All Stories

  1. Formulation of Antioxidant Gummies Based on Gelatin Enriched with Citrus Fruit Peels Extract

    Article • Foods, January 2024, MDPI AG

    PhD Francesca F Aiello

  2. Synthetic derivatives of natural cinnamic acids as potential anti‐colorectal cancer agents

    Article • Chemical Biology & Drug Design, December 2023, Wiley

    PhD Francesca F Aiello

  3. Synthesis and Characterization of a Biopolymer Pectin/Ethanolic Extract from Olive Mill Wastewater: In Vitro Safety and Efficacy Tests on Skin Wound Healing

    Article • International Journal of Molecular Sciences, October 2023, MDPI AG

    PhD Francesca F Aiello , Vittoria Rago

  4. Formulation of A Gluten-Free Carob-Based Bakery Product: Evaluation of Glycemic Index, Antioxidant Activity, Rheological Properties, and Sensory Features

    Article • Fermentation, August 2023, MDPI AG

    PhD Francesca F Aiello

  5. Unripe carob pods: an innovative source of antioxidant molecules for the preparation of high-added value gummies

    Article • British Food Journal, July 2023, Emerald

    PhD Francesca F Aiello

  6. Development of 1‐(2‐aminophenyl)pyrrole‐based amides acting as human topoisomerase I inhibitors

    Article • Archiv der Pharmazie, July 2023, Wiley

    PhD Francesca F Aiello

  7. In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists

    Article • Journal of Medicinal Chemistry, May 2023, American Chemical Society (ACS)

    PhD Francesca F Aiello

  8. Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity

    Article • Antioxidants, March 2023, MDPI AG

    PhD Francesca F Aiello

  9. Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing

    Article • Pharmaceutics, January 2023, MDPI AG

    PhD Francesca F Aiello

  10. Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress

    Article • International Journal of Molecular Sciences, November 2022, MDPI AG

    PhD Francesca F Aiello

  11. Chrysin: A polyedric flavone as a tool to explore new phytotherapeutic applications and drug design

    Article • Archiv der Pharmazie, October 2022, Wiley

    PhD Francesca F Aiello

  12. Development of Quercetin-DHA Ester-Based Pectin Conjugates as New Functional Supplement: Effects on Cell Viability and Migration

    Article • Nutraceuticals, October 2022, MDPI AG

    PhD Francesca F Aiello , Vittoria Rago

  13. Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels

    Article • Marine Drugs, August 2022, MDPI AG

    PhD Francesca F Aiello

  14. Kefir Enriched with Carob (Ceratonia siliqua L.) Leaves Extract as a New Ingredient during a Gluten-Free Bread-Making Process

    Article • Fermentation, June 2022, MDPI AG

    PhD Francesca F Aiello

  15. Editorial: Design, Synthesis, and Preclinical Testing of Innovative Anti-Cancer Compounds With a High Level of Selectivity of Action and Low Toxicity

    Article • Frontiers in Molecular Biosciences, April 2022, Frontiers

    PhD Francesca F Aiello

  16. Milk kefir enriched with inulin‐grafted seed extract from white wine pomace: chemical characterisation, antioxidant profile and in vitro gastrointestinal digestion

    Article • International Journal of Food Science & Technology, April 2022, Wiley

    PhD Francesca F Aiello

  17. Ultrasound-Assisted Extraction, Chemical Characterization, and Impact on Cell Viability of Food Wastes Derived from Southern Italy Autochthonous Citrus Fruits

    Article • Antioxidants, January 2022, MDPI AG

    PhD Francesca F Aiello

  18. A Tara Gum/Olive Mill Wastewaters Phytochemicals Conjugate as a New Ingredient for the Formulation of an Antioxidant-Enriched Pudding

    Article • Foods, January 2022, MDPI AG

    PhD Francesca F Aiello , Vittoria Rago

  19. Green Synthesis of New Pyrrolo [1,2-a] quinoxalines as Antiproliferative Agents in GPER-expressing Breast Cancer Cells

    Article • Journal of Chemistry, October 2021, Hindawi Publishing Corporation

    PhD Francesca F Aiello

  20. Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol

    Article • Bioorganic Chemistry, September 2021, Elsevier

    PhD Francesca F Aiello

  21. FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity

    Article • Bioorganic & Medicinal Chemistry Letters, June 2021, Elsevier

    PhD Francesca F Aiello

  22. 7-Docosahexaenoyl-Quercetin

    Article • Molbank, April 2021, MDPI AG

    PhD Francesca F Aiello

  23. GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery

    Article • Journal of Medicinal Chemistry, April 2021, American Chemical Society (ACS)

    PhD Francesca F Aiello

  24. A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels

    Article • Biochemical Pharmacology, March 2021, Elsevier

    PhD Francesca F Aiello

  25. Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway

    Article • Bioorganic Chemistry, March 2021, Elsevier

    PhD Francesca F Aiello

  26. Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

    Article • Pharmaceutics, February 2021, MDPI AG

    PhD Francesca F Aiello

  27. Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators

    Article • Bioorganic Chemistry, December 2020, Elsevier

    PhD Francesca F Aiello

  28. New Oleoyl Hybrids of Natural Antioxidants: Synthesis and In Vitro Evaluation as Inducers of Apoptosis in Colorectal Cancer Cells

    Article • Antioxidants, November 2020, MDPI AG

    PhD Francesca F Aiello

  29. Formulation of New Baking (+)-Catechin Based Leavening Agents: Effects on Rheology, Sensory and Antioxidant Features during Muffin Preparation

    Article • Foods, October 2020, MDPI AG

    PhD Francesca F Aiello

  30. Serinol-Based Benzoic Acid Esters as New Scaffolds for the Development of Adenovirus Infection Inhibitors: Design, Synthesis, and In Vitro Biological Evaluation

    Article • ACS Infectious Diseases, October 2020, American Chemical Society (ACS)

    PhD Francesca F Aiello

  31. Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes

    Article • Marine Drugs, October 2020, MDPI AG

    PhD Francesca F Aiello

  32. Quality parameters, chemical compositions and antioxidant activities of Calabrian (Italy) monovarietal extra virgin olive oils from autochthonous (Ottobratica) and allochthonous (Coratina, Leccino, and Nocellara Del Belice) varieties

    Article • Journal of Food Measurement & Characterization, September 2020, Springer Science + Business Media

    PhD Francesca F Aiello

  33. Exploration of piperazine-derived thioureas as antibacterial and anti-inflammatory agents. In vitro evaluation against clinical isolates of colistin-resistant Acinetobacter baumannii

    Article • Bioorganic & Medicinal Chemistry Letters, September 2020, Elsevier

    PhD Francesca F Aiello

  34. Improving Kefir Bioactive Properties by Functional Enrichment with Plant and Agro-Food Waste Extracts

    Article • Fermentation, August 2020, MDPI AG

    PhD Francesca F Aiello

  35. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity

    Article • Bioorganic & Medicinal Chemistry, June 2020, Elsevier

    PhD Francesca F Aiello

  36. Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation of In Vitro Wound-Healing and Anti-Inflammatory Activities

    Article • Pharmaceuticals, May 2020, MDPI AG

    PhD Francesca F Aiello

  37. Valorisation of olive oil pomace extracts for a functional pear beverage formulation

    Article • International Journal of Food Science & Technology, May 2020, Wiley

    PhD Francesca F Aiello

  38. Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv.

    Article • Pharmaceuticals, May 2020, MDPI AG

    PhD Francesca F Aiello

  39. Sweeteners

    Article • April 2020, Bentham Science Publishers

    PhD Francesca F Aiello

  40. A Walk in Nature: Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways

    Article • Current Medicinal Chemistry, March 2020, Bentham Science Publishers

    PhD Francesca F Aiello , James Adams

  41. Triazolopyrimidinium salts: discovery of a new class of agents for cancer therapy

    Article • Future Medicinal Chemistry, March 2020, Future Science

    PhD Francesca F Aiello

  42. Sangiovese cv Pomace Seeds Extract-Fortified Kefir Exerts Anti-Inflammatory Activity in an In Vitro Model of Intestinal Epithelium Using Caco-2 Cells

    Article • Antioxidants, January 2020, MDPI AG

    PhD Francesca F Aiello

  43. Optimization of piperazine-derived ureas privileged structures for effective antiadenovirus agents

    Article • European Journal of Medicinal Chemistry, January 2020, Elsevier

    PhD Francesca F Aiello

  44. 3-Amino-alkylated indoles: unexplored green products acting as anti-inflammatory agents

    Article • Future Medicinal Chemistry, January 2020, Future Science

    PhD Francesca F Aiello

  45. Quercetin and its Natural Sources in Wound Healing Management

    Article • Current Medicinal Chemistry, November 2019, Bentham Science Publishers

    PhD Francesca F Aiello

  46. Advances in the Tyrosinase Inhibitors from Plant Source

    Article • Current Medicinal Chemistry, September 2019, Bentham Science Publishers

    PhD Francesca F Aiello

  47. Corrigendum to “Synthesis and characterization of a (+)-catechin and L-(+)-ascorbic acid cocrystal as a new functional ingredient for tea drinks” [Heliyon 5 (8) (August 2019) e02291]

    Article • Heliyon, September 2019, Elsevier

    PhD Francesca F Aiello

  48. Quercetin‐3‐Oleate Contributes to Skin Wound Healing Targeting FFA1/GPR40

    Article • ChemistrySelect, August 2019, Wiley

    Mr Paolo Governa, PhD Francesca F Aiello

  49. Synthesis and characterization of a (+)-catechin and L-(+)-ascorbic acid cocrystal as a new functional ingredient for tea drinks

    Article • Heliyon, August 2019, Elsevier

    PhD Francesca F Aiello

  50. In vitro anti-proliferative and anti-bacterial properties of new C7 benzoate derivatives of pinocembrin

    Article • Natural Product Research, July 2019, Taylor & Francis

    PhD Francesca F Aiello , Maria Luisa Di Gioia, Vincenzo Pezzi

  51. Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation

    Article • Bioorganic & Medicinal Chemistry Letters, July 2019, Elsevier

    PhD Francesca F Aiello

  52. Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway

    Article • Antioxidants, June 2019, MDPI AG

    PhD Francesca F Aiello , Vittoria Rago

  53. Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development

    Article • Journal of Functional Foods, June 2019, Elsevier

    PhD Francesca F Aiello

  54. Corrigendum to “Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression” [Heliyon 5 (3) (March 2019) e01366]

    Article • Heliyon, April 2019, Elsevier

    PhD Francesca F Aiello

  55. Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds

    Article • Frontiers in Molecular Biosciences, March 2019, Frontiers

    PhD Francesca F Aiello

  56. Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression

    Article • Heliyon, March 2019, Elsevier

    PhD Francesca F Aiello

  57. Discovery of 1,4-Naphthoquinones as a New Class of Antiproliferative Agents Targeting GPR55

    Article • ACS Medicinal Chemistry Letters, February 2019, American Chemical Society (ACS)

    PhD Francesca F Aiello

  58. Comparison of the in vitro wound healing activity of diffetent Calabrian honey

    Article • Antioxidants, February 2019, MDPI AG

    Mr Paolo Governa, PhD Francesca F Aiello , Vittoria Rago

  59. Autochthonous white grape pomaces as bioactive source for functional jams

    Article • International Journal of Food Science & Technology, November 2018, Wiley

    PhD Francesca F Aiello , Vittoria Rago

  60. Quercetin-3-oleate

    Article • Molbank, July 2018, MDPI AG

    PhD Francesca F Aiello

  61. Bio-Catalytic Synthesis of Quercetin-3-Oleate

    Article • June 2018, MDPI AG

    PhD Francesca F Aiello

  62. Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2018, Elsevier

    PhD Francesca F Aiello

  63. An ancient remedial repurposing: synthesis of new pinocembrin fatty acid acyl derivatives as potential antimicrobial/anti-inflammatory agents

    Article • Natural Product Research, February 2018, Taylor & Francis

    PhD Francesca F Aiello

  64. 2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design

    Article • RSC Advances, January 2018, Royal Society of Chemistry

    PhD Francesca F Aiello

  65. Anti-inflammatory and Antioxidant Agents from Salvia Genus (Lamiaceae): An Assessment of the Current State of Knowledge

    Article • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, December 2017, Bentham Science Publishers

    PhD Francesca F Aiello , Giuseppe Antonio Malfa

  66. From the hive: Honey, a novel weapon against cancer

    Article • European Journal of Medicinal Chemistry, December 2017, Elsevier

    PhD Francesca F Aiello

  67. Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators

    Article • Future Medicinal Chemistry, October 2017, Future Science

    PhD Francesca F Aiello

  68. From Vegetable Waste to New Agents for Potential Health Applications: Antioxidant Properties and Effects of Extracts, Fractions and Pinocembrin from Glycyrrhiza glabra L. Aerial Parts on Viability of Five Human Cancer Cell Lines

    Article • Journal of Agricultural and Food Chemistry, September 2017, American Chemical Society (ACS)

    PhD Francesca F Aiello

  69. Synthesis and anti-proliferative activity of a small library of 7-substituted 5H-pyrrole [1,2-a][3,1]benzoxazin-5-one derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, July 2017, Elsevier

    PhD Francesca F Aiello

  70. Identification of Breast Cancer Inhibitors Specific for G Protein‐Coupled Estrogen Receptor (GPER)‐Expressing Cells

    Article • ChemMedChem, June 2017, Wiley

    PhD Francesca F Aiello

  71. Quercetin and derivatives: useful tools in inflammation and pain management

    Article • Future Medicinal Chemistry, January 2017, Future Science

    PhD Francesca F Aiello

  72. Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity

    Article • Journal of Chemistry, January 2017, Hindawi Publishing Corporation

    PhD Francesca F Aiello

  73. Structure–activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009–2016)

    Article • MedChemComm, January 2017, Royal Society of Chemistry

    PhD Francesca F Aiello

  74. Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of theN-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a S...

    Article • ACS Chemical Neuroscience, June 2016, American Chemical Society (ACS)

    PhD Francesca F Aiello

  75. TRPV1-FAAH-COX: TheCouples Gamein Pain Treatment

    Article • ChemMedChem, May 2016, Wiley

    PhD Francesca F Aiello

  76. Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1)

    Article • Molecular Informatics, April 2016, Wiley

    PhD Francesca F Aiello

  77. Antitubulinic effect of New Fluorazone Derivatives on Melanoma Cells

    Article • Anti-Cancer Agents in Medicinal Chemistry, March 2016, Bentham Science Publishers

    PhD Francesca F Aiello

  78. Identification and Preclinical Evaluation of SC144, a Novel Pyrroloquinoxaline Derivative with Broad-Spectrum Anticancer Activity

    Article • Mini-Reviews in Medicinal Chemistry, March 2016, Bentham Science Publishers

    PhD Francesca F Aiello

  79. Identification of novel 2-(1H-indol-1-yl)-benzohydrazides CXCR4 ligands impairing breast cancer growth and motility

    Article • Future Medicinal Chemistry, February 2016, Future Science

    Fedora Grande, PhD Francesca F Aiello

  80. Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts

    Article • Future Medicinal Chemistry, March 2015, Future Science

    Fedora Grande, PhD Francesca F Aiello

  81. Outdoor Air Pollutants

    Article • January 2015, Springer Science + Business Media

    PhD Francesca F Aiello

  82. Synthesis and Evaluation of Indole Based Molecules for Treatment of Oxidative Stress Related Diseases

    Article • Current Topics in Medicinal Chemistry, December 2014, Bentham Science Publishers

    PhD Francesca F Aiello

  83. Structure–affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

    Article • Bioorganic & Medicinal Chemistry, September 2014, Elsevier

    PhD Francesca F Aiello

  84. Active manganese dioxide promoted cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids to 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one derivatives

    Article • Tetrahedron, November 2013, Elsevier

    Fedora Grande, PhD Francesca F Aiello

  85. Design and Synthesis of 3-Carbamoylbenzoic Acid Derivatives as Inhibitors of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1)

    Article • ChemMedChem, September 2012, Wiley

    PhD Francesca F Aiello , Fedora Grande

  86. ChemInform Abstract: Convenient Synthesis of Fluorazone Derivatives by One-Pot Pyrrolation/Cyclization of Anthranilic Acids.

    Article • ChemInform, February 2012, Wiley

    PhD Francesca F Aiello

  87. Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 Receptor

    Article • Journal of Medicinal Chemistry, November 2011, American Chemical Society (ACS)

    PhD Francesca F Aiello

  88. Convenient synthesis of fluorazone derivatives by one-pot pyrrolation/cyclization of anthranilic acids

    Article • Tetrahedron Letters, November 2011, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  89. ChemInform Abstract: Direct Cyclization of ortho-(1H-Pyrrol-1-yl)aryl and Heteroaryl Carboxylic Acids into Fused Pyrrolizinones.

    Article • ChemInform, March 2011, Wiley

    PhD Francesca F Aiello

  90. Direct cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids into fused pyrrolizinones

    Article • Tetrahedron Letters, December 2010, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  91. ChemInform Abstract: Efficient Synthesis of 9H-Pyrrolo[1,2-a]indol-9-one Derivatives Based on Active Manganese Dioxide Promoted Intramolecular Cyclization.

    Article • ChemInform, May 2010, Wiley

    PhD Francesca F Aiello

  92. Efficient synthesis of 9H-pyrrolo[1,2-a]indol-9-one derivatives based on active manganese dioxide promoted intramolecular cyclization

    Article • Tetrahedron, January 2010, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  93. Synthesis and biological evaluation of novel hydrazide based cytotoxic agents

    Article • Expert Opinion on Investigational Drugs, April 2009, Informa Healthcare

    PhD Francesca F Aiello , Fedora Grande

  94. Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity

    Article • Cancer Biology & Therapy, March 2009, Taylor & Francis

    PhD Francesca F Aiello

  95. Discovery of Novel Anticancer Compounds Based on a Quinoxalinehydrazine Pharmacophore

    Article • ChemMedChem, November 2008, Wiley

    Fedora Grande, PhD Francesca F Aiello

  96. Naphthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation

    Article • ChemMedChem, June 2008, Wiley

    Fedora Grande, PhD Francesca F Aiello

  97. Synthesis and antitumor activities of a series of novel quinoxalinhydrazides

    Article • Bioorganic & Medicinal Chemistry, January 2007, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  98. An approach to the stereo-controlled synthesis of polycyclic derivatives of l-4-thiazolidinecarboxylic acid active against HIV-1 integrase

    Article • European Journal of Medicinal Chemistry, August 2006, Elsevier

    Fedora Grande, PhD Francesca F Aiello

  99. Discovery of Small Molecule Integrin αvβ3 Antagonists as Novel Anticancer Agents

    Article • Journal of Medicinal Chemistry, July 2006, American Chemical Society (ACS)

    PhD Francesca F Aiello

  100. Synthesis of novel thiazolothiazepine based HIV-1 integrase inhibitors

    Article • Bioorganic & Medicinal Chemistry, August 2004, Elsevier

    PhD Francesca F Aiello , Fedora Grande

  101. Multivariate least squares regression applied to the spectrophotometric analysis of manidipine and its main photoproduct

    Article • Il Farmaco, September 2003, Elsevier

    PhD Francesca F Aiello

  102. Synthesis and Pharmacological Evaluation of Potent and Highly Selective D 3 Receptor Ligands:  Inhibition of Cocaine-Seeking Behavior and the Role of Dopamine D 3 /D 2 Receptors †

    Article • Journal of Medicinal Chemistry, August 2003, American Chemical Society (ACS)

    Dr sandra gemma, Dr Stefania Butini, PhD Francesca F Aiello

  103. Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors. Further SAR Studies and Identification of a Novel Orally Bioavailable Hydrazine-Based Antiviral Agent

    Article • Journal of Medicinal Chemistry, January 2001, American Chemical Society (ACS)

    PhD Francesca F Aiello