All Stories

  1. An engineered construct of cFLIP provides insight into DED1 structure and interactions

    Article • Structure, November 2021, Elsevier

    Dr Maria Pellegrini

  2. A guide to prepare and crystallize the N-terminal domain of NEMO

    Article • Journal of Visualized Experiments, December 2019, MyJove Corporation

    Dr Maria Pellegrini

  3. The structure of a highly conserved picocyanobacterial protein reveals a Tudor domain with an RNA binding function

    Article • Journal of Biological Chemistry, August 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  4. The structure of the unbound IKK-binding domain of NEMO

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Dr Maria Pellegrini

  5. A pseudo-receiver domain in Atg32 is required for mitophagy

    Article • Autophagy, August 2018, Taylor & Francis

    Dr Maria Pellegrini, Katherine Bauer

  6. Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

    Article • Bioscience Reports, February 2018, Portland Press Ltd.

    Dr Maria Pellegrini

  7. Backbone and side chain resonance assignments for a structured domain within Atg32

    Article • Biomolecular NMR Assignments, August 2017, Springer Science + Business Media

    Dr Maria Pellegrini

  8. A small molecule ligand for AphB increases activity

    Article • Biochemistry, July 2017, American Chemical Society (ACS)

    Dr Maria Pellegrini

  9. The Peach RGF/GLV Signalling Peptide pCTG134 Is Involved In A Regulatory Circuit That Sustains Auxin And Ethylene Actions

    Article • May 2017, Cold Spring Harbor Laboratory Press

    Dr Maria Pellegrini

  10. Cholera toxins ToxR and ToxS interact and are affected by bile salts and pH.

    Article • Molecular Microbiology, May 2017, Wiley

    Dr Maria Pellegrini

  11. A new class of inhibitors of the AraC family virulence regulator Vibrio cholerae ToxT

    Article • Scientific Reports, March 2017, Nature

    Dr Maria Pellegrini

  12. Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin

    Article • PLoS ONE, November 2015, PLOS

    Dr Maria Pellegrini

  13. A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death

    Article • Scientific Reports, May 2015, Springer Science + Business Media

    Dr Maria Pellegrini

  14. Small-molecule inhibitors of JC polyomavirus infection

    Article • Journal of Peptide Science, December 2014, Wiley

    Dr Maria Pellegrini

  15. Phosphorylation of Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) by Akt Promotes Stability and Mitogenic Function of S-phase Kinase-associated Protein-2 (Skp2)

    Article • Journal of Biological Chemistry, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  16. Protein Engineering of the N-Terminus of NEMO: Structure Stabilization and Rescue of IKKβ Binding

    Article • Biochemistry, November 2014, American Chemical Society (ACS)

    Dr Maria Pellegrini

  17. Small Molecule Inhibition of the Na+/H+ Exchange Regulatory Factor 1 and Parathyroid Hormone 1 Receptor Interaction

    Article • Biochemistry, September 2014, American Chemical Society (ACS)

    Dr Maria Pellegrini

  18. Monitoring ATP hydrolysis and ATPase inhibitor screening using1H NMR

    Article • Chemical Communications, August 2014, Royal Society of Chemistry

    Dr Maria Pellegrini

  19. Engineering a soluble parathyroid hormone GPCR mimetic

    Article • Proteins Structure Function and Bioinformatics, January 2014, Wiley

    Dr Maria Pellegrini

  20. Recombinant production of TEV cleaved human parathyroid hormone

    Article • Journal of Peptide Science, June 2013, Wiley

    Dr Maria Pellegrini

  21. Structure of the extracellular domains of human andXenopusFn14: implications in the evolution of TWEAK and Fn14 interactions

    Article • FEBS Journal, March 2013, Wiley

    Dr Maria Pellegrini

  22. Reining in Polyoma Virus Associated Nephropathy: Design and Characterization of a Template Mimicking BK Viral Coat Protein Cellular Binding

    Article • Biochemistry, October 2012, American Chemical Society (ACS)

    Dr Maria Pellegrini

  23. A Stabilizing Influence: CAL PDZ Inhibition Extends the Half-Life of ΔF508-CFTR

    Article • Angewandte Chemie International Edition, November 2010, Wiley

    Dr Maria Pellegrini

  24. A Stabilizing Influence: CAL PDZ Inhibition Extends the Half-Life of ΔF508-CFTR

    Article • Angewandte Chemie, November 2010, Wiley

    Dr Maria Pellegrini

  25. ChemInform Abstract: Parathyroid Hormone and Parathyroid Hormone-Related Protein: Model Systems for the Development of an Osteoporosis Therapy

    Article • ChemInform, June 2010, Wiley

    Dr Maria Pellegrini

  26. Pharmacological stabilization of ΔF508-CFTR at the cell surface: design of CAL-selective PDZ inhibitors

    Article • Journal of Cystic Fibrosis, June 2010, Elsevier

    Dr Maria Pellegrini

  27. Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes

    Article • Proceedings of the National Academy of Sciences, February 2010, Proceedings of the National Academy of Sciences

    Dr Maria Pellegrini

  28. Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices

    Article • Biopolymers, July 2009, Wiley

    Dr Maria Pellegrini

  29. Conformational consequences of i, i + 3 cystine linkages: nucleation for α-helicity?

    Article • Journal of Peptide Research, January 2009, Wiley

    Dr Maria Pellegrini

  30. Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

    Article • Structure, May 2008, Elsevier

    Dr Maria Pellegrini

  31. Structural characterization of the parathyroid hormone receptor domains determinant for ligand binding

    Article • Biochemical Society Transactions, August 2007, Portland Press Ltd.

    Dr Maria Pellegrini

  32. N-Terminally PEGylated Human Interferon-β-1a with Improved Pharmacokinetic Properties and in Vivo Efficacy in a Melanoma Angiogenesis Model

    Article • Bioconjugate Chemistry, December 2005, American Chemical Society (ACS)

    Dr Maria Pellegrini

  33. The Δe13 Isoform of the Calcitonin Receptor Forms a Six-Transmembrane Domain Receptor with Dominant-Negative Effects on Receptor Surface Expression and Signaling

    Article • Molecular Endocrinology, August 2005, Endocrine Society

    Dr Maria Pellegrini

  34. A 13C NMR approach to categorizing potential limitations of α,β-unsaturated carbonyl systems in drug-like molecules

    Article • Bioorganic & Medicinal Chemistry Letters, November 2004, Elsevier

    Dr Maria Pellegrini

  35. Receptor–Ligand Interactions

    Article • January 2004, Elsevier

    Dr Maria Pellegrini

  36. Toward Parathyroid Hormone Minimization:  Conformational Studies of Cyclic PTH(1−14) Analogues

    Article • Biochemistry, December 2003, American Chemical Society (ACS)

    Dr Maria Pellegrini

  37. NMR studies of CCK-8/CCK1complex support membrane-associated pathway for ligand-receptor interaction

    Article • Canadian Journal of Physiology and Pharmacology, May 2002, Canadian Science Publishing

    Dr Maria Pellegrini

  38. The PDZ1 Domain of SAP90: CHARACTERIZATION OF STRUCTURE AND BINDING

    Article • Journal of Biological Chemistry, December 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  39. Structural characterization of lipopeptide agonists for the bradykinin B2 receptor

    Article • Biopolymers, April 2001, Wiley

    Dr Maria Pellegrini

  40. Molecular Characterization of the Substance P{middle dot}Neurokinin-1 Receptor Complex: DEVELOPMENT OF AN EXPERIMENTALLY BASED MODEL

    Article • Journal of Biological Chemistry, April 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  41. Photoaffinity Labeling of Mutant Neurokinin-1 Receptors Reveals Additional Structural Features of the Substance P/NK-1 Receptor Complex

    Article • Biochemistry, February 2001, American Chemical Society (ACS)

    Dr Maria Pellegrini

  42. Structural characterization of lipopeptide agonists for the bradykinin B2 receptor

    Article • Biopolymers, January 2001, Wiley

    Dr Maria Pellegrini

  43. CtrΔe13, a Calcitonin Receptor Isoform Lacking 14 Amino Acids in Transmembrane Helix 7: Structure and Topology

    Article • January 2001, Springer Science + Business Media

    Dr Maria Pellegrini

  44. Characterizing the Interactions Between Cholecystokinin and the G-Protein Coupled Receptors CCK1 and CCK2: An NMR-Based Study

    Article • January 2001, Springer Science + Business Media

    Dr Maria Pellegrini

  45. Probing the Importance of the N-Terminal Helix of Parathyroid Hormone: Introduction of Cyclohexylalanine to Tether to the Membrane

    Article • January 2001, Springer Science + Business Media

    Dr Maria Pellegrini

  46. Agonist Activity at the Kinin B1 Receptor:  Structural Requirements of the Central Tetrapeptide

    Article • Journal of Medicinal Chemistry, December 2000, American Chemical Society (ACS)

    Dr Maria Pellegrini

  47. Structure-Based Optimization of Peptide Inhibitors of Mammalian Ribonucleotide Reductase,

    Article • Biochemistry, September 2000, American Chemical Society (ACS)

    Dr Maria Pellegrini

  48. Molecular Complex of Cholecystokinin-8 and N-Terminus of the Cholecystokinin A Receptor by NMR Spectroscopy

    Article • Biochemistry, October 1999, American Chemical Society (ACS)

    Dr Maria Pellegrini

  49. Expression and Spectroscopic Analysis of Soluble Nicotinic Acetylcholine Receptor Fragments Derived from the Extracellular Domain of the α-Subunit †

    Article • Biochemistry, August 1999, American Chemical Society (ACS)

    Dr Maria Pellegrini

  50. Probing the Topological Arrangement of the N- and C-Terminal Residues of Bradykinin for Agonist Activity at the B1 Receptor

    Article • Journal of Medicinal Chemistry, July 1999, American Chemical Society (ACS)

    Dr Maria Pellegrini

  51. Molecular Characterization of the Receptor−Ligand Complex for Parathyroid Hormone

    Article • Biochemistry, April 1999, American Chemical Society (ACS)

    Dr Maria Pellegrini

  52. Structural characterization of peptide hormone/receptor interactions by NMR spectroscopy

    Article • Biopolymers, January 1999, Wiley

    Dr Maria Pellegrini

  53. Structural characterization of peptide hormone/receptor interactions by NMR spectroscopy

    Article • Biopolymers, January 1999, Wiley

    Dr Maria Pellegrini

  54. Motif Mutation of Bradykinin B2 Receptor Second Intracellular Loop and Proximal C Terminus Is Critical for Signal Transduction, Internalization, and Resensitization

    Article • Journal of Biological Chemistry, December 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  55. Parathyroid Hormone-Receptor Interactions Identified Directly by Photocross-linking and Molecular Modeling Studies

    Article • Journal of Biological Chemistry, August 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  56. Binding Domain of Human Parathyroid Hormone Receptor:  From Conformation to Function,

    Article • Biochemistry, August 1998, American Chemical Society (ACS)

    Dr Maria Pellegrini

  57. 1,2,5-Trisubstituted 1,4-diazepine-3-one: A novel dipeptidomimetic molecular scaffold

    Article • May 1998, Springer Science + Business Media

    Dr Maria Pellegrini

  58. Conformational investigation of a novel dipeptide based molecular scaffold

    Article • May 1998, Springer Science + Business Media

    Dr Maria Pellegrini

  59. Addressing the Tertiary Structure of Human Parathyroid Hormone-(1-34)

    Article • Journal of Biological Chemistry, April 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Maria Pellegrini

  60. Article • Letters in Peptide Science, January 1998, Springer Science + Business Media

    Dr Maria Pellegrini

  61. Structure, dynamics, and topological orientation of the polyether, ionophore antibiotic monensin, in a micellar environment

    Article • Biopolymers, December 1997, Wiley

    Dr Maria Pellegrini

  62. Structure, dynamics, and topological orientation of the polyether, ionophore antibiotic monensin, in a micellar environment

    Article • Biopolymers, December 1997, Wiley

    Dr Maria Pellegrini

  63. Conformational Studies of RS-66271, an Analog of Parathyroid Hormone-Related Protein with Pronounced Bone Anabolic Activity

    Article • Journal of Medicinal Chemistry, September 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  64. Synthesis of a Trisubstituted 1,4-Diazepin-3-one-Based Dipeptidomimetic as a Novel Molecular Scaffold

    Article • The Journal of Organic Chemistry, April 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  65. A Trisubstituted 1,4-Diazepine-3-one-Based Dipeptidomimetic:  Conformational Characterization by NMR and Computer Simulation

    Article • Journal of the American Chemical Society, March 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  66. Threonine6-Bradykinin:  Molecular Dynamics Simulations in a Biphasic Membrane Mimetic

    Article • Journal of Medicinal Chemistry, January 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  67. Threonine6-Bradykinin:  Structural Characterization in the Presence of Micelles by Nuclear Magnetic Resonance and Distance Geometry

    Article • Journal of Medicinal Chemistry, January 1997, American Chemical Society (ACS)

    Dr Maria Pellegrini

  68. Threonine6-bradykinin: Conformational study of a flexible peptide in dimethyl sulfoxide by NMR and ensemble calculations

    Article • Biopolymers, January 1996, Wiley

    Dr Maria Pellegrini

  69. Peptide Mimetic of the Third Cytoplasmic Loop of the PTH/PTHrP Receptor

    Article • Journal of the American Chemical Society, January 1996, American Chemical Society (ACS)

    Dr Maria Pellegrini

  70. Threonine6‐bradykinin: Conformational study of a flexible peptide in dimethyl sulfoxide by NMR and ensemble calculations

    Article • Biopolymers, January 1996, Wiley

    Dr Maria Pellegrini

  71. Conformational characterization of a peptide mimetic of the third cytoplasmic loop of the G-protein coupled parathyroid hormone/parathyroid hormone related protein receptor

    Article • Biopolymers, January 1996, Wiley

    Dr Maria Pellegrini

  72. Conformation of cyclobradykinin by nmr and distance geometry calculations

    Article • Biopolymers, October 1995, Wiley

    Dr Maria Pellegrini

  73. Conformation of parathyroid hormone antagonists by CD, nmr, and molecular dynamics simulations

    Article • Biopolymers, October 1995, Wiley

    Dr Maria Pellegrini

  74. RS-66271, a clinical candidate derived from parathyroid hormone related protein: The role of enhanced amphiphilic helicity

    Article • Springer Science + Business Media

    Dr Maria Pellegrini

  75. Molecular characterization of the interaction between parathyroid hormone and its receptor

    Article • Springer Science + Business Media

    Dr Maria Pellegrini

  76. Lactam cyclization [i to (i+4)] for nucleation/stabilization of α-helices?

    Article • Springer Science + Business Media

    Dr Maria Pellegrini

  77. Identification and exploitation of structural foci that influence conformational mobility in somatostatin agonists and antagonists

    Article • Springer Science + Business Media

    Dr Maria Pellegrini

  78. Secondary and tertiary fold of the human parathyroid hormone1–34 in different environments as a pathway to bioactive conformation

    Article • Springer Science + Business Media

    Dr Maria Pellegrini