All Stories

  1. Fatty acid amide hydrolase (FAAH) inhibitor design and preclinical studies: lessons learned from BIA 10–2474 and the challenges ahead

    Article • Expert Opinion on Drug Discovery, August 2026, Taylor & Francis

    Giovanni Lentini

  2. Suramin Interactions Across Biological Systems: From Molecular Targets to Therapeutic Implications

    Article • Biomolecules, April 2026, MDPI AG

    Giovanni Lentini

  3. N-Alkyl Derivatives of Deoxynojirimycin (DNJ) as Antiviral Agents: Overview and Update

    Article • Molecules, January 2026, MDPI AG

    Giovanni Lentini

  4. Active Edible Coatings to Mitigate Postharvest Diseases Causing Waste of Blueberries, Strawberries, and Cherry Tomatoes

    Article • Foods, December 2025, MDPI AG

    Giovanni Lentini

  5. Microwave-Assisted Extraction of Pleurotus Mushrooms Cultivated on ‘Nero di Troia’ Grape Pomace and Evaluation of the Antioxidant and Antiacetylcholinesterase Activities

    Article • Journal of Fungi, October 2025, MDPI AG

    Giovanni Lentini

  6. Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review

    Article • Molecules, July 2025, MDPI AG

    Giovanni Lentini

  7. In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors

    Article • Molecules, April 2025, MDPI AG

    Giovanni Lentini

  8. Xylazine, a Drug Adulterant Whose Use Is Spreading in the Human Population from the U.S. to the U.K. and All Europe: An Updated Review

    Article • Applied Sciences, March 2025, MDPI AG

    PhD Francesca F Aiello , Giovanni Lentini

  9. An Appealing, Robust Access to Furo-Fused Heteropolycycles

    Article • Molecules, February 2025, MDPI AG

    Giovanni Lentini

  10. Evaluating Dietary Red Lentil Screenings on Performance, Antioxidant Status, Caecal Environment, and Intestinal Morphometric Features in Rabbits

    Article • Agriculture, November 2024, MDPI AG

    Giovanni Lentini

  11. Hypoglycemic Properties of Leccinum scabrum Extracts—An In Vitro Study on α-Glucosidase and α-Amylase Inhibition and Metabolic Profile Determination

    Article • Journal of Fungi, October 2024, MDPI AG

    Giovanni Lentini

  12. Lentil Waste Extracts for Inflammatory Bowel Disease (IBD) Symptoms Control: Anti-Inflammatory and Spasmolytic Effects

    Article • Nutrients, September 2024, MDPI AG

    Giovanni Lentini

  13. Antiviral Properties of Moringa oleifera Leaf Extracts against Respiratory Viruses

    Article • Viruses, July 2024, MDPI AG

    Giovanni Lentini

  14. Drug Repositioning for Ovarian Cancer Treatment: An Update

    Article • Anti-Cancer Agents in Medicinal Chemistry, May 2024, Bentham Science Publishers

    Giovanni Lentini

  15. Molecular Insights into the Rescue Mechanism of an hERG Activator Against Severe LQT2 Mutations

    Article • March 2024, Cold Spring Harbor Laboratory Press

    Giovanni Lentini

  16. Antipsychotics: 70 Years

    Article • Biomedicines, November 2023, MDPI AG

    Giovanni Lentini

  17. A Comparative Study of the Inhibitory Action of Berberine Derivatives on the Recombinant Protein FtsZ of E. coli

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Giovanni Lentini

  18. Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective

    Article • Biomedicines, February 2023, MDPI AG

    Giovanni Lentini

  19. Biostimulant Formulations and Moringa oleifera Extracts to Improve Yield, Quality, and Storability of Hydroponic Lettuce

    Article • Molecules, January 2023, MDPI AG

    Giovanni Lentini

  20. Camel (Camelus spp.) Urine Bioactivity and Metabolome: A Systematic Review of Knowledge Gaps, Advances, and Directions for Future Research

    Article • International Journal of Molecular Sciences, November 2022, MDPI AG

    Giovanni Lentini

  21. Lubeluzole Repositioning as Chemosensitizing Agent on Multidrug-Resistant Human Ovarian A2780/DX3 Cancer Cells

    Article • Molecules, November 2022, MDPI AG

    Giovanni Lentini

  22. Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization

    Article • Molecules, November 2022, MDPI AG

    Giovanni Lentini

  23. Camel urine limits proliferation and modifies cell morphology in human renal tumoral and non-tumoral cells

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Giovanni Lentini

  24. Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs

    Article • Molecules, May 2022, MDPI AG

    Giovanni Lentini

  25. Corrigendum: Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use‐Dependent Inhibitors of Voltage‐Gated Sodium Channels

    Article • ChemMedChem, March 2022, Wiley

    Giovanni Lentini

  26. Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use‐Dependent Inhibitors of Voltage‐Gated Sodium Channels

    Article • ChemMedChem, October 2021, Wiley

    Giovanni Lentini

  27. Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity

    Article • Pharmaceutics, September 2021, MDPI AG

    Giovanni Lentini

  28. Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study

    Article • Journal of Chemical Information and Modeling, September 2021, American Chemical Society (ACS)

    Giovanni Lentini

  29. Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials

    Article • Molecules, June 2021, MDPI AG

    Giovanni Lentini

  30. Xanthenylacetic Acid Derivatives Effectively Target Lysophosphatidic Acid Receptor 6 to Inhibit Hepatocellular Carcinoma Cell Growth

    Article • ChemMedChem, June 2021, Wiley

    Giovanni Lentini

  31. Inverse Virtual Screening for the rapid re-evaluation of the presumed biological safe profile of natural products. The case of steviol from Stevia rebaudiana glycosides on farnesoid X receptor (FXR)

    Article • Bioorganic Chemistry, June 2021, Elsevier

    Giovanni Lentini

  32. Molecular Simplification of Natural Products: Synthesis, Antibacterial Activity, and Molecular Docking Studies of Berberine Open Models

    Article • Biomedicines, April 2021, MDPI AG

    Giovanni Lentini

  33. Targeting Penicillium expansum GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production

    Article • Biology, December 2020, MDPI AG

    Giovanni Lentini

  34. Ultrasound and deep eutectic solvents: An efficient combination to tune the mechanism of steviol glycosides extraction

    Article • Ultrasonics Sonochemistry, December 2020, Elsevier

    Giovanni Lentini

  35. Synthesis and Evaluation of Voltage‐Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities

    Article • ChemMedChem, October 2020, Wiley

    Giovanni Lentini

  36. Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies

    Article • Pharmacological Reports, October 2020, Springer Science + Business Media

    Giovanni Lentini

  37. From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

    Article • Molecules, July 2020, MDPI AG

    Giovanni Lentini

  38. COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help

    Article • Molecules, April 2020, MDPI AG

    Giovanni Lentini

  39. Repurposing therapeutic agents and herbal medicines to defeat viral nemesis

    Article • Drug Development Research, March 2020, Wiley

    Giovanni Lentini

  40. Targeting the pregnane X receptor using microbial metabolite mimicry

    Article • EMBO Molecular Medicine, March 2020, EMBO

    Giovanni Lentini

  41. Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design

    Article • Drug Discovery Today, February 2020, Elsevier

    Giovanni Lentini

  42. Optimization of Microwave-Assisted Extraction of Antioxidants from Bamboo Shoots of Phyllostachys pubescens

    Article • Molecules, January 2020, MDPI AG

    Giovanni Lentini

  43. Novel lysophosphatidic acid receptor 6 antagonists inhibit hepatocellular carcinoma growth through affecting mitochondrial function

    Article • Journal of Molecular Medicine, December 2019, Springer Science + Business Media

    Giovanni Lentini

  44. Structure-Based Identification and Design of Angiotensin Converting Enzyme-Inhibitory Peptides from Whey Proteins

    Article • Journal of Agricultural and Food Chemistry, December 2019, American Chemical Society (ACS)

    Giovanni Lentini

  45. Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Giovanni Lentini

  46. The therapeutic power of green

    Article • Schizophrenia Research, July 2019, Elsevier

    Giovanni Lentini

  47. Comment on “In Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach”

    Article • ACS Sustainable Chemistry & Engineering, March 2019, American Chemical Society (ACS)

    Giovanni Lentini

  48. (S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate

    Article • Molbank, February 2019, MDPI AG

    Giovanni Lentini

  49. A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues

    Article • Current Medicinal Chemistry, February 2019, Bentham Science Publishers

    Giovanni Lentini

  50. The Crystal Structure of N-[(2E)-3-(4-Chlorophenyl)prop-2-en-1-yl]-4-methoxy-N-methylbenzenesulfonamide

    Article • Journal of Chemical Crystallography, October 2018, Springer Science + Business Media

    Giovanni Lentini, PhD Dr. Rocco Caliandro

  51. Antimicrobial and Antibiofilm Activities of Citrus Water-Extracts Obtained by Microwave-Assisted and Conventional Methods

    Article • Biomedicines, June 2018, MDPI AG

    Giovanni Lentini

  52. Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin

    Article • Biomedicines, March 2018, MDPI AG

    Giovanni Lentini

  53. Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

    Article • Frontiers in Pharmacology, January 2018, Frontiers

    Giovanni Lentini

  54. Positional isomers of mannose–quinoline conjugates and their copper complexes: exploring the biological activity

    Article • New Journal of Chemistry, January 2018, Royal Society of Chemistry

    Giovanni Lentini

  55. Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole

    Article • Cellular Physiology and Biochemistry, January 2018, Karger Publishers

    Dr Francesco Tadini-Buoninsegni, Giovanni Lentini

  56. Discovery of a new mexiletine-derived agonist of the hERG K + channel

    Article • Biophysical Chemistry, October 2017, Elsevier

    Giovanni Lentini, Dr Francesco Tadini-Buoninsegni

  57. A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma

    Article • Current Medicinal Chemistry, September 2017, Bentham Science Publishers

    Giovanni Lentini

  58. Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition

    Article • Bioorganic & Medicinal Chemistry Letters, September 2017, Elsevier

    Giovanni Lentini

  59. Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective

    Article • Expert Opinion on Drug Discovery, August 2017, Taylor & Francis

    Giovanni Lentini

  60. The trivial names of citrus limonoids

    Article • Food Chemistry, June 2017, Elsevier

    Giovanni Lentini

  61. New doxorubicin nanocarriers based on cyclodextrins

    Article • Investigational New Drugs, April 2017, Springer Science + Business Media

    Dr Mattia Rocco, Giovanni Lentini

  62. 2-Arylazetidines as ligands for nicotinic acetylcholine receptors

    Article • Chemistry of Heterocyclic Compounds, March 2017, Springer Science + Business Media

    Giovanni Lentini

  63. Old Drug Scaffold, New Activity: Thalidomide-Correlated Compounds Exert Different Effects on Breast Cancer Cell Growth and Progression

    Article • ChemMedChem, January 2017, Wiley

    Giovanni Lentini

  64. Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents

    Article • Phytochemistry Letters, December 2016, Elsevier

    Giovanni Lentini

  65. The Chemistry and Pharmacology of Citrus Limonoids

    Article • Molecules, November 2016, MDPI AG

    Giovanni Lentini

  66. Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues

    Article • European Journal of Medicinal Chemistry, October 2016, Elsevier

    Giovanni Lentini

  67. Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules

    Article • ChemMedChem, November 2015, Wiley

    Giovanni Lentini

  68. Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine

    Article • Pharmacology Research & Perspectives, July 2015, Wiley

    Dr Francesco Tadini-Buoninsegni, Giovanni Lentini

  69. The Therapeutic Potential of Rutin for Diabetes: An Update

    Article • Mini-Reviews in Medicinal Chemistry, April 2015, Bentham Science Publishers

    Giovanni Lentini

  70. Plotting intersections

    Article • Nature Chemical Biology, April 2015, Springer Science + Business Media

    Giovanni Lentini

  71. Did Ebola Survivors Use Plant Medicines, and if so, Which Ones?

    Article • Phytotherapy Research, January 2015, Wiley

    Giovanni Lentini

  72. Ebola therapy: Developing new drugs or repurposing old ones?

    Article • International Journal of Cardiology, January 2015, Elsevier

    Giovanni Lentini

  73. Microchip capillary electrophoresis–electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: An intriguing case

    Article • Journal of Chromatography A, January 2014, Elsevier

    Giovanni Lentini

  74. Recent Trends and Future Prospects in Computational GPCR Drug Discovery: From Virtual Screening to Polypharmacology

    Article • Current Topics in Medicinal Chemistry, May 2013, Bentham Science Publishers

    Giovanni Lentini

  75. Stereospecific Synthesis of m-Hydroxymexiletine Enantiomers

    Article • Drug Metabolism Letters, March 2013, Bentham Science Publishers

    Giovanni Lentini

  76. Microwave-Assisted Synthesis of(±)-Mandelic Acid-d5, Optical Resolution, and Absolute Configuration Determination

    Article • Journal of Chemistry, January 2013, Hindawi Publishing Corporation

    Giovanni Lentini

  77. An Improved Synthesis of m-Hydroxymexiletine, a Potent Mexiletine Metabolite

    Article • Drug Metabolism Letters, June 2012, Bentham Science Publishers

    Giovanni Lentini

  78. Crystal structure of N-(2-{[(2E)-3-(4-chlorophenyl)-2-propenyl]- (methyl)ammonio}methylphenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide dihydrogen phosphate — methanol (1:1), [C26H30ClN2SO4][H2PO4] · CH4O

    Article • Zeitschrift für Kristallographie - New Crystal Structures, January 2012, De Gruyter

    Giovanni Lentini

  79. Hydroxylated Analogs of Mexiletine as Tools for Structural-Requirements Investigation of the Sodium Channel Blocking Activity

    Article • Archiv der Pharmazie, June 2010, Wiley

    Giovanni Lentini

  80. Fpocket: An open source platform for ligand pocket detection

    Article • BMC Bioinformatics, January 2009, Springer Science + Business Media

    Giovanni Lentini

  81. Facile Entry to Ethyl Tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate: a Versatile Pharmaceutical Intermediate

    Article • Heterocycles, January 2008, Japan Institute of Heterocyclic Chemistry

    Giovanni Lentini

  82. Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine, one of the major metabolites of mexiletine

    Article • Tetrahedron Asymmetry, October 2007, Elsevier

    Giovanni Lentini

  83. Synthesis and Biological Evaluation of Chiral α-Aminoanilides with Central Antinociceptive Activity

    Article • Journal of Medicinal Chemistry, April 2007, American Chemical Society (ACS)

    Giovanni Lentini

  84. Facile, alternative route to Lubeluzole, its enantiomer, and the racemate

    Article • Chirality, January 2006, Wiley

    Giovanni Lentini

  85. Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+Channels.

    Article • Journal of Medicinal Chemistry, April 2005, American Chemical Society (ACS)

    Giovanni Lentini

  86. Erratum to Alessia Catalano, Alessia Carocci, Giuseppe Fracchiolla, Carlo Franchini, Giovanni Lentini, Vincenzo Tortorella, Annamaria De Luca, Michela De Bellis, Jean-Francois Desaphy, Diana Conte Camerino, "Stereospecific synthesis of para-hydroxymexi...

    Article • Chirality, January 2005, Wiley

    Giovanni Lentini

  87. Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction

    Article • Tetrahedron Asymmetry, September 2000, Elsevier

    Giovanni Lentini

  88. Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, December 1995, Springer Science + Business Media

    Giovanni Lentini

  89. Stereospecific synthesis and absolute configuration of mexiletine

    Article • Chirality, January 1994, Wiley

    Giovanni Lentini

  90. Stereoselectivity in central analgesic action of tocainide and its analogs

    Article • Chirality, January 1993, Wiley

    Giovanni Lentini

  91. Pharmacological differences between R(-) and S(+) tocainide*1

    Article • Pharmacological Research, September 1992, Elsevier

    Giovanni Lentini

  92. The effects of tocainide and its chiral analogs on sodium channels of human muscle

    Article • Pharmacological Research, October 1990, Elsevier

    Giovanni Lentini