All Stories

  1. Novel markers for haemogenic endothelium and haematopoietic progenitors in the mouse yolk sac

    Article • November 2025, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  2. A neurovascular template guides the spatial and functional compartmentalization of the adrenal gland

    Article • July 2025, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  3. CreER activation transiently impairs angiogenesis by slowing endothelial proliferation

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  4. A Pax3 lineage gives rise to transient haematopoietic progenitors

    Article • Development, December 2024, The Company of Biologists

    Professor Christiana Ruhrberg

  5. APax3lineage gives rise to transient haematopoietic progenitors

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  6. The BulkECexplorer compiles endothelial bulk transcriptomes to predict functional versus leaky transcription

    Article • Nature Cardiovascular Research, March 2024, Springer Science + Business Media

    Professor Christiana Ruhrberg

  7. NRP1-expressing monocyte/macrophages promote arteriogenesis in the ischemic limb

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  8. VEGF counteracts shear stress-determined arterial fate specification during capillary remodeling

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  9. CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm

    Article • Development, January 2024, The Company of Biologists

    Professor Christiana Ruhrberg

  10. Targeting NRP1 with EG00229 induces neurovascular permeability

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  11. BulkECexplorer: a bulk RNAseq compendium of five endothelial subtypes that predicts whether genes are active or leaky

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  12. A Refined Single Cell Landscape of Haematopoiesis in the Mouse Foetal Liver

    Article • Journal of Developmental Biology, March 2023, MDPI AG

    Professor Christiana Ruhrberg

  13. Motor nerves direct the development of the sympathetic nervous system

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  14. A refined single cell landscape of haematopoiesis in the mouse foetal liver

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  15. Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia

    Article • Animal Welfare, January 2023, Cambridge University Press

    Professor Christiana Ruhrberg

  16. Cre toxicity in mouse models of cardiovascular physiology and disease

    Article • Nature Cardiovascular Research, September 2022, Springer Science + Business Media

    Professor Christiana Ruhrberg

  17. Mechanisms and cell lineages in lymphatic vascular development

    Article • Angiogenesis, April 2021, Springer Science + Business Media

    David Long, Professor Christiana Ruhrberg

  18. First blood: the endothelial origins of hematopoietic progenitors

    Article • Angiogenesis, March 2021, Springer Science + Business Media

    Professor Christiana Ruhrberg

  19. KIT is required for fetal liver erythropoiesis but dispensable for angiogenesis

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  20. Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion

    Article • Circulation Research, August 2020, Wolters Kluwer Health

    Professor Christiana Ruhrberg

  21. miR-96 and miR-183 differentially regulate neonatal and adult postinfarct neovascularization

    Article • JCI Insight, July 2020, American Society for Clinical Investigation

    Professor Christiana Ruhrberg

  22. PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons

    Article • Development, November 2019, The Company of Biologists

    Professor Christiana Ruhrberg

  23. The Mouse Hindbrain As a Model for Studying Embryonic Neurogenesis

    Article • Journal of Visualized Experiments, January 2018, MyJove Corporation

    Professor Christiana Ruhrberg

  24. VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels

    Article • Development, July 2017, The Company of Biologists

    Professor Christiana Ruhrberg

  25. Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Article • eLife, June 2017, eLife

    Professor Christiana Ruhrberg

  26. VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation

    Article • Journal of Experimental Medicine, March 2017, Rockefeller University Press

    Professor Christiana Ruhrberg

  27. Regulation of embryonic neurogenesis by germinal zone vasculature

    Article • Proceedings of the National Academy of Sciences, November 2016, Proceedings of the National Academy of Sciences

    Professor Christiana Ruhrberg

  28. NRP1 function and targeting in neurovascular development and eye disease

    Article • Progress in Retinal and Eye Research, May 2016, Elsevier

    Professor Christiana Ruhrberg

  29. Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation

    Article • Science Signaling, April 2016, American Association for the Advancement of Science

    Professor Christiana Ruhrberg

  30. 2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration

    Article • Development, April 2016, The Company of Biologists

    Professor Christiana Ruhrberg

  31. Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization—Brief Report

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 2016, Wolters Kluwer Health

    Professor Christiana Ruhrberg

  32. NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells

    Article • Cell Reports, December 2015, Elsevier

    Professor Christiana Ruhrberg

  33. Vascularisation of the central nervous system

    Article • Mechanisms of Development, November 2015, Elsevier

    Professor Christiana Ruhrberg

  34. Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves

    Article • Cell, August 2015, Elsevier

    Professor Christiana Ruhrberg

  35. Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

    Article • Disease Models & Mechanisms, July 2015, The Company of Biologists

    Professor Christiana Ruhrberg

  36. Role of plexin A1 in cortical development

    Article • The Journal of Comparative Neurology, July 2015, Wiley

    Dr William David Andrews, Professor Christiana Ruhrberg

  37. Neural crest–derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation

    Article • Journal of Clinical Investigation, June 2015, American Society for Clinical Investigation

    Professor Christiana Ruhrberg

  38. NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells

    Article • Cell Reports, June 2015, Elsevier

    Professor Christiana Ruhrberg

  39. State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization

    Article • Circulation Research, May 2015, Wolters Kluwer Health

    Professor Christiana Ruhrberg

  40. Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome

    Article • Journal of Clinical Investigation, May 2015, American Society for Clinical Investigation

    Professor Christiana Ruhrberg

  41. Neural crest cell-derived VEGF promotes embryonic jaw extension

    Article • Proceedings of the National Academy of Sciences, April 2015, Proceedings of the National Academy of Sciences

    Professor Christiana Ruhrberg

  42. Neuropilins in Development and Disease of the Nervous System

    Article • January 2015, Elsevier

    Professor Christiana Ruhrberg

  43. Neural Crest Cells in Cardiovascular Development

    Article • January 2015, Elsevier

    Professor Christiana Ruhrberg

  44. The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis

    Article • January 2015, Springer Science + Business Media

    Professor Christiana Ruhrberg

  45. VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain

    Article • Development, December 2014, The Company of Biologists

    Professor Christiana Ruhrberg

  46. Neuropilin regulation of angiogenesis: Figure 1

    Article • Biochemical Society Transactions, December 2014, Portland Press Ltd.

    Professor Christiana Ruhrberg

  47. The Mouse Hindbrain: An In Vivo Model to Analyze Developmental Angiogenesis

    Article • October 2014, Springer Science + Business Media

    Professor Christiana Ruhrberg

  48. Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells

    Article • Journal of Experimental Medicine, May 2014, Rockefeller University Press

    Professor Christiana Ruhrberg

  49. Neuropilin Regulation of Angiogenesis, Arteriogenesis, and Vascular Permeability

    Article • Microcirculation, May 2014, Wiley

    Professor Christiana Ruhrberg

  50. Mouse Hindbrain Ex Vivo Culture to Study Facial Branchiomotor Neuron Migration

    Article • Journal of Visualized Experiments, March 2014, MyJove Corporation

    Professor Christiana Ruhrberg

  51. Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

    Article • Development, January 2014, The Company of Biologists

    Professor Christiana Ruhrberg

  52. Vascularisation is not necessary for gut colonisation by enteric neural crest cells

    Article • Developmental Biology, January 2014, Elsevier

    Professor Christiana Ruhrberg

  53. The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover

    Article • FEBS Letters, September 2013, Wiley

    Professor Christiana Ruhrberg

  54. The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

    Article • Developmental Cell, April 2013, Elsevier

    Professor Christiana Ruhrberg

  55. Neurovascular development and links to disease

    Article • Cellular and Molecular Life Sciences, March 2013, Springer Science + Business Media

    Professor Christiana Ruhrberg

  56. Neuropilin signalling in vessels, neurons and tumours

    Article • Seminars in Cell and Developmental Biology, March 2013, Elsevier

    Professor Christiana Ruhrberg

  57. The embryonic mouse hindbrain as a qualitative and quantitative model for studying the molecular and cellular mechanisms of angiogenesis

    Article • Nature Protocols, January 2013, Springer Science + Business Media

    Professor Christiana Ruhrberg

  58. NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis

    Article • Blood, January 2013, American Society of Hematology

    Professor Christiana Ruhrberg

  59. Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity

    Article • Cell Adhesion & Migration, November 2012, Taylor & Francis

    Professor Christiana Ruhrberg

  60. NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system

    Article • Developmental Biology, September 2012, Elsevier

    Professor Christiana Ruhrberg

  61. Semaphorin3A, Neuropilin-1, and PlexinA1 Are Required for Lymphatic Valve Formation

    Article • Circulation Research, August 2012, Wolters Kluwer Health

    Professor Christiana Ruhrberg

  62. Neuropilin Signalling in Vascular Development and Pathology

    Article • Current Angiogenesis, May 2012, Bentham Science Publishers

    Professor Christiana Ruhrberg

  63. Diverse roles for VEGF-A in the nervous system

    Article • Development, March 2012, The Company of Biologists

    Professor Christiana Ruhrberg

  64. The Hormone of Love Attracts a Partner for Life

    Article • Developmental Cell, October 2011, Elsevier

    Professor Christiana Ruhrberg

  65. The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins

    Article • Development, August 2011, The Company of Biologists

    Professor Christiana Ruhrberg

  66. VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels

    Article • Development, August 2011, The Company of Biologists

    Professor Christiana Ruhrberg

  67. Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment

    Article • August 2011, Springer Science + Business Media

    Professor Christiana Ruhrberg

  68. VEGF Signaling through Neuropilin 1 Guides Commissural Axon Crossing at the Optic Chiasm

    Article • Neuron, June 2011, Elsevier

    Professor Christiana Ruhrberg

  69. Robo1 Regulates Semaphorin Signaling to Guide the Migration of Cortical Interneurons through the Ventral Forebrain

    Article • Journal of Neuroscience, April 2011, Society for Neuroscience

    Professor Christiana Ruhrberg

  70. Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

    Article • Journal of the American Society of Nephrology, February 2011, American Society of Nephrology

    Professor Christiana Ruhrberg

  71. Neural crest origin of olfactory ensheathing glia

    Article • Proceedings of the National Academy of Sciences, November 2010, Proceedings of the National Academy of Sciences

    Professor Christiana Ruhrberg

  72. Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism

    Article • Human Molecular Genetics, November 2010, Oxford University Press (OUP)

    Professor Christiana Ruhrberg

  73. In the beginning

    Article • Cell Adhesion & Migration, October 2010, Taylor & Francis

    Professor Christiana Ruhrberg

  74. A double agent in cancer: Deciphering macrophage roles in human tumors

    Article • Nature Medicine, August 2010, Springer Science + Business Media

    Professor Christiana Ruhrberg

  75. Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

    Article • Blood, April 2010, American Society of Hematology

    Professor Christiana Ruhrberg

  76. VEGF in the nervous system

    Article • Organogenesis, April 2010, Taylor & Francis

    Professor Christiana Ruhrberg

  77. VEGF receptor signaling in vertebrate development

    Article • Organogenesis, April 2010, Taylor & Francis

    Professor Christiana Ruhrberg

  78. Neuropilin, you gotta let me know

    Article • Cell Adhesion & Migration, January 2010, Taylor & Francis

    Professor Christiana Ruhrberg

  79. Neuropilin ligands in vascular and neuronal patterning: Figure 1

    Article • Biochemical Society Transactions, December 2009, Portland Press Ltd.

    Professor Christiana Ruhrberg

  80. Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia

    Article • Development, April 2009, The Company of Biologists

    Professor Christiana Ruhrberg

  81. Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification

    Article • Proceedings of the National Academy of Sciences, April 2009, Proceedings of the National Academy of Sciences

    Professor Christiana Ruhrberg

  82. Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells

    Article • Development, December 2008, The Company of Biologists

    Professor Christiana Ruhrberg

  83. Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development

    Article • Developmental Biology, December 2008, Elsevier

    Professor Christiana Ruhrberg

  84. Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

    Article • Nature, April 2008, Springer Science + Business Media

    Professor Christiana Ruhrberg

  85. Blood Vessel Maturation and Response to Vascular-Disrupting Therapy in Single Vascular Endothelial Growth Factor-A Isoform-Producing Tumors

    Article • Cancer Research, April 2008, American Association for Cancer Research (AACR)

    Professor Christiana Ruhrberg

  86. Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells

    Article • Development, March 2008, The Company of Biologists

    Professor Christiana Ruhrberg

  87. Selective requirements for NRP1 ligands during neurovascular patterning

    Article • Development, April 2007, The Company of Biologists

    Professor Christiana Ruhrberg

  88. Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve

    Article • Genes & Development, November 2004, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  89. Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system

    Article • Developmental Dynamics, November 2004, Wiley

    Professor Christiana Ruhrberg

  90. Mapping nucleolar and spliceosome localization sequences of neuregulin1-β3

    Article • Experimental Cell Research, September 2004, Elsevier

    Professor Christiana Ruhrberg

  91. Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes

    Article • Development, December 2003, The Company of Biologists

    Professor Christiana Ruhrberg

  92. Growing and shaping the vascular tree: multiple roles for VEGF

    Article • BioEssays, October 2003, Wiley

    Professor Christiana Ruhrberg

  93. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

    Article • Journal of Cell Biology, June 2003, Rockefeller University Press

    Dr Michael Jeltsch, Professor Christiana Ruhrberg

  94. Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport

    Article • Science, May 2003, American Association for the Advancement of Science

    Professor Christiana Ruhrberg

  95. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

    Article • Genes & Development, October 2002, Cold Spring Harbor Laboratory Press

    Professor Christiana Ruhrberg

  96. Structure and Regulation of the Envoplakin Gene

    Article • Journal of Biological Chemistry, March 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Fiona M Watt, Professor Christiana Ruhrberg

  97. Envoplakin, a Possible Candidate Gene for Focal NEPPK/Esophageal Cancer (TOC): The Integration of Genetic and Physical Maps of the TOC Region on 17q25

    Article • Genomics, July 1999, Elsevier

    Professor Fiona M Watt, Professor Christiana Ruhrberg

  98. The Mouse p97 (CDC48) Gene

    Article • Journal of Biological Chemistry, April 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Christiana Ruhrberg

  99. Envoplakin and Periplakin are Components of the Paraneoplastic Pemphigus Antigen Complex

    Article • Journal of Investigative Dermatology, December 1998, Elsevier

    Professor Fiona M Watt, Professor Christiana Ruhrberg

  100. The Human Surfeit Locus

    Article • Genomics, August 1998, Elsevier

    Professor Christiana Ruhrberg

  101. The Periplakin Gene Maps to 16p13.3 in Human and 16A–B1 in Mouse

    Article • Genomics, April 1998, Elsevier

    Professor Fiona M Watt, Professor Christiana Ruhrberg

  102. Periplakin, a Novel Component of Cornified Envelopes and Desmosomes That Belongs to the Plakin Family and Forms Complexes with Envoplakin

    Article • Journal of Cell Biology, December 1997, Rockefeller University Press

    Professor Fiona M Watt, Professor Christiana Ruhrberg

  103. The plakin family: versatile organizers of cytoskeletal architecture

    Article • Current Opinion in Genetics & Development, June 1997, Elsevier

    Professor Fiona M Watt, Professor Christiana Ruhrberg

  104. Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin

    Article • Journal of Cell Biology, August 1996, Rockefeller University Press

    Professor Fiona M Watt, Professor Christiana Ruhrberg

  105. Whole chromosome 17 loss in ovarian cancer

    Article • Genes Chromosomes and Cancer, November 1993, Wiley

    Professor Christiana Ruhrberg