All Stories

  1. Emeritus unbound
  2. Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP
  3. The Sherpa hypothesis: Phenotype-Preserving Disordered Proteins stabilize the phenotypes of neurons and oligodendrocytes
  4. Pharmacological targeting of α‐synuclein and TPPP /p25 in Parkinson's disease: challenges and opportunities in a Nutshell
  5. Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)
  6. Role of the microtubule-associated TPPP/p25 in Parkinson’s and related diseases and its therapeutic potential
  7. Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins
  8. Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study
  9. Strukturbasierte Entwicklung einer Affinitätssonde für Sirtuin 2
  10. Targeting the interface of the pathological complex of α-synuclein and TPPP/p25
  11. Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes
  12. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
  13. Modeling of sensing potency of cytoskeletal systems decorated with metabolic enzymes
  14. Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome
  15. Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors
  16. Dual life of TPPP/p25 evolved in physiological and pathological conditions
  17. Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25
  18. Sensor potency of the moonlighting enzyme-decorated cytoskeleton: the cytoskeleton as a metabolic sensor
  19. Microtubule assembly-derived by dimerization of TPPP/p25. Evaluation of thermodynamic parameters for multiple equilibrium system from ITC data
  20. Zn2+-Induced Rearrangement of the Disordered TPPP/p25 Affects Its Microtubule Assembly and GTPase Activity
  21. Moonlighting proteins in neurological disorders
  22. A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis
  23. Proteins without 3D structure: definition, detection and beyond
  24. Disordered TPPP/p25 binds GTP and displays Mg2+-dependent GTPase activity
  25. Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis
  26. Reappraisal of triosephosphate isomerase deficiency
  27. Triosephosphate isomerase deficiency: New insights into an enigmatic disease
  28. Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation
  29. An unstructured protein with destructive potential: TPPP/p25 in neurodegeneration
  30. Unique pharmacology of KAR-2, a potential anti-cancer agent: Absorption modelling and selective mitotic spindle targeting
  31. ChemInform Abstract: Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest.
  32. TPPP orthologs are ciliary proteins
  33. The tubulin polymerization promoting protein, TPPP/p25
  34. Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice
  35. Triosephosphate isomerase deficiency: Facts and doubts
  36. TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells
  37. The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases
  38. Tubulin Polymerization Promoting Proteins (TPPPs):  Members of a New Family with Distinct Structures and Functions†
  39. Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies
  40. Spotlight on…Judit Ovádi
  41. Triosephosphate isomerase deficiency: consequences of an inherited mutation at mRNA, protein and metabolic levels
  42. Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid
  43. Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies
  44. Functional aspects of cellular microcompartmentation in the development of neurodegeneration: Mutation induced aberrant protein-protein associations
  45. Glucose conversion by multiple pathways in brain extract: theoretical and experimental analysis
  46. A simple method for the determination of dissociation constants by displacement ELISA
  47. Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease
  48. Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease
  49. Dedications to Paul Srere
  50. Phosphofructokinases
  51. Tubulin and microtubule are potential targets for brain hexokinase binding
  52. Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease
  53. Organization-dependent effects of toxic bivalent ions
  54. Quantitative characterization of homo- and heteroassociations of muscle phosphofructokinase with aldolase
  55. Implications of Cytoarchitectural Analysis
  56. Substrate Channeling
  57. Paul A. Srere (1925–1999)
  58. Combined Enhancement of Microtubule Assembly and Glucose Metabolism in Neuronal Systems in Vitro: Decreased Sensitivity to Copper Toxicity
  59. Application of metabolic control analysis to the study of toxic effects of copper in muscle glycolysis
  60. Phosphofructokinase from Dictyostelium discoideum Is a Potent Inhibitor of Tubulin Polymerization †
  61. Macromolecular Compartmentation and Channeling
  62. Pyruvate Kinase as a Microtubule Destabilizing Factorin Vitro
  63. CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)
  64. Comparison of control analysis data using different approaches: modelling and experiments with muscle extract
  65. Interaction of a new bis-indol derivative, KAR-2 with tubulin and its antimitotic activity
  66. Crystallization and preliminary diffraction analysis of Ca2+-calmodulin-drug and apocalmodulin-drug complexes
  67. Characterization of Microtubule−Phosphofructokinase Complex:  Specific Effects of MgATP and Vinblastine †
  68. Metabolic Consequences of Enzyme Interactions
  69. Metabolic consequences of enzyme interactions
  70. Specific characteristics of phosphofructokinase-microtubule interaction
  71. Anti-calmodulin potency of indol alkaloids in in vitro systems
  72. Binding of malate dehydrogenase and NADH channelling to complex I
  73. Channel your energies
  74. Calmodulin and Dynamics of Interactions of Cytosolic Enzymes
  75. Quantitative evaluation of indirect ELISA effect of calmodulin antagonists on antibody binding to calmodulin
  76. Modulation of the interaction between aldolase and glycerol-phosphate dehydrogenase by fructose phosphates
  77. Calmodulin is a potent target for new hypothalamic neuropeptides
  78. Enzyme-enzyme interactions and their metabolic role
  79. Structurally distinct mammalian calmodulins
  80. Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action
  81. Tamás Keleti (1927–1989)
  82. Channelling and Channel Efficiency: Theory and Analytical Implications
  83. Effects of drugs on calmodulin-mediated enzymatic actions
  84. Kinetic and physico-chemical analysis of enzyme complexes and their possible role in the control of metabolism
  85. Old pathway — new concept: control of glycolysis by metabolite- modulated dynamic enzyme associations
  86. Modulation of phosphofructokinase action by macromolecular interactions. Quantitative analysis of the phosphofructokinase-aldolase-calmodulin system
  87. Control of Metabolism by Dynamic Macromolecular Interactions
  88. Aldolase decreases the dissociation-induced inactivation of muscle phosphofructokinase
  89. A simple approach to identify the mechanism of intermediate transfer: enzyme system related to triose phosphate metabolism
  90. A simple approach to detect active-site-directed enzyme-enzyme interactions. The aldolase/glycerol-phosphate-dehydrogenase enzyme system
  91. How to determine the efficiency of intermediate transfer in an interacting enzyme system?
  92. Quantitative determination of triosephosphates during enzymatic reaction by high performance liquid chromatography: effect of isomerase on aldolase activity
  93. Dynamic interactions of enzymes involved in triosephosphate metabolism
  94. Isolation and quantitative determination of some cardioactive glycosides from Digitalis lanata by high-performance liquid chromatography
  95. Phosphofructokinase and fructosebisphosphatase from muscle can interact at physiological concentrations with mutual effects on their kinetic behavior
  96. Interaction of the Dissociable Glycerol-3-phosphate Dehydrogenase and Fructose-1,6-bisphosphate Aldolase. Quantitative Analysis by an Extrinsic Fluorescence Probe
  97. Interaction between D-Fructose-1,6-bisphosphate aldolase and triosephosphate isomerase
  98. Kinetics of Coupled Reactions Catalyzed by Aspartate Aminotransferase and Glutamate Dehydrogenase
  99. Physico-chemical Evidence for the Interaction between Aldolase and Glyceraldehyde-3-phosphate Dehydrogenase
  100. SH groups masked by subunit interaction in glyceraldehyde-3-phosphate dehydrogenase
  101. TPPP/p25: A New Unstructured Protein Hallmarking Synucleinopathies