Professor Malcolm R Macleod

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The effect of heat exposure on mood disorders and psychosis: Protocol for a living systematic review of human and non-human studies (Preprint)

Article • April 2026, JMIR Publications Inc.

Professor Malcolm R Macleod
Pro-dopaminergic pharmacological interventions for anhedonia in depression: a living systematic review and network meta-analysis of human and animal studies

Article • EBioMedicine, October 2025, Elsevier

Professor Malcolm R Macleod
Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing

Article • F1000Research, September 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
A How-to Guide for Research Improvement within Research-Performing Institutions

Article • May 2025, Center for Open Science

Professor Malcolm R Macleod
Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Article • Wellcome Open Research, April 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod, Dr Ouma Simple
Building a synthesis-ready research ecosystem: fostering collaboration and open science to accelerate biomedical translation

Article • BMC Medical Research Methodology, March 2025, Springer Science + Business Media

Professor Malcolm R Macleod
The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies

Article • Wellcome Open Research, February 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod, Dr Ouma Simple
Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Article • Wellcome Open Research, January 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis

Article • F1000Research, January 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Testing the usefulness of a quality system in preclinical research

Article • Neuroscience Applied, January 2025, Elsevier

Professor Malcolm R Macleod
Triangulating evidence from the GALENOS living systematic review on trace amine-associated receptor 1 (TAAR1) agonists in psychosis

Article • The British Journal of Psychiatry, December 2024, Royal College of Psychiatrists

Professor Malcolm R Macleod
Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing

Article • F1000Research, December 2024, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Article • The Lancet Neurology, November 2024, Elsevier

Professor Malcolm R Macleod
A Systematic Online Living Evidence Summary of experimental Alzheimer’s disease research

Article • Journal of Neuroscience Methods, September 2024, Elsevier

Professor Malcolm R Macleod
Strategy for developing data standards in support of automation of Systematic Reviews

Article • EFSA Supporting Publications, July 2024, Wiley

Professor Malcolm R Macleod
Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications

Article • PLoS Biology, June 2024, PLOS

Professor Malcolm R Macleod
Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data

Article • Wellcome Open Research, April 2024, Faculty of 1000, Ltd.

Professor Malcolm R Macleod, Dr Ouma Simple
Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data

Article • Nature Reports Stem Cells, March 2024, Springer Science + Business Media

Professor Malcolm R Macleod
Genetically modified animals as models of neurodevelopmental conditions: A review of systematic review reporting quality

Article • Brain and Neuroscience Advances, January 2024, SAGE Publications

Professor Malcolm R Macleod
Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment

Article • The Lancet Regional Health - Europe, January 2024, Elsevier

Professor Malcolm R Macleod
Evaluating artificial intelligence software for delineating hemorrhage extent on CT brain imaging in stroke

Article • Journal of Stroke and Cerebrovascular Diseases, January 2024, Elsevier

Professor Malcolm R Macleod
Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality

Article • November 2023, Center for Open Science

Professor Malcolm R Macleod
Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Article • Wellcome Open Research, October 2023, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies

Article • Wellcome Open Research, October 2023, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
From data deluge to publomics: How AI can transform animal research

Article • Lab Animal, September 2023, Springer Science + Business Media

Professor Malcolm R Macleod
Blood biomarker changes following therapeutic hypothermia in ischemic stroke

Article • Brain and Behavior, September 2023, Wiley

Professor Malcolm R Macleod
A Systematic Online Living Evidence Summary of experimental Alzheimer’s disease research

Article • September 2023, Center for Open Science

Professor Malcolm R Macleod
The Automated Systematic Search Deduplicator (ASySD): a rapid, open-source, interoperable tool to remove duplicate citations in biomedical systematic reviews

Article • BMC Biology, September 2023, Springer Science + Business Media

Professor Malcolm R Macleod
The UK Reproducibility Network: A progress report

Article • Journal of Neuroscience Methods, September 2023, Elsevier

Professor Malcolm R Macleod, Professor Marcus R Munafo
Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies.

Article • Wellcome Open Research, August 2023, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis

Article • BMJ Mental Health, June 2023, BMJ

Professor Malcolm R Macleod
Identifying a research agenda for postgraduate taught education in the UK: lessons from a machine learning facilitated systematic scoping review

Article • Oxford Review of Education, May 2023, Taylor & Francis

Professor Malcolm R Macleod
Accuracy of artificial intelligence software for CT angiography in stroke

Article • Annals of Clinical and Translational Neurology, May 2023, Wiley

Professor Malcolm R Macleod
Systematic online living evidence summaries: emerging tools to accelerate evidence synthesis

Article • Clinical Science, May 2023, Portland Press Ltd.

Professor Malcolm R Macleod
Designing, conducting, and reporting reproducible animal experiments

Article • Journal of Endocrinology, April 2023, Bioscientifica

Professor Malcolm R Macleod
Advanced methods and implementations for the meta-analyses of animal models: Current practices and future recommendations

Article • Neuroscience & Biobehavioral Reviews, March 2023, Elsevier

Professor Malcolm R Macleod
Screening for in vitro systematic reviews: a comparison of screening methods and training of a machine learning classifier

Article • Clinical Science, January 2023, Portland Press Ltd.

Professor Malcolm R Macleod
EFFECTS OF GALACTO-OLIGOSACCHARIDE PREBIOTICS IN THE FLINDERS SENSITIVE LINE RAT MODEL OF DEPRESSION ON BEHAVIOURAL OUTCOMES

Article • December 2022, Center for Open Science

Professor Malcolm R Macleod
Frequency and Phenotype Associations of Rare Variants in 5 Monogenic Cerebral Small Vessel Disease Genes in 200,000 UK Biobank Participants

Article • Neurology Genetics, October 2022, Wolters Kluwer Health

Professor Malcolm R Macleod
PICO entity extraction for preclinical animal literature

Article • Systematic Reviews, September 2022, Springer Science + Business Media

Professor Malcolm R Macleod
The EQIPD framework for rigor in the design, conduct, analysis and documentation of animal experiments

Article • Nature Chemical Biology, September 2022, Springer Science + Business Media

Professor Malcolm R Macleod
Screening for in vitro systematic reviews: a comparison of screening methods and training of a machine learning classifier

Article • August 2022, Center for Open Science

Professor Malcolm R Macleod
Systematic Online Living Evidence Summaries: emerging tools to accelerate evidence synthesis

Article • August 2022, Center for Open Science

Professor Malcolm R Macleod
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

Article • BMJ Open, July 2022, BMJ

Professor Malcolm R Macleod
Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research

Article • BMJ Open Science, June 2022, Portico

Professor Malcolm R Macleod
Effectiveness of biomaterial-based combination strategies for spinal cord repair – a systematic review and meta-analysis of preclinical literature

Article • Spinal Cord, May 2022, Springer Science + Business Media

Professor Malcolm R Macleod
Improving the reproducibility and integrity of research: what can different stakeholders contribute?

Article • BMC Research Notes, April 2022, Springer Science + Business Media

Professor Malcolm R Macleod
A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease

Article • April 2022, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
MDAR (Material, Design, Analysis Reporting): A Modular Framework for Transparent Reporting in the Life Sciences

Article • Editorial Office News, April 2022, International Society for Managing and Technical Editors (ISMTE)

Professor Malcolm R Macleod
What has preclinical systematic review ever done for us?

Article • BMJ Open Science, March 2022, Portico

Professor Malcolm R Macleod
The reproducibility debate is an opportunity, not a crisis

Article • BMC Research Notes, February 2022, Springer Science + Business Media

Professor Malcolm R Macleod, Professor Marcus R Munafo
Improving research quality: the view from the UK Reproducibility Network institutional leads for research improvement

Article • BMC Research Notes, December 2021, Springer Science + Business Media

Professor Malcolm R Macleod, Professor Marcus R Munafo
From grassroots to global: A blueprint for building a reproducibility network

Article • PLoS Biology, November 2021, PLOS

Professor Malcolm R Macleod, Professor Marcus R Munafo
Risk of bias assessment in preclinical literature using natural language processing

Article • Research Synthesis Methods, November 2021, Wiley

Professor Malcolm R Macleod
Using median survival in meta-analysis of experimental time-to-event data

Article • Systematic Reviews, November 2021, Springer Science + Business Media

Professor Malcolm R Macleod
PICO Entity Extraction For Preclinical Animal Literature

Article • October 2021, Springer Science + Business Media

Professor Malcolm R Macleod
Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research

Article • October 2021, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Technological advances in preclinical meta-research

Article • BMJ Open Science, July 2021, Portico

Professor Malcolm R Macleod
Building a Systematic Online Living Evidence Summary of COVID-19 Research

Article • Journal of EAHIL, June 2021, European Association for Health Information and Libraries EAHIL

Professor Malcolm R Macleod
Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol

Article • Systematic Reviews, June 2021, Springer Science + Business Media

Professor Malcolm R Macleod
Risk of Bias Assessment in Preclinical Literature using Natural Language Processing

Article • June 2021, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Introduction to the EQIPD quality system

Article • eLife, May 2021, eLife

Professor Malcolm R Macleod
Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research

Article • PLoS Biology, May 2021, PLOS

Dr Shinichi Nakagawa, Alistair Senior, Professor Malcolm R Macleod
Epidemiology and reporting characteristics of preclinical systematic reviews

Article • PLoS Biology, May 2021, PLOS

Manoj Lalu, Professor Malcolm R Macleod
The Automated Systematic Search Deduplicator (ASySD): a rapid, open-source, interoperable tool to remove duplicate citations in biomedical systematic reviews

Article • May 2021, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
The MDAR (Materials Design Analysis Reporting) Framework for transparent reporting in the life sciences

Article • Proceedings of the National Academy of Sciences, April 2021, Proceedings of the National Academy of Sciences

Professor Malcolm R Macleod
Regulatory delays in a multinational clinical stroke trial

Article • European Stroke Journal, March 2021, SAGE Publications

Professor Malcolm R Macleod
Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain

Article • Pain, March 2021, Wolters Kluwer Health

Professor Malcolm R Macleod
Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)

Article • BMJ Open Science, March 2021, Portico

Professor Malcolm R Macleod
Results of a randomised controlled trial comparing two different incentives to improve survey response rates

Article • February 2021, Center for Open Science

Professor Malcolm R Macleod
Using Median Survival in Meta-analysis of Experimental Time-to-event Data

Article • February 2021, Springer Science + Business Media

Professor Malcolm R Macleod
Protocol for an analysis of in vivo reporting standards by journal, institution and funder

Article • February 2021, Center for Open Science

Professor Malcolm R Macleod
Comparison of commonly used methods in random effects meta-analysis: application to preclinical data in drug discovery research

Article • BMJ Open Science, February 2021, Portico

Professor Malcolm R Macleod
Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes

Article • Journal of Translational Medicine, December 2020, Springer Science + Business Media

Professor Malcolm R Macleod
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Article • The Lancet, November 2020, Elsevier

Director of the stroke unit, DMSci, clinical research associate professor Helle K. Iversen, Professor Malcolm R Macleod, Dr Toshimitsu Hamasaki
Feasibility of reporting results of large randomised controlled trials to participants: experience from the Fluoxetine Or Control Under Supervision (FOCUS) trial

Article • BMJ Open, November 2020, BMJ

Alison McLoughlin, Professor Malcolm R Macleod
Effects of dietary fat manipulation on cognition in mice and rats: protocol for a systematic review and meta-analysisEffects of dietary fat manipulation on cognition in mice and rats: protocol for a systematic review and meta-analysis

Article • BMJ Open Science, November 2020, Portico

Professor Malcolm R Macleod
Red Blood Cell Transfusion in Animal Models of Acute Brain Injuries: A Systematic Review Protocol

Article • October 2020, Springer Science + Business Media

Professor Malcolm R Macleod
Embrace heterogeneity to improve reproducibility: A perspective from meta-analysis of variation in preclinical research

Article • October 2020, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days

Article • F1000Research, October 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol

Article • F1000Research, October 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days

Article • F1000Research, October 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
A Systematic Review and Meta-Analysis of Hypothermia in Experimental Traumatic Brain Injury: Why Have Promising Animal Studies Not Been Replicated in Pragmatic Clinical Trials?

Article • Journal of Neurotrauma, October 2020, Mary Ann Liebert Inc

Professor Malcolm R Macleod
Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study

Article • The Lancet Psychiatry, October 2020, Elsevier

Professor Malcolm R Macleod, James Sun
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Article • PLoS Biology, July 2020, PLOS

Professor Malcolm R Macleod
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

Article • PLoS Biology, July 2020, PLOS

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Article • Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, July 2020, Wiley

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

Article • Journal of Cerebral Blood Flow & Metabolism, July 2020, SAGE Publications

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Article • BMC Veterinary Research, July 2020, Springer Science + Business Media

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Article • British Journal of Pharmacology, July 2020, Wiley

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

Article • The Journal of Physiology, July 2020, Wiley

Professor Malcolm R Macleod
Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol

Article • F1000Research, June 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod, David Ripsman, Manoj Lalu, Lindsey Sikora, Dr C.Glenn Begley
Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan

Article • AMRC Open Research, April 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals

Article • BMJ Open Science, April 2020, BMJ

Professor Malcolm R Macleod
FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research

Article • Journal of Neurotrauma, March 2020, Mary Ann Liebert Inc

Professor Malcolm R Macleod
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings

Article • Journal of Cerebral Blood Flow & Metabolism, March 2020, SAGE Publications

Dr Atticus H Hainsworth, Professor Malcolm R Macleod
Introducing our series: research synthesis and meta-research in biology

Article • BMC Biology, March 2020, Springer Science + Business Media

Professor Malcolm R Macleod
Framework for advancing rigorous research

Article • eLife, March 2020, eLife

Professor Malcolm R Macleod, Professor Marcus R Munafo
Meta-analysis of targeted temperature management in animal models of cardiac arrest

Article • Intensive Care Medicine Experimental, January 2020, Springer Science + Business Media

Professor Malcolm R Macleod
Research Culture and Reproducibility

Article • Trends in Cognitive Sciences, December 2019, Elsevier

Professor Marcus R Munafo, Professor Malcolm R Macleod
Ischaemic stroke

Article • Nature Reviews Disease Primers, October 2019, Springer Science + Business Media

Professor Malcolm R Macleod
Compressive Pressure Versus Time in Cauda Equina Syndrome

Article • Spine, September 2019, Wolters Kluwer Health

Professor Malcolm R Macleod
The ARRIVE guidelines 2019: updated guidelines for reporting animal research

Article • July 2019, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019

Article • July 2019, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Article • The Lancet Neurology, July 2019, Elsevier

Professor Malcolm R Macleod, Frank Sullivan, Dr William D Strain, Alison McLoughlin
Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

Article • The Lancet, July 2019, Elsevier

Professor Malcolm R Macleod
A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

Article • Research Integrity and Peer Review, June 2019, Springer Science + Business Media

Professor Malcolm R Macleod, Dr marco cascella
Outcome heterogeneity and bias in acute experimental spinal cord injury

Article • Neurology, June 2019, Wolters Kluwer Health

Professor Malcolm R Macleod
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

Article • The Lancet, June 2019, Elsevier

Professor Malcolm R Macleod, Frank Sullivan, Dr William D Strain, Alison McLoughlin
Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis

Article • PLoS Biology, May 2019, PLOS

Professor Malcolm R Macleod
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, May 2019, New England Journal of Medicine (NEJM/MMS)

Professor Malcolm R Macleod
Administration of galacto-oligosaccharide prebiotics in the Flinders Sensitive Line animal model of depression

Article • BMJ Open Science, May 2019, BMJ

Professor Malcolm R Macleod
Protocol for a systematic review and meta-analysis of data from preclinical studies employing forced swimming test: an update

Article • BMJ Open Science, May 2019, BMJ

Professor Malcolm R Macleod
Towards minimum reporting standards for life scientists

Article • April 2019, Center for Open Science

Professor Malcolm R Macleod
Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial

Article • European Stroke Journal, April 2019, SAGE Publications

Professor Malcolm R Macleod
A European initiative to unclog pipeline for new medicines

Article • Nature, April 2019, Springer Science + Business Media

Professor Malcolm R Macleod
The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews

Article • Wellcome Open Research, March 2019, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Reader response: Evaluating depression and suicidality in tetrabenazine users with Huntington disease

Article • Neurology, February 2019, Wolters Kluwer Health

Professor Malcolm R Macleod, Professor Marcus R Munafo
Did a change in Nature journals’ editorial policy for life sciences research improve reporting?

Article • BMJ Open Science, February 2019, Portico

Professor Malcolm R Macleod
Warlow's Stroke

Article • January 2019, Wiley

Professor Malcolm R Macleod
The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews

Article • Wellcome Open Research, January 2019, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Machine learning algorithms for systematic review: reducing workload in a preclinical review of animal studies and reducing human screening error

Article • Systematic Reviews, January 2019, Springer Science + Business Media

Professor Malcolm R Macleod
Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

Article • F1000Research, January 2019, Faculty of 1000, Ltd.

Manoj Lalu, Dale Corbett, Professor Malcolm R Macleod, Annette O'Connor, Fatima Haggar
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Article • The Lancet, January 2019, Elsevier

Associate Professor Erik Lundström, Professor Malcolm R Macleod, Frank Sullivan, Dr William D Strain, Alison McLoughlin, Professor Marian C Brady
Design of Meta-Analysis Studies

Article • January 2019, Springer Science + Business Media

Professor Malcolm R Macleod
Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis

Article • Brain Communications, January 2019, Oxford University Press (OUP)

Professor Malcolm R Macleod
Reproducibility and Rigor in Animal-Based Research

Article • ILAR Journal, January 2019, Oxford University Press (OUP)

Professor Malcolm R Macleod
The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews

Article • Wellcome Open Research, December 2018, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis

Article • BMJ, November 2018, BMJ

Professor Malcolm R Macleod
Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals

Article • BMJ Open Science, September 2018, BMJ

Professor Malcolm R Macleod
The reproducibility opportunity

Article • Nature Human Behaviour, August 2018, Springer Science + Business Media

Professor Malcolm R Macleod
NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons

Article • Journal of Stroke and Cerebrovascular Diseases, August 2018, Elsevier

Professor Malcolm R Macleod
A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

Article • July 2018, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. Rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment

Article • European Stroke Journal, April 2018, SAGE Publications

Professor Malcolm R Macleod
Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Article • Clinical Science, April 2018, Portland Press Ltd.

Professor Malcolm R Macleod, Dr Atticus H Hainsworth
Effect size and statistical power in the rodent fear conditioning literature – A systematic review

Article • PLOS One, April 2018, PLOS

Professor Malcolm R Macleod
Animal models of chemotherapy-induced peripheral neuropathy: a machine-assisted systematic review and meta-analysis A comprehensive summary of the field to inform robust experimental design

Article • April 2018, Cold Spring Harbor Laboratory Press

Rosemary Morland, Professor Malcolm R Macleod
Automation of citation screening in pre-clinical systematic reviews

Article • March 2018, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial

Article • Trials, March 2018, Springer Science + Business Media

Dr William D Strain, Alison McLoughlin, Professor Malcolm R Macleod
Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Article • The Lancet, March 2018, Elsevier

Alison McLoughlin, Professor Malcolm R Macleod
The use of text-mining and machine learning algorithms in systematic reviews: reducing workload in preclinical biomedical sciences and reducing human screening error

Article • January 2018, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

Article • Oncotarget, January 2018, Impact Journals, LLC

Professor Malcolm R Macleod
Estimating the statistical performance of different approaches to meta-analysis of data from animal studies in identifying the impact of aspects of study design

Article • January 2018, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

Article • PLOS One, January 2018, PLOS

Professor Malcolm R Macleod
Learning lessons from MVA85A, a failed booster vaccine for BCG

Article • BMJ, January 2018, BMJ

Professor Malcolm R Macleod
Transparency in the reporting of in vivo pre-clinical pain research: The relevance and implications of the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines

Article • Scandinavian Journal of Pain, December 2017, De Gruyter

Rosemary Morland, Professor Malcolm R Macleod
Correction: D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

Article • PLOS One, December 2017, PLOS

Professor Malcolm R Macleod
Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke

Article • Trials, November 2017, Springer Science + Business Media

Professor Malcolm R Macleod
Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE

Article • Epilepsia, November 2017, Wiley

Professor Malcolm R Macleod
Living systematic reviews: 2. Combining human and machine effort

Article • Journal of Clinical Epidemiology, November 2017, Elsevier

Dr Arwel W Jones, Professor Luke Wolfenden, Professor Malcolm R Macleod
Living systematic reviews: 3. Statistical methods for updating meta-analyses

Article • Journal of Clinical Epidemiology, November 2017, Elsevier

Dr Arwel W Jones, Professor Luke Wolfenden, Professor Malcolm R Macleod
Living systematic reviews: 4. Living guideline recommendations

Article • Journal of Clinical Epidemiology, November 2017, Elsevier

Dr Arwel W Jones, Professor Luke Wolfenden, Professor Malcolm R Macleod, Professor Marcus R Munafo
Risk of bias reporting in the recent animal focal cerebral ischaemia literature

Article • Clinical Science, October 2017, Portland Press Ltd.

Professor Malcolm R Macleod
Marine-derived n-3 fatty acids therapy for stroke

Article • Cochrane Database of Systematic Reviews, October 2017, Wiley

Professor Malcolm R Macleod
The Experimental Design Assistant

Article • Nature Chemical Biology, September 2017, Nature

Professor Malcolm R Macleod
The Experimental Design Assistant

Article • PLoS Biology, September 2017, PLOS

Professor Malcolm R Macleod
Findings of a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution

Article • September 2017, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Standardized mean differences cause funnel plot distortion in publication bias assessments

Article • eLife, September 2017, eLife

Professor Malcolm R Macleod
Living systematic review: 1. Introduction—the why, what, when, and how

Article • Journal of Clinical Epidemiology, September 2017, Elsevier

Mr John Hilton, Dr Arwel W Jones, Professor Luke Wolfenden, Professor Malcolm R Macleod, Professor Marcus R Munafo
D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

Article • PLOS One, August 2017, PLOS

Dr Saeed Sadigh-Eteghad, Professor Malcolm R Macleod
Development of a psychological intervention for fatigue after stroke

Article • PLOS One, August 2017, PLOS

Professor Malcolm R Macleod
The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Article • Journal of Cerebral Blood Flow & Metabolism, August 2017, SAGE Publications

Professor Malcolm R Macleod
Alpha Calcitonin Gene-Related Peptide Increases Cerebral Vessel Diameter in Animal Models of Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis

Article • Frontiers in Neurology, July 2017, Frontiers

Professor Malcolm R Macleod
Increasing value and reducing waste in stroke research

Article • The Lancet Neurology, May 2017, Elsevier

Professor Malcolm R Macleod
Conjugal amyotrophic lateral sclerosis: a case report from Scotland

Article • BMC Neurology, March 2017, Springer Science + Business Media

Professor Malcolm R Macleod
Effect size and statistical power in the rodent fear conditioning literature - a systematic review

Article • March 2017, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials

Article • PLOS One, February 2017, PLOS

Professor Malcolm R Macleod
No publication without confirmation

Article • Nature, February 2017, Springer Science + Business Media

Professor Malcolm R Macleod
Hypothermia revisited: Impact of ischaemic duration and between experiment variability

Article • Journal of Cerebral Blood Flow & Metabolism, January 2017, SAGE Publications

Professor Malcolm R Macleod
Improving our understanding of thein vivomodelling of psychotic disorders: A protocol for a systematic review and meta‐analysis

Article • Evidence-based Preclinical Medicine, December 2016, Wiley

Professor Malcolm R Macleod
Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis

Article • Evidence-based Preclinical Medicine, December 2016, Wiley

Professor Malcolm R Macleod
Understanding in vivo modelling of depression in non-human animals: a systematic review protocol

Article • Evidence-based Preclinical Medicine, December 2016, Wiley

Professor Malcolm R Macleod
Protocols for laboratory research

Article • Evidence-based Preclinical Medicine, December 2016, Wiley

Professor Malcolm R Macleod
Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

Article • eLife, November 2016, eLife

Professor Malcolm R Macleod
The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research

Article • PLOS One, November 2016, PLOS

Professor Malcolm R Macleod
Study protocol - A systematic review and meta-analysis of hypothermia in experimental traumatic brain injury: Why have promising animal studies not been replicated in pragmatic clinical trials?

Article • Evidence-based Preclinical Medicine, October 2016, Wiley

Professor Malcolm R Macleod
Multicenter Evaluation of Geometric Accuracy of MRI Protocols Used in Experimental Stroke

Article • PLOS One, September 2016, PLOS

Professor Malcolm R Macleod
Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke: an Update

Article • Translational Stroke Research, August 2016, Springer Science + Business Media

Professor Malcolm R Macleod
Protocol for a systematic review of effect sizes and statistical power in the rodent fear conditioning literature

Article • Evidence-based Preclinical Medicine, July 2016, Wiley

Professor Malcolm R Macleod
The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis

Article • PLOS One, July 2016, PLOS

Professor Malcolm R Macleod
From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer's disease mouse models

Article • Evidence-based Preclinical Medicine, July 2016, Wiley

Professor Malcolm R Macleod
A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

Article • Environmental Health, July 2016, Springer Science + Business Media

Professor Malcolm R Macleod, Professor Susan Jobling
Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets

Article • Nature Reviews Drug Discovery, June 2016, Nature

Professor Malcolm R Macleod
Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

Article • PLoS Biology, May 2016, PLOS

Professor Malcolm R Macleod
SWIFT-Review: a text-mining workbench for systematic review

Article • Systematic Reviews, May 2016, Springer Science + Business Media

Professor Malcolm R Macleod
Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals’ editorial policy for life sciences research on the completeness of reporting study design and execution

Article • Scientometrics, May 2016, Springer Science + Business Media

Professor Malcolm R Macleod
Cause of Death and Predictors of All‐Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF

Article • Journal of the American Heart Association, March 2016, Wolters Kluwer Health

Professor Malcolm R Macleod, Professor Dmitry Zateyshchikov, Professor Yuriy M. Sirenko
Cardiac Stem Cell Treatment in Myocardial InfarctionNovelty and Significance

Article • Circulation Research, February 2016, Wolters Kluwer Health

Professor Joost PG Sluijter, Professor Malcolm R Macleod
Corrigendum to ‘Meta-analysis of data from animal studies: A practical guide’

Article • Journal of Neuroscience Methods, February 2016, Elsevier

Professor Malcolm R Macleod
How to Avoid Bumping into the Translational Roadblock

Article • January 2016, Springer Science + Business Media

Professor Malcolm R Macleod
AVERT 2 (a very early rehabilitation trial, a very effective reproductive trigger): retrospective observational analysis of the number of babies born to trial staff

Article • BMJ, December 2015, BMJ

Professor Julie Bernhardt, Professor Malcolm R Macleod, Professor Amanda G Thrift
Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke

Article • Neurology, December 2015, Wolters Kluwer Health

Professor Malcolm R Macleod
Correction: Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Article • PLoS Biology, November 2015, PLOS

Professor Malcolm R Macleod
Informatics: Make sense of health data

Article • Nature, November 2015, Nature

Professor Malcolm R Macleod
How individual participant data meta-analyses have influenced trial design, conduct, and analysis

Article • Journal of Clinical Epidemiology, November 2015, Elsevier

Professor Malcolm R Macleod
Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

Article • Cardiovascular Research, October 2015, European Society of Cardiology

Professor Malcolm R Macleod
Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Article • PLoS Biology, October 2015, PLOS

Professor Malcolm R Macleod
The Clots in Legs Or sTockings after Stroke (CLOTS) 3 trial: a randomised controlled trial to determine whether or not intermittent pneumatic compression reduces the risk of post-stroke deep vein thrombosis and to estimate its cost-effectiveness

Article • Health Technology Assessment, September 2015, National Institute for Health Research

Professor Malcolm R Macleod
Consent for Brain Tissue Donation after Intracerebral Haemorrhage: A Community-Based Study

Article • PLOS One, August 2015, PLOS

Professor Malcolm R Macleod
Exploring threats to generalisability in a large international rehabilitation trial (AVERT)

Article • BMJ Open, August 2015, BMJ

Professor Malcolm R Macleod, Professor Julie Bernhardt, Professor Amanda G Thrift
Interventions for post-stroke fatigue

Article • Cochrane Database of Systematic Reviews, July 2015, Wiley

Professor Malcolm R Macleod
Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial

Article • The Lancet, July 2015, Elsevier

Professor Malcolm R Macleod, Professor Julie Bernhardt, Professor Amanda G Thrift
Effect of Endothelin Receptor Antagonists on Clinically Relevant Outcomes after Experimental Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

Article • Journal of Cerebral Blood Flow & Metabolism, July 2015, SAGE Publications

Professor Malcolm R Macleod
Prof Benchie and Dr Athena-A modern tragedy…

Article • Evidence-based Preclinical Medicine, June 2015, Wiley

Professor Malcolm R Macleod
Increasing value and reducing waste in animal models of rheumatological disease

Article • International Journal of Rheumatic Diseases, June 2015, Wiley

Professor Malcolm R Macleod
Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis

Article • PLOS One, April 2015, PLOS

Professor Malcolm R Macleod
Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial

Article • The Lancet Neurology, April 2015, Elsevier

Professor Malcolm R Macleod
Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium

Article • Scandinavian Journal of Pain, April 2015, De Gruyter

Professor Malcolm R Macleod
Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

Article • BMJ, March 2015, BMJ

Professor Malcolm R Macleod
Magnetic Resonance Imaging in Experimental Stroke and Comparison With Histology

Article • Stroke, February 2015, Wolters Kluwer Health

Professor Malcolm R Macleod
Model of Understanding Fatigue After Stroke

Article • Stroke, February 2015, Wolters Kluwer Health

Professor Malcolm R Macleod, Trudie Chalder
Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome

Article • Stroke, February 2015, Wolters Kluwer Health

Professor Malcolm R Macleod
A systematic review and meta‐analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

Article • Evidence-based Preclinical Medicine, December 2014, Wiley

Professor Malcolm R Macleod
Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

Article • Pain, December 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Effect of intermittent pneumatic compression on disability, living circumstances, quality of life, and hospital costs after stroke: secondary analyses from CLOTS 3, a randomised trial

Article • The Lancet Neurology, December 2014, Elsevier

Professor Malcolm R Macleod
Similar Effect of Autologous and Allogeneic Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-Analysis of Large Animal Studies

Article • Circulation Research, September 2014, Wolters Kluwer Health

Miss Sanne J. Jansen of Lorkeers, Professor Malcolm R Macleod
Efficacy of Antidepressants in Animal Models of Ischemic Stroke: A Systematic Review and Meta-Analysis

Article • Stroke, September 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Preclinical research: Design animal studies better

Article • Nature, June 2014, Nature

Professor Malcolm R Macleod
Efficacy and Safety of Rivaroxaban Compared With Warfarin Among Elderly Patients With Nonvalvular Atrial Fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embol...

Article • Circulation, June 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
EuroHYP-1: European Multicenter, Randomized, Phase III Clinical Trial of Therapeutic Hypothermia plus Best Medical Treatment vs. Best Medical Treatment Alone for Acute Ischemic Stroke

Article • International Journal of Stroke, May 2014, SAGE Publications

Professor Malcolm R Macleod
End-of-life decisions in patients with severe acute brain injury

Article • The Lancet Neurology, May 2014, Elsevier

Professor Malcolm R Macleod
Psychological Associations of Poststroke Fatigue: A Systematic Review and Meta-Analysis

Article • Stroke, April 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Using Animal Models to Understand Cancer Pain in Humans

Article • Current Review of Pain, April 2014, Springer Science + Business Media

Professor Malcolm R Macleod
Outcome After Conservative Management or Intervention for Unruptured Brain Arteriovenous Malformations

Article • JAMA, April 2014, American Medical Association (AMA)

Professor Malcolm R Macleod
Clopidogrel Plus Aspirin Versus Warfarin in Patients With Stroke and Aortic Arch Plaques

Article • Stroke, April 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Research: increasing value, reducing waste – Authors' reply

Article • The Lancet, March 2014, Elsevier

Professor Malcolm R Macleod
Systematic Reviews and Meta-Analysis of Preclinical Studies: Why Perform Them and How to Appraise Them Critically

Article • Journal of Cerebral Blood Flow & Metabolism, February 2014, SAGE Publications

Professor Malcolm R Macleod
Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery

Article • Neurorehabilitation and Neural Repair, February 2014, SAGE Publications

Professor Malcolm R Macleod, Professor Julie Bernhardt
Therapeutic Hypothermia and the Risk of Infection

Article • Critical Care Medicine, February 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
A (mini) pill for stroke?

Article • Brain, February 2014, Oxford University Press (OUP)

Professor Malcolm R Macleod
Some Salt with Your Statin, Professor?

Article • PLoS Biology, January 2014, PLOS

Professor Malcolm R Macleod
Hypothermia Protects Human Neurons

Article • International Journal of Stroke, January 2014, SAGE Publications

Professor Malcolm R Macleod
Systematic Review and Meta-Analysis of Interventions Tested in Animal Models of Lacunar Stroke

Article • Stroke, January 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Meta-analysis of data from animal studies: A practical guide

Article • Journal of Neuroscience Methods, January 2014, Elsevier

Professor Malcolm R Macleod
Increasing value and reducing waste in research design, conduct, and analysis

Article • The Lancet, January 2014, Elsevier

Professor Malcolm R Macleod
Increasing value and reducing waste in biomedical research regulation and management

Article • The Lancet, January 2014, Elsevier

Professor Malcolm R Macleod, Bob Phillips
Effect and Reporting Bias of RhoA/ROCK-Blockade Intervention on Locomotor Recovery After Spinal Cord Injury

Article • JAMA Neurology, January 2014, American Medical Association (AMA)

Professor Malcolm R Macleod
Biomedical research: increasing value, reducing waste

Article • The Lancet, January 2014, Elsevier

Professor Malcolm R Macleod
Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol

Article • Systematic Reviews, January 2014, Springer Science + Business Media

Professor Malcolm R Macleod
Stem Cell Transplantation in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Animal Studies

Article • PLoS Biology, December 2013, PLOS

Professor Malcolm R Macleod
Edoxaban versus Warfarin in Patients with Atrial Fibrillation

Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, November 2013, New England Journal of Medicine (NEJM/MMS)

Professor Malcolm R Macleod, Prof. Elisabeta Badila, Director of the stroke unit, DMSci, clinical research associate professor Helle K. Iversen, Professor Dmitry Zateyshchikov, Professor Yuriy M. Sirenko
Bringing rigour to translational medicine

Article • Nature Reviews Neurology, November 2013, Springer Science + Business Media

Professor Malcolm R Macleod
Edaravone Improves Functional and Structural Outcomes in Animal Models of Focal Cerebral Ischemia: A Systematic Review

Article • International Journal of Stroke, October 2013, SAGE Publications

Professor Malcolm R Macleod
Meta-Analysis of Pre-Clinical Studies of Early Decompression in Acute Spinal Cord Injury: A Battle of Time and Pressure

Article • PLOS One, August 2013, PLOS

Professor Malcolm R Macleod
Systematic Review and Meta-Analysis of Therapeutic Hypothermia in Animal Models of Spinal Cord Injury

Article • PLOS One, August 2013, PLOS

Professor Malcolm R Macleod
Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial

Article • The Lancet, August 2013, Elsevier

Professor Malcolm R Macleod
Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

Article • PLoS Biology, July 2013, PLOS

Professor Malcolm R Macleod
Hypertension and Experimental Stroke Therapies

Article • Journal of Cerebral Blood Flow & Metabolism, June 2013, SAGE Publications

Professor Malcolm R Macleod
Animal models of bone cancer pain: Systematic review and meta-analyses

Article • Pain, June 2013, Wolters Kluwer Health

Professor Malcolm R Macleod
Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke

Article • Systematic Reviews, May 2013, Springer Science + Business Media

Professor Malcolm R Macleod
Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis

Article • Pain, May 2013, Wolters Kluwer Health

Professor Malcolm R Macleod
A Concerted Appeal for International Cooperation in Preclinical Stroke Research

Article • Stroke, April 2013, Wolters Kluwer Health

Professor Malcolm R Macleod
Evidence-based Translational Medicine

Article • Stroke, April 2013, Wolters Kluwer Health

Professor Malcolm R Macleod
Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?

Article • British Journal of Cancer, January 2013, Springer Science + Business Media

Professor Malcolm R Macleod
Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial

Article • Trials, October 2012, Springer Science + Business Media

Professor Malcolm R Macleod
A call for transparent reporting to optimize the predictive value of preclinical research

Article • Nature, October 2012, Springer Science + Business Media

Professor Malcolm R Macleod, John Huguenard
Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial

Article • The Lancet, October 2012, Elsevier

Professor Malcolm R Macleod
The Benefit of Hypothermia in Experimental Ischemic Stroke is Not Affected by Pethidine

Article • International Journal of Stroke, July 2012, SAGE Publications

Professor Malcolm R Macleod
Improving the Efficiency of the Development of Drugs for Stroke

Article • International Journal of Stroke, June 2012, SAGE Publications

Professor Malcolm R Macleod
Translational Research

Article • International Journal of Stroke, June 2012, SAGE Publications

Professor Malcolm R Macleod
Stem Cell-Based Therapy for Experimental Stroke: A Systematic Review and Meta-Analysis

Article • International Journal of Stroke, June 2012, SAGE Publications

Professor Malcolm R Macleod
Voltage-gated potassium channel antibody-related encephalopathy: a case which may extend the documented phenotype of this condition

Article • BMJ Case Reports, June 2012, BMJ

Professor Malcolm R Macleod
The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

Article • The Lancet, June 2012, Elsevier

Professor Malcolm R Macleod, Dr William D Strain, Associate Professor Erik Lundström
Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial

Article • The Lancet Neurology, June 2012, Elsevier

Professor Malcolm R Macleod, Prof. J. David Spence
Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

Article • Journal of Cerebral Blood Flow & Metabolism, April 2012, SAGE Publications

Professor Malcolm R Macleod
Vorapaxar in the Secondary Prevention of Atherothrombotic Events

Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, April 2012, New England Journal of Medicine (NEJM/MMS)

Professor Malcolm R Macleod, M.D Ph.D Serge Timsit, Director of the stroke unit, DMSci, clinical research associate professor Helle K. Iversen
Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF

Article • The Lancet Neurology, April 2012, Elsevier

Professor Malcolm R Macleod
Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study

Article • The Lancet Neurology, March 2012, Elsevier

Professor Malcolm R Macleod
Evaluation of Combination Therapy in Animal Models of Cerebral Ischemia

Article • Journal of Cerebral Blood Flow & Metabolism, February 2012, SAGE Publications

Professor Malcolm R Macleod
Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited

Article • Trials, November 2011, Springer Science + Business Media

Professor Malcolm R Macleod, Associate Professor Erik Lundström
The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials

Article • Journal of Thrombosis and Haemostasis, November 2011, Wiley

Professor Malcolm R Macleod
Preclinical studies of human disease: Time to take methodological quality seriously

Article • Journal of Molecular and Cellular Cardiology, October 2011, Elsevier

Professor Malcolm R Macleod
Why animal research needs to improve

Article • Nature, September 2011, Springer Science + Business Media

Professor Malcolm R Macleod
Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, September 2011, New England Journal of Medicine (NEJM/MMS)

Professor Malcolm R Macleod
Sodium and chloride channelopathies with myositis: Coincidence or connection?

Article • Muscle & Nerve, June 2011, Wiley

Professor Malcolm R Macleod
Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial

Article • The Lancet, June 2011, Elsevier

Professor Malcolm R Macleod, Prof. Dr. Otto W. Witte, Professor Ivan G. Milanov
Dopamine agonists in animal models of Parkinson’s disease: A systematic review and meta-analysis

Article • Parkinsonism & Related Disorders, June 2011, Elsevier

Professor Malcolm R Macleod
Not Tonight, Darling, I Might Get a Headache

Article • Stroke, May 2011, Wolters Kluwer Health

Professor Malcolm R Macleod
Systematic Survey of the Design, Statistical Analysis, and Reporting of Studies Published in the 2008 Volume of the Journal of Cerebral Blood Flow and Metabolism

Article • Journal of Cerebral Blood Flow & Metabolism, April 2011, SAGE Publications

Professor Malcolm R Macleod
Treatment of intracerebral hemorrhage in animal models: Meta-analysis

Article • Annals of Neurology, February 2011, Wiley

Professor Malcolm R Macleod
Systematic Survey of the Design, Statistical Analysis, and Reporting of Studies Published in the 2008 Volume of theJournal of Cerebral Blood Flow and Metabolism

Article • Journal of Cerebral Blood Flow & Metabolism, December 2010, SAGE Publications

Professor Malcolm R Macleod
Animal models of neurological disease: are there any babies in the bathwater?

Article • Practical Neurology, November 2010, BMJ

Professor Malcolm R Macleod
Hypothermia for Stroke: Call to Action 2010

Article • International Journal of Stroke, November 2010, SAGE Publications

Professor Malcolm R Macleod
Preclinical Drug Evaluation for Combination Therapy in Acute Stroke Using Systematic Review, Meta-Analysis, and Subsequent Experimental Testing

Article • Journal of Cerebral Blood Flow & Metabolism, October 2010, SAGE Publications

Professor Malcolm R Macleod
B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial

Article • The Lancet Neurology, September 2010, Elsevier

Professor Malcolm R Macleod, Prof. J. David Spence
Improving the translational hit of experimental treatments in multiple sclerosis

Article • Multiple Sclerosis Journal, August 2010, SAGE Publications

Professor Malcolm R Macleod
Factors Affecting the Apparent Efficacy and Safety of Tissue Plasminogen Activator in Thrombotic Occlusion Models of Stroke: Systematic Review and Meta-Analysis

Article • Journal of Cerebral Blood Flow & Metabolism, July 2010, SAGE Publications

Professor Malcolm R Macleod
Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia

Article • Journal of Cerebral Blood Flow & Metabolism, May 2010, SAGE Publications

Professor Malcolm R Macleod
Comment on "Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome"

Article • Science, May 2010, American Association for the Advancement of Science

Professor Malcolm R Macleod
Therapeutic Hypothermia for Acute Ischemic Stroke: Ready to Start Large Randomized Trials?

Article • Journal of Cerebral Blood Flow & Metabolism, March 2010, SAGE Publications

Professor Malcolm R Macleod
Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Article • PLoS Biology, March 2010, PLOS

Professor Malcolm R Macleod
Can Animal Models of Disease Reliably Inform Human Studies?

Article • PLoS Medicine, March 2010, PLOS

Professor Malcolm R Macleod
How to Avoid Bumping into the Translational Roadblock

Article • January 2010, Springer Science + Business Media

Professor Malcolm R Macleod
A Systematic Review and Meta-Analysis of Erythropoietin in Experimental Stroke

Article • Journal of Cerebral Blood Flow & Metabolism, December 2009, SAGE Publications

Professor Malcolm R Macleod
Emulating Multicentre Clinical Stroke Trials: A New Paradigm for Studying Novel Interventions in Experimental Models of Stroke

Article • International Journal of Stroke, December 2009, SAGE Publications

Professor Malcolm R Macleod
Bacterial meningitis associated with a complex ischiorectal abscess

Article • Journal of Clinical Neuroscience, December 2009, Elsevier

Professor Malcolm R Macleod
Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice

Article • British Journal of Pharmacology, August 2009, Wiley

Professor Malcolm R Macleod
Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke

Article • Journal of Stroke and Cerebrovascular Diseases, July 2009, Elsevier

Professor Malcolm R Macleod
Scope of Preclinical Testing Versus Quality Control Within Experiments

Article • Stroke, June 2009, Wolters Kluwer Health

Professor Malcolm R Macleod
Injury-induced mineralocorticoid receptor expression involves differential promoter usage: A novel role for the rat MRβ variant

Article • Molecular and Cellular Endocrinology, June 2009, Elsevier

Professor Malcolm R Macleod
Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial

Article • The Lancet, June 2009, Elsevier

Professor Malcolm R Macleod
Reprint: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Article • Journal of Cerebral Blood Flow & Metabolism, June 2009, SAGE Publications

Professor Malcolm R Macleod
Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for Extended Window Acute Stroke Therapy Trials

Article • Stroke, May 2009, Wolters Kluwer Health

Professor Malcolm R Macleod
Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial

Article • The Lancet Neurology, April 2009, Elsevier

Professor Malcolm R Macleod
Mineralocorticoid receptor mRNA expression is increased in human hippocampus following brief cerebral ischaemia

Article • Neuropathology and Applied Neurobiology, April 2009, Wiley

Professor Malcolm R Macleod
Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

Article • Stroke, February 2009, Wolters Kluwer Health

Professor Malcolm R Macleod
REPRINT: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Article • International Journal of Stroke, February 2009, SAGE Publications

Professor Malcolm R Macleod
Effect of hyperthermia and anoxia on glucocorticoid and mineralocorticoid receptor expression in neonatal rat hippocampus

Article • Neuroscience Letters, January 2009, Elsevier

Professor Malcolm R Macleod
Rationale and Design of a Randomized, Double-Blind, Parallel-Group Study of Terutroban 30 mg/day versus Aspirin 100 mg/day in Stroke Patients: The Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin with Terutroban in Patients wi...

Article • Cerebrovascular Diseases, January 2009, Karger Publishers

Professor Malcolm R Macleod, Prof. Dr. Otto W. Witte, Professor Ivan G. Milanov
General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial

Article • The Lancet, December 2008, Elsevier

Professor Malcolm R Macleod, Alba Piroli, Professor David Torgerson, Dr. Ron Milo
The Future of Restorative Neurosciences in Stroke: Driving the Translational Research Pipeline From Basic Science to Rehabilitation of People After Stroke

Article • Neurorehabilitation and Neural Repair, November 2008, SAGE Publications

Professor Malcolm R Macleod
What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma

Article • Journal of Neuro-Oncology, September 2008, Springer Science + Business Media

Professor Malcolm R Macleod
Reprint: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Article • Journal of Cerebral Blood Flow & Metabolism, September 2008, SAGE Publications

Professor Malcolm R Macleod
Secondary prevention of stroke – Authors' reply

Article • The Lancet, September 2008, Elsevier

Professor Malcolm R Macleod
Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Article • Stroke, August 2008, Wolters Kluwer Health

Professor Malcolm R Macleod
Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Article • Stroke, July 2008, Wolters Kluwer Health

Professor Malcolm R Macleod
Stroke

Article • The Lancet, May 2008, Elsevier

Professor Malcolm R Macleod
Predicting outcome in hyper-acute stroke: validation of a prognostic model in the Third International Stroke Trial (IST3)

Article • Journal of Neurology Neurosurgery & Psychiatry, April 2008, BMJ

Professor Malcolm R Macleod
Outcome after interventional or conservative management of unruptured brain arteriovenous malformations: a prospective, population-based cohort study

Article • The Lancet Neurology, March 2008, Elsevier

Professor Malcolm R Macleod
Empirical Evidence of Bias in the Design of Experimental Stroke Studies: A Metaepidemiologic Approach

Article • Stroke, January 2008, Wolters Kluwer Health

Professor Malcolm R Macleod
A Systematic Review and Meta-Analysis of the Efficacy of Piracetam and Piracetam-Like Compounds in Experimental Stroke

Article • Cerebrovascular Diseases, November 2007, Karger Publishers

Professor Malcolm R Macleod
How can we improve the pre-clinical development of drugs for stroke?

Article • Trends in Neurosciences, September 2007, Elsevier

Professor Malcolm R Macleod
Vanishing diplopia: a problem case

Article • Practical Neurology, August 2007, BMJ

Professor Malcolm R Macleod
Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis

Article • Brain, May 2007, Oxford University Press (OUP)

Professor Malcolm R Macleod
Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia

Article • European Journal of Neuroscience, April 2007, Wiley

Professor Malcolm R Macleod
Systematic Review and Meta-Analysis of the Efficacy of Tirilazad in Experimental Stroke

Article • Stroke, January 2007, Wolters Kluwer Health

Professor Malcolm R Macleod
Comparison of treatment effects between animal experiments and clinical trials: systematic review

Article • BMJ, December 2006, BMJ

Professor Malcolm R Macleod
Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction

Article • Trials, September 2006, Springer Science + Business Media

Professor Malcolm R Macleod
Aortic Arch Atheroma

Article • International Journal of Stroke, May 2006, SAGE Publications

Professor Malcolm R Macleod
1,026 Experimental treatments in acute stroke

Article • Annals of Neurology, March 2006, Wiley

Professor Malcolm R Macleod
Greater Incidence of Both Fatal and Nonfatal Strokes in Disadvantaged Areas: The Northeast Melbourne Stroke Incidence Study

Article • Stroke, January 2006, Wolters Kluwer Health

Professor Malcolm R Macleod, Professor Amanda G Thrift
Current Issues in the Treatment of Acute Posterior Circulation Stroke

Article • CNS Drugs, January 2006, Springer Science + Business Media

Professor Malcolm R Macleod
Epilepsy update

Article • The Lancet Neurology, October 2005, Elsevier

Professor Malcolm R Macleod
Surveying the literature from animal experiments: Systematic review and meta-analysis are important contributions

Article • BMJ, July 2005, BMJ

Professor Malcolm R Macleod
Neuro-oncology for non-oncologists

Article • The Lancet Neurology, June 2005, Elsevier

Professor Malcolm R Macleod
Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells

Article • Molecular Brain Research, April 2005, Elsevier

Professor Malcolm R Macleod
Systematic Review and Metaanalysis of the Efficacy of FK506 in Experimental Stroke

Article • Journal of Cerebral Blood Flow & Metabolism, February 2005, SAGE Publications

Professor Malcolm R Macleod
Gender and deprivation and rates of referral and thereby admission to a national neurorehabilitation service

Article • Clinical Rehabilitation, February 2005, SAGE Publications

Professor Malcolm R Macleod
Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke

Article • Journal of Pineal Research, January 2005, Wiley

Professor Malcolm R Macleod
Results of a Multicentre, Randomised Controlled Trial of Intra-Arterial Urokinase in the Treatment of Acute Posterior Circulation Ischaemic Stroke

Article • Cerebrovascular Diseases, January 2005, Karger Publishers

Professor Malcolm R Macleod
MicroRNA – Taking Regulation of Protein Synthesis to Another Level

Article • Cerebrovascular Diseases, January 2005, Karger Publishers

Professor Malcolm R Macleod
Nicotinamide Attenuates Focal Ischemic Brain Injury: Meta-Analysis or Mechanism of Protection

Article • Stroke, December 2004, Wolters Kluwer Health

Professor Malcolm R Macleod
Atheroma of the aortic arch: an important and poorly recognised factor in the aetiology of stroke

Article • The Lancet Neurology, July 2004, Elsevier

Professor Malcolm R Macleod
Pooling of Animal Experimental Data Reveals Influence of Study Design and Publication Bias

Article • Stroke, April 2004, Wolters Kluwer Health

Professor Malcolm R Macleod
Media Watch

Article • The Lancet Neurology, December 2003, Elsevier

Professor Malcolm R Macleod
Atheroma of the aortic arch: the missing link in the secondary prevention of stroke?

Article • Expert Review of Cardiovascular Therapy, November 2003, Taylor & Francis

Professor Malcolm R Macleod
Inequalities in the incidence and management of, and outcome from, neurological diseases in older people

Article • Reviews in Clinical Gerontology, August 2003, Cambridge University Press

Professor Malcolm R Macleod
Mineralocorticoid receptor expression and increased survival following neuronal injury

Article • European Journal of Neuroscience, April 2003, Wiley

Professor Malcolm R Macleod
Effect of deprivation on time to hospital in acute stroke

Article • Journal of Neurology Neurosurgery & Psychiatry, April 2003, BMJ

Professor Malcolm R Macleod
Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein

Article • Neuroreport, February 2003, Wolters Kluwer Health

Professor Malcolm R Macleod
PubMed: http://www.pubmed.org

Article • Journal of Neurology Neurosurgery & Psychiatry, December 2002, BMJ

Professor Malcolm R Macleod
Effect of deprivation and gender on the incidence and management of acute brain disorders

Article • Intensive Care Medicine, December 2002, Springer Science + Business Media

Professor Malcolm R Macleod
What's a good doctor and how do you make one?

Article • BMJ, September 2002, BMJ

Professor Malcolm R Macleod
Nitric-oxide-synthase-mediated cyclic guanosine monophosphate production in neonatal rat cerebellar prisms is resistant to calcineurin inhibition

Article • Neuroscience Letters, March 2002, Elsevier

Professor Malcolm R Macleod
Serum withdrawal causes apoptosis in SHSY 5Y cells

Article • Brain Research, January 2001, Elsevier

Professor Malcolm R Macleod
Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis

Article • Cell Death and Differentiation, September 2000, Springer Science + Business Media

Professor Malcolm R Macleod
The effect of tumour associated epilepsy on performance/handicap scales used in cerebral glioma

Article • British Journal of Neurosurgery, January 1995, Taylor & Francis

Professor Malcolm R Macleod
Ischaemic heart disease and cholesterol There's more to heart disease than cholesterol

Article • BMJ, April 1994, BMJ

Professor Malcolm R Macleod

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