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  1. Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia

    Article • Hypertension, January 2024, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  2. One-health approach to canine cognitive decline: Dogs Overcoming Geriatric Memory and Aging Initiative for early detection of cognitive decline

    Article • American Journal of Veterinary Research, September 2023, American Veterinary Medical Association (AVMA)

    Dr Atticus H Hainsworth

  3. PDE5 inhibitor drugs for use in dementia

    Article • Alzheimer s & Dementia Translational Research & Clinical Interventions, July 2023, Wiley

    Dr Atticus H Hainsworth

  4. Clinical trials in vascular cognitive impairment following SPRINT-MIND: An international perspective

    Article • Cell Reports Medicine, June 2023, Elsevier

    Dr Atticus H Hainsworth

  5. ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics

    Article • Acta Neuropathologica Communications, May 2023, Springer Science + Business Media

    Dr Atticus H Hainsworth

  6. A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

    Article • Cerebral Circulation - Cognition and Behavior, January 2023, Elsevier

    Dr Atticus H Hainsworth

  7. Testing the cognitive effects of tadalafil. Neuropsychological secondary outcomes from the PASTIS trial

    Article • Cerebral Circulation - Cognition and Behavior, January 2023, Elsevier

    Dr Atticus H Hainsworth

  8. Vascular Collagen Type-IV in Hypertension and Cerebral Small Vessel Disease

    Article • Stroke, December 2022, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  9. Correction to: Innate Immune Anti-Inflammatory Response in Human Spontaneous Intracerebral Hemorrhage

    Article • Stroke, April 2022, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  10. The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment

    Article • Alzheimer s & Dementia, February 2022, Wiley

    Anan Shtaya, Dr Atticus H Hainsworth

  11. Vasculocentric Axonal NfH in Small Vessel Disease

    Article • Journal of Neuropathology & Experimental Neurology, January 2022, Oxford University Press (OUP)

    Dr Atticus H Hainsworth

  12. Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease

    Article • Translational Stroke Research, January 2022, Springer Science + Business Media

    Anan Shtaya, Dr Atticus H Hainsworth

  13. Vascular cognitive impairment and dementia: An early career researcher perspective

    Article • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, January 2022, Wiley

    Dr Fabricio Ferreira de Oliveira, Dr Atticus H Hainsworth

  14. What does aducanumab treatment of Alzheimer's disease mean for research on vascular cognitive disorders?

    Article • Cerebral Circulation - Cognition and Behavior, January 2022, Elsevier

    Dr Atticus H Hainsworth

  15. The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven't lived up to expectations, and where do we go from here?

    Article • Alzheimer s & Dementia, November 2021, Wiley

    Dr Atticus H Hainsworth

  16. Innate Immune Anti-Inflammatory Response in Human Spontaneous Intracerebral Hemorrhage

    Article • Stroke, November 2021, Wolters Kluwer Health

    Anan Shtaya, Dr Atticus H Hainsworth

  17. EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel

    Article • Neurobiology of Aging, July 2021, Elsevier

    Dr Atticus H Hainsworth

  18. Cerebral amyloid angiopathy distribution in older people: A cautionary note

    Article • Alzheimer s & Dementia Translational Research & Clinical Interventions, January 2021, Wiley

    Dr Atticus H Hainsworth

  19. Dementia risk reduction: why haven't the pharmacological risk reduction trials worked? An in‐depth exploration of seven established risk factors

    Article • Alzheimer s & Dementia Translational Research & Clinical Interventions, January 2021, Wiley

    Dr Atticus H Hainsworth

  20. An introduction to therapeutic approaches to vascular cognitive impairment

    Article • Cerebral Circulation - Cognition and Behavior, January 2021, Elsevier

    Dr Atticus H Hainsworth

  21. Strokectomy for malignant middle cerebral artery infarction: experience and meta-analysis of current evidence

    Article • Journal of Neurology, December 2020, Springer Science + Business Media

    Anan Shtaya, Dr Atticus H Hainsworth

  22. Association of White Matter Hyperintensities and Cardiovascular Disease

    Article • Circulation Cardiovascular Imaging, August 2020, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  23. UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings

    Article • Journal of Cerebral Blood Flow & Metabolism, March 2020, SAGE Publications

    Dr Atticus H Hainsworth

  24. Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)

    Article • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, January 2020, Wiley

    Dr Atticus H Hainsworth

  25. Cyclic nucleotide phosphodiesterases (PDEs) and endothelial function in ischaemic stroke. A review

    Article • Cellular Signalling, September 2019, Elsevier

    Dr Atticus H Hainsworth

  26. Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older

    Article • Journal of Neuropathology & Experimental Neurology, August 2019, Oxford University Press (OUP)

    Dr Atticus H Hainsworth

  27. Rapid neuroinflammatory changes in human acute intracerebral hemorrhage

    Article • Annals of Clinical and Translational Neurology, July 2019, Wiley

    Anan Shtaya, Dr Atticus H Hainsworth

  28. White matter lesions in cerebral small vessel disease

    Article • Neurology, March 2019, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  29. WM1-4 Decompressive craniectomy versus strokectomy for malignant middle cerebral artery (MCA) infarction

    Article • Journal of Neurology Neurosurgery & Psychiatry, February 2019, BMJ

    Anan Shtaya, Dr Atticus H Hainsworth

  30. P112 Management and outcome of subarachnoid haemorrhage (SAH) in older people: a centre series

    Article • Journal of Neurology Neurosurgery & Psychiatry, February 2019, BMJ

    Anan Shtaya, Dr Atticus H Hainsworth

  31. P117 Predictive factors of outcome in poor grade subarachnoid haemorrhage (SAH)

    Article • Journal of Neurology Neurosurgery & Psychiatry, February 2019, BMJ

    Anan Shtaya, Dr Atticus H Hainsworth

  32. WP1-23 Vascular collagen 4A1 in subcortical white matter of older people and primates

    Article • Journal of Neurology Neurosurgery & Psychiatry, February 2019, BMJ

    Anan Shtaya, Dr Atticus H Hainsworth

  33. Small‐Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need, and Future Directions

    Article • Journal of the American Heart Association, February 2019, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  34. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

    Article • Alzheimer s & Dementia Translational Research & Clinical Interventions, January 2019, Wiley

    Dr Atticus H Hainsworth

  35. The cGMP-Degrading Enzyme Phosphodiesterase-5 (PDE5) in Cerebral Small Arteries of Older People

    Article • Journal of Neuropathology & Experimental Neurology, December 2018, Oxford University Press (OUP)

    Dr Atticus H Hainsworth

  36. Lesional and perilesional tissue characterization by automated image processing in a novel gyrencephalic animal model of peracute intracerebral hemorrhage

    Article • Journal of Cerebral Blood Flow & Metabolism, September 2018, SAGE Publications

    Dr Atticus H Hainsworth

  37. Post-trial follow-up methodology in large randomised controlled trials: a systematic review

    Article • Trials, May 2018, Springer Science + Business Media

    Dr Atticus H Hainsworth

  38. Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

    Article • Clinical Science, April 2018, Portland Press Ltd.

    Professor Malcolm R Macleod, Dr Atticus H Hainsworth

  39. A common drug turns on a protein enzyme that reduces stroke-like brain damage

    Article • Journal of Cerebral Blood Flow & Metabolism, December 2017, SAGE Publications

    Dr Atticus H Hainsworth, Anan Shtaya

  40. The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review

    Article • Journal of Cerebral Blood Flow & Metabolism, December 2017, SAGE Publications

    Dr Atticus H Hainsworth

  41. Neuropathology of White Matter Lesions, Blood–Brain Barrier Dysfunction, and Dementia

    Article • Stroke, October 2017, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  42. Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: A systematic review of preclinical studies

    Article • Cellular Signalling, October 2017, Elsevier

    Dr Atticus H Hainsworth

  43. Super-resolution imaging of subcortical white matter using stochastic optical reconstruction microscopy (STORM) and super-resolution optical fluctuation imaging (SOFI)

    Article • Neuropathology and Applied Neurobiology, August 2017, Wiley

    Dr Atticus H Hainsworth

  44. [P4-129]: A VASCULOCENTRIC PATTERN OF AXONAL DAMAGE AND NEUROFILAMENT PHOSPHORYLATION IN SUBCORTICAL WHITE MATTER OF OLDER PEOPLE

    Article • Alzheimer s & Dementia, July 2017, Wiley

    Dr Atticus H Hainsworth

  45. Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial

    Article • Trials, May 2017, Springer Science + Business Media

    Dr Atticus H Hainsworth

  46. Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment

    Article • Neurochemistry International, May 2017, Elsevier

    Dr Atticus H Hainsworth

  47. Effect of phosphodiesterase-5 inhibitors on cerebral blood flow in human beings: a systematic review

    Article • The Lancet, February 2017, Elsevier

    Dr Atticus H Hainsworth

  48. Translational models for vascular cognitive impairment: a review including larger species

    Article • BMC Medicine, January 2017, Springer Science + Business Media

    Dr Atticus H Hainsworth

  49. A dysfunctional blood–brain barrier and cerebral small vessel disease

    Article • Neurology, December 2016, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  50. Post-mortem assessment in vascular dementia: advances and aspirations

    Article • BMC Medicine, August 2016, Springer Science + Business Media

    Dr Atticus H Hainsworth, Dr Ricardo Taipa

  51. Vascular Contributions to Cognitive Impairment and Dementia

    Article • Stroke, July 2016, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  52. F3-01-03: Blood-Brain Barrier Dysfunction, Small Vessel Disease and Dementia: Studies in Human Brain Tissue

    Article • Alzheimer s & Dementia, July 2016, Wiley

    Dr Atticus H Hainsworth

  53. P2-071: Super Resolution Microscopy of Intact Brain White Matter

    Article • Alzheimer s & Dementia, July 2016, Wiley

    Dr Atticus H Hainsworth

  54. Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL, and healthy brains

    Article • Neurobiology of Aging, June 2016, Elsevier

    Dr Atticus H Hainsworth

  55. Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID)

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, May 2016, Elsevier

    Dr Atticus H Hainsworth

  56. Catecholamine-Based Treatment in AD Patients: Expectations and Delusions

    Article • Frontiers in Aging Neuroscience, May 2015, Frontiers

    Dr Atticus H Hainsworth

  57. Endothelial Cells and Human Cerebral Small Vessel Disease

    Article • Brain Pathology, December 2014, Wiley

    Dr Atticus H Hainsworth

  58. Blood-Brain Barrier Dysfunction and Cerebral Small Vessel Disease (Arteriolosclerosis) in Brains of Older People

    Article • Journal of Neuropathology & Experimental Neurology, November 2014, Oxford University Press (OUP)

    Dr Atticus H Hainsworth

  59. P4-259: PHOSPHODIESTERASE 5 (PDE5) AS A POTENTIAL THERAPEUTIC TARGET IN SMALL ARTERIES OF AGED HUMAN BRAINS

    Article • Alzheimer s & Dementia, July 2014, Wiley

    Dr Atticus H Hainsworth

  60. The cell survival kinase SGK1 and its targets FOXO3a and NDRG1 in aged human brain

    Article • Neuropathology and Applied Neurobiology, September 2013, Wiley

    Dr Atticus H Hainsworth

  61. Transgene Delivery to Endothelial Cultures Derived from Porcine Carotid Artery Ex Vivo

    Article • Translational Stroke Research, May 2013, Springer Science + Business Media

    Dr Atticus H Hainsworth

  62. Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis

    Article • Stroke, May 2013, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  63. An MRI-Histological Study of White Matter in Stroke-Free SHRSP

    Article • Journal of Cerebral Blood Flow & Metabolism, February 2013, SAGE Publications

    Dr Christopher McCabe, Dr Atticus H Hainsworth

  64. Pre-clinical models of human cerebral small vessel disease: Utility for clinical application

    Article • Journal of the Neurological Sciences, November 2012, Elsevier

    Dr Atticus H Hainsworth

  65. Whole-Cell Patch-Clamp Recording of Voltage-Sensitive Ca2+ Channel Currents in Single Cells: Heterologous Expression Systems and Neurones

    Article • August 2012, Springer Science + Business Media

    Dr Atticus H Hainsworth

  66. Neuropathologic evidence of endothelial changes in cerebral small vessel disease

    Article • Neurology, December 2011, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  67. Experimental models of vascular dementia and vascular cognitive impairment: a systematic review

    Article • Journal of Neurochemistry, October 2010, Wiley

    Dr Atticus H Hainsworth

  68. Pharmacology of capsaicin-, anandamide-, and N -arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population

    Article • British Journal of Anaesthesia, May 2010, Elsevier

    Dr Atticus H Hainsworth

  69. Death-associated protein kinase (DAPK1) in cerebral cortex of late-onset Alzheimer's disease patients and aged controls

    Article • Neuropathology and Applied Neurobiology, February 2010, Wiley

    Dr Atticus H Hainsworth

  70. CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer's and mixed dementia

    Article • Journal of the Neurological Sciences, August 2009, Elsevier

    Dr Atticus H Hainsworth

  71. Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease

    Article • Parkinsonism & Related Disorders, June 2009, Elsevier

    Professor Ernesto Fedele, Dr Atticus H Hainsworth

  72. Doin vivoExperimental Models Reflect Human Cerebral Small Vessel Disease? a Systematic Review

    Article • Journal of Cerebral Blood Flow & Metabolism, August 2008, SAGE Publications

    Dr Atticus H Hainsworth

  73. The Nitrone Disodium 2,4-Sulphophenyl-N-Tert-Butylnitrone is Without Cytoprotective Effect on Sodium Nitroprusside-Induced Cell Death in N1E-115 Neuroblastoma Cells in vitro

    Article • Journal of Cerebral Blood Flow & Metabolism, June 2007, SAGE Publications

    Dr Atticus H Hainsworth

  74. Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca2+]i, initiates neurotransmitter release and promotes delayed cell death

    Article • Journal of Neurochemistry, March 2007, Wiley

    Dr Atticus H Hainsworth

  75. Glutamate receptor-mediated inhibition of l-glutamate efflux from cerebral cortex in vitro

    Article • Brain Research, October 2006, Elsevier

    Dr Atticus H Hainsworth

  76. Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor

    Article • CNS Drug Reviews, June 2006, Wiley

    Dr Atticus H Hainsworth

  77. Deep brain stimulation in Parkinson’s disease patients: biochemical evidence

    Article • January 2006, Springer Science + Business Media

    Dr Atticus H Hainsworth

  78. Spontaneous sleep modulates the firing pattern of Parkinsonian subthalamic nucleus

    Article • Experimental Brain Research, November 2005, Springer Science + Business Media

    Dr Atticus H Hainsworth

  79. Expression of Cellular FLICE Inhibitory Proteins (cFLIP) in Normal and Traumatic Murine and Human Cerebral Cortex

    Article • Journal of Cerebral Blood Flow & Metabolism, April 2005, SAGE Publications

    Dr Atticus H Hainsworth

  80. Supercritical carbon dioxide foaming of elastomer/heterocyclic methacrylate blends as scaffolds for tissue engineering

    Article • Journal of Materials Chemistry, January 2005, Royal Society of Chemistry

    Dr Atticus H Hainsworth

  81. Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients

    Article • Annals of Neurology, January 2005, Wiley

    Professor Ernesto Fedele, Dr Atticus H Hainsworth

  82. Gabapentin-Mediated Effects on Voltage- and Ligand-Gated Currents

    Article • Current Neuropharmacology, September 2003, Bentham Science Publishers

    Dr Atticus H Hainsworth

  83. Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents

    Article • European Journal of Pharmacology, April 2003, Elsevier

    Dr Atticus H Hainsworth

  84. Actions of the sodium channel inhibitor 202W92 on rat midbrain dopaminergic neurons

    Article • Synapse, March 2003, Wiley

    Dr Atticus H Hainsworth

  85. Pharmacology of ischemia-induced glutamate efflux from rat cerebral cortex in vitro

    Article • Brain Research, February 2003, Elsevier

    Dr Atticus H Hainsworth

  86. Electrophysiological actions of γ-aminobutyric acid and clomethiazole on recombinant GABAA receptors

    Article • European Journal of Pharmacology, October 2002, Elsevier

    Dr Atticus H Hainsworth

  87. Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons

    Article • Neuroreport, July 2002, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  88. Neuroprotective actions in vivo and electrophysiological actions in vitro of 202W92

    Article • Brain Research, November 2001, Elsevier

    Dr Atticus H Hainsworth

  89. Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro

    Article • Neuropharmacology, August 2001, Elsevier

    Dr Atticus H Hainsworth

  90. The interaction of AR-A008055 and its enantiomers with the GABAA receptor complex and their sedative, muscle relaxant and anticonvulsant activity

    Article • Neuropharmacology, August 2001, Elsevier

    Dr Atticus H Hainsworth

  91. Effects of extracellular pH on the interaction of sipatrigine and lamotrigine with high-voltage-activated (HVA) calcium channels in dissociated neurones of rat cortex

    Article • Neuropharmacology, May 2001, Elsevier

    Dr Atticus H Hainsworth

  92. Nociceptin/orphanin FQ inhibits ischaemiainduced glutamate efflux from rat cerebrocortical slices

    Article • Neuroreport, November 2000, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  93. GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke

    Article • Neuropharmacology, August 2000, Elsevier

    Dr Atticus H Hainsworth

  94. On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA;in vitrostudies with GABA, clomethiazole and pentobarbitone

    Article • British Journal of Pharmacology, July 2000, Wiley

    Dr Atticus H Hainsworth

  95. Inhibition of recombinant low-voltage-activated Ca2+ channels by the neuroprotective agent BW619C89 (Sipatrigine)

    Article • Neuropharmacology, June 2000, Elsevier

    Dr Atticus H Hainsworth

  96. Is Pharmacological Neuroprotection Dependent on Reduced Glutamate Release?

    Article • Stroke, March 2000, Wolters Kluwer Health

    Dr Atticus H Hainsworth

  97. Electrophysiology of Sipatrigine: A Lamotrigine Derivative Exhibiting Neuroprotective Effects

    Article • Experimental Neurology, March 2000, Elsevier

    Dr Atticus H Hainsworth

  98. On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89

    Article • British Journal of Pharmacology, November 1998, Wiley

    Dr Atticus H Hainsworth

  99. Acute effects of interleukin-1β on noradrenaline release from the human neuroblastoma cell line SH-SY5Y

    Article • Neuroscience Letters, July 1998, Elsevier

    Dr Atticus H Hainsworth

  100. Inhibition of human N-type voltage-gated Ca2+ channels by the neuroprotective agent BW619C89

    Article • Neuropharmacology, November 1997, Elsevier

    Dr Atticus H Hainsworth

  101. Hypotonicity-induced anion fluxes in cells expressing the multidrug-resistance-associated protein, MRP

    Article • Pflügers Archiv - European Journal of Physiology, June 1996, Springer Science + Business Media

    Dr Atticus H Hainsworth

  102. Origins of open-channel noise in the large potassium channel of sarcoplasmic reticulum.

    Article • The Journal of General Physiology, November 1994, Rockefeller University Press

    Dr Atticus H Hainsworth

  103. Identification and electrophysiology of isolated pars compacta neurons from guinea-pig substantia nigra

    Article • Neuroscience, January 1991, Elsevier

    Dr Atticus H Hainsworth

  104. Tolbutamide reverses membrane hyperpolarisation induced by activation of D2 receptors and GABAB receptors in isolated substantia nigra neurones

    Article • Pflügers Archiv - European Journal of Physiology, June 1990, Springer Science + Business Media

    Dr Atticus H Hainsworth

  105. Gramicidin-mediated currents at very low permeant ion concentrations

    Article • Biophysical Journal, July 1987, Elsevier

    Dr Atticus H Hainsworth

  106. Effects of double-layer polarization on ion transport

    Article • Biophysical Journal, January 1987, Elsevier

    Dr Atticus H Hainsworth

  107. Whole-Cell Patch Clamp Recording of Voltage-Sensitive Ca2+ Channel Currents: Heterologous Expression Systems and Dissociated Brain Neurons

    Article • Springer Science + Business Media

    Dr Atticus H Hainsworth

  108. Experimental animal models of cerebral small vessel disease

    Article • Cambridge University Press

    Dr Atticus H Hainsworth