All Stories

  1. The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition

    Article • Structure, February 2025, Elsevier

    Dr Maria Pellegrini

  2. The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Dr Maria Pellegrini

  3. An engineered construct of cFLIP provides insight into DED1 structure and interactions

    Article • Structure, November 2021, Elsevier

    Dr Maria Pellegrini

  4. A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Dr Maria Pellegrini

  5. A guide to prepare and crystallize the N-terminal domain of NEMO

    Article • Journal of Visualized Experiments, December 2019, MyJove Corporation

    Dr Maria Pellegrini

  6. The structure of a highly conserved picocyanobacterial protein reveals a Tudor domain with an RNA binding function

    Article • Journal of Biological Chemistry, August 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  7. The structure of the unbound IKK-binding domain of NEMO

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Dr Maria Pellegrini

  8. A pseudo-receiver domain in Atg32 is required for mitophagy

    Article • Autophagy, August 2018, Taylor & Francis

    Dr Maria Pellegrini, Katherine Bauer

  9. Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

    Article • Bioscience Reports, February 2018, Portland Press Ltd.

    Dr Maria Pellegrini

  10. Backbone and side chain resonance assignments for a structured domain within Atg32

    Article • Biomolecular NMR Assignments, August 2017, Springer Science + Business Media

    Dr Maria Pellegrini

  11. A small molecule ligand for AphB increases activity

    Article • Biochemistry, July 2017, American Chemical Society (ACS)

    Dr Maria Pellegrini

  12. The Peach RGF/GLV Signalling Peptide pCTG134 Is Involved In A Regulatory Circuit That Sustains Auxin And Ethylene Actions

    Article • May 2017, Cold Spring Harbor Laboratory Press

    Dr Maria Pellegrini

  13. Cholera toxins ToxR and ToxS interact and are affected by bile salts and pH.

    Article • Molecular Microbiology, May 2017, Wiley

    Dr Maria Pellegrini

  14. A new class of inhibitors of the AraC family virulence regulator Vibrio cholerae ToxT

    Article • Scientific Reports, March 2017, Nature

    Dr Maria Pellegrini

  15. Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin

    Article • PLOS One, November 2015, PLOS

    Dr Maria Pellegrini

  16. A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death

    Article • Scientific Reports, May 2015, Springer Science + Business Media

    Dr Maria Pellegrini

  17. Small-molecule inhibitors of JC polyomavirus infection

    Article • Journal of Peptide Science, December 2014, Wiley

    Dr Maria Pellegrini

  18. Phosphorylation of Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) by Akt Promotes Stability and Mitogenic Function of S-phase Kinase-associated Protein-2 (Skp2)

    Article • Journal of Biological Chemistry, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  19. Protein Engineering of the N-Terminus of NEMO: Structure Stabilization and Rescue of IKKβ Binding

    Article • Biochemistry, November 2014, American Chemical Society (ACS)

    Dr Maria Pellegrini

  20. Small Molecule Inhibition of the Na+/H+ Exchange Regulatory Factor 1 and Parathyroid Hormone 1 Receptor Interaction

    Article • Biochemistry, September 2014, American Chemical Society (ACS)

    Dr Maria Pellegrini

  21. Monitoring ATP hydrolysis and ATPase inhibitor screening using1H NMR

    Article • Chemical Communications, August 2014, Royal Society of Chemistry

    Dr Maria Pellegrini

  22. Engineering a soluble parathyroid hormone GPCR mimetic

    Article • Proteins Structure Function and Bioinformatics, January 2014, Wiley

    Dr Maria Pellegrini

  23. Recombinant production of TEV cleaved human parathyroid hormone

    Article • Journal of Peptide Science, June 2013, Wiley

    Dr Maria Pellegrini

  24. Structure of the extracellular domains of human andXenopusFn14: implications in the evolution of TWEAK and Fn14 interactions

    Article • FEBS Journal, March 2013, Wiley

    Dr Maria Pellegrini

  25. Reining in Polyoma Virus Associated Nephropathy: Design and Characterization of a Template Mimicking BK Viral Coat Protein Cellular Binding

    Article • Biochemistry, October 2012, American Chemical Society (ACS)

    Dr Maria Pellegrini

  26. A Stabilizing Influence: CAL PDZ Inhibition Extends the Half-Life of ΔF508-CFTR

    Article • Angewandte Chemie, November 2010, Wiley

    Dr Maria Pellegrini

  27. A Stabilizing Influence: CAL PDZ Inhibition Extends the Half-Life of ΔF508-CFTR

    Article • Angewandte Chemie, November 2010, Wiley

    Dr Maria Pellegrini

  28. ChemInform Abstract: Parathyroid Hormone and Parathyroid Hormone-Related Protein: Model Systems for the Development of an Osteoporosis Therapy

    Article • ChemInform, June 2010, Wiley

    Dr Maria Pellegrini

  29. Pharmacological stabilization of ΔF508-CFTR at the cell surface: design of CAL-selective PDZ inhibitors

    Article • Journal of Cystic Fibrosis, June 2010, Elsevier

    Dr Maria Pellegrini

  30. Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes

    Article • Proceedings of the National Academy of Sciences, February 2010, Proceedings of the National Academy of Sciences

    Dr Maria Pellegrini

  31. Structural analysis of the human cannabinoid receptor one carboxyl‐terminus identifies two amphipathic helices

    Article • Biopolymers, March 2009, Wiley

    Dr Maria Pellegrini

  32. Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

    Article • Structure, May 2008, Elsevier

    Dr Maria Pellegrini

  33. Structural characterization of the parathyroid hormone receptor domains determinant for ligand binding

    Article • Biochemical Society Transactions, August 2007, Portland Press Ltd.

    Dr Maria Pellegrini

  34. N-Terminally PEGylated Human Interferon-β-1a with Improved Pharmacokinetic Properties and in Vivo Efficacy in a Melanoma Angiogenesis Model

    Article • Bioconjugate Chemistry, December 2005, American Chemical Society (ACS)

    Dr Maria Pellegrini

  35. The Δe13 Isoform of the Calcitonin Receptor Forms a Six-Transmembrane Domain Receptor with Dominant-Negative Effects on Receptor Surface Expression and Signaling

    Article • Molecular Endocrinology, August 2005, Endocrine Society

    Dr Maria Pellegrini

  36. A 13C NMR approach to categorizing potential limitations of α,β-unsaturated carbonyl systems in drug-like molecules

    Article • Bioorganic & Medicinal Chemistry Letters, November 2004, Elsevier

    Dr Maria Pellegrini

  37. Receptor–Ligand Interactions

    Article • January 2004, Elsevier

    Dr Maria Pellegrini

  38. Toward Parathyroid Hormone Minimization:  Conformational Studies of Cyclic PTH(1−14) Analogues

    Article • Biochemistry, December 2003, American Chemical Society (ACS)

    Dr Maria Pellegrini

  39. NMR studies of CCK-8/CCK1complex support membrane-associated pathway for ligand-receptor interaction

    Article • Canadian Journal of Physiology and Pharmacology, May 2002, Canadian Science Publishing

    Dr Maria Pellegrini

  40. The PDZ1 Domain of SAP90: CHARACTERIZATION OF STRUCTURE AND BINDING

    Article • Journal of Biological Chemistry, December 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  41. Structural characterization of lipopeptide agonists for the bradykinin B2 receptor

    Article • Biopolymers, April 2001, Wiley

    Dr Maria Pellegrini

  42. Molecular Characterization of the Substance P{middle dot}Neurokinin-1 Receptor Complex: DEVELOPMENT OF AN EXPERIMENTALLY BASED MODEL

    Article • Journal of Biological Chemistry, April 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  43. Photoaffinity Labeling of Mutant Neurokinin-1 Receptors Reveals Additional Structural Features of the Substance P/NK-1 Receptor Complex

    Article • Biochemistry, February 2001, American Chemical Society (ACS)

    Dr Maria Pellegrini

  44. Structural characterization of lipopeptide agonists for the bradykinin B2 receptor

    Article • Biopolymers, January 2001, Wiley

    Dr Maria Pellegrini

  45. CtrΔe13, a Calcitonin Receptor Isoform Lacking 14 Amino Acids in Transmembrane Helix 7: Structure and Topology

    Article • January 2001, Springer Science + Business Media

    Dr Maria Pellegrini

  46. Characterizing the Interactions Between Cholecystokinin and the G-Protein Coupled Receptors CCK1 and CCK2: An NMR-Based Study

    Article • January 2001, Springer Science + Business Media

    Dr Maria Pellegrini

  47. Probing the Importance of the N-Terminal Helix of Parathyroid Hormone: Introduction of Cyclohexylalanine to Tether to the Membrane

    Article • January 2001, Springer Science + Business Media

    Dr Maria Pellegrini

  48. Agonist Activity at the Kinin B1 Receptor:  Structural Requirements of the Central Tetrapeptide

    Article • Journal of Medicinal Chemistry, December 2000, American Chemical Society (ACS)

    Dr Maria Pellegrini

  49. Structure-Based Optimization of Peptide Inhibitors of Mammalian Ribonucleotide Reductase,

    Article • Biochemistry, September 2000, American Chemical Society (ACS)

    Dr Maria Pellegrini

  50. Molecular Complex of Cholecystokinin-8 and N-Terminus of the Cholecystokinin A Receptor by NMR Spectroscopy

    Article • Biochemistry, October 1999, American Chemical Society (ACS)

    Dr Maria Pellegrini

  51. Expression and Spectroscopic Analysis of Soluble Nicotinic Acetylcholine Receptor Fragments Derived from the Extracellular Domain of the α-Subunit †

    Article • Biochemistry, August 1999, American Chemical Society (ACS)

    Dr Maria Pellegrini

  52. Probing the Topological Arrangement of the N- and C-Terminal Residues of Bradykinin for Agonist Activity at the B1 Receptor

    Article • Journal of Medicinal Chemistry, July 1999, American Chemical Society (ACS)

    Dr Maria Pellegrini

  53. Molecular Characterization of the Receptor−Ligand Complex for Parathyroid Hormone

    Article • Biochemistry, April 1999, American Chemical Society (ACS)

    Dr Maria Pellegrini

  54. Structural characterization of peptide hormone/receptor interactions by NMR spectroscopy

    Article • Biopolymers, January 1999, Wiley

    Dr Maria Pellegrini

  55. Structural characterization of peptide hormone/receptor interactions by NMR spectroscopy

    Article • Biopolymers, January 1999, Wiley

    Dr Maria Pellegrini

  56. Motif Mutation of Bradykinin B2 Receptor Second Intracellular Loop and Proximal C Terminus Is Critical for Signal Transduction, Internalization, and Resensitization

    Article • Journal of Biological Chemistry, December 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  57. Parathyroid Hormone-Receptor Interactions Identified Directly by Photocross-linking and Molecular Modeling Studies

    Article • Journal of Biological Chemistry, August 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  58. Binding Domain of Human Parathyroid Hormone Receptor:  From Conformation to Function,

    Article • Biochemistry, August 1998, American Chemical Society (ACS)

    Dr Maria Pellegrini

  59. 1,2,5-Trisubstituted 1,4-diazepine-3-one: A novel dipeptidomimetic molecular scaffold

    Article • May 1998, Springer Science + Business Media

    Dr Maria Pellegrini

  60. Conformational investigation of a novel dipeptide based molecular scaffold

    Article • May 1998, Springer Science + Business Media

    Dr Maria Pellegrini

  61. Addressing the Tertiary Structure of Human Parathyroid Hormone-(1-34)

    Article • Journal of Biological Chemistry, April 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  62. Article • International Journal of Peptide Research and Therapeutics, January 1998, Springer Science + Business Media

    Dr Maria Pellegrini

  63. Structure, dynamics, and topological orientation of the polyether, ionophore antibiotic monensin, in a micellar environment

    Article • Biopolymers, December 1997, Wiley

    Dr Maria Pellegrini

  64. Structure, dynamics, and topological orientation of the polyether, ionophore antibiotic monensin, in a micellar environment

    Article • Biopolymers, December 1997, Wiley

    Dr Maria Pellegrini

  65. Conformational Studies of RS-66271, an Analog of Parathyroid Hormone-Related Protein with Pronounced Bone Anabolic Activity

    Article • Journal of Medicinal Chemistry, September 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  66. Conformational consequences of i, i + 3 cystine linkages: nucleation for α‐helicity?

    Article • Journal of Peptide Research, May 1997, Wiley

    Dr Maria Pellegrini

  67. Synthesis of a Trisubstituted 1,4-Diazepin-3-one-Based Dipeptidomimetic as a Novel Molecular Scaffold

    Article • The Journal of Organic Chemistry, April 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  68. A Trisubstituted 1,4-Diazepine-3-one-Based Dipeptidomimetic:  Conformational Characterization by NMR and Computer Simulation

    Article • Journal of the American Chemical Society, March 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  69. Threonine6-Bradykinin:  Molecular Dynamics Simulations in a Biphasic Membrane Mimetic

    Article • Journal of Medicinal Chemistry, January 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  70. Threonine6-Bradykinin:  Structural Characterization in the Presence of Micelles by Nuclear Magnetic Resonance and Distance Geometry

    Article • Journal of Medicinal Chemistry, January 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  71. Threonine6-bradykinin: Conformational study of a flexible peptide in dimethyl sulfoxide by NMR and ensemble calculations

    Article • Biopolymers, January 1996, Wiley

    Dr Maria Pellegrini

  72. Peptide Mimetic of the Third Cytoplasmic Loop of the PTH/PTHrP Receptor

    Article • Journal of the American Chemical Society, January 1996, American Chemical Society (ACS)

    Dr Maria Pellegrini

  73. Threonine6‐bradykinin: Conformational study of a flexible peptide in dimethyl sulfoxide by NMR and ensemble calculations

    Article • Biopolymers, January 1996, Wiley

    Dr Maria Pellegrini

  74. Conformational characterization of a peptide mimetic of the third cytoplasmic loop of the G-protein coupled parathyroid hormone/parathyroid hormone related protein receptor

    Article • Biopolymers, January 1996, Wiley

    Dr Maria Pellegrini

  75. Conformation of cyclobradykinin by nmr and distance geometry calculations

    Article • Biopolymers, October 1995, Wiley

    Dr Maria Pellegrini

  76. Conformation of parathyroid hormone antagonists by CD, nmr, and molecular dynamics simulations

    Article • Biopolymers, October 1995, Wiley

    Dr Maria Pellegrini

  77. RS-66271, a clinical candidate derived from parathyroid hormone related protein: The role of enhanced amphiphilic helicity

    Article • Springer Science + Business Media

    Dr Maria Pellegrini

  78. Molecular characterization of the interaction between parathyroid hormone and its receptor

    Article • Springer Science + Business Media

    Dr Maria Pellegrini

  79. Lactam cyclization [i to (i+4)] for nucleation/stabilization of α-helices?

    Article • Springer Science + Business Media

    Dr Maria Pellegrini

  80. Identification and exploitation of structural foci that influence conformational mobility in somatostatin agonists and antagonists

    Article • Springer Science + Business Media

    Dr Maria Pellegrini

  81. Secondary and tertiary fold of the human parathyroid hormone1–34 in different environments as a pathway to bioactive conformation

    Article • Springer Science + Business Media

    Dr Maria Pellegrini