All Stories

  1. Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study
  2. Heart failure-induced atrial remodelling promotes electrical and conduction alternans
  3. A Combined Fully Convolutional Networks and Deformable Model for Automatic Left Ventricle Segmentation Based on 3D Echocardiography
  4. The virtual heart as a platform for screening drug cardiotoxicity
  5. Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of atrial fibrillation: a computer simulation
  6. Importance of Gradients in Membrane Properties and Electrical Coupling in Sinoatrial Node Pacing
  7. In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation
  8. Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model
  9. Stability and bifurcation analysis of Hodgkin-Huxley model
  10. A novel seeding method based on spatial sliding volume filter for neuron reconstruction
  11. Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition
  12. hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment
  13. Effects of external stimuli on the pacemaker function of the sinoatrial node in sodium channel gene mutations models
  14. Pro‐arrhythmogenic effects of atrial fibrillation‐induced electrical remodelling: insights from the three‐dimensional virtual human atria
  15. Simulating cell apoptosis induced sinus node dysfunction
  16. Simulating the role of anisotropy in human atrial cardioversion
  17. The positive T-wave: insights from a 3D anatomical and electrophysiological model of the rabbit ventricles
  18. The effect of AF-induced electrical remodelling on regional electrical heterogeneity and tissue vulnerability to atrial fibrillation—insights from modelling
  19. Multi-scale integrative model of the human atria and torso: a platform for the investigation of atrial arrhythmias
  20. Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of atrial fibrillation: a computer simulation
  21. In silico investigation of the electromechanical consequences of the short QT syndrome
  22. Reply to Matelot, Schnell, Kervio, Thillaye du Boullay, and Carre
  23. Theoretical investigation of the mechanism of heart failure using a canine ventricular cell model: Especially the role of up-regulated CaMKII and SR Ca2+ leak
  24. Antenatal architecture and activity of the human heart
  25. Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation
  26. A novel computational sheep atria model for the study of atrial fibrillation
  27. Viewpoint: Is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone?
  28. Effect of cardiac ventricular mechanical contraction on the characteristics of the ECG: A simulation study
  29. In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling
  30. Atrial Fibrosis and Atrial Fibrillation: A Computer Simulation in the Posterior Left Atrium
  31. Application of Micro-Computed Tomography With Iodine Staining to Cardiac Imaging, Segmentation, and Computational Model Development
  32. Image-Based Model of Atrial Anatomy and Electrical Activation: A Computational Platform for Investigating Atrial Arrhythmia
  33. Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K+ Channel
  34. Integration of Genetics into a Systems Model of Electrocardiographic Traits Using HumanCVD BeadChip
  35. High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment
  36. Dynamics of drug binding to the hERG channel: An in silico cardiac action potential model for early safety assessment
  37. Development of biophysically detailed electrophysiological models for pacemaking and non-pacemaking human pulmonary vein cardiomyocytes
  38. Arrhythmogenic substrate for atrial fibrillation: Insights from an integrative computational model of pulmonary veins
  39. Myofiber orientation and electrical activation in human and sheep atrial models
  40. Postnatal development of transmural gradients in expression of ion channels and Ca2+-handling proteins in the ventricle
  41. Virtual tissue engineering of the human atrium: Modelling pharmacological actions on atrial arrhythmogenesis
  42. Pro‐arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling
  43. Mechanisms by which Cytoplasmic Calcium Wave Propagation and Alternans Are Generated in Cardiac Atrial Myocytes Lacking T-Tubules—Insights from a Simulation Study
  44. Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling
  45. Cyclical modulation of human ventricular repolarization by respiration
  46. Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node
  47. Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome
  48. Anatomical and molecular mapping of the left and right ventricular His–Purkinje conduction networks
  49. Correction: A Computational Model of the Ionic Currents, Ca2+Dynamics and Action Potentials Underlying Contraction of Isolated Uterine Smooth Muscle
  50. Effective transfer function for interactive visualization and multivariate volume data
  51. Correlation Between P-Wave Morphology and Origin of Atrial Focal Tachycardia—Insights From Realistic Models of the Human Atria and Torso
  52. 3D virtual human atria: A computational platform for studying clinical atrial fibrillation
  53. Towards a computational reconstruction of the electrodynamics of premature and full term human labour
  54. Computer Simulation of Noise Effect on the Sodium Channel Conductance in Sinoatrail Node System
  55. Electrophysiological models for the heterogeneous canine atria: Computational platform for studying rapid atrial arrhythmias
  56. Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions
  57. TGF-β 1 -Mediated Fibrosis and Ion Channel Remodeling Are Key Mechanisms in Producing the Sinus Node Dysfunction Associated With SCN5A Deficiency and Aging
  58. A Computational Model of the Ionic Currents, Ca2+ Dynamics and Action Potentials Underlying Contraction of Isolated Uterine Smooth Muscle
  59. Computer Three‐Dimensional Anatomical Reconstruction of the Human Sinus Node and a Novel Paranodal Area
  60. Mitogen-activated Protein Kinase Kinase 4 Deficiency in Cardiomyocytes Causes Connexin 43 Reduction and Couples Hypertrophic Signals to Ventricular Arrhythmogenesis
  61. The Short QT Syndrome
  62. Cardiac cell modelling: Observations from the heart of the cardiac physiome project
  63. 17 Quantification of spatial dynamics of cardiac arrhythmias
  64. Construction of 3D Realistic Purkinje System: A Locally Linear Embedding-Based Method
  65. Mechanistic Links Between Na + Channel (SCN5A) Mutations and Impaired Cardiac Pacemaking in Sick Sinus Syndrome
  66. Response: Optimal Velocity Can Arise from Various Discontinuities
  67. Ionic Mechanisms for Electrical Heterogeneity between Rabbit Purkinje Fiber and Ventricular Cells
  68. Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation
  69. Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome
  70. Studying Ion Channel Dysfunction and Arrythmogenesis in the Human Atrium: A Computational Approach
  71. One-Dimensional Mathematical Model of the Atrioventricular Node Including Atrio-Nodal, Nodal, and Nodal-His Cells
  72. Electrophysiological substrate for a dominant reentrant source during atrial fibrillation
  73. Effects of elevated Homocysteine hormone on electrical activity in the human atrium: A simulation study
  74. hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome
  75. Optimal Velocity and Safety of Discontinuous Conduction through the Heterogeneous Purkinje-Ventricular Junction
  76. Mechanisms of defibrillation by standing waves in the bidomain ventricular tissue with voltage applied in an external bath
  77. Remodelling of cellular excitation (reaction) and intercellular coupling (diffusion) by chronic atrial fibrillation represented by a reaction-diffusion system
  78. Stochastic vagal modulation of cardiac pacemaking may lead to erroneous identification of cardiac “chaos”
  79. The role of transient outward K+ current in electrical remodelling induced by voluntary exercise in female rat hearts
  80. Mathematical models of the electrical action potential of Purkinje fibre cells
  81. Three‐dimensional electron microscopic reconstruction of intracellular organellar arrangements in vascular smooth muscle – further evidence of nanospaces and contacts
  82. Modelling changes in transmural propagation and susceptibility to arrhythmia induced by volatile anaesthetics in ventricular tissue
  83. Mechanisms of Transition from Normal to Reentrant Electrical Activity in a Model of Rabbit Atrial Tissue: Interaction of Tissue Heterogeneity and Anisotropy
  84. Left to Right Atrial Electrophysiological Differences: Substrate for a Dominant Reentrant Source during Atrial Fibrillation
  85. A Global Sensitivity Index for Biophysically Detailed Cardiac Cell Models: A Computational Approach
  86. Atrial proarrhythmia due to increased inward rectifier current (IK1) arising from KCNJ2 mutation – A simulation study
  87. Effects of the intracellular Ca2+ dynamics on restitution properties and stability of reentry in rabbit atrial tissue model
  88. Optimal safety of conduction through the Purkinje-ventricular junction
  89. Electrophysiologically detailed models of the right and left rabbit atria: Pharmacological impacts on propagation and arrhythmogenesis
  90. Simulating the effects of atrial fibrillation induced electrical remodeling: A comprehensive simulation study
  91. Regional differences in rabbit atrial action potential properties: Mechanisms, consequences and pharmacological implications
  92. Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle
  93. Simulation of clinical electrophysiology in 3D human atria: a high‐performance computing and high‐performance visualization application
  94. Computer Three-Dimensional Reconstruction of the Atrioventricular Node
  95. Peroxynitrite formation mediates LPC-induced augmentation of cardiac late sodium currents
  96. Mechanisms underlying adaptation of action potential duration by pacing rate in rat myocytes
  97. The canine virtual ventricular wall: A platform for dissecting pharmacological effects on propagation and arrhythmogenesis
  98. Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation—A simulation study
  99. The Sinoatrial Node: Cell Size Does Matter
  100. Modelling conduction through the Purkinje ventricular junction and the short-QT syndrome associated with HERG mutation in the rabbit ventricles
  101. Stability of scroll excitation waves in human atria during fibrillation: A computational study
  102. Screening patients with paroxysmal atrial fibrillation (PAF) from non-PAF heart rhythm using HRV data analysis
  103. Mechanistic insights to pro-arrhythmogenesis of short-QT syndrome associated with KCNQ1 gene mutation
  104. Differential pharmacology of the cardiac anionic background current IAB
  105. An outwardly rectifying anionic background current in atrial myocytes from the human heart
  106. Recognize a Special Structure in Palmprint for Palm Medicine
  107. Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterus
  108. Computational investigation of the adaptation of action potential duration by pacing rate in rat myocytes
  109. Actions of an External Electrical Shock on Human Atrial Excitation – A Computer Model Study
  110. Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving
  111. Gain of function in Kir2.1 and its effects on atrial fibrillation in homogeneous virtual human atrial tissue: a computer simulation study
  112. Computer reconstruction of the rabbit sinoatrial node
  113. Simulation of Brugada syndrome using cellular and three-dimensional whole-heart modeling approaches
  114. Heterogeneous three-dimensional anatomical and electrophysiological model of human atria
  115. P3-23
  116. AB31-2
  117. Connexins in the Sinoatrial and Atrioventricular Nodes
  118. Imaging the heart: computer 3-dimensional anatomic models of the heart
  119. Role of up-regulation of in action potential shortening associated with atrial fibrillation in humans
  120. Functional atrial conduction alternans generated by rapid FOCI in homogeneous virtual human atrial tissue
  121. Competitive interactions between ectopic foci and reentry in virtual human atrium
  122. Vulnerability in a one-dimensional transmural model of human ventricular tissue in heart failure
  123. Stability of genetically engineered cardiac pacemaker - role of intracellular CA/sup 2+/ handling
  124. Hypertrophy in Rat Virtual Left Ventricular Cells and Tissue
  125. In silico study of action potential and QT interval shortening due to loss of inactivation of the cardiac rapid delayed rectifier potassium current
  126. Defibrillation threshold computed from normal and supernormal excitable cardiac tissue
  127. STRUCTURE-FUNCTION RELATIONSHIPS OF THE SINOATRIAL NODE
  128. DYNAMICS OF CARDIAC INTRACELLULAR Ca 2+ HANDLING — FROM EXPERIMENTS TO VIRTUAL CELLS
  129. ONSET AND TERMINATION OF REENTRANT EXCITATION IN HOMOGENEOUS HUMAN VIRTUAL ATRIAL TISSUE
  130. MODELING EXCITATION AND PROPAGATION OF ACTION POTENTIALS ACROSS INHOMOGENEOUS VENTRICULAR TISSUE
  131. Heterogeneous Sinoatrial Node of Rabbit Heart - Molecular and Electrical Mapping and Biophysical Reconstruction
  132. Cellular modelling of electrical remodelling in two different models of human atrial myocytes
  133. Sustained Inward Current and Pacemaker Activity of Mammalian Sinoatrial Node
  134. Computational approaches to the ionic basis of pacemaker activity – from channel kinetics to the regional differences in rhythm
  135. Analysis of the Chronotropic Effect of Acetylcholine on Sinoatrial Node Cells
  136. The Sinoatrial Node Gap Junction Distribution and Impulse Propagation
  137. Control of the pacemaker activity of the sinoatrial node by intracellular Ca2+. Experiments and modelling
  138. Gradient Model Versus Mosaic Model of the Sinoatrial Node
  139. Re-entrant Excitation Initiated in Models of Inhomogeneous Atrial Tissue
  140. The pacemaking system of the heart: From coupled oscillators to nonlinear waves
  141. A Model for the Action of External Current onto Excitable Tissue
  142. One-dimensional Modelling of the Vulnerability to Re-entry to Homogeneous Atrial Tissue
  143. RECONSTRUCTION OF EXCITABLE TISSUE PHYSIOLOGY AND PATHOPHYSIOLOGY FROM CELLULAR MODELS
  144. Characteristics of atrial re-entry and meander computed from a model of a rabbit single atrial cell
  145. Atrial modulation of sinoatrial pacemaker rate
  146. Chaotic meander of spiral waves in the FitzHugh-Nagumo system
  147. Coupling CMLs and the synchronization of a multilayer neural computing system
  148. Tension of Organizing Filaments of Scroll Waves
  149. The behaviour of the Lyapunov exponent of a map simulating neural activity
  150. Computing with the Unpredictable
  151. Modelling propagation and re-entry in anisotropic and smoothly heterogeneous cardiac tissue
  152. Estimation of the persistence of strain from a time series as a measure of the Geometry of an attractor
  153. Estimation of the persistence of strain from experimental recordings from cardiac tissue
  154. Coupled map lattices as computational systems
  155. Lyapunov exponent spectrum for a generalized coupled map lattice
  156. Bifurcating Neurones
  157. Theoretical framework for analysing the behaviour of real and simulated neural networks
  158. A Novel Approach to Extract Sublingual Vein from Color Image
  159. Scroll Waves in 3D Virtual Human Atria: A Computational Study
  160. Simulation of hypertrophy in rat left ventricular cells
  161. Computational study of the relative contribution of channel and gap junction remodelling on human atrial conduction during fibrillation