Professor Malcolm R Macleod

All Stories

The GALENOS approach to triangulating evidence: a structured approach for integrating information from human and animal studies

Article • BMC Medical Research Methodology, June 2026, Springer Science + Business Media

Professor Malcolm R Macleod
The effect of heat exposure on mood disorders and psychosis: Protocol for a living systematic review of human and non-human studies (Preprint)

Article • April 2026, JMIR Publications Inc.

Professor Malcolm R Macleod
Pro-dopaminergic pharmacological interventions for anhedonia in depression: a living systematic review and network meta-analysis of human and animal studies

Article • EBioMedicine, October 2025, Elsevier

Professor Malcolm R Macleod
Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing

Article • F1000Research, September 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
A How-to Guide for Research Improvement within Research-Performing Institutions

Article • May 2025, Center for Open Science

Professor Malcolm R Macleod
Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Article • Wellcome Open Research, April 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod, Dr Ouma Simple
Building a synthesis-ready research ecosystem: fostering collaboration and open science to accelerate biomedical translation

Article • BMC Medical Research Methodology, March 2025, Springer Science + Business Media

Professor Malcolm R Macleod
The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies

Article • Wellcome Open Research, February 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod, Dr Ouma Simple
Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Article • Wellcome Open Research, January 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis

Article • F1000Research, January 2025, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Testing the usefulness of a quality system in preclinical research

Article • Neuroscience Applied, January 2025, Elsevier

Professor Malcolm R Macleod
Triangulating evidence from the GALENOS living systematic review on trace amine-associated receptor 1 (TAAR1) agonists in psychosis

Article • The British Journal of Psychiatry, December 2024, Royal College of Psychiatrists

Professor Malcolm R Macleod
Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing

Article • F1000Research, December 2024, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Article • The Lancet Neurology, November 2024, Elsevier

Professor Malcolm R Macleod
A Systematic Online Living Evidence Summary of experimental Alzheimer’s disease research

Article • Journal of Neuroscience Methods, September 2024, Elsevier

Professor Malcolm R Macleod
Strategy for developing data standards in support of automation of Systematic Reviews

Article • EFSA Supporting Publications, July 2024, Wiley

Professor Malcolm R Macleod
Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications

Article • PLoS Biology, June 2024, PLOS

Professor Malcolm R Macleod
Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data

Article • Wellcome Open Research, April 2024, Faculty of 1000, Ltd.

Professor Malcolm R Macleod, Dr Ouma Simple
Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data

Article • Nature Medicine, March 2024, Springer Science + Business Media

Professor Malcolm R Macleod
Genetically modified animals as models of neurodevelopmental conditions: A review of systematic review reporting quality

Article • Brain and Neuroscience Advances, January 2024, SAGE Publications

Professor Malcolm R Macleod
Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment

Article • The Lancet Regional Health - Europe, January 2024, Elsevier

Professor Malcolm R Macleod
Evaluating artificial intelligence software for delineating hemorrhage extent on CT brain imaging in stroke

Article • Journal of Stroke and Cerebrovascular Diseases, January 2024, Elsevier

Professor Malcolm R Macleod
Genetically-modified animals as models of neurodevelopmental conditions: a review of systematic review reporting quality

Article • November 2023, Center for Open Science

Professor Malcolm R Macleod
Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Article • Wellcome Open Research, October 2023, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies

Article • Wellcome Open Research, October 2023, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
From data deluge to publomics: How AI can transform animal research

Article • Lab Animal, September 2023, Springer Science + Business Media

Professor Malcolm R Macleod
Blood biomarker changes following therapeutic hypothermia in ischemic stroke

Article • Brain and Behavior, September 2023, Wiley

Professor Malcolm R Macleod
A Systematic Online Living Evidence Summary of experimental Alzheimer’s disease research

Article • September 2023, Center for Open Science

Professor Malcolm R Macleod
The Automated Systematic Search Deduplicator (ASySD): a rapid, open-source, interoperable tool to remove duplicate citations in biomedical systematic reviews

Article • BMC Biology, September 2023, Springer Science + Business Media

Professor Malcolm R Macleod
The UK Reproducibility Network: A progress report

Article • Journal of Neuroscience Methods, September 2023, Elsevier

Professor Malcolm R Macleod, Professor Marcus R Munafo
Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies.

Article • Wellcome Open Research, August 2023, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis

Article • BMJ Mental Health, June 2023, BMJ

Professor Malcolm R Macleod
Identifying a research agenda for postgraduate taught education in the UK: lessons from a machine learning facilitated systematic scoping review

Article • Oxford Review of Education, May 2023, Taylor & Francis

Professor Malcolm R Macleod
Accuracy of artificial intelligence software for CT angiography in stroke

Article • Annals of Clinical and Translational Neurology, May 2023, Wiley

Professor Malcolm R Macleod
Systematic online living evidence summaries: emerging tools to accelerate evidence synthesis

Article • Clinical Science, May 2023, Portland Press Ltd.

Professor Malcolm R Macleod
Designing, conducting, and reporting reproducible animal experiments

Article • Journal of Endocrinology, April 2023, Bioscientifica

Professor Malcolm R Macleod
Advanced methods and implementations for the meta-analyses of animal models: Current practices and future recommendations

Article • Neuroscience & Biobehavioral Reviews, March 2023, Elsevier

Professor Malcolm R Macleod
Screening for in vitro systematic reviews: a comparison of screening methods and training of a machine learning classifier

Article • Clinical Science, January 2023, Portland Press Ltd.

Professor Malcolm R Macleod
EFFECTS OF GALACTO-OLIGOSACCHARIDE PREBIOTICS IN THE FLINDERS SENSITIVE LINE RAT MODEL OF DEPRESSION ON BEHAVIOURAL OUTCOMES

Article • December 2022, Center for Open Science

Professor Malcolm R Macleod
Frequency and Phenotype Associations of Rare Variants in 5 Monogenic Cerebral Small Vessel Disease Genes in 200,000 UK Biobank Participants

Article • Neurology Genetics, October 2022, Wolters Kluwer Health

Professor Malcolm R Macleod
PICO entity extraction for preclinical animal literature

Article • Systematic Reviews, September 2022, Springer Science + Business Media

Professor Malcolm R Macleod
The EQIPD framework for rigor in the design, conduct, analysis and documentation of animal experiments

Article • Nature Chemical Biology, September 2022, Springer Science + Business Media

Professor Malcolm R Macleod
Screening for in vitro systematic reviews: a comparison of screening methods and training of a machine learning classifier

Article • August 2022, Center for Open Science

Professor Malcolm R Macleod
Systematic Online Living Evidence Summaries: emerging tools to accelerate evidence synthesis

Article • August 2022, Center for Open Science

Professor Malcolm R Macleod
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

Article • BMJ Open, July 2022, BMJ

Professor Malcolm R Macleod
Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research

Article • BMJ Open Science, June 2022, Portico

Professor Malcolm R Macleod
Effectiveness of biomaterial-based combination strategies for spinal cord repair – a systematic review and meta-analysis of preclinical literature

Article • Spinal Cord, May 2022, Springer Science + Business Media

Professor Malcolm R Macleod
Improving the reproducibility and integrity of research: what can different stakeholders contribute?

Article • BMC Research Notes, April 2022, Springer Science + Business Media

Professor Malcolm R Macleod
A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease

Article • April 2022, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
MDAR (Material, Design, Analysis Reporting): A Modular Framework for Transparent Reporting in the Life Sciences

Article • Editorial Office News, April 2022, International Society for Managing and Technical Editors (ISMTE)

Professor Malcolm R Macleod
What has preclinical systematic review ever done for us?

Article • BMJ Open Science, March 2022, Portico

Professor Malcolm R Macleod
The reproducibility debate is an opportunity, not a crisis

Article • BMC Research Notes, February 2022, Springer Science + Business Media

Professor Malcolm R Macleod, Professor Marcus R Munafo
Improving research quality: the view from the UK Reproducibility Network institutional leads for research improvement

Article • BMC Research Notes, December 2021, Springer Science + Business Media

Professor Malcolm R Macleod, Professor Marcus R Munafo
From grassroots to global: A blueprint for building a reproducibility network

Article • PLoS Biology, November 2021, PLOS

Professor Malcolm R Macleod, Professor Marcus R Munafo
Risk of bias assessment in preclinical literature using natural language processing

Article • Research Synthesis Methods, November 2021, Wiley

Professor Malcolm R Macleod
Using median survival in meta-analysis of experimental time-to-event data

Article • Systematic Reviews, November 2021, Springer Science + Business Media

Professor Malcolm R Macleod
PICO Entity Extraction For Preclinical Animal Literature

Article • October 2021, Springer Science + Business Media

Professor Malcolm R Macleod
Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research

Article • October 2021, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Technological advances in preclinical meta-research

Article • BMJ Open Science, July 2021, Portico

Professor Malcolm R Macleod
Building a Systematic Online Living Evidence Summary of COVID-19 Research

Article • Journal of EAHIL, June 2021, European Association for Health Information and Libraries EAHIL

Professor Malcolm R Macleod
Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol

Article • Systematic Reviews, June 2021, Springer Science + Business Media

Professor Malcolm R Macleod
Risk of Bias Assessment in Preclinical Literature using Natural Language Processing

Article • June 2021, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Introduction to the EQIPD quality system

Article • eLife, May 2021, eLife

Professor Malcolm R Macleod
Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research

Article • PLoS Biology, May 2021, PLOS

Dr Shinichi Nakagawa, Alistair Senior, Professor Malcolm R Macleod
Epidemiology and reporting characteristics of preclinical systematic reviews

Article • PLoS Biology, May 2021, PLOS

Manoj Lalu, Professor Malcolm R Macleod
The Automated Systematic Search Deduplicator (ASySD): a rapid, open-source, interoperable tool to remove duplicate citations in biomedical systematic reviews

Article • May 2021, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
The MDAR (Materials Design Analysis Reporting) Framework for transparent reporting in the life sciences

Article • Proceedings of the National Academy of Sciences, April 2021, Proceedings of the National Academy of Sciences

Professor Malcolm R Macleod
Regulatory delays in a multinational clinical stroke trial

Article • European Stroke Journal, March 2021, SAGE Publications

Professor Malcolm R Macleod
Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in animal models of injury-related or pathological persistent pain

Article • Pain, March 2021, Wolters Kluwer Health

Professor Malcolm R Macleod
Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)

Article • BMJ Open Science, March 2021, Portico

Professor Malcolm R Macleod
Results of a randomised controlled trial comparing two different incentives to improve survey response rates

Article • February 2021, Center for Open Science

Professor Malcolm R Macleod
Using Median Survival in Meta-analysis of Experimental Time-to-event Data

Article • February 2021, Springer Science + Business Media

Professor Malcolm R Macleod
Protocol for an analysis of in vivo reporting standards by journal, institution and funder

Article • February 2021, Center for Open Science

Professor Malcolm R Macleod
Comparison of commonly used methods in random effects meta-analysis: application to preclinical data in drug discovery research

Article • BMJ Open Science, February 2021, Portico

Professor Malcolm R Macleod
Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes

Article • Journal of Translational Medicine, December 2020, Springer Science + Business Media

Professor Malcolm R Macleod
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Article • The Lancet, November 2020, Elsevier

DMSci, Neurologist Helle K. Iversen, Professor Malcolm R Macleod, Dr Toshimitsu Hamasaki
Feasibility of reporting results of large randomised controlled trials to participants: experience from the Fluoxetine Or Control Under Supervision (FOCUS) trial

Article • BMJ Open, November 2020, BMJ

Alison McLoughlin, Professor Malcolm R Macleod
Effects of dietary fat manipulation on cognition in mice and rats: protocol for a systematic review and meta-analysisEffects of dietary fat manipulation on cognition in mice and rats: protocol for a systematic review and meta-analysis

Article • BMJ Open Science, November 2020, Portico

Professor Malcolm R Macleod
Red Blood Cell Transfusion in Animal Models of Acute Brain Injuries: A Systematic Review Protocol

Article • October 2020, Springer Science + Business Media

Professor Malcolm R Macleod
Embrace heterogeneity to improve reproducibility: A perspective from meta-analysis of variation in preclinical research

Article • October 2020, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days

Article • F1000Research, October 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol

Article • F1000Research, October 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days

Article • F1000Research, October 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
A Systematic Review and Meta-Analysis of Hypothermia in Experimental Traumatic Brain Injury: Why Have Promising Animal Studies Not Been Replicated in Pragmatic Clinical Trials?

Article • Journal of Neurotrauma, October 2020, Mary Ann Liebert Inc

Professor Malcolm R Macleod
Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study

Article • The Lancet Psychiatry, October 2020, Elsevier

Professor Malcolm R Macleod, James Sun
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Article • PLoS Biology, July 2020, PLOS

Professor Malcolm R Macleod
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

Article • PLoS Biology, July 2020, PLOS

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Article • Experimental Physiology, July 2020, Wiley

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

Article • Journal of Cerebral Blood Flow & Metabolism, July 2020, SAGE Publications

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Article • BMC Veterinary Research, July 2020, Springer Science + Business Media

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Article • British Journal of Pharmacology, July 2020, Wiley

Professor Malcolm R Macleod
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

Article • The Journal of Physiology, July 2020, Wiley

Professor Malcolm R Macleod
Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol

Article • F1000Research, June 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod, David Ripsman, Manoj Lalu, Lindsey Sikora, Dr C.Glenn Begley
Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan

Article • AMRC Open Research, April 2020, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals

Article • BMJ Open Science, April 2020, BMJ

Professor Malcolm R Macleod
FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research

Article • Journal of Neurotrauma, March 2020, Mary Ann Liebert Inc

Professor Malcolm R Macleod
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings

Article • Journal of Cerebral Blood Flow & Metabolism, March 2020, SAGE Publications

Dr Atticus H Hainsworth, Professor Malcolm R Macleod
Introducing our series: research synthesis and meta-research in biology

Article • BMC Biology, March 2020, Springer Science + Business Media

Professor Malcolm R Macleod
Framework for advancing rigorous research

Article • eLife, March 2020, eLife

Professor Malcolm R Macleod, Professor Marcus R Munafo
Meta-analysis of targeted temperature management in animal models of cardiac arrest

Article • Intensive Care Medicine Experimental, January 2020, Springer Science + Business Media

Professor Malcolm R Macleod
Research Culture and Reproducibility

Article • Trends in Cognitive Sciences, December 2019, Elsevier

Professor Marcus R Munafo, Professor Malcolm R Macleod
Ischaemic stroke

Article • Nature Reviews Disease Primers, October 2019, Springer Science + Business Media

Professor Malcolm R Macleod
Compressive Pressure Versus Time in Cauda Equina Syndrome

Article • Spine, September 2019, Wolters Kluwer Health

Professor Malcolm R Macleod
The ARRIVE guidelines 2019: updated guidelines for reporting animal research

Article • July 2019, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019

Article • July 2019, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Article • The Lancet Neurology, July 2019, Elsevier

Professor Malcolm R Macleod, Frank Sullivan, Dr William D Strain, Alison McLoughlin
Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

Article • The Lancet, July 2019, Elsevier

Professor Malcolm R Macleod
A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

Article • Research Integrity and Peer Review, June 2019, Springer Science + Business Media

Professor Malcolm R Macleod, Dr marco cascella
Outcome heterogeneity and bias in acute experimental spinal cord injury

Article • Neurology, June 2019, Wolters Kluwer Health

Professor Malcolm R Macleod
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

Article • The Lancet, June 2019, Elsevier

Professor Malcolm R Macleod, Frank Sullivan, Dr William D Strain, Alison McLoughlin
Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis

Article • PLoS Biology, May 2019, PLOS

Professor Malcolm R Macleod
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, May 2019, New England Journal of Medicine (NEJM/MMS)

Professor Malcolm R Macleod
Administration of galacto-oligosaccharide prebiotics in the Flinders Sensitive Line animal model of depression

Article • BMJ Open Science, May 2019, BMJ

Professor Malcolm R Macleod
Protocol for a systematic review and meta-analysis of data from preclinical studies employing forced swimming test: an update

Article • BMJ Open Science, May 2019, BMJ

Professor Malcolm R Macleod
Towards minimum reporting standards for life scientists

Article • April 2019, Center for Open Science

Professor Malcolm R Macleod
Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial

Article • European Stroke Journal, April 2019, SAGE Publications

Professor Malcolm R Macleod
A European initiative to unclog pipeline for new medicines

Article • Nature, April 2019, Springer Science + Business Media

Professor Malcolm R Macleod
The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews

Article • Wellcome Open Research, March 2019, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Reader response: Evaluating depression and suicidality in tetrabenazine users with Huntington disease

Article • Neurology, February 2019, Wolters Kluwer Health

Professor Malcolm R Macleod, Professor Marcus R Munafo
Did a change in Nature journals’ editorial policy for life sciences research improve reporting?

Article • BMJ Open Science, February 2019, Portico

Professor Malcolm R Macleod
Warlow's Stroke

Article • January 2019, Wiley

Professor Malcolm R Macleod
The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews

Article • Wellcome Open Research, January 2019, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Machine learning algorithms for systematic review: reducing workload in a preclinical review of animal studies and reducing human screening error

Article • Systematic Reviews, January 2019, Springer Science + Business Media

Professor Malcolm R Macleod
Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

Article • F1000Research, January 2019, Faculty of 1000, Ltd.

Manoj Lalu, Dale Corbett, Professor Malcolm R Macleod, Annette O'Connor, Fatima Haggar
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Article • The Lancet, January 2019, Elsevier

Associate Professor Erik Lundström, Professor Malcolm R Macleod, Frank Sullivan, Dr William D Strain, Alison McLoughlin, Professor Marian C Brady
Design of Meta-Analysis Studies

Article • January 2019, Springer Science + Business Media

Professor Malcolm R Macleod
Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis

Article • Brain Communications, January 2019, Oxford University Press (OUP)

Professor Malcolm R Macleod
Reproducibility and Rigor in Animal-Based Research

Article • ILAR Journal, January 2019, Oxford University Press (OUP)

Professor Malcolm R Macleod
The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews

Article • Wellcome Open Research, December 2018, Faculty of 1000, Ltd.

Professor Malcolm R Macleod
Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis

Article • BMJ, November 2018, BMJ

Professor Malcolm R Macleod
Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals

Article • BMJ Open Science, September 2018, BMJ

Professor Malcolm R Macleod
The reproducibility opportunity

Article • Nature Human Behaviour, August 2018, Springer Science + Business Media

Professor Malcolm R Macleod
NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons

Article • Journal of Stroke and Cerebrovascular Diseases, August 2018, Elsevier

Professor Malcolm R Macleod
A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

Article • July 2018, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. Rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment

Article • European Stroke Journal, April 2018, SAGE Publications

Professor Malcolm R Macleod
Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Article • Clinical Science, April 2018, Portland Press Ltd.

Professor Malcolm R Macleod, Dr Atticus H Hainsworth
Effect size and statistical power in the rodent fear conditioning literature – A systematic review

Article • PLOS One, April 2018, PLOS

Professor Malcolm R Macleod
Animal models of chemotherapy-induced peripheral neuropathy: a machine-assisted systematic review and meta-analysis A comprehensive summary of the field to inform robust experimental design

Article • April 2018, Cold Spring Harbor Laboratory Press

Rosemary Morland, Professor Malcolm R Macleod
Automation of citation screening in pre-clinical systematic reviews

Article • March 2018, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial

Article • Trials, March 2018, Springer Science + Business Media

Dr William D Strain, Alison McLoughlin, Professor Malcolm R Macleod
Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Article • The Lancet, March 2018, Elsevier

Alison McLoughlin, Professor Malcolm R Macleod
The use of text-mining and machine learning algorithms in systematic reviews: reducing workload in preclinical biomedical sciences and reducing human screening error

Article • January 2018, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

Article • Oncotarget, January 2018, Impact Journals, LLC

Professor Malcolm R Macleod
Estimating the statistical performance of different approaches to meta-analysis of data from animal studies in identifying the impact of aspects of study design

Article • January 2018, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

Article • PLOS One, January 2018, PLOS

Professor Malcolm R Macleod
Learning lessons from MVA85A, a failed booster vaccine for BCG

Article • BMJ, January 2018, BMJ

Professor Malcolm R Macleod
Transparency in the reporting of in vivo pre-clinical pain research: The relevance and implications of the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines

Article • Scandinavian Journal of Pain, December 2017, De Gruyter

Rosemary Morland, Professor Malcolm R Macleod
Correction: D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

Article • PLOS One, December 2017, PLOS

Professor Malcolm R Macleod
Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke

Article • Trials, November 2017, Springer Science + Business Media

Professor Malcolm R Macleod
Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE

Article • Epilepsia, November 2017, Wiley

Professor Malcolm R Macleod
Living systematic reviews: 2. Combining human and machine effort

Article • Journal of Clinical Epidemiology, November 2017, Elsevier

Dr Arwel W Jones, Professor Luke Wolfenden, Professor Malcolm R Macleod
Living systematic reviews: 3. Statistical methods for updating meta-analyses

Article • Journal of Clinical Epidemiology, November 2017, Elsevier

Dr Arwel W Jones, Professor Luke Wolfenden, Professor Malcolm R Macleod
Living systematic reviews: 4. Living guideline recommendations

Article • Journal of Clinical Epidemiology, November 2017, Elsevier

Dr Arwel W Jones, Professor Luke Wolfenden, Professor Malcolm R Macleod, Professor Marcus R Munafo
Risk of bias reporting in the recent animal focal cerebral ischaemia literature

Article • Clinical Science, October 2017, Portland Press Ltd.

Professor Malcolm R Macleod
Marine-derived n-3 fatty acids therapy for stroke

Article • Cochrane Database of Systematic Reviews, October 2017, Wiley

Professor Malcolm R Macleod
The Experimental Design Assistant

Article • Nature Chemical Biology, September 2017, Nature

Professor Malcolm R Macleod
The Experimental Design Assistant

Article • PLoS Biology, September 2017, PLOS

Professor Malcolm R Macleod
Findings of a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution

Article • September 2017, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Standardized mean differences cause funnel plot distortion in publication bias assessments

Article • eLife, September 2017, eLife

Professor Malcolm R Macleod
Living systematic review: 1. Introduction—the why, what, when, and how

Article • Journal of Clinical Epidemiology, September 2017, Elsevier

Mr John Hilton, Dr Arwel W Jones, Professor Luke Wolfenden, Professor Malcolm R Macleod, Professor Marcus R Munafo
D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

Article • PLOS One, August 2017, PLOS

Dr Saeed Sadigh-Eteghad, Professor Malcolm R Macleod
Development of a psychological intervention for fatigue after stroke

Article • PLOS One, August 2017, PLOS

Professor Malcolm R Macleod
The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Article • Journal of Cerebral Blood Flow & Metabolism, August 2017, SAGE Publications

Professor Malcolm R Macleod
Alpha Calcitonin Gene-Related Peptide Increases Cerebral Vessel Diameter in Animal Models of Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis

Article • Frontiers in Neurology, July 2017, Frontiers

Professor Malcolm R Macleod
Increasing value and reducing waste in stroke research

Article • The Lancet Neurology, May 2017, Elsevier

Professor Malcolm R Macleod
Conjugal amyotrophic lateral sclerosis: a case report from Scotland

Article • BMC Neurology, March 2017, Springer Science + Business Media

Professor Malcolm R Macleod
Effect size and statistical power in the rodent fear conditioning literature - a systematic review

Article • March 2017, Cold Spring Harbor Laboratory Press

Professor Malcolm R Macleod
Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials

Article • PLOS One, February 2017, PLOS

Professor Malcolm R Macleod
No publication without confirmation

Article • Nature, February 2017, Springer Science + Business Media

Professor Malcolm R Macleod
Hypothermia revisited: Impact of ischaemic duration and between experiment variability

Article • Journal of Cerebral Blood Flow & Metabolism, January 2017, SAGE Publications

Professor Malcolm R Macleod
Improving our understanding of thein vivomodelling of psychotic disorders: A protocol for a systematic review and meta‐analysis

Article • Evidence-based Preclinical Medicine, December 2016, Wiley

Professor Malcolm R Macleod
Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis

Article • Evidence-based Preclinical Medicine, December 2016, Wiley

Professor Malcolm R Macleod
Understanding in vivo modelling of depression in non-human animals: a systematic review protocol

Article • Evidence-based Preclinical Medicine, December 2016, Wiley

Professor Malcolm R Macleod
Protocols for laboratory research

Article • Evidence-based Preclinical Medicine, December 2016, Wiley

Professor Malcolm R Macleod
Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

Article • eLife, November 2016, eLife

Professor Malcolm R Macleod
The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research

Article • PLOS One, November 2016, PLOS

Professor Malcolm R Macleod
Study protocol - A systematic review and meta-analysis of hypothermia in experimental traumatic brain injury: Why have promising animal studies not been replicated in pragmatic clinical trials?

Article • Evidence-based Preclinical Medicine, October 2016, Wiley

Professor Malcolm R Macleod
Multicenter Evaluation of Geometric Accuracy of MRI Protocols Used in Experimental Stroke

Article • PLOS One, September 2016, PLOS

Professor Malcolm R Macleod
Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke: an Update

Article • Translational Stroke Research, August 2016, Springer Science + Business Media

Professor Malcolm R Macleod
Protocol for a systematic review of effect sizes and statistical power in the rodent fear conditioning literature

Article • Evidence-based Preclinical Medicine, July 2016, Wiley

Professor Malcolm R Macleod
The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis

Article • PLOS One, July 2016, PLOS

Professor Malcolm R Macleod
From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer's disease mouse models

Article • Evidence-based Preclinical Medicine, July 2016, Wiley

Professor Malcolm R Macleod
A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

Article • Environmental Health, July 2016, Springer Science + Business Media

Professor Malcolm R Macleod, Professor Susan Jobling
Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets

Article • Nature Reviews Cancer, June 2016, Nature

Professor Malcolm R Macleod
Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

Article • PLoS Biology, May 2016, PLOS

Professor Malcolm R Macleod
SWIFT-Review: a text-mining workbench for systematic review

Article • Systematic Reviews, May 2016, Springer Science + Business Media

Professor Malcolm R Macleod
Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals’ editorial policy for life sciences research on the completeness of reporting study design and execution

Article • Scientometrics, May 2016, Springer Science + Business Media

Professor Malcolm R Macleod
Cause of Death and Predictors of All‐Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF

Article • Journal of the American Heart Association, March 2016, Wolters Kluwer Health

Professor Malcolm R Macleod, Professor Dmitry Zateyshchikov, Professor Yuriy M. Sirenko
Cardiac Stem Cell Treatment in Myocardial InfarctionNovelty and Significance

Article • Circulation Research, February 2016, Wolters Kluwer Health

Professor Joost PG Sluijter, Professor Malcolm R Macleod
Corrigendum to ‘Meta-analysis of data from animal studies: A practical guide’

Article • Journal of Neuroscience Methods, February 2016, Elsevier

Professor Malcolm R Macleod
How to Avoid Bumping into the Translational Roadblock

Article • January 2016, Springer Science + Business Media

Professor Malcolm R Macleod
AVERT 2 (a very early rehabilitation trial, a very effective reproductive trigger): retrospective observational analysis of the number of babies born to trial staff

Article • BMJ, December 2015, BMJ

Professor Julie Bernhardt, Professor Malcolm R Macleod, Professor Amanda G Thrift
Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke

Article • Neurology, December 2015, Wolters Kluwer Health

Professor Malcolm R Macleod
Correction: Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Article • PLoS Biology, November 2015, PLOS

Professor Malcolm R Macleod
Informatics: Make sense of health data

Article • Nature, November 2015, Nature

Professor Malcolm R Macleod
How individual participant data meta-analyses have influenced trial design, conduct, and analysis

Article • Journal of Clinical Epidemiology, November 2015, Elsevier

Professor Malcolm R Macleod
Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

Article • Cardiovascular Research, October 2015, European Society of Cardiology

Professor Malcolm R Macleod
Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Article • PLoS Biology, October 2015, PLOS

Professor Malcolm R Macleod
The Clots in Legs Or sTockings after Stroke (CLOTS) 3 trial: a randomised controlled trial to determine whether or not intermittent pneumatic compression reduces the risk of post-stroke deep vein thrombosis and to estimate its cost-effectiveness

Article • Health Technology Assessment, September 2015, National Institute for Health Research

Professor Malcolm R Macleod
Consent for Brain Tissue Donation after Intracerebral Haemorrhage: A Community-Based Study

Article • PLOS One, August 2015, PLOS

Professor Malcolm R Macleod
Exploring threats to generalisability in a large international rehabilitation trial (AVERT)

Article • BMJ Open, August 2015, BMJ

Professor Malcolm R Macleod, Professor Julie Bernhardt, Professor Amanda G Thrift
Interventions for post-stroke fatigue

Article • Cochrane Database of Systematic Reviews, July 2015, Wiley

Professor Malcolm R Macleod
Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial

Article • The Lancet, July 2015, Elsevier

Professor Malcolm R Macleod, Professor Julie Bernhardt, Professor Amanda G Thrift
Effect of Endothelin Receptor Antagonists on Clinically Relevant Outcomes after Experimental Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

Article • Journal of Cerebral Blood Flow & Metabolism, July 2015, SAGE Publications

Professor Malcolm R Macleod
Prof Benchie and Dr Athena-A modern tragedy…

Article • Evidence-based Preclinical Medicine, June 2015, Wiley

Professor Malcolm R Macleod
Increasing value and reducing waste in animal models of rheumatological disease

Article • International Journal of Rheumatic Diseases, June 2015, Wiley

Professor Malcolm R Macleod
Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis

Article • PLOS One, April 2015, PLOS

Professor Malcolm R Macleod
Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial

Article • The Lancet Neurology, April 2015, Elsevier

Professor Malcolm R Macleod
Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium

Article • Scandinavian Journal of Pain, April 2015, De Gruyter

Professor Malcolm R Macleod
Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

Article • BMJ, March 2015, BMJ

Professor Malcolm R Macleod
Magnetic Resonance Imaging in Experimental Stroke and Comparison With Histology

Article • Stroke, February 2015, Wolters Kluwer Health

Professor Malcolm R Macleod
Model of Understanding Fatigue After Stroke

Article • Stroke, February 2015, Wolters Kluwer Health

Professor Malcolm R Macleod, Trudie Chalder
Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome

Article • Stroke, February 2015, Wolters Kluwer Health

Professor Malcolm R Macleod
A systematic review and meta‐analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

Article • Evidence-based Preclinical Medicine, December 2014, Wiley

Professor Malcolm R Macleod
Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

Article • Pain, December 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Effect of intermittent pneumatic compression on disability, living circumstances, quality of life, and hospital costs after stroke: secondary analyses from CLOTS 3, a randomised trial

Article • The Lancet Neurology, December 2014, Elsevier

Professor Malcolm R Macleod
Similar Effect of Autologous and Allogeneic Cell Therapy for Ischemic Heart Disease: Systematic Review and Meta-Analysis of Large Animal Studies

Article • Circulation Research, September 2014, Wolters Kluwer Health

Miss Sanne J. Jansen of Lorkeers, Professor Malcolm R Macleod
Efficacy of Antidepressants in Animal Models of Ischemic Stroke: A Systematic Review and Meta-Analysis

Article • Stroke, September 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Preclinical research: Design animal studies better

Article • Nature, June 2014, Nature

Professor Malcolm R Macleod
Efficacy and Safety of Rivaroxaban Compared With Warfarin Among Elderly Patients With Nonvalvular Atrial Fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embol...

Article • Circulation, June 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
EuroHYP-1: European Multicenter, Randomized, Phase III Clinical Trial of Therapeutic Hypothermia plus Best Medical Treatment vs. Best Medical Treatment Alone for Acute Ischemic Stroke

Article • International Journal of Stroke, May 2014, SAGE Publications

Professor Malcolm R Macleod
End-of-life decisions in patients with severe acute brain injury

Article • The Lancet Neurology, May 2014, Elsevier

Professor Malcolm R Macleod
Psychological Associations of Poststroke Fatigue: A Systematic Review and Meta-Analysis

Article • Stroke, April 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Using Animal Models to Understand Cancer Pain in Humans

Article • Current Review of Pain, April 2014, Springer Science + Business Media

Professor Malcolm R Macleod
Outcome After Conservative Management or Intervention for Unruptured Brain Arteriovenous Malformations

Article • JAMA, April 2014, American Medical Association (AMA)

Professor Malcolm R Macleod
Clopidogrel Plus Aspirin Versus Warfarin in Patients With Stroke and Aortic Arch Plaques

Article • Stroke, April 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Research: increasing value, reducing waste – Authors' reply

Article • The Lancet, March 2014, Elsevier

Professor Malcolm R Macleod
Systematic Reviews and Meta-Analysis of Preclinical Studies: Why Perform Them and How to Appraise Them Critically

Article • Journal of Cerebral Blood Flow & Metabolism, February 2014, SAGE Publications

Professor Malcolm R Macleod
Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery

Article • Neurorehabilitation and Neural Repair, February 2014, SAGE Publications

Professor Malcolm R Macleod, Professor Julie Bernhardt
Therapeutic Hypothermia and the Risk of Infection

Article • Critical Care Medicine, February 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
A (mini) pill for stroke?

Article • Brain, February 2014, Oxford University Press (OUP)

Professor Malcolm R Macleod
Some Salt with Your Statin, Professor?

Article • PLoS Biology, January 2014, PLOS

Professor Malcolm R Macleod
Hypothermia Protects Human Neurons

Article • International Journal of Stroke, January 2014, SAGE Publications

Professor Malcolm R Macleod
Systematic Review and Meta-Analysis of Interventions Tested in Animal Models of Lacunar Stroke

Article • Stroke, January 2014, Wolters Kluwer Health

Professor Malcolm R Macleod
Meta-analysis of data from animal studies: A practical guide

Article • Journal of Neuroscience Methods, January 2014, Elsevier

Professor Malcolm R Macleod
Increasing value and reducing waste in research design, conduct, and analysis

Article • The Lancet, January 2014, Elsevier

Professor Malcolm R Macleod
Increasing value and reducing waste in biomedical research regulation and management

Article • The Lancet, January 2014, Elsevier

Professor Malcolm R Macleod, Bob Phillips
Effect and Reporting Bias of RhoA/ROCK-Blockade Intervention on Locomotor Recovery After Spinal Cord Injury

Article • JAMA Neurology, January 2014, American Medical Association (AMA)

Professor Malcolm R Macleod
Biomedical research: increasing value, reducing waste

Article • The Lancet, January 2014, Elsevier

Professor Malcolm R Macleod
Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol

Article • Systematic Reviews, January 2014, Springer Science + Business Media

Professor Malcolm R Macleod
Stem Cell Transplantation in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Animal Studies

Article • PLoS Biology, December 2013, PLOS

Professor Malcolm R Macleod
Edoxaban versus Warfarin in Patients with Atrial Fibrillation

Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, November 2013, New England Journal of Medicine (NEJM/MMS)

Professor Malcolm R Macleod, Prof. Elisabeta Badila, DMSci, Neurologist Helle K. Iversen, Professor Dmitry Zateyshchikov, Professor Yuriy M. Sirenko
Bringing rigour to translational medicine

Article • Nature Reviews Neurology, November 2013, Springer Science + Business Media

Professor Malcolm R Macleod
Edaravone Improves Functional and Structural Outcomes in Animal Models of Focal Cerebral Ischemia: A Systematic Review

Article • International Journal of Stroke, October 2013, SAGE Publications

Professor Malcolm R Macleod
Meta-Analysis of Pre-Clinical Studies of Early Decompression in Acute Spinal Cord Injury: A Battle of Time and Pressure

Article • PLOS One, August 2013, PLOS

Professor Malcolm R Macleod
Systematic Review and Meta-Analysis of Therapeutic Hypothermia in Animal Models of Spinal Cord Injury

Article • PLOS One, August 2013, PLOS

Professor Malcolm R Macleod
Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial

Article • The Lancet, August 2013, Elsevier

Professor Malcolm R Macleod
Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

Article • PLoS Biology, July 2013, PLOS

Professor Malcolm R Macleod
Hypertension and Experimental Stroke Therapies

Article • Journal of Cerebral Blood Flow & Metabolism, June 2013, SAGE Publications

Professor Malcolm R Macleod
Animal models of bone cancer pain: Systematic review and meta-analyses

Article • Pain, June 2013, Wolters Kluwer Health

Professor Malcolm R Macleod
Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke

Article • Systematic Reviews, May 2013, Springer Science + Business Media

Professor Malcolm R Macleod
Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis

Article • Pain, May 2013, Wolters Kluwer Health

Professor Malcolm R Macleod
A Concerted Appeal for International Cooperation in Preclinical Stroke Research

Article • Stroke, April 2013, Wolters Kluwer Health

Professor Malcolm R Macleod
Evidence-based Translational Medicine

Article • Stroke, April 2013, Wolters Kluwer Health

Professor Malcolm R Macleod
Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?

Article • British Journal of Cancer, January 2013, Springer Science + Business Media

Professor Malcolm R Macleod
Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial

Article • Trials, October 2012, Springer Science + Business Media

Professor Malcolm R Macleod
A call for transparent reporting to optimize the predictive value of preclinical research

Article • Nature, October 2012, Springer Science + Business Media

Professor Malcolm R Macleod, John Huguenard
Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial

Article • The Lancet, October 2012, Elsevier

Professor Malcolm R Macleod
The Benefit of Hypothermia in Experimental Ischemic Stroke is Not Affected by Pethidine

Article • International Journal of Stroke, July 2012, SAGE Publications

Professor Malcolm R Macleod
Improving the Efficiency of the Development of Drugs for Stroke

Article • International Journal of Stroke, June 2012, SAGE Publications

Professor Malcolm R Macleod
Translational Research

Article • International Journal of Stroke, June 2012, SAGE Publications

Professor Malcolm R Macleod
Stem Cell-Based Therapy for Experimental Stroke: A Systematic Review and Meta-Analysis

Article • International Journal of Stroke, June 2012, SAGE Publications

Professor Malcolm R Macleod
Voltage-gated potassium channel antibody-related encephalopathy: a case which may extend the documented phenotype of this condition

Article • BMJ Case Reports, June 2012, BMJ

Professor Malcolm R Macleod
The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

Article • The Lancet, June 2012, Elsevier

Professor Malcolm R Macleod, Dr William D Strain, Associate Professor Erik Lundström
Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial

Article • The Lancet Neurology, June 2012, Elsevier

Professor Malcolm R Macleod, Prof. J. David Spence
Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

Article • Journal of Cerebral Blood Flow & Metabolism, April 2012, SAGE Publications

Professor Malcolm R Macleod
Vorapaxar in the Secondary Prevention of Atherothrombotic Events

Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, April 2012, New England Journal of Medicine (NEJM/MMS)

Professor Malcolm R Macleod, M.D Ph.D Serge Timsit, DMSci, Neurologist Helle K. Iversen
Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF

Article • The Lancet Neurology, April 2012, Elsevier

Professor Malcolm R Macleod
Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study

Article • The Lancet Neurology, March 2012, Elsevier

Professor Malcolm R Macleod
Evaluation of Combination Therapy in Animal Models of Cerebral Ischemia

Article • Journal of Cerebral Blood Flow & Metabolism, February 2012, SAGE Publications

Professor Malcolm R Macleod
Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited

Article • Trials, November 2011, Springer Science + Business Media

Professor Malcolm R Macleod, Associate Professor Erik Lundström
The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials

Article • Journal of Thrombosis and Haemostasis, November 2011, Wiley

Professor Malcolm R Macleod
Preclinical studies of human disease: Time to take methodological quality seriously

Article • Journal of Molecular and Cellular Cardiology, October 2011, Elsevier

Professor Malcolm R Macleod
Why animal research needs to improve

Article • Nature, September 2011, Springer Science + Business Media

Professor Malcolm R Macleod
Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, September 2011, New England Journal of Medicine (NEJM/MMS)

Professor Malcolm R Macleod
Sodium and chloride channelopathies with myositis: Coincidence or connection?

Article • Muscle & Nerve, June 2011, Wiley

Professor Malcolm R Macleod
Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial

Article • The Lancet, June 2011, Elsevier

Professor Malcolm R Macleod, Prof. Dr. Otto W. Witte, Professor Ivan G. Milanov
Dopamine agonists in animal models of Parkinson’s disease: A systematic review and meta-analysis

Article • Parkinsonism & Related Disorders, June 2011, Elsevier

Professor Malcolm R Macleod
Not Tonight, Darling, I Might Get a Headache

Article • Stroke, May 2011, Wolters Kluwer Health

Professor Malcolm R Macleod
Systematic Survey of the Design, Statistical Analysis, and Reporting of Studies Published in the 2008 Volume of the Journal of Cerebral Blood Flow and Metabolism

Article • Journal of Cerebral Blood Flow & Metabolism, April 2011, SAGE Publications

Professor Malcolm R Macleod
Treatment of intracerebral hemorrhage in animal models: Meta-analysis

Article • Annals of Neurology, February 2011, Wiley

Professor Malcolm R Macleod
Systematic Survey of the Design, Statistical Analysis, and Reporting of Studies Published in the 2008 Volume of theJournal of Cerebral Blood Flow and Metabolism

Article • Journal of Cerebral Blood Flow & Metabolism, December 2010, SAGE Publications

Professor Malcolm R Macleod
Animal models of neurological disease: are there any babies in the bathwater?

Article • Practical Neurology, November 2010, BMJ

Professor Malcolm R Macleod
Hypothermia for Stroke: Call to Action 2010

Article • International Journal of Stroke, November 2010, SAGE Publications

Professor Malcolm R Macleod
Preclinical Drug Evaluation for Combination Therapy in Acute Stroke Using Systematic Review, Meta-Analysis, and Subsequent Experimental Testing

Article • Journal of Cerebral Blood Flow & Metabolism, October 2010, SAGE Publications

Professor Malcolm R Macleod
B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial

Article • The Lancet Neurology, September 2010, Elsevier

Professor Malcolm R Macleod, Prof. J. David Spence
Improving the translational hit of experimental treatments in multiple sclerosis

Article • Multiple Sclerosis Journal, August 2010, SAGE Publications

Professor Malcolm R Macleod
Factors Affecting the Apparent Efficacy and Safety of Tissue Plasminogen Activator in Thrombotic Occlusion Models of Stroke: Systematic Review and Meta-Analysis

Article • Journal of Cerebral Blood Flow & Metabolism, July 2010, SAGE Publications

Professor Malcolm R Macleod
Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia

Article • Journal of Cerebral Blood Flow & Metabolism, May 2010, SAGE Publications

Professor Malcolm R Macleod
Comment on "Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome"

Article • Science, May 2010, American Association for the Advancement of Science

Professor Malcolm R Macleod
Therapeutic Hypothermia for Acute Ischemic Stroke: Ready to Start Large Randomized Trials?

Article • Journal of Cerebral Blood Flow & Metabolism, March 2010, SAGE Publications

Professor Malcolm R Macleod
Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Article • PLoS Biology, March 2010, PLOS

Professor Malcolm R Macleod
Can Animal Models of Disease Reliably Inform Human Studies?

Article • PLoS Medicine, March 2010, PLOS

Professor Malcolm R Macleod
How to Avoid Bumping into the Translational Roadblock

Article • January 2010, Springer Science + Business Media

Professor Malcolm R Macleod
A Systematic Review and Meta-Analysis of Erythropoietin in Experimental Stroke

Article • Journal of Cerebral Blood Flow & Metabolism, December 2009, SAGE Publications

Professor Malcolm R Macleod
Emulating Multicentre Clinical Stroke Trials: A New Paradigm for Studying Novel Interventions in Experimental Models of Stroke

Article • International Journal of Stroke, December 2009, SAGE Publications

Professor Malcolm R Macleod
Bacterial meningitis associated with a complex ischiorectal abscess

Article • Journal of Clinical Neuroscience, December 2009, Elsevier

Professor Malcolm R Macleod
Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice

Article • British Journal of Pharmacology, August 2009, Wiley

Professor Malcolm R Macleod
Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke

Article • Journal of Stroke and Cerebrovascular Diseases, July 2009, Elsevier

Professor Malcolm R Macleod
Scope of Preclinical Testing Versus Quality Control Within Experiments

Article • Stroke, June 2009, Wolters Kluwer Health

Professor Malcolm R Macleod
Injury-induced mineralocorticoid receptor expression involves differential promoter usage: A novel role for the rat MRβ variant

Article • Molecular and Cellular Endocrinology, June 2009, Elsevier

Professor Malcolm R Macleod
Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial

Article • The Lancet, June 2009, Elsevier

Professor Malcolm R Macleod
Reprint: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Article • Journal of Cerebral Blood Flow & Metabolism, June 2009, SAGE Publications

Professor Malcolm R Macleod
Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for Extended Window Acute Stroke Therapy Trials

Article • Stroke, May 2009, Wolters Kluwer Health

Professor Malcolm R Macleod
Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial

Article • The Lancet Neurology, April 2009, Elsevier

Professor Malcolm R Macleod
Mineralocorticoid receptor mRNA expression is increased in human hippocampus following brief cerebral ischaemia

Article • Neuropathology and Applied Neurobiology, April 2009, Wiley

Professor Malcolm R Macleod
Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

Article • Stroke, February 2009, Wolters Kluwer Health

Professor Malcolm R Macleod
REPRINT: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Article • International Journal of Stroke, February 2009, SAGE Publications

Professor Malcolm R Macleod
Effect of hyperthermia and anoxia on glucocorticoid and mineralocorticoid receptor expression in neonatal rat hippocampus

Article • Neuroscience Letters, January 2009, Elsevier

Professor Malcolm R Macleod
Rationale and Design of a Randomized, Double-Blind, Parallel-Group Study of Terutroban 30 mg/day versus Aspirin 100 mg/day in Stroke Patients: The Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin with Terutroban in Patients wi...

Article • Cerebrovascular Diseases, January 2009, Karger Publishers

Professor Malcolm R Macleod, Prof. Dr. Otto W. Witte, Professor Ivan G. Milanov
General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial

Article • The Lancet, December 2008, Elsevier

Professor Malcolm R Macleod, Alba Piroli, Professor David Torgerson, Dr. Ron Milo, Prof. Endre Pal
The Future of Restorative Neurosciences in Stroke: Driving the Translational Research Pipeline From Basic Science to Rehabilitation of People After Stroke

Article • Neurorehabilitation and Neural Repair, November 2008, SAGE Publications

Professor Malcolm R Macleod
What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma

Article • Journal of Neuro-Oncology, September 2008, Springer Science + Business Media

Professor Malcolm R Macleod
Reprint: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Article • Journal of Cerebral Blood Flow & Metabolism, September 2008, SAGE Publications

Professor Malcolm R Macleod
Secondary prevention of stroke – Authors' reply

Article • The Lancet, September 2008, Elsevier

Professor Malcolm R Macleod
Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Article • Stroke, August 2008, Wolters Kluwer Health

Professor Malcolm R Macleod
Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Article • Stroke, July 2008, Wolters Kluwer Health

Professor Malcolm R Macleod
Stroke

Article • The Lancet, May 2008, Elsevier

Professor Malcolm R Macleod
Predicting outcome in hyper-acute stroke: validation of a prognostic model in the Third International Stroke Trial (IST3)

Article • Journal of Neurology Neurosurgery & Psychiatry, April 2008, BMJ

Professor Malcolm R Macleod
Outcome after interventional or conservative management of unruptured brain arteriovenous malformations: a prospective, population-based cohort study

Article • The Lancet Neurology, March 2008, Elsevier

Professor Malcolm R Macleod
Empirical Evidence of Bias in the Design of Experimental Stroke Studies: A Metaepidemiologic Approach

Article • Stroke, January 2008, Wolters Kluwer Health

Professor Malcolm R Macleod
A Systematic Review and Meta-Analysis of the Efficacy of Piracetam and Piracetam-Like Compounds in Experimental Stroke

Article • Cerebrovascular Diseases, November 2007, Karger Publishers

Professor Malcolm R Macleod
How can we improve the pre-clinical development of drugs for stroke?

Article • Trends in Neurosciences, September 2007, Elsevier

Professor Malcolm R Macleod
Vanishing diplopia: a problem case

Article • Practical Neurology, August 2007, BMJ

Professor Malcolm R Macleod
Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis

Article • Brain, May 2007, Oxford University Press (OUP)

Professor Malcolm R Macleod
Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia

Article • European Journal of Neuroscience, April 2007, Wiley

Professor Malcolm R Macleod
Systematic Review and Meta-Analysis of the Efficacy of Tirilazad in Experimental Stroke

Article • Stroke, January 2007, Wolters Kluwer Health

Professor Malcolm R Macleod
Comparison of treatment effects between animal experiments and clinical trials: systematic review

Article • BMJ, December 2006, BMJ

Professor Malcolm R Macleod
Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction

Article • Trials, September 2006, Springer Science + Business Media

Professor Malcolm R Macleod
Aortic Arch Atheroma

Article • International Journal of Stroke, May 2006, SAGE Publications

Professor Malcolm R Macleod
1,026 Experimental treatments in acute stroke

Article • Annals of Neurology, March 2006, Wiley

Professor Malcolm R Macleod
Greater Incidence of Both Fatal and Nonfatal Strokes in Disadvantaged Areas: The Northeast Melbourne Stroke Incidence Study

Article • Stroke, January 2006, Wolters Kluwer Health

Professor Malcolm R Macleod, Professor Amanda G Thrift
Current Issues in the Treatment of Acute Posterior Circulation Stroke

Article • CNS Drugs, January 2006, Springer Science + Business Media

Professor Malcolm R Macleod
Epilepsy update

Article • The Lancet Neurology, October 2005, Elsevier

Professor Malcolm R Macleod
Surveying the literature from animal experiments: Systematic review and meta-analysis are important contributions

Article • BMJ, July 2005, BMJ

Professor Malcolm R Macleod
Neuro-oncology for non-oncologists

Article • The Lancet Neurology, June 2005, Elsevier

Professor Malcolm R Macleod
Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells

Article • Molecular Brain Research, April 2005, Elsevier

Professor Malcolm R Macleod
Systematic Review and Metaanalysis of the Efficacy of FK506 in Experimental Stroke

Article • Journal of Cerebral Blood Flow & Metabolism, February 2005, SAGE Publications

Professor Malcolm R Macleod
Gender and deprivation and rates of referral and thereby admission to a national neurorehabilitation service

Article • Clinical Rehabilitation, February 2005, SAGE Publications

Professor Malcolm R Macleod
Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke

Article • Journal of Pineal Research, January 2005, Wiley

Professor Malcolm R Macleod
Results of a Multicentre, Randomised Controlled Trial of Intra-Arterial Urokinase in the Treatment of Acute Posterior Circulation Ischaemic Stroke

Article • Cerebrovascular Diseases, January 2005, Karger Publishers

Professor Malcolm R Macleod
MicroRNA – Taking Regulation of Protein Synthesis to Another Level

Article • Cerebrovascular Diseases, January 2005, Karger Publishers

Professor Malcolm R Macleod
Nicotinamide Attenuates Focal Ischemic Brain Injury: Meta-Analysis or Mechanism of Protection

Article • Stroke, December 2004, Wolters Kluwer Health

Professor Malcolm R Macleod
Atheroma of the aortic arch: an important and poorly recognised factor in the aetiology of stroke

Article • The Lancet Neurology, July 2004, Elsevier

Professor Malcolm R Macleod
Pooling of Animal Experimental Data Reveals Influence of Study Design and Publication Bias

Article • Stroke, April 2004, Wolters Kluwer Health

Professor Malcolm R Macleod
Media Watch

Article • The Lancet Neurology, December 2003, Elsevier

Professor Malcolm R Macleod
Atheroma of the aortic arch: the missing link in the secondary prevention of stroke?

Article • Expert Review of Cardiovascular Therapy, November 2003, Taylor & Francis

Professor Malcolm R Macleod
Inequalities in the incidence and management of, and outcome from, neurological diseases in older people

Article • Reviews in Clinical Gerontology, August 2003, Cambridge University Press

Professor Malcolm R Macleod
Mineralocorticoid receptor expression and increased survival following neuronal injury

Article • European Journal of Neuroscience, April 2003, Wiley

Professor Malcolm R Macleod
Effect of deprivation on time to hospital in acute stroke

Article • Journal of Neurology Neurosurgery & Psychiatry, April 2003, BMJ

Professor Malcolm R Macleod
Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein

Article • Neuroreport, February 2003, Wolters Kluwer Health

Professor Malcolm R Macleod
PubMed: http://www.pubmed.org

Article • Journal of Neurology Neurosurgery & Psychiatry, December 2002, BMJ

Professor Malcolm R Macleod
Effect of deprivation and gender on the incidence and management of acute brain disorders

Article • Intensive Care Medicine, December 2002, Springer Science + Business Media

Professor Malcolm R Macleod
What's a good doctor and how do you make one?

Article • BMJ, September 2002, BMJ

Professor Malcolm R Macleod
Nitric-oxide-synthase-mediated cyclic guanosine monophosphate production in neonatal rat cerebellar prisms is resistant to calcineurin inhibition

Article • Neuroscience Letters, March 2002, Elsevier

Professor Malcolm R Macleod
Serum withdrawal causes apoptosis in SHSY 5Y cells

Article • Brain Research, January 2001, Elsevier

Professor Malcolm R Macleod
Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis

Article • Cell Death and Differentiation, September 2000, Springer Science + Business Media

Professor Malcolm R Macleod
The effect of tumour associated epilepsy on performance/handicap scales used in cerebral glioma

Article • British Journal of Neurosurgery, January 1995, Taylor & Francis

Professor Malcolm R Macleod
Ischaemic heart disease and cholesterol There's more to heart disease than cholesterol

Article • BMJ, April 1994, BMJ

Professor Malcolm R Macleod

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