All Stories

  1. Thyroxine hormones visualized by the cryo-EM structure of bovine thyroglobulin
  2. Discovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureus
  3. The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers
  4. Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L
  5. Free kick instead of cross-validation in maximum-likelihood refinement of macromolecular crystal structures
  6. Fungal β-trefoil trypsin inhibitors cnispin and cospin demonstrate the plasticity of the β-trefoil fold
  7. A novel β‐trefoil lectin from the parasol mushroom (Macrolepiota procera) is nematotoxic
  8. Partial rotational lattice order–disorder in stefin B crystals
  9. Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C
  10. MAINsoftware for density averaging, model building, structure refinement and validation
  11. Dipeptidyl-Peptidase I
  12. β-Trefoil inhibitors – from the work of Kunitz onward
  13. Structure-Based Discovery of Substituted 4,5′-Bithiazoles as Novel DNA Gyrase Inhibitors
  14. Expression, purification and assembly of soluble multimeric MHC class II–invariant chain complexes
  15. Protease signalling: the cutting edge
  16. Cysteine cathepsins: From structure, function and regulation to new frontiers
  17. Mechanisms of amyloid fibril formation – focus on domain‐swapping
  18. Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds
  19. Modulation of Contact Order Effects in the Two-State Folding of Stefins A and B
  20. Amyloid fibril formation by human stefins: Structure, mechanism & putative functions
  21. Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft
  22. Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions
  23. Averaged kick maps: less noise, more signal…and probably less bias
  24. Essential role of Pro 74 in stefin B amyloid‐fibril formation: Dual action of cyclophilin A on the process
  25. Autocatalytic processing of procathepsin B is triggered by proenzyme activity
  26. PURY: a database of geometric restraints of hetero compounds for refinement in complexes with macromolecular structures
  27. Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B
  28. Two decades of thyroglobulin type-1 domain research
  29. 4-Substituted Trinems as Broad Spectrum β-Lactamase Inhibitors:  Structure-Based Design, Synthesis, and Biological Activity
  30. Mo6S9-xIx Nanowire Recognitive Molecular-Scale Connectivity
  31. Interpretation of ensembles created by multiple iterative rebuilding of macromolecular models
  32. Essential Role of Proline Isomerization in Stefin B Tetramer Formation
  33. Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets
  34. Density Modification In Main
  35. Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets
  36. Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain‐like endo‐ and exopeptidases
  37. Crystallization and preliminary X-ray crystallographic analysis of the cysteine protease inhibitor clitocypin
  38. Folding and amyloid‐fibril formation for a series of human stefins' chimeras: Any correlation?
  39. Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors as Guardians and Regulators
  40. Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L
  41. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft
  42. Different propensity to form amyloid fibrils by two homologous proteins—Human stefins A and B: Searching for an explanation
  43. The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis
  44. Crystal Structure of Stefin A in Complex with Cathepsin H: N-terminal Residues of Inhibitors can Adapt to the Active Sites of Endo- and Exopeptidases
  45. Lysosomal cysteine proteases (cathepsins): promising drug targets
  46. Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors As Guardians and Regulators
  47. Thiol Proteinases
  48. Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer
  49. Crystal Structure of the Soluble Form of Equinatoxin II, a Pore-Forming Toxin from the Sea Anemone Actinia equina
  50. Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase
  51. Crystal structure of the apoptotic suppressor CrmA in its cleaved form
  52. Lysosomal cysteine proteases: more than scavengers
  53. Crystal structure of cathepsin X: a flip–flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease
  54. Inhibition Mechanism of Cathepsin L-Specific Inhibitors Based on the Crystal Structure of Papain–CLIK148 Complex
  55. The p41 Fragment Story
  56. The p41 Fragment Story
  57. Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S
  58. Lysosomal cysteine proteinases: Structure and regulation
  59. Proteases New Perspectives
  60. Revised Definition of Substrate Binding Sites of Papain-Like Cysteine Proteases
  61. Crystal structure of porcine cathepsin H determined at 2.1 å resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function
  62. Crystal structure of the wild-type human procathepsin B at 2.5 Å resolution reveals the native active site of a papain-like cysteine protease zymogen
  63. Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain‐like cysteine protease and its propeptide
  64. Studies on the Lumazine Synthase/Riboflavin Synthase Complex ofBacillus subtilis: Crystal Structure Analysis of Reconstituted, Icosahedral β-subunit Capsids with Bound Substrate Analogue Inhibitor at 2.4 Å Resolution
  65. Regulation of the Activity of Lysosomal Cysteine Proteinases by pH-Induced Inactivation and/or Endogenous Protein Inhibitors, Cystatins
  66. Human Cathepsin B Is a Metastable Enzyme Stabilized by Specific Ionic Interactions Associated with the Active Site
  67. Crystallographic Determination of Thrombin Complexes With Small Synthetic Inhibitors as a Starting Point for the Receptor-Based Design of Antithrombotics
  68. Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA
  69. Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2·0Åresolution
  70. The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited humanα-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships
  71. Interactions of Thrombin with Benzamidine-based Inhibitors
  72. Geometry of binding of the Nα‐tosylated piperidides of m‐amidino‐, p‐amidino‐ and p‐guanidino phenylalanine to thrombin and trypsin
  73. Immunological studies of the toxic site in ammodytoxin A
  74. Geometry of binding of the benzamidine‐ and arginine‐based inhibitors Nα‐(2‐naphthyl‐sulphonyl‐glycyl)‐dl‐p‐amidinophenylalanyl‐piperidine (NAPAP) and (2R,4R)‐4‐methyl‐1‐[Nα‐(3‐methyl‐...
  75. Primary structure of ammodytoxin C further reveals the toxic site of ammodytoxin