegated dendrimers
  78. Probing the Flexibility of the DsbA Oxidoreductase from Vibrio cholerae—a 15N - 1H Heteronuclear NMR Relaxation Analysis of Oxidized and Reduced Forms of DsbA
  79. Backbone and side chain 1H, 15N and 13C assignments for the reduced form of the oxidoreductase protein DsbA from Vibrio cholerae
  80. Examination of the Role of Intestinal Fatty Acid-Binding Protein in Drug Absorption Using a Parallel Artificial Membrane Permeability Assay
  81. The Cysteine-rich Secretory Protein Domain of Tpx-1 Is Related to Ion Channel Toxins and Regulates Ryanodine Receptor Ca2+ Signaling
  82. The binding interaction of synthetic ozonide antimalarials with natural and modified β-cyclodextrins
  83. An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli
  84. A Three-dimensional Model of the Human Immunodeficiency Virus Type 1 Integration Complex
  85. The Interaction of Lipophilic Drugs with Intestinal Fatty Acid-binding Protein
  86. Isolation, Solution Structure, and Insecticidal Activity of Kalata B2, a Circular Protein with a Twist:  Do Möbius Strips Exist in Nature?†,‡
  87. Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3
  88. Difficult Macrocyclizations:  New Strategies for Synthesizing Highly Strained Cyclic Tetrapeptides
  89. The Three-dimensional Solution Structure of NaD1, a New Floral Defensin from Nicotiana alata and its Application to a Homology Model of the Crop Defense Protein alfAFP
  90. Conformationally Constrained Macrocycles That Mimic Tripeptide β-Strands in Water and Aprotic Solvents
  91. Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology
  92. Solution Structure of BSTI:  A New Trypsin Inhibitor from Skin Secretions ofBombina bombina†,‡
  93. The solution structure of C1-T1, a two-domain proteinase inhibitor derived from a circular precursor protein from Nicotiana alata11Edited by P. E. Wright
  94. Conformational Selection of Inhibitors and Substrates by Proteolytic Enzymes:  Implications for Drug Design and Polypeptide Processing
  95. Pharmaceutical applications of NMR
  96. A Marine Snail Neurotoxin Shares with Scorpion Toxins a Convergent Mechanism of Blockade on the Pore of Voltage-Gated K Channels
  97. Structure of a putative ancestral protein encoded by a single sequence repeat from a multidomain proteinase inhibitor gene fromNicotiana alata
  98. A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization:  Synthesis of Stylostatin 1†,§
  99. Cyclooligomerization of Thiazole-Containing Tetrapeptides. Symmetrical Macrocycles with up to 76 Amino Acids
  101. Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A
  102. A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions
  103. Primary sequence determination and molecular modelling of the variable region of an antiMUC1 mucin monoclonal antibody
  104. Peptide epitope binding and fluorescence quenching with the anti-mucin antibody C595