Prof. Patrick M. Woster

KDM4B inhibition reduces inflammatory cytokines, and thus inflammation and bone destruc...

• Epigenetics
• August 2018

Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identi...

• European Journal of Medicinal Chemistry
• March 2018

Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as pot...

• Bioorganic & Medicinal Chemistry
• August 2015

Structure–activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 i...

• Bioorganic & Medicinal Chemistry
• April 2015

Transcriptional Activity of the Islet β Cell Factor Pdx1 Is Augmented by Lysine Methyla...

• Journal of Biological Chemistry
• February 2015

Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group

• MedChemComm
• January 2015

Epigenetics: Novel Therapeutics Targeting Epigenetics

• Journal of Medicinal Chemistry
• December 2014

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Co...

• Oncogene
• September 2014

P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted phar...

• Journal of Molecular Graphics and Modelling
• February 2014

3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inh...

• MedChemComm
• January 2014

Design of small molecule epigenetic modulators

• Bioorganic & Medicinal Chemistry Letters
• January 2014

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 pr...

• Bioorganic & Medicinal Chemistry
• December 2013

Synthesis and Evaluation of Novel Cyclic Peptide Inhibitors of Lysine-Specific Demethyl...

• ACS Medicinal Chemistry Letters
• November 2013

Histone Deacetylase Inhibition Overcomes Drug Resistance through a miRNA-Dependent Mech...

• Molecular Cancer Therapeutics
• August 2013

Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating th...

• Amino Acids
• July 2013

99 Polyamines Mediate Helicobacter priori-Induced Gastric Carcinogenesis in Gerbils

• Gastroenterology
• May 2013

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogu...

• Amino Acids
• March 2013

Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expressi...

• Biochemical Journal
• January 2013

Polyamines and cancer: implications for chemotherapy and chemoprevention

• Expert Reviews in Molecular Medicine
• January 2013

Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demeth...

• Journal of Medicinal Chemistry
• September 2012

Polyamine Drug Discovery. Edited by Patrick Woster and Robert A. Casero, Jr.

• June 2012

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent ant...

• May 2012

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid diff...

• news nature com
• March 2012

Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational a...

• Journal of Inorganic Biochemistry
• March 2012

Polyamine-based small molecule epigenetic modulators

• MedChemComm
• January 2012

Alternative Spermidine Biosynthetic Route Is Critical for Growth ofCampylobacter jejuni...

• Journal of Biological Chemistry
• October 2011

Discovery of Novel Alkylated (bis)Urea and (bis)Thiourea Polyamine Analogues with Poten...

• Journal of Medicinal Chemistry
• October 2011

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon ...

• Proceedings of the National Academy of Sciences
• August 2011

Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leadin...

• Amino Acids
• August 2011

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 ...

• Amino Acids
• July 2011

Polyamine Drug Discovery

• January 2011

Chapter 1. Polyamine Drug Discovery: Synthetic Approaches to Therapeutic Modulators of ...

• January 2011

Chapter 10. The Design and Development of Polyamine-Based Analogs with Epigenetic Targets

• January 2011

Chapter 5. Symmetrical- and Unsymmetrical Terminally Alkylated Polyamines

• January 2011

Use of Polyamine Derivatives as Selective Histone Deacetylase Inhibitors

• January 2011

Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the...

• BMC Cancer
• October 2010

Antiprotozoal/Antiparasitic Agents

• September 2010

(Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic M...

• Journal of Medicinal Chemistry
• July 2010

Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimala...

• Journal of Medicinal Chemistry
• May 2010

ChemInform Abstract: Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal ...

• ChemInform
• May 2010

Suppression of Exogenous Gene Expression by Spermidine/SpermineN1-Acetyltransferase 1 (...

• Journal of Biological Chemistry
• March 2010

Epigenetic Targets and Cancer Drug Discovery

• January 2010

Foreword: American Chemical Society Division of Medicinal Chemistry. Celebrating 100 Ye...

• Journal of Medicinal Chemistry
• December 2009

Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpressio...

• Clinical Cancer Research
• November 2009

Design of polyamine-based therapeutic agents: new targets and new directions

• Essays in Biochemistry
• October 2009

Polyamine analogues targeting epigenetic gene regulation

• Essays in Biochemistry
• October 2009

A Small Molecule Polyamine Oxidase Inhibitor Blocks Androgen-Induced Oxidative Stress a...

• Cancer Research
• September 2009

The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of ...

• Cancer Chemotherapy and Pharmacology
• August 2009

Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and ...

• Biochemical Journal
• August 2009

Recent Advances in the Development of Polyamine Analogues as Antitumor Agents§

• Journal of Medicinal Chemistry
• August 2009

A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in p...

• Journal of Cellular and Molecular Medicine
• August 2009

A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in ...

• Journal of Cellular and Molecular Medicine
• August 2009

Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian ...

• Antimicrobial Agents and Chemotherapy
• February 2009

Elevated Ornithine Decarboxylase Levels Activate Ataxia Telangiectasia Mutated-DNA Dama...

• Cancer Research
• April 2008

Polyaminohydroxamic Acids and Polyaminobenzamides as Isoform Selective Histone Deacetyl...

• Journal of Medicinal Chemistry
• April 2008

Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase ac...

• Carcinogenesis
• September 2007

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpress...

• Proceedings of the National Academy of Sciences
• April 2007

Polyamine-based analogues as biochemical probes and potential therapeutics

• Biochemical Society Transactions
• April 2007

Spermine and spermidine mediate protection against oxidative damage caused by hydrogen ...

• Amino Acids
• March 2007

Antiprotozoal Agents (African Trypanosomiasis, Chagas Disease, and Leishmaniasis)

• January 2007

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosoma...

• Bioorganic & Medicinal Chemistry Letters
• June 2006

Effect of pro-inflammatory cytokines on the toxicity of the arylhydroxylamine metabolit...

• Toxicology
• February 2006

Spermine Oxidase SMO(PAOh1), NotN1-Acetylpolyamine Oxidase PAO, Is the Primary Source o...

• Journal of Biological Chemistry
• October 2005

Alkyl-Substituted Polyaminohydroxamic Acids:  A Novel Class of Targeted Histone Deacety...

• Journal of Medicinal Chemistry
• October 2005

Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibit...

• Cancer Biology & Therapy
• September 2005

Reactive oxygen species generation and its role in the differential cytotoxicity of the...

• Biochemical Pharmacology
• July 2005

A Charge-Deficient Analogue of Spermine with Chelating Properties

• Russian Journal of Bioorganic Chemistry
• May 2005

Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in de...

• Cancer Chemotherapy and Pharmacology
• March 2005

Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA s...

• Biochemical Journal
• March 2005

Bergamottin contribution to the grapefruit juice?felodipine interaction and disposition...

• December 2004

Fundamentals of Medicinal Chemistry By Gareth Thomas. John Wiley and Sons, Ltd., West S...

• Journal of Medicinal Chemistry
• July 2004

Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carci...

• Cancer Chemotherapy and Pharmacology
• November 2003

Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

• May 2003

The role of polyamine catabolism in anti-tumour drug response

• Biochemical Society Transactions
• April 2003

The Activator-Binding Site of Onchocerca volvulus S-Adenosylmethionine Decarboxylase, a...

• January 2003

Chapter 21. New therapies for malaria

• January 2003

Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue ...

• Biochemical Journal
• October 2002

Cloning and characterization of the mouse polyamine-modulatedfactor-1 (mPMF-1) gene: an...

• October 2001

Cloning and characterization of the mouse polyamine-modulatedfactor-1 (mPMF-1) gene: an...

• Biochemical Journal
• October 2001

Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidia...

• Bioorganic & Medicinal Chemistry Letters
• June 2001

Terminally Alkylated Polyamine Analogues as Chemotherapeutic Agents

• Journal of Medicinal Chemistry
• January 2001

A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfona...

• June 2000

Molecular basis for the polyamine-OmpF porin interactions: inhibitor and mutant studies...

• Journal of Molecular Biology
• April 2000

Erratum: Nairn LM, Lindsay GS, Woster PM, and Wallace HM (2000): Cytotoxicity of novel ...

• Journal of Cellular Physiology
• April 2000

Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis ...

• Journal of Cellular Physiology
• February 2000

1-(N-Alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes:  Simple Synthetic Polyamine Anal...

• Journal of Medicinal Chemistry
• April 1999

6 ́,7 ́-Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on c...

• March 1999

Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target ...

• Endocrine Related Cancer
• March 1999

82 Comparison of poryamine analogue toxicity in two cell lines (HL-60 & MCF-7)

• Biochemical Society Transactions
• November 1998

The natural polyamine spermine functions directly as a free radical scavenger

• Proceedings of the National Academy of Sciences
• September 1998

Comparison of the In Vitro Cytotoxicity of Hydroxylamine Metabolites of Sulfamethoxazol...

• Biochemical Pharmacology
• March 1998

Structural Specificity of Polyamines and Polyamine Analogues in the Protection of DNA f...

• March 1998

Synthesis of protected allylic amines via palladium(0)-catalyzed amination of allylic a...

• Tetrahedron Letters
• March 1998

The role of polyamine catabolism in polyamine analogue-induced programmed cell death

• Proceedings of the National Academy of Sciences
• October 1997

Synthesis and biological evaluation of 6′,7′-dihydroxybergamottin (6,7-DHB), a naturall...

• Bioorganic & Medicinal Chemistry Letters
• October 1997

Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or ant...

• Bioorganic & Medicinal Chemistry Letters
• November 1996

Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-s...

• Bioorganic & Medicinal Chemistry
• June 1996

Photoaffinity Labeling of a Cell Surface Polyamine Binding Protein

• Journal of Biological Chemistry
• December 1995

S-(5'-Deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): An Irrev...

• Journal of Medicinal Chemistry
• May 1995

Irreversible inhibition of human S -adenosylmethionine decarboxylase by the pure diast...

• Biochemical Pharmacology
• April 1995

Growth and biochemical effects of unsymmetrically substituted polyamine analogues in hu...

• Cancer Chemotherapy and Pharmacology
• January 1995

Dapsone-Induced Hematologic Toxicity: Comparison of the Methemoglobin-Forming Ability o...

• December 1994

α-cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activat...

• Bioorganic & Medicinal Chemistry Letters
• December 1993

Preparation of the pure diastereomeric forms of S- (5′-deoxy-5′-adenosyl)-1-ammonio-4-m...

• Bioorganic & Medicinal Chemistry
• November 1993

Synthesis and evaluation of unsymmetrically substituted polyamine analogs as modulators...

• Journal of Medicinal Chemistry
• October 1993

Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitor...

• Bioorganic & Medicinal Chemistry Letters
• February 1993

S-(5'-Deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: a potent, enzyme-...

• Journal of Medicinal Chemistry
• August 1992

Restricted rotation analogs of decarboxylated S-adenosylmethionine as inhibitors of pol...

• Bioorganic & Medicinal Chemistry Letters
• January 1991

Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibit...

• Biochemistry
• October 1989

Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a ...

• Journal of Medicinal Chemistry
• June 1989

Synthesis and biological evaluation of cyclic analogs of l-carnitine as potential agent...

• Journal of Medicinal Chemistry
• May 1986

Polyamine Structure and Synthetic Analogs